Therapeutic response in children with post malignancy chronic HCV genotype 1 infection Original Article

Abstract

Aim: The aim of this study was to assess and compare the efficacy of interferon INF and its combination with ribavirin RBV treatment in children infected with Genotype 1b HCV Material and Method: Twenty seven children who had malignancy in remission for at least 12 months and were followed up for chronic hepatitis C infection between the years 1998 and 2000 were included Patients diagnosed after the year 2000 were given INF a 2b plus RBV in oral form Group 1 and patients diagnosed before the year 2000 were given INF a Group 2 for twelve months respectively Results: In Group 1 end of treatment response and sustained virological response SVR rates were 75 and 56 respectively In Group 2 the rates were 27 2 and 18 18 respectively The difference in the end of treatment response rates between the two groups were statistically significant p lt;0 05 whereas the difference in SVR rates was insignificant p gt;0 05 Duration of infection before treatment in Group 1 was significantly lower than in Group 2 p=0 001 Conclusions: Better response rates were observed with combined therapy as compared to mono therapy Higher response rate of combination therapy may be related to shorter initial infection period Turk Arch Ped 2009; 44: 68 72 Key words: Children hepatitis C interferon a 2b malignancy ribavirin

Keywords

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Kanser sonrası kronik HCV genotip 1 enfeksiyonu olan çocuklarda tedavi yanıtı Orijinal Araştırma

Öz

Amaç: Genotip 1b HCV ile enfekte kanserli çocuklarda interferon INF ve ribavirin RBV ikili tedavisi ile İNF a tekli tedavisinin yanıt oranlarının karşılaştırılması amaçlandı Gereç ve Yöntem: 1998 2008 tarihleri arasında Çocuk Gastroenteroloji Bölümü’nde kronik hepatit C tanısı ile izlenen önceden kanser hastası olup tedavisi kesilmiş ve en az bir yıldır remisyonda olan 27 hasta çalışmaya alındı 2000 yılından sonra tanı alanlara INF a 2b ve ağızdan RBV Grup 1 önce tanı alınanlara INF a Grup 2 12 ay süre ile verildi Bulgular: Tedavi sonu yanıt oranı TSY ve kalıcı virolojik yanıt KVY oranı Grup 1’in 75 ve 56 iken Grup 2’nin 27 2 ve 18 18 idi İki grup arasındaki TSY anlamlı olup p lt;0 05 KVY arasındaki fark anlamlı değildi p gt;0 05 Tedavi öncesi enfeksiyon süresi Grup 1’de Grup 2’dekilere göre anlamlı derecede düşük bulundu p=0 001 Çıkarımlar: Çalışmamızda ikili tedavinin tekli tedaviye göre daha iyi yanıt sağladığı saptandı İkili tedavideki yüksek tedavi yanıtının tedavi öncesi enfeksiyon süresinin kısalığı ile de ilişkili olabileceği düşünüldü Türk Ped Arş 2009; 44: 68 72 Anahtar kelimeler: Çocuk hepatit C interferon a 2b kanser ribavirin

Anahtar Kelimeler

• Çocuk, hepatit C, interferon-α 2b, kanser, ribavirin

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