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Hospital acquired bloodstream infections in neonatal intensive care unit

Year 2011, Volume: 46 Issue: 2, 37 - 43, 01.06.2011

Fatih Bolat Sinan Uslu Ali Bülbül Serdar Cömert Emrah Can Evrim Kıray Baş Ömer Güran Asiye Nuhoğlu

https://doi.org/10.4274/tpa.46.61

Abstract

Aim: The aim of this study was to evaluate the risk factors for term and pretem newborns etiological agents antibiotic susceptibility and rate of hospital acquired bloodstream infections in newborns hospitalized in our Neonatal Intensive Care Unit during 2008

Keywords

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References

  • Philip AG. The changing face of neonatal infection: experience at a regional medical center. Pediatr Infect Dis J 1994; 13: 1098-102.
  • Gladstone IM, Ehrenkranz RA, Edberg SC, Baltimore RS. A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience. Pediatr Infect Dis J 1990; 9: 819-25.
  • Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110: 285-91.
  • Gray JW. Surveillance of infection in neonatal intensive care units. Early Hum Dev 2007; 83: 157-63.
  • Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients: results from the first national point-prevalence survey. J Pediatr 2001; 139: 821-7.
  • Singh N. Large infection problems in small patients merit a renewed emphasis on prevention. Infect Control Hosp Epidemiol 2004; 25: 714-6.
  • Clark R, Powers R, White R, Bloom B, Sanchez P, Benjamin DK Jr. Nosocomial infection in the NICU: a medical complica- tion or unavoidable problem? J Perinatol 2004; 24: 382-8.
  • Drews MB, Ludwig AC, Leititis JU, Daschner FD. Low birth weight and nosocomial infection of neonates in a neonatal intensive care unit. J Hosp Infect 1995; 30: 65-72.
  • Nagata E, Brito AS, Matsuo T. Nosocomial infections in a neonatal intensive care unit: incidence and risk factors. Am J Infect Control 2002; 30: 26-31.
  • Efird MM, Rojas MA, Lozano JM, et al. Epidemiology of nosocomial infections in selected neonatal intensive care units in Colombia, South America. J Perinatol 2005; 25: 531-6.
  • Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005; 365: 1175-88.
  • Mahieu LM, De Muynck AO, Ieven MM, De Dooy JJ, Goossens HJ, Van Reempts PJ. Risk factors for central vascular catheter-associated bloodstream infections among patients in a neonatal intensive care unit. J Hosp Infect 2001; 48: 108-16.
  • Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European Study Group. Infect Control Hosp Epidemiol 2000; 21: 260-3.
  • Campins M, Vaque J, Rossello J, et al. Nosocomial infections in pediatric patients: a prevalence study in Spanish hospitals. EPINE Working Group. Am J Infect Control 1993; 21: 58-63.
  • Yapicioglu H, Satar M, Ozcan K, et al. A 6-year prospective surveillance of healthcare-associated infections in a neonatal intensive care unit from southern part of Turkey. J Paediatr Child Health 2010; 46: 337-42.
  • Bülbül A, Taşdemir M, Pullu M, Okan F, Bülbül L, Nuhoğlu A. Yenidoğan yoğun bakım birimindeki hastane enfeksiyonları. Şişli Etfal Hastanesi Tıp Bülteni 2009; 43: 27-32.
  • Babazono A, Kitajima H, Nishimaki S, et al. Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS). Acta Med Okayama 2008; 62: 261-8.
  • Yapicioglu H, Ozcan K, Sertdemir Y, et al. Health care- associated infections in a neonatal intensive care unit in Turkey in 2008: Incidence and risk factors, a prospective study. J Trop Pediatr 2010. [Epub ahead of print]
  • National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32: 470-85.
  • Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units. Am J Infect Control 2007; 35: 177-82.
  • Yuan TM, Chen LH, Yu HM. Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients. J Perinat Med 2007; 35: 334-8.
  • Mahieu LM, Buitenweg N, Beutels P, De Dooy JJ. Additional hospital stay and charges due to hospital-acquired infections in a neonatal intensive care unit. J Hosp Infect 2001; 47: 223-9.
  • Macharashvili N, Kourbatova E, Butsashvili M, Tsertsvadze T, McNutt LA, Leonard MK. Etiology of neonatal blood stream infections in Tbilisi, Republic of Georgia. Int J Infect Dis 2009; 13: 499-505.
  • Su BH, Hsieh HY, Chiu HY, Lin HC. Nosocomial infection in a neonatal intensive care unit: a prospective study in Taiwan. Am J Infect Control 2007; 35: 190-5.
  • Couto RC, Carvalho EA, Pedrosa TM, Pedroso ER, Neto MC, Biscione FM. A 10-year prospective surveillance of nosocomi- al infections in neonatal intensive care units. Am J Infect Control 2007; 35: 183-9.
  • Nosocomial infections in neonatal units in Turkey: epidemiolo- gy, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010; 52: 50-7.
  • Yalaz M, Cetin H, Akisu M, Aydemir S, Tunger A, Kultursay N. Neonatal nosocomial sepsis in a level-III NICU: evaluation of the causative agents and antimicrobial susceptibilities. Turk J Pediatr 2006; 48: 13-8.
  • Bizzarro MJ, Gallagher PG. Antibiotic-resistant organisms in the neonatal intensive care unit. Semin Perinatol 2007; 31: 26-32.
  • Aurangzeb B, Hameed A. Neonatal sepsis in hospital-born babies: bacterial isolates and antibiotic susceptibility patterns. J Coll Physicians Surg Pak 2003; 13: 629-32.

Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları

Year 2011, Volume: 46 Issue: 2, 37 - 43, 01.06.2011

Fatih Bolat Sinan Uslu Ali Bülbül Serdar Cömert Emrah Can Evrim Kıray Baş Ömer Güran Asiye Nuhoğlu

https://doi.org/10.4274/tpa.46.61

Abstract

Amaç: Yenido¤an Yo¤un Bak›m Birimi’nde 2008 y›l›nda hastane kökenli kan ak›m enfeksiyon h›z›n›, etkenlerini, antibiyotik duyarl›l›¤›n›, zaman›ndan önce ve zaman›nda do¤mufl bebeklerde risk etkenlerini incelemek.

Gereç ve Yöntem: Hastalar›n dosyalar› geriye dönük olarak incelendi. Zam›ndan önce ve zaman›nda do¤mufl bebekler için risk etmenleri “multivariate logistic regression” analizi ile de¤erlendirildi.

Bulgular: Bir y›ll›k süre içerisinde 807 hasta 72 saatten daha uzun süre yatt›. Kan kültüründe üreme say›s› 97 idi. Üreme olanlar›n %65,6’s› erken do¤mufl, %34,4’ü zaman›nda do¤mufl bebeklerdi. En s›k elde edilen mikrorganizmalar koagülaz negatif stafilokok ve Klebsiella pneumonia türüydü. Kan ak›m enfeksiyon h›z› 5,9:1000 gün, katetere ba¤l› kan ak›m› enfeksiyon h›z› 9,6:1000 gün, ventilatörle iliflkili pnömoni h›z› 13,8:1000 gün olarak bulundu. Gram pozitif mikroorganizmalarda glikopeptit direnci görülmedi. Hastane enfeksiyonu için hastane yat›fl süresi, mekanik ventilasyon ve kateter varl›¤›n›n anlaml› risk etmenleri oldu¤u saptand›. Kan kültüründe üreme olanlarda ölüm oran› %12,5 idi.

Çıkarımlar: Hastane enfeksiyonlar› yenido¤an yo¤un bak›m biriminde önemli hastal›k ve ölüm nedenidir. Zaman›ndan önce ve zaman›nda do¤mufl bebeklerde risk etmenlerinin azalt›lmas› sa¤kal›m üzerine önemli katk›lar sa¤layacakt›r. (Türk Ped Arfl 2011; 46: 137-43)

Keywords

Etkenler hastane enfeksiyonu risk faktörleri yenidoğan

References

  • Philip AG. The changing face of neonatal infection: experience at a regional medical center. Pediatr Infect Dis J 1994; 13: 1098-102.
  • Gladstone IM, Ehrenkranz RA, Edberg SC, Baltimore RS. A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience. Pediatr Infect Dis J 1990; 9: 819-25.
  • Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110: 285-91.
  • Gray JW. Surveillance of infection in neonatal intensive care units. Early Hum Dev 2007; 83: 157-63.
  • Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients: results from the first national point-prevalence survey. J Pediatr 2001; 139: 821-7.
  • Singh N. Large infection problems in small patients merit a renewed emphasis on prevention. Infect Control Hosp Epidemiol 2004; 25: 714-6.
  • Clark R, Powers R, White R, Bloom B, Sanchez P, Benjamin DK Jr. Nosocomial infection in the NICU: a medical complica- tion or unavoidable problem? J Perinatol 2004; 24: 382-8.
  • Drews MB, Ludwig AC, Leititis JU, Daschner FD. Low birth weight and nosocomial infection of neonates in a neonatal intensive care unit. J Hosp Infect 1995; 30: 65-72.
  • Nagata E, Brito AS, Matsuo T. Nosocomial infections in a neonatal intensive care unit: incidence and risk factors. Am J Infect Control 2002; 30: 26-31.
  • Efird MM, Rojas MA, Lozano JM, et al. Epidemiology of nosocomial infections in selected neonatal intensive care units in Colombia, South America. J Perinatol 2005; 25: 531-6.
  • Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005; 365: 1175-88.
  • Mahieu LM, De Muynck AO, Ieven MM, De Dooy JJ, Goossens HJ, Van Reempts PJ. Risk factors for central vascular catheter-associated bloodstream infections among patients in a neonatal intensive care unit. J Hosp Infect 2001; 48: 108-16.
  • Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European Study Group. Infect Control Hosp Epidemiol 2000; 21: 260-3.
  • Campins M, Vaque J, Rossello J, et al. Nosocomial infections in pediatric patients: a prevalence study in Spanish hospitals. EPINE Working Group. Am J Infect Control 1993; 21: 58-63.
  • Yapicioglu H, Satar M, Ozcan K, et al. A 6-year prospective surveillance of healthcare-associated infections in a neonatal intensive care unit from southern part of Turkey. J Paediatr Child Health 2010; 46: 337-42.
  • Bülbül A, Taşdemir M, Pullu M, Okan F, Bülbül L, Nuhoğlu A. Yenidoğan yoğun bakım birimindeki hastane enfeksiyonları. Şişli Etfal Hastanesi Tıp Bülteni 2009; 43: 27-32.
  • Babazono A, Kitajima H, Nishimaki S, et al. Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS). Acta Med Okayama 2008; 62: 261-8.
  • Yapicioglu H, Ozcan K, Sertdemir Y, et al. Health care- associated infections in a neonatal intensive care unit in Turkey in 2008: Incidence and risk factors, a prospective study. J Trop Pediatr 2010. [Epub ahead of print]
  • National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32: 470-85.
  • Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units. Am J Infect Control 2007; 35: 177-82.
  • Yuan TM, Chen LH, Yu HM. Risk factors and outcomes for ventilator-associated pneumonia in neonatal intensive care unit patients. J Perinat Med 2007; 35: 334-8.
  • Mahieu LM, Buitenweg N, Beutels P, De Dooy JJ. Additional hospital stay and charges due to hospital-acquired infections in a neonatal intensive care unit. J Hosp Infect 2001; 47: 223-9.
  • Macharashvili N, Kourbatova E, Butsashvili M, Tsertsvadze T, McNutt LA, Leonard MK. Etiology of neonatal blood stream infections in Tbilisi, Republic of Georgia. Int J Infect Dis 2009; 13: 499-505.
  • Su BH, Hsieh HY, Chiu HY, Lin HC. Nosocomial infection in a neonatal intensive care unit: a prospective study in Taiwan. Am J Infect Control 2007; 35: 190-5.
  • Couto RC, Carvalho EA, Pedrosa TM, Pedroso ER, Neto MC, Biscione FM. A 10-year prospective surveillance of nosocomi- al infections in neonatal intensive care units. Am J Infect Control 2007; 35: 183-9.
  • Nosocomial infections in neonatal units in Turkey: epidemiolo- gy, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010; 52: 50-7.
  • Yalaz M, Cetin H, Akisu M, Aydemir S, Tunger A, Kultursay N. Neonatal nosocomial sepsis in a level-III NICU: evaluation of the causative agents and antimicrobial susceptibilities. Turk J Pediatr 2006; 48: 13-8.
  • Bizzarro MJ, Gallagher PG. Antibiotic-resistant organisms in the neonatal intensive care unit. Semin Perinatol 2007; 31: 26-32.
  • Aurangzeb B, Hameed A. Neonatal sepsis in hospital-born babies: bacterial isolates and antibiotic susceptibility patterns. J Coll Physicians Surg Pak 2003; 13: 629-32.
There are 29 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Article
Authors

Fatih Bolat This is me

Sinan Uslu This is me

Ali Bülbül This is me

Serdar Cömert This is me

Emrah Can This is me

Evrim Kıray Baş This is me

Ömer Güran This is me

Asiye Nuhoğlu This is me

Publication Date June 1, 2011
Published in Issue Year 2011 Volume: 46 Issue: 2

Cite

APA Bolat, F., Uslu, S., Bülbül, A., Cömert, S., et al. (2011). Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları. Türk Pediatri Arşivi, 46(2), 37-43. https://doi.org/10.4274/tpa.46.61
AMA Bolat F, Uslu S, Bülbül A, Cömert S, Can E, Baş EK, Güran Ö, Nuhoğlu A. Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları. Türk Pediatri Arşivi. June 2011;46(2):37-43. doi:10.4274/tpa.46.61
Chicago Bolat, Fatih, Sinan Uslu, Ali Bülbül, Serdar Cömert, Emrah Can, Evrim Kıray Baş, Ömer Güran, and Asiye Nuhoğlu. “Yenidoğan yoğun bakım Biriminde Hastane kökenli Kan akım Enfeksiyonları”. Türk Pediatri Arşivi 46, no. 2 (June 2011): 37-43. https://doi.org/10.4274/tpa.46.61.
EndNote Bolat F, Uslu S, Bülbül A, Cömert S, Can E, Baş EK, Güran Ö, Nuhoğlu A (June 1, 2011) Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları. Türk Pediatri Arşivi 46 2 37–43.
IEEE F. Bolat, S. Uslu, A. Bülbül, S. Cömert, E. Can, E. K. Baş, Ö. Güran, and A. Nuhoğlu, “Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları”, Türk Pediatri Arşivi, vol. 46, no. 2, pp. 37–43, 2011, doi: 10.4274/tpa.46.61.
ISNAD Bolat, Fatih et al. “Yenidoğan yoğun bakım Biriminde Hastane kökenli Kan akım Enfeksiyonları”. Türk Pediatri Arşivi 46/2 (June 2011), 37-43. https://doi.org/10.4274/tpa.46.61.
JAMA Bolat F, Uslu S, Bülbül A, Cömert S, Can E, Baş EK, Güran Ö, Nuhoğlu A. Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları. Türk Pediatri Arşivi. 2011;46:37–43.
MLA Bolat, Fatih et al. “Yenidoğan yoğun bakım Biriminde Hastane kökenli Kan akım Enfeksiyonları”. Türk Pediatri Arşivi, vol. 46, no. 2, 2011, pp. 37-43, doi:10.4274/tpa.46.61.
Vancouver Bolat F, Uslu S, Bülbül A, Cömert S, Can E, Baş EK, Güran Ö, Nuhoğlu A. Yenidoğan yoğun bakım biriminde hastane kökenli kan akım enfeksiyonları. Türk Pediatri Arşivi. 2011;46(2):37-43.