Chemical study of two natural substances extracted from Medicago sativa grown on different soils and analysis of their effects on the growth of some pathogenic bacteria

Abstract

To identify new phytotherapeutic molecules economically accessible and with an effective biological activity we are interested to Medicago sativa leaves extracts. Our first objective is to analysis the edaphic factor effect on the chemical characters of flavonoids and saponins. This could make easier a better control of the aspects of these extract with a view to a pharmaceutical preparation. The second objective is to determinate their antibacterial effect on some bacterial strains known for their pathogenicity in humans. The results show that the soil has an impact on the chemical composition of plant extracts.The microbial tests translate significant effects. Among the sensitivity degrees vary bacterial strains and plant extracts. These results have been encouraged to promote Medicago sativa on an appropriate soil and it is necessary to conduct additional tests to confirm the use of these substances to treat the bacterial infection.These preliminary tests allow us to justify the use of this species in traditional pharmacopoeia suggesting that their leaves possess an interesting antibacterial compounds

Keywords

• Medicago sativa, actives substances, flavonoïds, saponins, antibacterienne activity impact du facteur édaphique

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