Neurodevelopmental and psychiatric assessments at corrected age of 1 3 years in very preterm infants

Year 2011, Volume: 46 Issue: 4, 280 - 285, 01.12.2011

Işık Görker Betül Acunaş

https://doi.org/10.4274/tpa.46.89

Abstract

Aim: To assess the neurodevelopmental and psychiatric outcomes of very preterm vs preterm infants at 1 3 years of corrected age Material and Method: Between years 2005 2008 premature infants followed up in the NICU designated as Group 1 lt;32 wks;n=36 were evaluated in comparison to Group 2 33 37wks; n=56 with the approval of Ethics Committee TUTFEK 2008 083 in terms of neurodevelopmental and psychiatric development by using Denver developmental screening test the brief infant toddler social emotional assessment childcare provider version Mothers rsquo; psychiatric symptoms were assessed by the brief symptom inventory Socioeconomic status was determined by using SES scale t test or Mann Whitney U tests chi square and Spearman tests were used for statistical analysis Results: In Group 1 paternal education level and psychodevelopmental score was lower than group 2 abnormal outcome in Denver developmental test was more frequent Psychiatric problem score was higher in boys whereas psychodevelopmental score was higher in girls Psychosocial developmental score was lower in those infants with intraventricular hemorrhage and this score showed positive correlation with Denver developmental test results There was no difference between the two groups in terms of brief symptom inventory Conclusions: Although very preterm infants more frequently showed abnormal neuropsychological development they were not significantly different with regard to psychiatric problems Girls were more advantegous than boys in terms of psychodevelopment We conclude that these findings should be validated by larger and further studies Turk Arch Ped 2011; 46: 280 5

Keywords

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İleri derecede erken doğmuş yenidoğanların düzeltilmiş 1 3 yaşlarındaki nörogelişimsel ve psikiyatrik değerlendirmesi

Abstract

Amaç: İleri derecede erken doğmuş yenidoğanlarla orta derecede ve sınırda erken doğmuş yenidoğanların düzeltilmiş 1 3 yaşlarındaki gelişimsel ve psikiyatrik değerlendirme sonuçlarının karşılaştırılması. 

Gereç ve Yöntem: 2005 2008 tarihleri arasında Yenidoğan Birimi rsquo;nde izlenen grup 1 lt;32 gebelik haftası;n=36 ve grup 2 rsquo;deki 33 37 gebelik haftası; n=56 yenidoğanlar Etik Kurul onayı alınarak TÜTFEK 2008 083 düzeltilmiş 13 yaşlarındaki Denver gelişimsel testi ve kısa 1 3 yaş sosyal duygusal değerlendirme ölçeği ile gelişimsel sosyal duygusal ve psikiyatrik sorunlar yönünden değerlendirildi Annelerine kısa semptom envanteri uygulandı Ailelerin sosyoekonomik durumu sosyo ekonomik durum ölçeğiyle belirlendi İstatistiksel analizde t testi veya Mann Whitney U testi ki kare ve Spearman testi kullanıldı

Bulgular: Grup 1 rsquo;de baba eğitim düzeyi psikogelişimsel skor ortalaması grup 2 rsquo;ye göre daha düşük anormal Denver gelişim test oranı daha yüksek saptandı Psikiyatrik sorun skoru erkeklerde psikososyal gelişim skoru ise kızlarda daha yüksekti Psikososyal gelişim skoru ventrikül içine kanaması olanlarda daha düşüktü ve bu skor ile Denver gelişim tesiti arasında pozitif ilişki saptandı Kısa semptom envanteri açısından farklılık yoktu.

Çıkarımlar: İleri derecede erken doğmuş yenidoğanlar daha sık anormal nöropsikolojik gelişim gösterdikleri halde psikiyatrik sorun açısından farklı bulunmadılar Psikogelişimsel yönden kızlar erkeklere göre daha önde idi Bu bulguların daha geniş ve ileri çalışmalarla desteklenmesi gerektiği sonucuna varıldı.

Keywords

Erken doğmuş bebek, ileri derecede erken doğmuş bebek, nörogelişim, psikiyatrik değerlendirme

References

• Chapieski ML, Evankovich KD. Behavioral effects of prematurity. Semin Perinatol 1997; 21(3): 221-39.
• Latal B. Prediction of neurodevelopment outcome after preterm birth. Pediatr Neurol 2009; 40(6): 413-9.
• Jennische M, Sedin G. Speech and language skills in children who required neonatal intensive care. I: spontaneous speech at 6.5 years of age. Acta Pediatr 1998; 87: 654-66.
• Resnick MB, Gueorguieva RV, Carter RL, et al. The impact of low birth weight, perinatal conditions, and sociodemographic factors on educational outcome in kindergarten. Pediatrics 1999; 104: e74.
• Delobel-Ayoub M, Kaminski M, Marret S, et al. Behavioral outcome at 3 years of age in very preterm infants: The EPIPAGE study. Pediatrics 2006; 117: 1996-2005.
• Horwood LJ, Mogridge N, Darlow BA. Cognitive, educational, and behavioral outcomes at 7 to 8 years in a national very low birthweight cohort. Arch Dis Child Fetal neonatal Ed 1998; 79: F12-20.
• Constantinou JC, Adamson-Macedo EN, Mirmiran M, et al. Neurobehavioral assessment predicts differential outcome between WLBW and ELBW preterm infants. J Perinatol 2005; 25: 788-93.
• Anderson P, Doyle LW, Victorian Infant Collaborative Study Group. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA 2003; 289(24): 3264-72.
• Doussard-Roosevelt JA, McClenny BD, Porges SW. Neonatal cardiac vagal tone and school age developmental outcome in very low birth weight infants. Dev Psychobiol 2001; 38: 56-6.
• Ballard JL, Khoury JC, Wedig K, et al New Ballard Score, expanded to include extremely premature infants. J Pediatr 1991; 119: 417-23.
• Gomella TL. Assessment of gestational age. In: Gomella TL, Cunningham MD, Eyal FG, Zenk KE, (eds). Lange neonatology. 4 th ed. Stamford: A Simon & Schuster Company, 1999: 21-8.
• Greenough A, Roberton NRC. Acute respiratory disease in the newborn. In: Rennie JM, Roberton NRC, (eds). Texbook of neonatology. 3th ed. Edinburgh: Churchill Livingstone, 1999: 481-514.
• Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 163: 1723-9.
• Papile LA, Burstein J, Burstein R, et al. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weight less than 1500 g. J Peditr 1977; 92: 529-34.
• International commitee for the classification of retinopathy of prematurity. The International classification of retinopathy of prematurity revisited. Arch Ophthalmol 2005; 123(7): 991-9.
• Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978; 187(1): 1-7.
• Stormorken A, Powell KR. Sepsis and shock. In: Behrman RE, Kliegman RM, Jenson HB, (eds). Nelson textbook of pediatrics.17th ed. Philadelphia: WB Saunders Company, 2004: 846-50.
• Neyzi O, Alp H, Orhon A. Sex maturation in Turkish girls. Ann Hum Biol 1975; 2: 49 -59.
• Anlar B, Yalaz K. Denver II gelişimsel tarama testi, Türk çocuklarına uyarlanması ve standardizasyonu. Ankara: Meteksan Anonim Şirketi,1995: 1-43.
• Frankenburg WK, Dodds JB. Denver developmental screening test II- technical manual. Denver: Denver developmental materials, 1990.
• Karabekiroğlu K, Rodopman-Arman A, Ay P, ve ark. Kısa 1-3 yaş sos- yal duygusal değerlendirme ölçeği (K-1/3-SDD-TR) Türkçe versiyonu- nun geçerlilik ve güvenilirliği. 17. Ulusal Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Kongresi, 19-22 Nisan, İzmir, 2007.
• Briggs-Gowan MJ, Carter AS, Carter AS, et al. The brief infant-toddler social and emotional assessment: screening for social-emotional problems and delays in competence J Pediatr Psycho 2004; 9(2): 143-55.
• Şahin N, Durak A. Kısa semptom envanteri: Türk gençleri için uyarlan- ması. Türk Psikoloji Dergisi 1994; 9: 44-56.
• Dalobel-Ayoub M, Arnaud C, White-Koning M, et al. Behavioral problems and cognitive performance at 5 years of age after very preterm birth: the EPIPAGE study. Pediatrics 2009, 123(6); 1485-92.
• Doyle LW. The Victorian infant collaborative study group. Evaluation of neonatal intensive care for extremely low birthweight infants in Victoria over two decades: I. Effectiveness. Pediatrics 2004; 113: 505-9.
• Pedersen SJ, Sommerfelt K, Markestad T. Early motor development of premature infants with birthweight less than 2000 grams. Acta Paediatr 2000; 89: 1456-61.
• Bhutta AT, Cleves MA, Casey PH, et al. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta- analysis. JAMA 2002; 288: 728-37.
• Hartman T, Voigt RG, Katusic SK, Weaver AL, Olsen RD, Barbaresi WJ. Assessment of risk of neurodevelopmental esquelae in preterm infants: a comparison of the neurodevelopmental risk and neurobiologic risk score methods. Paediatr Child Health 2009; 19: S1, S11-4.
• Spittle AJ, Brown NC, Doyle LW, et al. Quality of general movements is related to white matter pathology in very preterm infants. Pediatrics 2008; 121: e1184-9.
• Halsey CL, Collin M, Anderson CL. Extremely low-birth-weight children and their peers. A comparison of school-age outcomes. Arch Pediatr Adolesc Med 1998; 150(8): 790-4.
• Vohr BR, Wright LL, Dusick AM, et al. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics 2000; 105: 1216-26.
• Hogan DP, Park JM. Family factors and social support in the developmental outcomes of very-low birth weight children. Clin Perinatol 2000; 27: 433-59.
• Hintz SR, Kendrick DE, Vohr BR, et al. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely- low-birthweight infants. Acta Paediatr 2006; 95(10): 1239-48.
• Gargus RA, Vohr BR, Tyson JE, et al. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics 2009; 124 (1): 112-21.