VANILLIN: IS IT JUST AN AROMATIC OR A CURE FOR CANCER?
Abstract
Abstract: Cancer is one of the most challenging diseases mankind has confronted, and it is listed as the second most common reason of death according to the World Health Organization. Its damage to global economy is valued trillions of dollars and it is increasing day by day. This literature review is aiming to reflect on vanillin's anticancer potential, a natural chemical being used in different industrial areas. Beside flavour, it is a powerful antioxidant and a strong antimutagenic. Oxidative stress and mutati-ons are two major reasons for carcinogenesis. Therefore, the cancer prevention and/or therapeutic potential of vanillin is being investigated. Many studies using different cell lines have noted that vanillin had positive effects on cancer. Keywords: Cancer, reactive oxygen species, oxidative stress, vanillin
Keywords
References
- 1. Ohta T, Watanabe M, Watanabe K et al. Inhibitory effects of flavo-rings on mutagenesis induced by chemicals in bacteria. Food Chem Toxicol 1986;24:51–4.
- 2. Ho K, Yazan LS, Ismail N et al. Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. Cancer Epidemiology 2009;33:155–60.
- 3. Bythrow JD. Vanilla as a medicinal plant. Semin Integr Med 2005;3:129–31.
- 4. Raffai G, Khang G, Vanhoutte PM. Vanillin and vanillin analogs relax porcine coronary and basilar arteries by inhibiting L-type Ca21 channels. J Pharmacol Exp Ther 2015;352(1):14–22.
- 5. World Health Organization. Cancer (serial online) 2018 Sep (cited 2019 August 2). Available from: URL:https://www.who.int/news-ro-om/fact-sheets/detail/cancer.
- 6. World Health Organization. World cancer report 2014 (serial on-line) 2014 (cited 2019 August 2). Available from: URL: https://www.drugsandalcohol.ie/28525/1/World%20Cancer%20Report.pdf.
- 7. Durand N, Storz P. Targeting reactive oxygen species in develop-ment and progression of pancreatic cancer. Expert Rev Anticancer Ther 2017;17(1):19–31.
- 8. Allen JA, Coombs MM. Covalent binding of polycyclic aro-matic compounds to mitochondrial and nuclear DNA. Nature 1980;287(5779):244-5.
Details
Primary Language
English
Subjects
Clinical Sciences
Journal Section
Review
Authors
İlker Dıbırdık
This is me
Publication Date
October 30, 2019
Submission Date
September 1, 2019
Acceptance Date
October 2, 2019
Published in Issue
Year 2019 Volume: 6 Number: 3