Abstract
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Keywords
References
- Celkan T. Akut Lenfoblastik lösemi. İçinde: Alp Özkan (yazar). Pediatrik Onkoloji. İstanbul: Nobel kitapevi, 2009; 451-63.
- Miers MK, Exton MG, Daniele C. Cell-counting and coagula- tion instrumentation. In: Bernadette FR (ed). Diagnostic Hematology. Philedelphia: WB Saunders, 1995: 599-631.
- Breedveld FC, Bieger R, van Wermeskerken RK. The clinical significance of macrocytosis. Acta Med Scand 1981; 209: 319-22.
- Keenan WF Jr. Macrocytosis as an indicator of human disease. J Am Board Fam Pract 1989; 2: 252-6.
- Wymer A, Becker DM. Recognition and evaluation of red blood cell macrocytosis in the primary care setting. J Gen Intern Med 1990; 5: 192-7.
- Davidson RJ, Hamilton PJ. High mean red cell volume: its incidence and significance in routine haematology. J Clin Pathol 1978; 31: 493-8.
- Pappo AS, Fields BW, Buchanan GR. Etiology of red blood cell macrocytosis during childhood: impact of new diseases and therapies. Pediatrics 1992; 89: 1063-7.
- Akira Yokoyama, Tetsuji Yokoyama, Taro Muramatsu. Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis, 2003; 24: 1773- 8.
- Fujimori S, Kishida T, Mitsui K, et al. Mean corpuscular volume (MCV) and the risk of colorectal adenoma in menopausal women. Hepatogastroenterology 2003; 50: 392-5.
- Outeirino Perez JJ, Sanchez Fayos J, Outeirino Hernanz J, et al. Hematologic significance of erythrocytic macrocytosis: prospective analysis of 109 successively studied cases. Sangre (Barc) 1989; 34: 32-40.
- Bessman JD, Banks D. Spurious macrocytosis, a common clue to erythrocyte cold agglutinins. Am J Clin Pathol 1980 ;74: 797-800.
- White DH, Chapman PT, O'Donnell JL, James J, Frampton C, Stamp LK. Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis. Intern Med J 2010; 40: 561-5.
- Song MK, Chung JS, Seol YM, et al. Mean cell volume can be an early predictor for the cytogenetic response of chronic myeloid leukemia patients treated with imatinib? Leuk Res 2009; 33: 1459-62.
Abstract
Amaç: Eritrosit ortalama hacmi (MCV) özellikle anemilerin s›n›fland›r›lmas›nda kullan›lan, otomatik kan say›m cihazlar›n›n günlük kullan›ma girmesinden sonra kolay de¤erlendirilebilen bir kan de¤iflkenidir. Folik asit antagonistleri, DNA sentez inhibitörleri ve siklofosfamid içeren protokollerin kullan›ld›¤› kemoterapi yönteminde eritrosit ortalama hacmi’nin yükseldi¤i bilinmektedir. Lösemili hastalar›m›zda kemoterapi etkisi ile MCV de¤ifliminin ve tedavi sonras› de¤erlerinin seyir ve nüks ile iliflkisini incelemeyi hedefledik.
Gereç ve Yöntem: Ocak 1995 sonras›nda Cerrahpafla T›p Fakültesi, Çocuk Hematoloji-Onkoloji Bilim Dal›’nda tan› ve tedavi alm›fl 125 akut lenfoblastik lösemi hastas›n›n dosyas› geriye dönük olarak incelendi. Olgular›n (yafllar› 1-15 ortalama 5,99+ 3,94 olan 42 k›z, 83 erkek) tan› s›ras›nda, yo¤un kemoterapi bitiminde ve idame tedavi sonras›nda MCV de¤erlerine bak›ld›. Bulgular: Hastalar›n tan› s›ras›nda, yo¤un kemoterapi bitiminde ve idame tedavi sonras›nda MCV de¤erleri s›ras› ile 78,5+3,9 fL; 89,1+6,8 fL ve 95,6+3,8 fL olarak bulundu. Tedavi sonras›nda MCV de¤erlerinin ortalama ayda 1 fL geriledi¤ini saptand›. Bir talasemi minör olan olgumuzun antimetabolitlere ra¤men MCV de¤erlerinin maksimum 73 fL oldu¤unu gördük. Nüks saptanan 15 olgunun verileri 110 nüks saptanmayan olgu ile karfl›laflt›r›ld›. Aralar›nda MCV de¤erleri aç›s›ndan anlaml› fark saptanmad› (p>0,05).
Çıkarımlar: Eritrosit ortalama hacmi’nin lösemi izleminde seyir ve nüks aç›s›ndan önemi gösterilememifltir.
References
- Celkan T. Akut Lenfoblastik lösemi. İçinde: Alp Özkan (yazar). Pediatrik Onkoloji. İstanbul: Nobel kitapevi, 2009; 451-63.
- Miers MK, Exton MG, Daniele C. Cell-counting and coagula- tion instrumentation. In: Bernadette FR (ed). Diagnostic Hematology. Philedelphia: WB Saunders, 1995: 599-631.
- Breedveld FC, Bieger R, van Wermeskerken RK. The clinical significance of macrocytosis. Acta Med Scand 1981; 209: 319-22.
- Keenan WF Jr. Macrocytosis as an indicator of human disease. J Am Board Fam Pract 1989; 2: 252-6.
- Wymer A, Becker DM. Recognition and evaluation of red blood cell macrocytosis in the primary care setting. J Gen Intern Med 1990; 5: 192-7.
- Davidson RJ, Hamilton PJ. High mean red cell volume: its incidence and significance in routine haematology. J Clin Pathol 1978; 31: 493-8.
- Pappo AS, Fields BW, Buchanan GR. Etiology of red blood cell macrocytosis during childhood: impact of new diseases and therapies. Pediatrics 1992; 89: 1063-7.
- Akira Yokoyama, Tetsuji Yokoyama, Taro Muramatsu. Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis, 2003; 24: 1773- 8.
- Fujimori S, Kishida T, Mitsui K, et al. Mean corpuscular volume (MCV) and the risk of colorectal adenoma in menopausal women. Hepatogastroenterology 2003; 50: 392-5.
- Outeirino Perez JJ, Sanchez Fayos J, Outeirino Hernanz J, et al. Hematologic significance of erythrocytic macrocytosis: prospective analysis of 109 successively studied cases. Sangre (Barc) 1989; 34: 32-40.
- Bessman JD, Banks D. Spurious macrocytosis, a common clue to erythrocyte cold agglutinins. Am J Clin Pathol 1980 ;74: 797-800.
- White DH, Chapman PT, O'Donnell JL, James J, Frampton C, Stamp LK. Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis. Intern Med J 2010; 40: 561-5.
- Song MK, Chung JS, Seol YM, et al. Mean cell volume can be an early predictor for the cytogenetic response of chronic myeloid leukemia patients treated with imatinib? Leuk Res 2009; 33: 1459-62.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Publication Date | June 1, 2011 |
| Published in Issue | Year 2011 |