The effect of age at the time of diagnosis in atopic dermatitis on development of additional allergic disease

Abstract

Aim: The aim of this study is to determine the effect of age at the time of diagnosis on the development of additional allergic diseases and aeroallergen sensitivity in pediatric patients with a diagnosis of AD Material and Method: The study includes 114 pediatric patients who were diagnosed with atopic dermatitis according to Hanifin and Rajka criteria After all patients were divided into two groups according to age at the time of diagnosis as less than 24 months and more than 24 months total serum IgE inhalant spesific IgE ECP levels and skin prick tests were made The additional allergic diseases developed during the follow up were recorded Results: 90 patients 78 9 were under 24 months of age 24 21 1 patients were over 24 months of age according to age at the time of diagnosis In our study group mean age at the time of diagnosis was 14 0 plusmn;21 4 months the duration for the development of additional allergic disease was 23 8 plusmn;22 3 months and mean follow up duration was 58 7 plusmn;41 2 months min 8 months max 180months ; median 50 5 months In the group who were under 24 months of age at the time of diagnosis a significant difference was determined for the development of asthma in the future p=0 042 Conclusions: To prevent the allergic process in cases in whom atopic dermatitis findings start at an early age the families should be warned about the allergic diseases associated with the respiratory system and should protect their children from the inhalant allergens Turk Arch Ped 2011; 46: 308 12

Keywords

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Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi

Öz

Amaç: Bu çalışmada atopik dermatit tanısı almış çocuk hastalarda tanı yaşının ek alerjik hastalık ve aeroalerjen duyarlılığı gelişimi üzerine etkisinin araştırılması amaçlanmıştır. 

Gereç ve Yöntem: Hanifin ve Rajka ölçütlerine göre atopik dermatit tanısı konulan 114 çocuk hasta çalışmaya alındı Tüm hastalar tanı yaşı bakımından 24 ay altı ve üstü olarak gruplandırıldıktan sonra; total serum IgE inhalan spesifik IgE eozinofil katyonik protein ECP düzeyleri deri prik testleri yapıldı İzlem süresinde gelişen ek alerjik hastalıkları kaydedildi Bu çalışma için Uludağ Üniversitesi Yerel Etik Kurul izni alındı.

Bulgular: Tanı yaşı bakımından hastalar 24 ay altı ve üstü olarak gruplandırıldığında; 90 hasta 78 9 24 ay altında 24 hasta 21 1 ise 24 ay üzerinde tanı almıştı Çalışma grubumuzdaki olguların ortalama tanı yaşı 14 0 plusmn;21 4 ay olup ek alerjik hastalık gelişimi için geçen süre 23 8 plusmn;22 3 ay ortalama izlem süresi 58 7 plusmn;41 2 ay en az 8 en fazla 180 ay; ortanca 50 5 ay olarak tespit edildi Yirmi dört ay altında tanı alanlarda ileride astım gelişimi için anlamlı bir fark saptandı p=0 042.

Çıkarımlar: Erken dönemde atopik dermatit bulguları başlayan olgularda alerjik sürecin önlenebilmesi için ailelerin solunum sistemi ile ilgili alerjik hastalıklar konusunda uyarılması ve inhalen alerjenlerden korunması bu ilerleyişte bir çözüm sağlayabilir.

Anahtar Kelimeler

• Alerji
• atopik
• atopik yürüyüş
• dermatit
• tanı yaşı

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