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Neonatal morbidity and mortality results in preterm premature rupture of membranes

Year 2011, Volume: 46 Issue: 4, 296 - 301, 01.12.2011
https://doi.org/10.4274/tpa.46.1394

Abstract

Aim: To investigate the effect of whole body hypothermia on short term neonatal morbidities and long term neurodevelopmental outcome in term neonates with hypoxic ischemic encephalopathy Material and Method: Neonates with perinatal asphyxia and hypoxic ischemic encepholopathy stage 2 and 3 were enrolled Patients were divided into 2 groups according to findings observed on amplitude integrated electroencephalography aEEG Patients with abnormal aEEG pattern in the first six hours after birth were defined as group 1 and others as group 2 Patients in group 1 were treated with whole body hypothermia Neurodevelopmental outcome was evaluated at 18 months of age in survivors using Bayley Scales of Infant Development II Mental developmental index and psychomotor development index scores were calculated Results: Thirty five patients were enrolled M F=17 18 18 51 of whom were treated with hypothermia Bradycardia was observed in 44 4 of patients in group 1 and 5 9 of patients in group 2 p=0 04 Incidence of other possible adverse events related to hypothermia were similar between the two groups Mortality was higher in group 1 p=0 03 In group 1 70 of the patients and in group 2 86 of the patients were evaluated using Bayley Scales of Infant Development II Although patients treated with hypothermia had a higher mental developmental index and psychomotor development index scores the difference was not statistically significant Conclusions: Whole body hypothermia can be safely applied in term neonates with HIE Hypothermia may improve neurodevelopmental outcome Turk Arch Ped 2011; 46: 286 91

References

  • ACOG practice bulletin. Premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Number 1, June 1998. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 1998; 63: 75-84.
  • Duff P. Premature rupture of the membranes in term patients. Semin Perinatol 1996; 20: 401-8.
  • Hannah ME, Ohlsson A, Farine D, et al. Induction of labor compared with expectant management for prelabor rupture of the membranes at term. TERMPROM Study Group. N Engl J Med 1996; 334: 1005-10.
  • ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol 2007; 109: 1007-19.
  • Bengtson JM, Van Marter, Barss VA, Greene MF, Tuomala RE, Epstein MF. Pregnancy outcome after premature rupture of membranes at or before 26 weeks’ gestation. Obstet Gynecol 1989; 73: 921-7.
  • Osmanagaoglu MA, Unal S, Bozkaya H. Chorioamnionitis risk and neonatal outcome in preterm premature rupture of membranes. Arch Gynecol Obstet 2005; 271: 33-9.
  • Karabulut AA, Durukan T. Prematür membran rüptürü: maternal ve neonatal etkilerin incelenmesi. Perinatoloji Dergisi 1999; 7: 248-54.
  • Tanir HM, Sener T, Tekin N, Aksit A, Ardic N. Preterm premature rupture of membranes and neonatal outcome prior to 34 weeks of gestation. Int J Gynaecol Obstet 2003; 82: 167-72.
  • Seo K, McGregor JA, French JI. Preterm birth is associated with increased risk of maternal and neonatal infection. Obstet Gynecol 1992; 79: 75-80.
  • Alexander JM, Cox SM. Clinical course of premature ruptures of membranes. Semin Perinatol 1996; 20: 369-75.
  • Alger L, Putkin M. Etiology of premature rupture of membranes. Clin Obstet Gynecol 1986; 29: 758-70.
  • Verbers IG, Pearce JM, New LC, Hamilton PA, Davies EG. Prolonged rupture of fetal membranes. J Perinat Med 1989; 17: 469-76.
  • Ramsey PS, Lieman JM, Brumfield CG, Carlo W. Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. Am J Obstet Gynecol 2005; 192: 1162-6.
  • Alexander JM, Mercer BM, Miodivnik M, et al. The impact of digital cervical examination on expectantly managed preterm rupture of membranes. Am J Obstet Gynecol 2000; 183: 1003-7.
  • Dexter SC, Malee MP, Pinar H, Hogan JW, Carpenter MW, Vohr BR. Influence of chorioamnionitis on developmental outcome in very low birth weight infants. Obstet Gynceol 1999; 94: 267-73.
  • Morales WJ. The effect of chorioamnionitis on the developmental outcome of preterm infants at one year. Obset Gynecol 1987; 70: 183-6.
  • Beazley D. Impact of amnionitis and antepartum antibiotic treatment on neonatal outcome after PPROM. Am J Obstet Gynecol 1998; 178: S15.
  • Vintzileus AM. Tests of fetal well-being in premature rupture of membranes; rationals and results. Clin North Am Obstet Gynecol 1992; 19: 281-309.
  • Lewis DF, Adair CD, Robichaux AG, et al. Antibiotic therapy in preterm premature rupture of membranes: are seven days necessary? A preliminary, randomized clinical trial. Am J Obset Gynecol 2003; 188: 1413-6.
  • Pasquier JC, Rabilloud M, Picaud JC, et al. A prospective population-based study of 598 cases of PPROM between 24 and 34 weeks' gestation: description, management, and mortality. Eur J Obstet Gynecol Reprod Biol 2005; 121: 164-70.
  • Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad spectrum antibiotics for preterm rupture of membranes. Cochrane Database of Systematic Reviews 2003, Issue 2. Art No: CD001058. DOI: 10.1002/14651858.CD001058.
  • Obi SN, Ozumba BC. Pre-term premature rupture of fetal membranes: the dilemma of management in a developing nation. J Obstet Gynecol 2007; 27: 37-40.

Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları

Year 2011, Volume: 46 Issue: 4, 296 - 301, 01.12.2011
https://doi.org/10.4274/tpa.46.1394

Abstract

Amaç: Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçlarını araştırmaktır Gereç ve Yöntem: Preterm erken mebran rüptürü tanısı ile 1996 2005 yılları arasında kliniğimizde takip edilen 228 tekiz gebelik geriye dönük incelendi.

Bulgular: Preterm erken mebran rüptüründe en sık görülen yenidoğan hastalıkları sıkıntılı solunum sendromu SSS sepsis ve ventrikül içi kanamadır VİK Olgularında doğum şekli yenidoğan yoğun bakım birimi YYBB gereksinimi perinatal asfiksi sepsis ve VİK oranlarını etkilememektedir APGAR skoru lt;5 olduğunda YYBB ve pozitif basınçlı ventilasyon gereksinimi SSS sepsis ve VİK oranları artmaktadır Aradaki süre uzadıkça yenidoğan hastalık ve ölüm oranları artmaktadır Yatışta CRP son CRP doğum kilosu ve beşinci dakika APGAR skoru YYBB gereksinimyle; sadece beşinci dakika APGAR skoru SSS ile; son lökosit sayısı ve hematokrit ise sepsis ve pnömoniyle bağımsız olarak ilişkili bulunmuştur.

Çıkarımlar: Preterm erken mebran rüptürü olgularında sonuçları öngörebilmek için yatışta CRP son CRP doğum kilosu beşinci dakika APGAR skoru son lökosit sayısı ve annenin hemotokriti gözönünde bulundurulmalıdır.

References

  • ACOG practice bulletin. Premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Number 1, June 1998. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 1998; 63: 75-84.
  • Duff P. Premature rupture of the membranes in term patients. Semin Perinatol 1996; 20: 401-8.
  • Hannah ME, Ohlsson A, Farine D, et al. Induction of labor compared with expectant management for prelabor rupture of the membranes at term. TERMPROM Study Group. N Engl J Med 1996; 334: 1005-10.
  • ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol 2007; 109: 1007-19.
  • Bengtson JM, Van Marter, Barss VA, Greene MF, Tuomala RE, Epstein MF. Pregnancy outcome after premature rupture of membranes at or before 26 weeks’ gestation. Obstet Gynecol 1989; 73: 921-7.
  • Osmanagaoglu MA, Unal S, Bozkaya H. Chorioamnionitis risk and neonatal outcome in preterm premature rupture of membranes. Arch Gynecol Obstet 2005; 271: 33-9.
  • Karabulut AA, Durukan T. Prematür membran rüptürü: maternal ve neonatal etkilerin incelenmesi. Perinatoloji Dergisi 1999; 7: 248-54.
  • Tanir HM, Sener T, Tekin N, Aksit A, Ardic N. Preterm premature rupture of membranes and neonatal outcome prior to 34 weeks of gestation. Int J Gynaecol Obstet 2003; 82: 167-72.
  • Seo K, McGregor JA, French JI. Preterm birth is associated with increased risk of maternal and neonatal infection. Obstet Gynecol 1992; 79: 75-80.
  • Alexander JM, Cox SM. Clinical course of premature ruptures of membranes. Semin Perinatol 1996; 20: 369-75.
  • Alger L, Putkin M. Etiology of premature rupture of membranes. Clin Obstet Gynecol 1986; 29: 758-70.
  • Verbers IG, Pearce JM, New LC, Hamilton PA, Davies EG. Prolonged rupture of fetal membranes. J Perinat Med 1989; 17: 469-76.
  • Ramsey PS, Lieman JM, Brumfield CG, Carlo W. Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes. Am J Obstet Gynecol 2005; 192: 1162-6.
  • Alexander JM, Mercer BM, Miodivnik M, et al. The impact of digital cervical examination on expectantly managed preterm rupture of membranes. Am J Obstet Gynecol 2000; 183: 1003-7.
  • Dexter SC, Malee MP, Pinar H, Hogan JW, Carpenter MW, Vohr BR. Influence of chorioamnionitis on developmental outcome in very low birth weight infants. Obstet Gynceol 1999; 94: 267-73.
  • Morales WJ. The effect of chorioamnionitis on the developmental outcome of preterm infants at one year. Obset Gynecol 1987; 70: 183-6.
  • Beazley D. Impact of amnionitis and antepartum antibiotic treatment on neonatal outcome after PPROM. Am J Obstet Gynecol 1998; 178: S15.
  • Vintzileus AM. Tests of fetal well-being in premature rupture of membranes; rationals and results. Clin North Am Obstet Gynecol 1992; 19: 281-309.
  • Lewis DF, Adair CD, Robichaux AG, et al. Antibiotic therapy in preterm premature rupture of membranes: are seven days necessary? A preliminary, randomized clinical trial. Am J Obset Gynecol 2003; 188: 1413-6.
  • Pasquier JC, Rabilloud M, Picaud JC, et al. A prospective population-based study of 598 cases of PPROM between 24 and 34 weeks' gestation: description, management, and mortality. Eur J Obstet Gynecol Reprod Biol 2005; 121: 164-70.
  • Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad spectrum antibiotics for preterm rupture of membranes. Cochrane Database of Systematic Reviews 2003, Issue 2. Art No: CD001058. DOI: 10.1002/14651858.CD001058.
  • Obi SN, Ozumba BC. Pre-term premature rupture of fetal membranes: the dilemma of management in a developing nation. J Obstet Gynecol 2007; 27: 37-40.
There are 22 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Research
Authors

Altay Gezer This is me

Ezcan Parafit Yalçıner This is me

Onur Güralp This is me

Veli Yedigöz This is me

Barbaros Ilıkkan This is me

Tarık Altınok This is me

Rıza Madazlı This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 46 Issue: 4

Cite

APA Gezer, A., Yalçıner, E. P., Güralp, O., Yedigöz, V., et al. (2011). Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi, 46(4), 296-301. https://doi.org/10.4274/tpa.46.1394
AMA Gezer A, Yalçıner EP, Güralp O, Yedigöz V, Ilıkkan B, Altınok T, Madazlı R. Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi. December 2011;46(4):296-301. doi:10.4274/tpa.46.1394
Chicago Gezer, Altay, Ezcan Parafit Yalçıner, Onur Güralp, Veli Yedigöz, Barbaros Ilıkkan, Tarık Altınok, and Rıza Madazlı. “Preterm Erken Membran rüptürü olgularında yenidoğan hastalık Ve ölüm Oranı sonuçları”. Türk Pediatri Arşivi 46, no. 4 (December 2011): 296-301. https://doi.org/10.4274/tpa.46.1394.
EndNote Gezer A, Yalçıner EP, Güralp O, Yedigöz V, Ilıkkan B, Altınok T, Madazlı R (December 1, 2011) Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi 46 4 296–301.
IEEE A. Gezer, “Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları”, Türk Pediatri Arşivi, vol. 46, no. 4, pp. 296–301, 2011, doi: 10.4274/tpa.46.1394.
ISNAD Gezer, Altay et al. “Preterm Erken Membran rüptürü olgularında yenidoğan hastalık Ve ölüm Oranı sonuçları”. Türk Pediatri Arşivi 46/4 (December 2011), 296-301. https://doi.org/10.4274/tpa.46.1394.
JAMA Gezer A, Yalçıner EP, Güralp O, Yedigöz V, Ilıkkan B, Altınok T, Madazlı R. Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi. 2011;46:296–301.
MLA Gezer, Altay et al. “Preterm Erken Membran rüptürü olgularında yenidoğan hastalık Ve ölüm Oranı sonuçları”. Türk Pediatri Arşivi, vol. 46, no. 4, 2011, pp. 296-01, doi:10.4274/tpa.46.1394.
Vancouver Gezer A, Yalçıner EP, Güralp O, Yedigöz V, Ilıkkan B, Altınok T, Madazlı R. Preterm erken membran rüptürü olgularında yenidoğan hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi. 2011;46(4):296-301.