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Cystatin C: can it be more reliable marker for estimation of glomerular filtration rate in children with reduced renal function?

Year 2011, , 18 - 23, 01.06.2011

Nurdan Yıldız Salim Çalışkan Levent Kabasakal Lale Sever Nil Arısoy

https://doi.org/10.4274/tpa.46.57

Abstract

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Keywords

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References

  • Rahn KH, Heidenreich S, Bruckner D. How to assess glomerular function and damage in humans. J Hypertens 1999; 17: 309-17.
  • Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38: 1933-53.
  • Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 1985; 28: 830-8.
  • Blaufox MD, Aurell M, Bubeck B, et al. Report of the radionu- clides in Nephrology committee on renal clearance. J Nucl Med 1996; 37: 1883-90.
  • Peters AM, Allison H, Ussov W. Measurement of the ratio of glomerular filtration rate to plasma volume from the tech- netium-99m diethylene triamine pentaacetic acid renogram: comparison with glomerular filtration rate in relation to extra- cellular fluid volume. Eur J Nucl Med 1994; 21: 322-7.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C-a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 1998; 101: 875-81.
  • Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 1992; 38: 20-7.
  • Jung K, Jung M. Cystatin C. A promising marker of glomerular filtration rate to replace creatinine. Nephron 1995; 70: 370-1.
  • Reed CH. Diagnostic applications of cystatin C. Br J Biomed Sci 2000; 57: 323-9.
  • Ylinen EA, Ala-Houhala M, Harmoinen APT, Knip M. Cystatin C as a marker for glomerular filtration rate in pediatric patients. Pediatr Nephrol 1999; 13: 506-9.
  • Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma concentrations of cystatin C and creatinine to inuline clearance in a pediatric population. Clin Chem 1998; 44: 1334-8.
  • Filler G, Priem F, Lepage N, et al. Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detect- ing impaired glomerular filtration rates in children. Clin Chem 2002; 48: 729-36.
  • Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 1987; 34: 571-90.
  • Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259-63.
  • Ham HR, Piepsz A. Estimation of glomerular filtration rate in infants and children using a single-plasma sample method. J Nucl Med 1991; 32: 1294-7.
  • Seikaly MG, Browne R, Bajaj G, Arant BS Jr. Limitations to body lenght/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatr Nephrol 1996; 10: 709-11.
  • Filler G, Bökenkamp A, Hofmann W, Le Bricon T, Martinez Bru C, Grubb A. Cystatin C as a marker of GFR-history, indications, and future research. Clin Biochem 2005; 38: 1-8.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Reference values for cystatin C serum concentra- tions in children. Pediatr Nephrol 1998; 12: 125-9.
  • Newman DJ, Thakkar H, Edwards RG, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47: 312-8.
  • Finney H, Newman DJ, Thakkar H, Fell JM, Price CP. Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 2000; 82: 71-5.
  • Grubb A, Nyman U, Bjork J, et al. A simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem 2005; 51: 1420-31.
  • Zappitelli M, Parvex P, Joseph L, et al. Derivation and validation of cystatin C-based prediction equations for GFR in children. Am J Kidney Dis 2006; 48: 221-30.
  • Hojs R, Bevc S, Ekart R, Gorenjak M, Puklave L. Serum cystatin C-based formulas for prediction of glomerular filtration rate in patients with chronic kidney disease. Nephron Clin Pract 2010; 114: 118-26.
  • Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 2003; 18: 981-5.
  • Filler G, Priem F, Vollmer I, Gellermann J, Jung K. Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol 1999; 13: 501-5.
  • Eriksen BO, Mathisen UD, Melsom T, et al. Cystatin C is not a better estimator of GFR than plasma creatinine in the general population. Kidney Int 2010; 78: 1305-11.
  • Andersen TB, Jensen AE, Frokiaer J, Brochner-Mortensen J. Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review. Pediatr nephrol 2009; 24: 929-41.
  • Bouvet Y, Bouissou F, Coulais Y, et al. GFR is better estimated by considering both serum cystatin C and creatinine levels. Pediatr Nephrol 2006; 21: 1299-306.
  • Mussap M, Ruzzante N, Varagnolo M, Plebani M. Quantitative automated particle-enhanced immunonephelometric assay for the routinary measurement of human cystatin C. Clin Chem Lab Med 1998; 36: 859-65.
  • Kyhse-Andersen J, Schmidt C, Nordin G, et al. Serum Cystatin C, determined by a rapid, automated particle-enhanced tur- bidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem 1994; 40: 1921-6.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C- a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 1998; 101: 875-81.
  • Çabukoğlu S, Alpay H, Bıyıklı NK, Noşari OA, Topçu G. Spina bifidalı çocuklarda dietilen triamin pentaasetik asit klirensi temel alınarak serum sistatin C ve kreatinin değerlerinin karşılaştırılması. Türk Nefroloji Diyaliz Transplantasyon Dergisi 2002; 11: 241-5.
  • Herget-Rosenthal S, Marggraf G, Hüsing J, et al. Early detection of acute renal failure by serum cystatin C. Kidney Int 2004; 66: 1115-22.
  • Nejat M, Pickering JW, Walker RJ, Endre ZH. Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol Dial Transplant 2010; 25: 3283-9.
  • Risch L, Herklotz R, Blumberg A, Huber AR. Effects of glucocorticoid immunosupression on serum cystatin C concentrations in renal transplant patients. Clin Chem 2001; 47: 2055-9.
  • Okura T, Jotoku M , Irita J, et al. Association between cystatin C and inflammation in patients with essential hypertension. Clin Exp Nephrol 2010; 14: 584-8.
  • den Hollander JG, Wulkan RW, Mantel MJ, Berghout A. Is cystatin C a marker of glomerular filtration rate in thyroid dysfunction? Clin Chem 2003; 49: 1558-9.
  • Sahakyan K, Klein BEK, Lee KE, Tsai MY, Klein R. Serum Cystatin C and the incidence of hypertension in type 1 diabetes mellitus. Am J Hypertens 2010; 24: 59-63.
  • Shlipak MG, Katz R, Cushman M, et al. Cystatin-C and inflammatory markers in the ambulatory elderly. Am J Med 2005; 118: 1416.

Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?

Year 2011, , 18 - 23, 01.06.2011

Nurdan Yıldız Salim Çalışkan Levent Kabasakal Lale Sever Nil Arısoy

https://doi.org/10.4274/tpa.46.57

Abstract

Amaç: Bu çal›flmada böbrek ifllevleri azalmakta olan çocuklarda glomerül filtrasyon h›z› tayininde serum sistatin C’nin kreatinine göre daha iyi bir de¤iflken olup olmad›¤› araflt›r›ld›. Gereç ve

Yöntem: Göztepe E¤itim-Araflt›rma Hastanesi ve Cerrahpafla T›p Fakültesi Çocuk Nefroloji Poliklinikleri’nde izlenen 100 çocuk (53 k›z/47 erkek) çal›flmaya al›nd›. Çal›flmada alt›n standart olarak dietilen triamin penta asetat (DTPA) klirensi al›nd›. Dietilen triamin penta asetat klirensi 80mL/dak/1,73m2’nin üstünde olan olgular birinci gruba (n=64), alt›ndakiler ikinci gruba (n=36) al›nd›. Olgular›n serum sistatin C ve kreatinin düzeyleri ölçüldü, glomerül filtrasyon h›z› Schwartz formülüyle (GFH schw) hesapland›. De¤iflkenlerin tan›sal de¤erleri ROC analizi ile de¤erlendirildi. Tüm çocuklar›n ailelerinden imzalanm›fl ayd›nlat›lm›fl onay formu al›nd›.

Bulgular: Olgular›n 53’ü k›z, 47’si erkek olup yafllar› ortalama 8,4±5,1 (0,17-20,5) y›l idi. Birinci gruba 64 olgu, ikinci gruba 36 olgu al›nd›. Olgular›n serum sistatin C ve kreatinin düzeyleri ile GFHSchw aras›nda her iki grupta anlaml› bir iliflki saptand› (p<0,01). Serum kreatinin ve sistatin C düzeyleri ile GFHDTPA aras›nda böbrek ifllevi azalm›fl olgularda anlaml› bir iliflki bulundu, böbrek ifllevleri normal olgularda ise iliflki bulunmad›. Sonuçlar ROC analiziyle  ¤erlendirildi¤inde serum sistatin C ve GFHSchw için ROC e¤risi alt›nda kalan alan de¤erleri istatistiksel olarak anlaml› bulundu ancak alan de¤erleri aras›nda belirgin farkl›l›k gözlenmedi.

Çıkarımlar: Serum sistatin C düzeyleri GFH ölçümünde yararl› ancak serum kreatinin ve GFHSchw‘e üstünlü¤ü olmayan bir de¤iflkendir. Böbrek ifllevleri normal ve azalm›fl çocuklarda GFH izleminde GFHSchw basit ve yeterli bir yöntemdir.

Keywords

Böbrek işlevleri glomerül filtrasyon hızı Schwartz formülü sistatin C

References

  • Rahn KH, Heidenreich S, Bruckner D. How to assess glomerular function and damage in humans. J Hypertens 1999; 17: 309-17.
  • Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38: 1933-53.
  • Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 1985; 28: 830-8.
  • Blaufox MD, Aurell M, Bubeck B, et al. Report of the radionu- clides in Nephrology committee on renal clearance. J Nucl Med 1996; 37: 1883-90.
  • Peters AM, Allison H, Ussov W. Measurement of the ratio of glomerular filtration rate to plasma volume from the tech- netium-99m diethylene triamine pentaacetic acid renogram: comparison with glomerular filtration rate in relation to extra- cellular fluid volume. Eur J Nucl Med 1994; 21: 322-7.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C-a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 1998; 101: 875-81.
  • Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 1992; 38: 20-7.
  • Jung K, Jung M. Cystatin C. A promising marker of glomerular filtration rate to replace creatinine. Nephron 1995; 70: 370-1.
  • Reed CH. Diagnostic applications of cystatin C. Br J Biomed Sci 2000; 57: 323-9.
  • Ylinen EA, Ala-Houhala M, Harmoinen APT, Knip M. Cystatin C as a marker for glomerular filtration rate in pediatric patients. Pediatr Nephrol 1999; 13: 506-9.
  • Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma concentrations of cystatin C and creatinine to inuline clearance in a pediatric population. Clin Chem 1998; 44: 1334-8.
  • Filler G, Priem F, Lepage N, et al. Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detect- ing impaired glomerular filtration rates in children. Clin Chem 2002; 48: 729-36.
  • Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 1987; 34: 571-90.
  • Schwartz GJ, Haycock GB, Edelman CM Jr, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259-63.
  • Ham HR, Piepsz A. Estimation of glomerular filtration rate in infants and children using a single-plasma sample method. J Nucl Med 1991; 32: 1294-7.
  • Seikaly MG, Browne R, Bajaj G, Arant BS Jr. Limitations to body lenght/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatr Nephrol 1996; 10: 709-11.
  • Filler G, Bökenkamp A, Hofmann W, Le Bricon T, Martinez Bru C, Grubb A. Cystatin C as a marker of GFR-history, indications, and future research. Clin Biochem 2005; 38: 1-8.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Reference values for cystatin C serum concentra- tions in children. Pediatr Nephrol 1998; 12: 125-9.
  • Newman DJ, Thakkar H, Edwards RG, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47: 312-8.
  • Finney H, Newman DJ, Thakkar H, Fell JM, Price CP. Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 2000; 82: 71-5.
  • Grubb A, Nyman U, Bjork J, et al. A simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem 2005; 51: 1420-31.
  • Zappitelli M, Parvex P, Joseph L, et al. Derivation and validation of cystatin C-based prediction equations for GFR in children. Am J Kidney Dis 2006; 48: 221-30.
  • Hojs R, Bevc S, Ekart R, Gorenjak M, Puklave L. Serum cystatin C-based formulas for prediction of glomerular filtration rate in patients with chronic kidney disease. Nephron Clin Pract 2010; 114: 118-26.
  • Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 2003; 18: 981-5.
  • Filler G, Priem F, Vollmer I, Gellermann J, Jung K. Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol 1999; 13: 501-5.
  • Eriksen BO, Mathisen UD, Melsom T, et al. Cystatin C is not a better estimator of GFR than plasma creatinine in the general population. Kidney Int 2010; 78: 1305-11.
  • Andersen TB, Jensen AE, Frokiaer J, Brochner-Mortensen J. Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review. Pediatr nephrol 2009; 24: 929-41.
  • Bouvet Y, Bouissou F, Coulais Y, et al. GFR is better estimated by considering both serum cystatin C and creatinine levels. Pediatr Nephrol 2006; 21: 1299-306.
  • Mussap M, Ruzzante N, Varagnolo M, Plebani M. Quantitative automated particle-enhanced immunonephelometric assay for the routinary measurement of human cystatin C. Clin Chem Lab Med 1998; 36: 859-65.
  • Kyhse-Andersen J, Schmidt C, Nordin G, et al. Serum Cystatin C, determined by a rapid, automated particle-enhanced tur- bidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem 1994; 40: 1921-6.
  • Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C- a new marker of glomerular filtration rate in children independent of age and height. Pediatrics 1998; 101: 875-81.
  • Çabukoğlu S, Alpay H, Bıyıklı NK, Noşari OA, Topçu G. Spina bifidalı çocuklarda dietilen triamin pentaasetik asit klirensi temel alınarak serum sistatin C ve kreatinin değerlerinin karşılaştırılması. Türk Nefroloji Diyaliz Transplantasyon Dergisi 2002; 11: 241-5.
  • Herget-Rosenthal S, Marggraf G, Hüsing J, et al. Early detection of acute renal failure by serum cystatin C. Kidney Int 2004; 66: 1115-22.
  • Nejat M, Pickering JW, Walker RJ, Endre ZH. Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol Dial Transplant 2010; 25: 3283-9.
  • Risch L, Herklotz R, Blumberg A, Huber AR. Effects of glucocorticoid immunosupression on serum cystatin C concentrations in renal transplant patients. Clin Chem 2001; 47: 2055-9.
  • Okura T, Jotoku M , Irita J, et al. Association between cystatin C and inflammation in patients with essential hypertension. Clin Exp Nephrol 2010; 14: 584-8.
  • den Hollander JG, Wulkan RW, Mantel MJ, Berghout A. Is cystatin C a marker of glomerular filtration rate in thyroid dysfunction? Clin Chem 2003; 49: 1558-9.
  • Sahakyan K, Klein BEK, Lee KE, Tsai MY, Klein R. Serum Cystatin C and the incidence of hypertension in type 1 diabetes mellitus. Am J Hypertens 2010; 24: 59-63.
  • Shlipak MG, Katz R, Cushman M, et al. Cystatin-C and inflammatory markers in the ambulatory elderly. Am J Med 2005; 118: 1416.
There are 39 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Article
Authors

Nurdan Yıldız This is me

Salim Çalışkan This is me

Levent Kabasakal This is me

Lale Sever This is me

Nil Arısoy This is me

Publication Date June 1, 2011
Published in Issue Year 2011

Cite

APA Yıldız, N., Çalışkan, S., Kabasakal, L., Sever, L., et al. (2011). Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?. Türk Pediatri Arşivi, 46(2), 18-23. https://doi.org/10.4274/tpa.46.57
AMA Yıldız N, Çalışkan S, Kabasakal L, Sever L, Arısoy N. Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?. Türk Pediatri Arşivi. June 2011;46(2):18-23. doi:10.4274/tpa.46.57
Chicago Yıldız, Nurdan, Salim Çalışkan, Levent Kabasakal, Lale Sever, and Nil Arısoy. “Sistatin C: Böbrek işlevleri Azalmakta Olan çocuklarda glomerüler Filtrasyon hızı ölçümünde Daha Yararlı Bir değişken Olabilir Mi?”. Türk Pediatri Arşivi 46, no. 2 (June 2011): 18-23. https://doi.org/10.4274/tpa.46.57.
EndNote Yıldız N, Çalışkan S, Kabasakal L, Sever L, Arısoy N (June 1, 2011) Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?. Türk Pediatri Arşivi 46 2 18–23.
IEEE N. Yıldız, S. Çalışkan, L. Kabasakal, L. Sever, and N. . Arısoy, “Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?”, Türk Pediatri Arşivi, vol. 46, no. 2, pp. 18–23, 2011, doi: 10.4274/tpa.46.57.
ISNAD Yıldız, Nurdan et al. “Sistatin C: Böbrek işlevleri Azalmakta Olan çocuklarda glomerüler Filtrasyon hızı ölçümünde Daha Yararlı Bir değişken Olabilir Mi?”. Türk Pediatri Arşivi 46/2 (June 2011), 18-23. https://doi.org/10.4274/tpa.46.57.
JAMA Yıldız N, Çalışkan S, Kabasakal L, Sever L, Arısoy N. Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?. Türk Pediatri Arşivi. 2011;46:18–23.
MLA Yıldız, Nurdan et al. “Sistatin C: Böbrek işlevleri Azalmakta Olan çocuklarda glomerüler Filtrasyon hızı ölçümünde Daha Yararlı Bir değişken Olabilir Mi?”. Türk Pediatri Arşivi, vol. 46, no. 2, 2011, pp. 18-23, doi:10.4274/tpa.46.57.
Vancouver Yıldız N, Çalışkan S, Kabasakal L, Sever L, Arısoy N. Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?. Türk Pediatri Arşivi. 2011;46(2):18-23.