Level of serum 25 OHD in healthy children aged 0 36 months in Van Original Article

Abstract

Summary Aim: In recent studies it has been shown that prevalence of rachitism and vitamin D deficiency depend on regional differences such as climate socioeconomic level and changing benefits of people from health services Even if no clinical symptom has occurred serum 25 hydroxy D 25 OHD level which is the best indicator of vitamin D can be found low Material and Method: In this study serum 25 OHD levels of 112 healthy children aging 0 36 months who applied to the outpatient clinic of the Pediatrics and Gynecology Hospital for a routine control in Van were analyzed Nutrition style of mothers and their babies duration of exposing to sunlight and taken vitamin supplements were evaluated Serum Ca P alkaline phosphatase and 25 OHD levels were studied and the left wrist x rays were obtained Abdominal ultrasonography was performed only the babies with serum 25 OHD level gt;150 ng mL Results: In our study despite no clinical symptoms of rachitism regardless of gender 25 OHD level lt;40 ng mL was determined in 53 5 of the children and in 13 3 of these childrens serum level of 25 OHD was as low as lt;5 ng mL and suffering from heavy vitamin D deficieny Conclusions: The breast fed babies with no vitamin supplement did not show any sign of vitamin deficiency but in 25 OHD levels were significantly low compared to the breast fed babies with vitamin supplement Turk Arch Ped 2010; 45: 286 90 Key words: Alkaline phosphatese calcium phosphorus rachitism vitamin 25 OHD

Keywords

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Van ilindeki 0 36 ay arası sağlıklı çocuklarda serum 25 OHD düzeyi Özgün Araştırma

Abstract

Özet Amaç: Günümüzde yapılan çalışmalarda raşitizmin ve D vitamini eksikliği görülme sıklığının iklime toplumun sosyoekonomik düzeyine ve bölgenin sağlık hizmetlerinden faydalanma derecesine göre yöresel değişmelere bağlı olduğu gösterilmiştir Herhangi bir klinik belirti ortaya çıkmamış olsa bile vücut D vitamini düzeyinin en iyi göstergesi olan serum 25 hidroksi D 25 OHD düzeyi düşük saptanabilir Gereç ve Yöntem: Bu çalışmada normal kontrol için Van Kadın Doğum ve Çocuk Hastalıkları Hastanesi Çocuk Polikliniği rsquo;ne başvuran 0 36 ay arası sağlıklı 112 çocukta serum 25 OHD düzeyi araştırıldı Bu amaçla annelerin ve bebeklerin beslenme tipi ve D vitamini desteği alıp almadığı güneş ışığından yararlanma süresi değerlendirildi; Serum Ca P alkalen fosfataz ve 25 OHD düzeyleri çalışıldı Sol el bilek grafileri çekildi Serum 25 OHD düzeyi gt;150 ng mL saptanan bebeklere karın ultrasonografisi yapıldı Bulgular: Çalışmamızda raşitizmin herhangi bir klinik bulgusu olmamasına karşın ve cinsiyet farkı gözetmeksizin incelendiğinde çocukların 53 5 rsquo;inde serum 25 OHD düzeyi lt;40 ng mL saptandı bu çocukların 13 3 rsquo;ünde ise serum 25 OHD düzeyi lt;5 ng mL olup ağır D vitamini yetersizliği vardı Çıkarımlar: D vitamini desteği olmadan anne sütü alan bebeklerin altı aya kadar D vitamini yetersizliği lehine herhangi bir bulgu göstermedikleri ancak serum 25 OHD düzeylerinin D vitamini desteği ile beraber anne sütü alan bebeklere göre belirgin olarak düşük olduğu saptandı Türk Ped Arş 2010; 45: 286 90 Anahtar sözcükler: Alkalen fosfataz fosfor kalsiyum raşitzm 25 OHD vitamini

Keywords

• Alkalen fosfataz, fosfor, kalsiyum, raşitzm, 25-OHD vitamini

References

1. Steven A, Abrams M. Nutritional rickets: an old disease re- turns. Nutr Rev 2002; 60: 111-5. (Abstract) / (Full Text)
2. Özturk A, Hasanoğlu A, Vurgun N. Kayseri ve çevresinde 0-3 yaş grubu çocuklarda raşitizm görülme sıklığı. Erciyes Tıp Der- gisi 1989; 11: 212-7.
3. Hochberg Z. Consensus development for the suplementation of vitamin D in childhood and adolescence. Endocr Dev 2003; 6: 259-81.
4. Hochberg Z. Rickets-past and present. Endocr Dev 2003; 6: 1-13. (Abstract)
5. Frank R, Greer M. Vitamin D deficiency- it’s more than rickets. J Pediatr 2003; 143: 422-3. (Abstract) / (Full Text) / (PDF)
6. Shelley R, Robert P, Henry N, et al. Nutrional rickets in African American breastfed infant. J Pediatr 2000; 137: 153-7.
7. Jean T, Spence M, Janet R. Secondary prevention of vitamin D deficiency rickets. Pediatrics 2004; 113: 70-2. (Abstract) / (Full Text) / (PDF)
8. Markestad T, Kolmannskog S, Arntzen E, Toftegaard L, Hane- berg B, Aksnes L. Serum concentarations of vitamin D meta- bolites in exclusively breast-fed infants at 70 North. Acta Pa- ediatr Scand 1984; 73: 29-32. (Abstract)

9. Reeve LE, Chesney RW, DeLuca HF. Vitamin D of human milk: identification of biologically active forms. Am J Clin Nutr 1982; 36: 122-6. (Abstract) / (PDF)
10. Hollis BW, Roos BA, Draper HH, Lambert PW. Vitamin D and its metabolites in human and bovine milk. J Nutr 1981; 111: 1240-8. (Abstract) / (PDF)
11. Guzel R, Kozanoğlu E, Guler-Uysal F, Soyupak S, Sarpel T. Vi- tamin D status and bone mineral density of veiled and unvei- led Turkish women. J Women Health Gend Based Med 2001; 10: 765-70. (Abstract) / (Full Text) / (PDF)
12. Alagol F, Shihadeh Y, Boztepe H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000; 23: 173-7. (Abstract)
13. Gartner LM, Greer FR. Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics 2003; 111: 908-10. (Abstract) / (Full Text) / (PDF)
14. Thomson K, Morley R, Grover SR, Zacharin MR. Postnatal evaluation of vitamin D and bone health in women who were vitamin deficient in pregnancy, and in their infants. Med J 2004; 181: 486-8. (Abstract) / (Full Text) / (PDF)
15. Canadian Pediatric Society. Vitamin D supplementation in northern native communities. J Paediatr Child Health 2002; 7: 459-63.
16. Baker SS, Cochran WJ, Flores CA, et al. Calcium requirements of infants, children, and adolescents. Pediatrics 1999; 104; 1152-7. (Abstract) / (Full Text) / (PDF)
17. Holick MF. Sunlight and vitamin D. J Gern Intern Med 2002; 17: 733-5.
18. Peng LF, Serwint JR. A comparison of breastfed children with nutritional rickets who present during and after the first years of life. Clin Pediatr 2003; 42: 711-7. (Abstract) / (PDF)
19. Wharton B, Bishop N. Rickets. Lancet 2003; 362: 1389-400. (Abstract) / (Full Text) / (PDF)
20. Cannell JJ, Hollis BW, Zasloff M, RP Heaney. Diagnosis ant treatment of vitamin D deficiency. Expert Opin Pharmacother 2008; 9: 107-18 (Abstract) / (Full Text) / (PDF)
21. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentration, and safety. Am J Clin Nutr 1999; 69: 842-56. (Abstract) / (Full Text) / (PDF)