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Year 2010, Volume: 45 Issue: 4, 66 - 70, 01.12.2010

Pınar Erkekoğlu Belma Giray Orhan Derman

https://doi.org/10.4274/tpa.45.366

Abstract

Malpractice has gained an alarming dimension especially along with the introduction of compulsory professional liability insurance On the other hand it is quite difficult to say that malpractice is discussed by considering all responsible determinants According to individual focused approach the error is caused by single individual so the solution can be achieved by punishing the individual It is known that this approach does not reduce errors and adversely affect services due to high compensations and increased insurance premiums In Turkey malpractice is simply considered in the customer seller relationship context and individual focused approach is adopted However it is well established that this ldquo;blame culture rdquo; has negative effects on service provided social perception of the profession and job satisfaction Beside recognizing individual professional responsibilities basically it should be stressed that declaring healthcare workers as mainly responsible would not be fair In addition it violates right to health because of increasing the preventable errors and harms Turk Arch Ped 2011; 46: 6 11

Keywords

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References

  • Nebesio TD, Pescovitz OH. Part VII: Environmental effects on puberty. The role of endocrine disruptors in pubertal develop- ment. In: Walvoord EC, Pescovitz OH, (eds). When Puberty is Precocious: Scientific and Clinical Aspects. New Jersey: Humana Press; 2007; 425-42. 2. Frederiksen H, Skakkebaek NE, Andersson AM. Metabolism of phthalates in humans. Mol Nutr Food Res 2007; 51: 899-911.
  • ATDSR. Toxicological Profile for Diethylphthalate. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta; USA, 1995.
  • Kai H, Shono T, Tajiri T, Suita S. Long-term effects of intrauterine exposure to mono-n-butyl phthalate on the repro- ductive function of postnatal rats. J Pediatr Surg 2005; 40: 429–33.
  • National Toxicology Program Center for the Evaluation of Risks to Human Reproduction NTP-CERHR Expert Panel Report NPT-CERHR-DEHP-00 (National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, Washington DC; USA, 2000.
  • Narula HS, Carlson HE. Gynecomastia. Endocrinol Metab Clin North Am 2007; 36: 497-519.
  • Ma NS, Geffner Mitchell E. Gynecomastia in prepubertal and pubertal men. Curr Opin Pediatr 2008; 20: 465-70.
  • Henley DV, Lipson N, Korach KS, Bloch CA. Pubertal gyneco- mastia linked to lavender and tea tree oils. N Engl J Med 2007; 356: 479-85.
  • Klaunig JE, Babich MA, Baetcke KP, et al. PPARalpha ago- nist-induced rodent tumors: modes of action and human rel- evance. Crit Rev Toxicol 2003; 33: 655-780.
  • Ropero AB, Alonso-Magdalena P, García-García E, Ripoll C, Fuentes E, Nadal A. Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis. Int J Androl 2008; 31: 194-200.
  • Lott JA. Inflammatory diseases of the pancreas. Crit Rev Clin Lab Sci 1982; 17: 201-28.
  • Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 1990; 19: 793-810.
  • Eckfeldt JH, Levitt MD. Diagnostic enzymes for pancreatic disease. Clin Lab Med 1989; 9: 731-43.
  • Durmaz E, Ozmert EN, Erkekoglu P, et al. Plasma phthalate levels in pubertal gynecomastia. Pediatrics 2010; 125: 122-9.
  • Paris I, Ruggieri F, Mazzeo P, Carlucci G. Simultaneous deter- mination of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in human plasma by HPLC. Anal Lett 2003; 36: 2645-54.
  • Miura Y, Naito M, Ablake M, et al. Short-term effects of di-(2- ethylhexyl) phthalate on testes, liver, kidneys and pancreas in mice. Asian J Androl 2007; 9: 199-205.
  • Mocchiutti NO, Bernal CA. Effects of chronic di(2-ethylhexyl) phthalate intake on the secretion and removal rate of triglyceride-rich lipoproteins in rats. Food Chem Toxicol 1997; 35: 1017-21.
  • Venkata NG, Robinson JA, Cabot PJ, Davis B, Monteith GR, Roberts-Thomson SJ. Mono (2-ethylhexyl) phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast. Toxicol Lett 2006; 163: 224-34.
  • Chen C, Xu S, Wang WX, et al. Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury. Arch Med Res 2009; 40: 79-88.

Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma

Year 2010, Volume: 45 Issue: 4, 66 - 70, 01.12.2010

Pınar Erkekoğlu Belma Giray Orhan Derman

https://doi.org/10.4274/tpa.45.366

Abstract

Özet Amaç: Bu çalışmanın amacı endokrin bozucu etkileri bilinen di 2 etilhekzil fitalat DEHP ve metaboliti mono 2 etilhekzil fitalat nbsp; MEHP plazma düzeylerinin yüksek olduğu belirlenen pubertal jinekomasti hastalarında plazma fitalat düzeyleri ile pankreatik lipaz ve a amilaz düzeyleri arasındaki ilişkinin incelenmesi ve fitalatların pankreas üzerindeki olası etkilerinin değerlendirilmesidir Gereç ve Yöntem: Çalışma grubu 40 pubertal jinekomasti hastasından oluşmaktadır Plazma fitalat düzeyleri DEHP ve MEHP mono 2 etikhekzil Yüksek basınçlı sıvı kromatografisi high pressure liquid chromatography kullanılarak belirlenmiştir Lipaz ve a amilaz düzeyleri enzimatik kolorimetrik yöntemle ölçülmüştür İncelenen değişkenler arasındaki ilişki ilişki katsayısı saptanarak incelenmiştir Bulgular: Jinekomasti hastalarındaki plazma DEHP ve MEHP düzeyleri kontrol grubuna oranla önemli düzeyde yüksek bulunmuştur Alfa amilaz ve MEHP düzeyleri arasında jinekomasti hastalarında r= 0 388 p lt;0 05 ve tüm çalışma grubunda r= 0 353 p lt;0 05 negatif ilişki saptanmıştır DEHP ve a amilaz düzeyleri arasında da tüm çalışma grubunda önemli düzeyde negatif ilişki r= 0 323 p lt;0 05 saptanmıştır Çıkarımlar: Sonuçlar fitalat varlığının a amilaz salgılanmasında belirgin azalmalara neden olabileceğine işaret etmektedir Gözlenen bu ters ilişki fitalatların PPARg peroxisome proliferator activated receptor gamma etkinliği ile açıklanabilir nbsp; Türk Ped Arş 2010; 45: 366 70 Anahtar sözcükler: a amilaz di 2 etilhekzil fitalat jinekomasti lipaz mono 2 etilhekzil fitalat nbsp;

Keywords

α-amilaz di (2-etilhekzil) fitalat jinekomasti lipaz mono (2-etilhekzil) fitalat

References

  • Nebesio TD, Pescovitz OH. Part VII: Environmental effects on puberty. The role of endocrine disruptors in pubertal develop- ment. In: Walvoord EC, Pescovitz OH, (eds). When Puberty is Precocious: Scientific and Clinical Aspects. New Jersey: Humana Press; 2007; 425-42. 2. Frederiksen H, Skakkebaek NE, Andersson AM. Metabolism of phthalates in humans. Mol Nutr Food Res 2007; 51: 899-911.
  • ATDSR. Toxicological Profile for Diethylphthalate. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta; USA, 1995.
  • Kai H, Shono T, Tajiri T, Suita S. Long-term effects of intrauterine exposure to mono-n-butyl phthalate on the repro- ductive function of postnatal rats. J Pediatr Surg 2005; 40: 429–33.
  • National Toxicology Program Center for the Evaluation of Risks to Human Reproduction NTP-CERHR Expert Panel Report NPT-CERHR-DEHP-00 (National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, Washington DC; USA, 2000.
  • Narula HS, Carlson HE. Gynecomastia. Endocrinol Metab Clin North Am 2007; 36: 497-519.
  • Ma NS, Geffner Mitchell E. Gynecomastia in prepubertal and pubertal men. Curr Opin Pediatr 2008; 20: 465-70.
  • Henley DV, Lipson N, Korach KS, Bloch CA. Pubertal gyneco- mastia linked to lavender and tea tree oils. N Engl J Med 2007; 356: 479-85.
  • Klaunig JE, Babich MA, Baetcke KP, et al. PPARalpha ago- nist-induced rodent tumors: modes of action and human rel- evance. Crit Rev Toxicol 2003; 33: 655-780.
  • Ropero AB, Alonso-Magdalena P, García-García E, Ripoll C, Fuentes E, Nadal A. Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis. Int J Androl 2008; 31: 194-200.
  • Lott JA. Inflammatory diseases of the pancreas. Crit Rev Clin Lab Sci 1982; 17: 201-28.
  • Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 1990; 19: 793-810.
  • Eckfeldt JH, Levitt MD. Diagnostic enzymes for pancreatic disease. Clin Lab Med 1989; 9: 731-43.
  • Durmaz E, Ozmert EN, Erkekoglu P, et al. Plasma phthalate levels in pubertal gynecomastia. Pediatrics 2010; 125: 122-9.
  • Paris I, Ruggieri F, Mazzeo P, Carlucci G. Simultaneous deter- mination of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in human plasma by HPLC. Anal Lett 2003; 36: 2645-54.
  • Miura Y, Naito M, Ablake M, et al. Short-term effects of di-(2- ethylhexyl) phthalate on testes, liver, kidneys and pancreas in mice. Asian J Androl 2007; 9: 199-205.
  • Mocchiutti NO, Bernal CA. Effects of chronic di(2-ethylhexyl) phthalate intake on the secretion and removal rate of triglyceride-rich lipoproteins in rats. Food Chem Toxicol 1997; 35: 1017-21.
  • Venkata NG, Robinson JA, Cabot PJ, Davis B, Monteith GR, Roberts-Thomson SJ. Mono (2-ethylhexyl) phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast. Toxicol Lett 2006; 163: 224-34.
  • Chen C, Xu S, Wang WX, et al. Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury. Arch Med Res 2009; 40: 79-88.
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Original Research
Authors

Pınar Erkekoğlu This is me

Belma Giray This is me

Orhan Derman This is me

Publication Date December 1, 2010
Published in Issue Year 2010 Volume: 45 Issue: 4

Cite

APA Erkekoğlu, P., Giray, B., & Derman, O. (2010). Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma. Türk Pediatri Arşivi, 45(4), 66-70. https://doi.org/10.4274/tpa.45.366
AMA Erkekoğlu P, Giray B, Derman O. Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma. Türk Pediatri Arşivi. December 2010;45(4):66-70. doi:10.4274/tpa.45.366
Chicago Erkekoğlu, Pınar, Belma Giray, and Orhan Derman. “Fitalat Teması Ile Plazma Amilaz Ve Lipaz düzeyleri arasındaki ilişkinin Pubertal Jinekomasti hastalarında değerlendirilmesi Özgün Araştırma”. Türk Pediatri Arşivi 45, no. 4 (December 2010): 66-70. https://doi.org/10.4274/tpa.45.366.
EndNote Erkekoğlu P, Giray B, Derman O (December 1, 2010) Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma. Türk Pediatri Arşivi 45 4 66–70.
IEEE P. Erkekoğlu, B. Giray, and O. Derman, “Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma”, Türk Pediatri Arşivi, vol. 45, no. 4, pp. 66–70, 2010, doi: 10.4274/tpa.45.366.
ISNAD Erkekoğlu, Pınar et al. “Fitalat Teması Ile Plazma Amilaz Ve Lipaz düzeyleri arasındaki ilişkinin Pubertal Jinekomasti hastalarında değerlendirilmesi Özgün Araştırma”. Türk Pediatri Arşivi 45/4 (December 2010), 66-70. https://doi.org/10.4274/tpa.45.366.
JAMA Erkekoğlu P, Giray B, Derman O. Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma. Türk Pediatri Arşivi. 2010;45:66–70.
MLA Erkekoğlu, Pınar et al. “Fitalat Teması Ile Plazma Amilaz Ve Lipaz düzeyleri arasındaki ilişkinin Pubertal Jinekomasti hastalarında değerlendirilmesi Özgün Araştırma”. Türk Pediatri Arşivi, vol. 45, no. 4, 2010, pp. 66-70, doi:10.4274/tpa.45.366.
Vancouver Erkekoğlu P, Giray B, Derman O. Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi Özgün Araştırma. Türk Pediatri Arşivi. 2010;45(4):66-70.