The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture

Abstract

Aim: In this paper, it was purposed to evaluate the antioxidant effect of fraxin against acute organ
damage induced by cecal ligation and puncture model (CLP) in rats. Material and Methods: For this
purpose in our study, all experimental animals were randomly grouped. These groups were stated as shamcontrol, CLP, CLP+Fraxin 50 mg/kg, CLP+Fraxin 100 mg/kg groups. TAS, TOS, OSI, MDA levels, MPO
and SOD activities were evaluated in kidney and lung tissues of all rats. Results: TOS, OSI, MDA levels and
MPO activity of kidney and lung tissues were higher in the CLP group than in the sham-control group, but
TAS level and SOD activity were lower. However, these results were significantly changed in the fraxin
treatment groups. Conclusion: In light of these results, it can be stated that fraxin shows a positive effect by
raising the level of SOD and TAS by decreasing TOS, MPO and MDA levels on kidney and lung tissue in the
model of sepsis caused by CLP.

Keywords

• Cecal ligation and puncture
• fraxin
• sepsis
• rat

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