Year 2019, Volume 3 , Issue 1, Pages 13 - 20 2019-04-30

The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats

Evan Abdulkarim Mahmood [1] , Tahir Kahraman [2]


Objective:Juniperus communis (JC) oil, which is among the medicinal plants, has many pharmacological activities. In this study, effects of JC oil on serum paraoxonase and pancreatic enzymes levels, lipid levels in experimental diabetic rats were investigated.

Materials and Methods:Thirty two male Wistar-Albino rats (250-300 g) were used as material. The rats were divided into four groups of control (C), diabetes (D), JC oil (J),  and diabetes + JC oil (DJ). D and DJ groups were treated with 45 mg/kg streptozotocin (STZ) (i.p.). JC oil (dissolved in distilled water (0.5% CMC)  was administered as 200 mg/kg/21 days by oral gavage in J and DJ groups.

Results:Total cholesterol (TC) and total  triglyceride (TG) levels were observed to have significantly decreased in the J and DJ groups to C and D groups (p≤0.001). There was no difference in TG levels between D group and control group. (p≥0.05). Lipoprotein levels were not statistically significant among all groups (p≥0.05). According to the control group in the diabetes and DJ groups; significantly decreased amylase levels and increased lipase levels (p≤0.001). Paraoxonase activity was have a significant decrease in D group  (p≤0.05). It was identified that the PON levels were significantly increase in the study groups when compared to the diabet group (p≤0.05).

Conclusion:The application of JC oil was effective in antihyperglycemia, antihyperlipidemic diabetes. In the other hand the antioxidant PON caused an increase. As a result, it can be effective in reducing the complications that may occur with lipids in diabetes.


Diabetes, Juniperus communis oil, Paraoxonase, Lipoproteins, Lipids
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Primary Language en
Subjects Veterinary
Journal Section 2019 Volume 3 Number 1
Authors

Orcid: 0000-0002-1960-8951
Author: Evan Abdulkarim Mahmood
Institution: Head of Pharmacy Department, National Institute of Technology, Suleymaniah
Country: Iraq


Author: Tahir Kahraman (Primary Author)
Institution: Karabuk University, Faculty of Medicine
Country: Turkey


Dates

Publication Date : April 30, 2019

Bibtex @research article { tjvr538036, journal = {Turkish Journal of Veterinary Research}, issn = {}, eissn = {2602-3695}, address = {}, publisher = {Ebubekir CEYLAN}, year = {2019}, volume = {3}, pages = {13 - 20}, doi = {}, title = {The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats}, key = {cite}, author = {Mahmood, Evan Abdulkarim and Kahraman, Tahir} }
APA Mahmood, E , Kahraman, T . (2019). The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats. Turkish Journal of Veterinary Research , 3 (1) , 13-20 . Retrieved from https://dergipark.org.tr/en/pub/tjvr/issue/44815/538036
MLA Mahmood, E , Kahraman, T . "The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats". Turkish Journal of Veterinary Research 3 (2019 ): 13-20 <https://dergipark.org.tr/en/pub/tjvr/issue/44815/538036>
Chicago Mahmood, E , Kahraman, T . "The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats". Turkish Journal of Veterinary Research 3 (2019 ): 13-20
RIS TY - JOUR T1 - The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats AU - Evan Abdulkarim Mahmood , Tahir Kahraman Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Veterinary Research JF - Journal JO - JOR SP - 13 EP - 20 VL - 3 IS - 1 SN - -2602-3695 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Veterinary Research The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats %A Evan Abdulkarim Mahmood , Tahir Kahraman %T The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats %D 2019 %J Turkish Journal of Veterinary Research %P -2602-3695 %V 3 %N 1 %R %U
ISNAD Mahmood, Evan Abdulkarim , Kahraman, Tahir . "The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats". Turkish Journal of Veterinary Research 3 / 1 (April 2019): 13-20 .
AMA Mahmood E , Kahraman T . The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats. TJVR. 2019; 3(1): 13-20.
Vancouver Mahmood E , Kahraman T . The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats. Turkish Journal of Veterinary Research. 2019; 3(1): 20-13.