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Elevated TSH levels in obese children: What kind of problem is it?

Year 2011, , 33 - 36, 01.03.2011
https://doi.org/10.4274/tpa.46.06

Abstract

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References

  • Nyrnes A, Jorde R, Sundsfjord J. Serum TSH is positively associated with BMI. Int J Obes (Lond) 2006; 30: 100-5. (Abstract) / (Full Text)
  • Knudsen N, Laurberg P, Rasmussen LB, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. Clin Endocrinol Metab 2005; 90: 4019-24. (Abstract) / (Full Text) / (PDF)
  • Moulin de Moraes CM, Mancini MC, de Melo ME, et al. Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass. Obes Surg 2005; 15: 1287-91. (Abstract) / (PDF)
  • Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 115: 500-3. (Abstract) / (Full Text) / (PDF)
  • Stichel H, l'Allemand D, Grüters A. Thyroid function and obesity in children and adolescents. Horm Res 2000; 54: 14-9. (Abstract) / (Full Text) / (PDF)
  • Dekelbab BH, Abou Ouf HA, Jain I. Prevalence of elevated thyroid-stimulating hormone levels in obese children and adolescents. Endocr Pract 2010;16:187-90. (Abstract) / (PDF)
  • Reinehr T, Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child 2002; 87: 320-3. (Abstract) / (Full Text) / (PDF)
  • Erdoğan MF, Ağbaht K, Altunsu T, et al. Current iodine status in Turkey. J Endocrinol Invest 2009; 32: 617-22. (Abstract)
  • Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol 2010; 316: 165-71. (Abstract) / (PDF)
  • Rohner-Jeanrenaud F, Jeanrenaud B. The discovery of leptin and its impact in the understanding of obesity. Euro J Endocrinol 1996; 135: 649-50. (Abstract) / (PDF)
  • Légrádi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced supression of prothyrotropin- releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997;138: 2569-76. (Abstract) / (Full Text) / (PDF)
  • Kim MS, Small CJ, Stanley SA, et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 2000; 105: 1005-11. (Abstract) / (PDF)
  • Bastemir M, Akin F, Alkis E, Kaptanoglu B. Obesity is associa- ted with increased serum TSH level, independent of thyroid function. Swiss Med Wkly 2007; 137: 431-4. (Abstract) / (PDF)
  • Hari Kumar KV, Verma A, Muthukrishnan J, Modi KD. Obesity and thyrotropinemia. Indian J Pediatr 2009; 76: 933-5. (Abstract) / (PDF)
  • Galofré JC, Pujante P, Abreu C, et al. Relationship between thyroid-stimulating hormone and insulin in euthyroid obese men. Ann Nutr Metab 2008; 53: 188- 94. (Abstract) / (Full Text) / (PDF)
  • Eliakim A, Barzilai M, Wolach B, Nemet D. Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents ? Int J Pediatr Obes 2006; 1: 217-21. (Abstract)

Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?

Year 2011, , 33 - 36, 01.03.2011
https://doi.org/10.4274/tpa.46.06

Abstract

Amaç: fiiflmanl›¤›n çocuklarda tiroid hormonlar› üzerine etkilerinin araflt›r›lmas›.

Gereç ve Yöntem: Çocuk endokrinoloji ve diyabet poliklini¤inde Mart 2006- May›s 2009 tarihleri aras›nda fliflmanl›k tan›s› ile izlenen 132 olgunun dosyalar› geriye dönük olarak incelendi. Antropometrik ölçümleri, kan lipit düzeyleri, tiroid hormon düzeyleri, açl›k kan flekeri ve insulin düzeyleri de¤erlendirildi. HOMA-IR (homeostasis model assessment of insulin resistance) <3,16 olan ile >3,16 olan olgular›n TSH (tiroid uyar›c› hormon) düzeyleri karfl›laflt›r›ld›. Tiroid uyar›c› düzeyi ile beden kitle indeksi (BK‹) ve HOMA-IR düzeyleri aras›ndaki iliflki incelendi. Veriler SPSS 13.0 istatistik program› ile analiz edildi. Ba¤›ms›z gruplar aras›ndaki karfl›laflt›rmalar ki-kare testi ile, korelasyon analizi ‘Pearson yöntemi’ ile yap›ld›. Anlaml›l›k s›n›r› p<0,05 olarak kabul edildi.

Bulgular: On yedi olgunun TSH de¤eri (%12,9) 97,5 persantilin üzerinde, 51 olgunun (%38,7) TSH de¤eri ise 90. persantilin üzerinde saptand›. TSH de¤eri >97,5 persantil olan hiçbir olgunun serbest/total T4 düzeyi normalin alt›nda de¤ildi. HOMA-IR<3,16 olan olgular ile HOMA-IR >3,16 olan olgular TSH düzeyleri aç›s›ndan karfl›laflt›r›ld›¤›nda istatistiksel olarak anlaml› fark bulunmad›. TSH ile BK‹ ve HOMA-IR de¤eri aras›nda pozitif yönde, zay›f derecede, istatistiksel olarak anlaml› olmayan bir iliflki saptand›.

Çıkarımlar: fiiflman çocuklarda TSH düzeyi, tiroid ifllevleri etkilenmeksizin yükselmifl olabilir, bu durum hipotiroidi lehine de¤erlendirilmemeli ve ilk de¤erlendirmede L-tiroksin tedavisi bafllanmamal›d›r. 

References

  • Nyrnes A, Jorde R, Sundsfjord J. Serum TSH is positively associated with BMI. Int J Obes (Lond) 2006; 30: 100-5. (Abstract) / (Full Text)
  • Knudsen N, Laurberg P, Rasmussen LB, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. Clin Endocrinol Metab 2005; 90: 4019-24. (Abstract) / (Full Text) / (PDF)
  • Moulin de Moraes CM, Mancini MC, de Melo ME, et al. Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass. Obes Surg 2005; 15: 1287-91. (Abstract) / (PDF)
  • Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 115: 500-3. (Abstract) / (Full Text) / (PDF)
  • Stichel H, l'Allemand D, Grüters A. Thyroid function and obesity in children and adolescents. Horm Res 2000; 54: 14-9. (Abstract) / (Full Text) / (PDF)
  • Dekelbab BH, Abou Ouf HA, Jain I. Prevalence of elevated thyroid-stimulating hormone levels in obese children and adolescents. Endocr Pract 2010;16:187-90. (Abstract) / (PDF)
  • Reinehr T, Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child 2002; 87: 320-3. (Abstract) / (Full Text) / (PDF)
  • Erdoğan MF, Ağbaht K, Altunsu T, et al. Current iodine status in Turkey. J Endocrinol Invest 2009; 32: 617-22. (Abstract)
  • Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol 2010; 316: 165-71. (Abstract) / (PDF)
  • Rohner-Jeanrenaud F, Jeanrenaud B. The discovery of leptin and its impact in the understanding of obesity. Euro J Endocrinol 1996; 135: 649-50. (Abstract) / (PDF)
  • Légrádi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced supression of prothyrotropin- releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997;138: 2569-76. (Abstract) / (Full Text) / (PDF)
  • Kim MS, Small CJ, Stanley SA, et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 2000; 105: 1005-11. (Abstract) / (PDF)
  • Bastemir M, Akin F, Alkis E, Kaptanoglu B. Obesity is associa- ted with increased serum TSH level, independent of thyroid function. Swiss Med Wkly 2007; 137: 431-4. (Abstract) / (PDF)
  • Hari Kumar KV, Verma A, Muthukrishnan J, Modi KD. Obesity and thyrotropinemia. Indian J Pediatr 2009; 76: 933-5. (Abstract) / (PDF)
  • Galofré JC, Pujante P, Abreu C, et al. Relationship between thyroid-stimulating hormone and insulin in euthyroid obese men. Ann Nutr Metab 2008; 53: 188- 94. (Abstract) / (Full Text) / (PDF)
  • Eliakim A, Barzilai M, Wolach B, Nemet D. Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents ? Int J Pediatr Obes 2006; 1: 217-21. (Abstract)
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Research
Authors

R. Gül Yeşiltepe Mutlu This is me

Elif Özsu This is me

Filiz Mine Çizmecioğlu This is me

Şükrü Hatun This is me

Publication Date March 1, 2011
Published in Issue Year 2011

Cite

APA Mutlu, R. G. Y., Özsu, E., Çizmecioğlu, F. M., Hatun, Ş. (2011). Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?. Türk Pediatri Arşivi, 46(1), 33-36. https://doi.org/10.4274/tpa.46.06
AMA Mutlu RGY, Özsu E, Çizmecioğlu FM, Hatun Ş. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?. Türk Pediatri Arşivi. March 2011;46(1):33-36. doi:10.4274/tpa.46.06
Chicago Mutlu, R. Gül Yeşiltepe, Elif Özsu, Filiz Mine Çizmecioğlu, and Şükrü Hatun. “Şişman çocuklarda Hafif TSH yüksekliği: Nasıl Bir Sorun?”. Türk Pediatri Arşivi 46, no. 1 (March 2011): 33-36. https://doi.org/10.4274/tpa.46.06.
EndNote Mutlu RGY, Özsu E, Çizmecioğlu FM, Hatun Ş (March 1, 2011) Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?. Türk Pediatri Arşivi 46 1 33–36.
IEEE R. G. Y. Mutlu, E. Özsu, F. M. Çizmecioğlu, and Ş. Hatun, “Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?”, Türk Pediatri Arşivi, vol. 46, no. 1, pp. 33–36, 2011, doi: 10.4274/tpa.46.06.
ISNAD Mutlu, R. Gül Yeşiltepe et al. “Şişman çocuklarda Hafif TSH yüksekliği: Nasıl Bir Sorun?”. Türk Pediatri Arşivi 46/1 (March 2011), 33-36. https://doi.org/10.4274/tpa.46.06.
JAMA Mutlu RGY, Özsu E, Çizmecioğlu FM, Hatun Ş. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?. Türk Pediatri Arşivi. 2011;46:33–36.
MLA Mutlu, R. Gül Yeşiltepe et al. “Şişman çocuklarda Hafif TSH yüksekliği: Nasıl Bir Sorun?”. Türk Pediatri Arşivi, vol. 46, no. 1, 2011, pp. 33-36, doi:10.4274/tpa.46.06.
Vancouver Mutlu RGY, Özsu E, Çizmecioğlu FM, Hatun Ş. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun?. Türk Pediatri Arşivi. 2011;46(1):33-6.