POSSIBLE BENEFICIAL EFFECTS OF VITAMIN K AND OSTEOCALCIN ON GLUCOSE METABOLISM

Abstract

The role of vitamin K, in bone metabolism and its effects on insulin resistance and Type-2 diabetes, have been discussed. The mechanism of vitamin K’s beneficial effect on insulin sensitivity and glucose homeostasis is not yet known. Various biological active molecules such as adiponectin, leptin, and resistin, which is secreted from adipose tissue and have important roles in glu- cose metabolism, have been proposed to regulate bone metabolism. Some studies have suggested that bone metabolism is also effective on adipose tissue and energy metabolism. It is thought that osteocalcin, a vitamin K dependent protein is effective in glucose metabolism. The role of Vitamin K in glucose metabolism is thought to be partly due to the modulation of diabetes-re- lated cytokines and other metabolic risk markers, as inflammation lies at the bottom of chronic metabolic diseases. The aim of this review is to explain the effect of Vitamin K and osteocalcin on glucose metabolism and its possible mechanisms of action.

Keywords

• Vitamin K
• osteocalcin
• glucose metabolism
• type 2 diabetes
• insulin resistance

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