Idiopathic thrombocytopenic purpura in a child with acute poststreptococcal glomerulonephritis

Abstract

Acute poststreptococcal glomerulonephritis APSGN is one of the most common causes of hematuria in childhood nbsp; The hematological changes are not typical in APSGN except anemia due to hemodilution and mild hemolysis The concurrent occurence of idiopathic nbsp;thrombocytopenic purpura ITP and APSGN has very rarely been reported In this article due to its rarity we report a 13 year old boy with APSGN who simultaneously developed ITP Turk Arch Ped 2011; 46: 171 3

Keywords

• -

Akut poststreptokoksik glomerülonefritli bir çocuk hastada idiyopatik trombositopenik purpura

Öz

Akut poststreptokoksik glomerülonefrit (APSGN) çocukluk ça¤›n›n en s›k hematüri nedenlerinden biridir. Akut poststreptokoksik glomerülonefritde hematolojik de¤ifliklikler hemodilüsyon ve hafif düzeyde hemoliz nedeniyle geliflebilen anemi d›fl›nda tipik de¤ildir. ‹diyopatik trombositopenik purpura (‹TP) ve APSGN birlikteli¤i ise nadiren bildirilmektedir. Bu makalede efl zamanl› APSGN ve ‹TP saptanan 13 yafl›nda bir hasta nadir görülmesi nedeniyle sunulmufltur.

Anahtar Kelimeler

• Akut poststreptokoksik glomerülonefrit
• immün trombositopenik purpura
• çocukluk çağı

References

1. Davis ID. Idiopathic Thorombocytopenic Purpura. In: Behrman RE, Kliegman RM, Jenson HB, (eds). Textbook of Pediatrics. 18th ed. Philadelphia: WB Saunders Company, 2007: 2082.
2. Nordstrand A, Norgren M, Holm SE. Pathogenic mechanism of acute post-streptococcal glomerulonephritis. Scand J Infect Dis 1999; 31: 523-37.
3. Bolton-Maggs PH. Idiopathic thrombocytopenic purpura. Arch Dis Child 2000; 83: 220-2.
4. Guerrero AP, Musgrave JE, Lee EK. Immune globulin- responsive thrombocytopenia in acute post-streptococcal glomerulonephritis: report of a case in Hawai'i. Hawaii Med J 2009; 68: 56-8.
5. Qasim ZA, Partridge RA. Thrombotic thrombocytopenic purpura presenting as bilateral flank pain and hematuria: a case report. J Emerg Med 2001; 21: 15-20.
6. Scott J P. Acute poststreptococcal glomerulonephritis. In: Behrman RE, Kliegman RM, Jenson HB, (eds). Textbook of Pediatrics. 18th ed. Philadelphia: WB Saunders Company: 2007: 2173.
7. Kaplan BS, Esseltine D. Thrombocytopenia in patients with acute post-streptococcal glomerulonephritis. J Pediatr 1978; 93: 974-5.
8. Rizkallah MF, Ghandour MH, Sabbah R, Akhtar M. Acute thrombocytopenic purpura and poststreptococcal acute glomerulonephritis in a child. Clin Pediatr 1984; 23: 581-3.

9. Muguruma T, Koyama T, Kanadani T, Furujo M, Shiraga H, Ichiba Y. Acute thrombocytopenia associated with post- streptococcal acute glomerulonephritis. J Paediatr Child Health 2000; 36: 401-2.
10. Tasic V, Polenakovic M. Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. Turk J Pediatr 2003; 45: 148-51.
11. Toprak D, Demirdal T, Aşçı Z, Orhan S, Çetinkaya Z, Demirtürk N. Sağlıklı okul çocuklarında nazofarenksde A grubu beta hemolitik streptokok taşıyıcılığı. Düzce Tıp Fak Derg 2008; 2: 26-9. Bal ve ark.
12. APSGN ve İTP/APSGN and ITP
13. TTuurrkk AArrcchh PPeedd 22001111;; 4466:: 117711--33