Summary Eosinophilic esophagitis is a recently recognized disorder receiving increasing attention Patients present with symptoms of gastroesophageal reflux and are not responsive to standard or aggressive reflux medications Development of diagnostic guidelines consisting of symptoms as well as endoscopic and histopathologic criteria has improved the awareness of clinicians and the diagnosis of eosinophilic esophagitis The clinically challenging discrimination of eosinophilic esophagitis from gastroesophageal reflux disease has become more obvious and has avoked the need for more individualized therapy options Food allergies are causative in more than 90 of patients A better understanding of the pathogenesis of this disorder would improve the clinical recognition and diagnostic adequacy and ultimately provide patients with more optimal treatment options Turk Arch Ped 2010; 45: 232 7 Key words: Childhood eosinophilic esophagitis food allergies
Spergel JM. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol 2007; 7: 274-8. (Abstract)
Noel RJ, Putnam PE, Rothenberg ME. Eosinofilic esophagitis. N Engl J Med 2004; 351: 940-1. (Abstract) / (
Blanchard C, Wang N, Rothenberg ME. Eosinophilic esophagi- tis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol 2006; 118: 1054-9. (Abstract) / (Full Text) / (PDF)
Spergel JM, Brown-Whitehorn TF, Beausoleil JL, et al. 14 years of eosinophilic esophagitis: clinical features and progno- sis. J Pediatr Gastroenterol Nutr 2009; 48:30-6. (Abstract) / (Full Text) / (PDF)
Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatmant of eosinophilic esophagitis with spe- sific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 2005; 95: 336-43. (Abstract) / (PDF)
Simon D, Marti H, Heer P, Simon HU, Breathen LR, Straumann A. Eosiniphilic esophagitis is frequently associated with IgE- mediated allergic airway diseases. J Allergy Clin Immunol 2005; 115:1090-2. (Abstract) / (Full Text) / (PDF)
Dobbins JW, Sheahan DG, Behar J. Eosinophilic gastroenteri- tis with esophageal involvent. Gastroenterology 1977; 72: 1312-6. (Abstract)
Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroe- sophageal reflux: improvement with an aminoacid-based for- mula. Gastroenterology 1995; 109: 1503-12. (Abstract) / (PDF)
Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 2003; 98: 777-82. (Abstract) / (PDF)
Liacuras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005; 3: 1198-206. (Abstract) / (Full Text) / (PDF)
Çocukluklarda eozinofilik özofajitin doğal seyri (5)
Spergel JM, Beausoleil JL, Fiedler JM, Ginsberg J, Wagner K, Pawlowski NA. Correlation of initial food reactions to observed reactions on challenges. Ann Allergy Asthma Immmunol 2004; 92: 217-24. (Abstract) / (PDF)
Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol 2002; 363-8. (Abstract) / (Full Text) / (PDF)
Chedade M, Aveves SS. Food allergy and eosinophilic esophagi- tis. Curr Opin Allergy Clin Immunol 2010; 10: 231-7. (Abstract)
Attwood S, Smyrk T, Demeester T, Jones J. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syn- drome. Dig Dis Sci 1993; 38: 109-16. (Abstract)
Straumann A, Spichtin HP, Bernoulli R, Loosli J, Vogtlin J. Idiopathic eosinophilic esophagitis: a frequently overlooked dis- ease with typical clinical aspects and discrete endoscopic find- ings. SchweizMed Wochenschr 1994; 124: 1419-29. (Abstract)
Desai TK, Stecevis V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc 2005; 61: 795-801. (Abstract) / (Full Text) / (PDF)
Croese J, Fairley SK, Masson JW, et al. Clinical and endoscopics features of eosinophilic esophagitis in adults. Gastrointest Endosc 2003; 58: 516-22. (Abstract) / (Full Text) / (PDF)
Potter JW, Saeian K, Staff D, et al. Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features.Gastrointest Endosc 2004; 59: 355-61. (Abstract) / (Full Text) / (PDF)
Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003; 125: 1660-9. (Abstract) / (Full Text) / (PDF)
Orenstein S, Shalaby T, Lorenzo CD, Putnan P, Sigurdsson L, Kocochis S. The spectrum of pediatric eosinophilic esophagi- tis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000; 95: 1422-30. (Abstract)
Strauman A, Hruz P. What’s new in the diagnosis and therapy of eosinophilic esophagitis? Curr Opin Gastroenterol 2009; 25: 366-71. (Abstract)
Furuta GT, Straumann A. Review article: the pathogenesis and management of eosinophilic esophagitis. Aliment Pharmacol Ther 2006; 24: 173-82. (Abstract) / (Full Text) / (PDF)
Mungan Z, Pınarbaşı B, Kaymakoğlu S. Eosinophilic esophagitis: case report. Turk J Gastroenterol 2007; 18: 100-2. (PDF)
Straumann A, Degen L, Felder S, et al. Budesonide as induc- tion treatment for active eosinophilic asophagitis in adoles- cents and adults: a randomized, double-blind, placebo-con- trolled study. Gastroenterology 2008; 134: A-104.
Walsh S. Antonioli D, Goldman H, et al. Allergic esophagitis in children–a clinicopathological entity. Am J Surg Pathol 199; 23: 390-6.(Abstract)
Straumann A, Bauer M, Ficher B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a T(H)2- type allergic inflammatory response. J Allergy Clin Immunol 2001; 108: 954-61. (Abstract) / (Full Text) / (PDF)
Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to con- ventional gastroesophageal reflux therapy. Peditr Dev Pathol 1999; 2: 15-8. (Abstract) / (PDF)
Yan BM, Shaffer EA. Eosinophilic esophagitis: a newly established cause of dysphagia. World J Gastroenterol 2006; 12: 2328-34. (Abstract) / (Full Text) / (PDF)
Liacouras CA, Wenner WJ, Brown K, Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr 1998; 26: 380-5. (Abstract) / (Full Text)
Orenstein SR, Shalaby TM, Di Lorenzo C, et al. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000; 95: 1422-30. (Abstract)
Gonsalves N, Policarpio-Nicolas M, Zhang Q, Rao MS, Hirano I. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc 2006; 64: 313-9. (Abstract) / (Full Text) / (PDF)
Steiner SJ, Kernek KM, Fitzgerald JF. Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2006; 42: 506-9. (Abstract)
Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic rewiew and con- sensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342-63. (Abstract) / (Full Text) / (PDF)
Teitelbaum JE, Fox VL, Twarog FT, et al. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology 2002; 122: 1216-25. (Abstract) / (Full Text) / (PDF)
Konikoff MR, Noel RJ, Blanchard C, et al. A randomized, double- blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilc esophagitis. Gastroenterology 2006; 131: 1381-91. (Abstract) / (Full Text) / (PDF)
Schaafer ET, Fitzgerald JF, Molleston JP, et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis; a randomized trial in children. Clin Gastroenterol Hepatol 2008; 6: 165-73.
Netzer P, Gschossman KM, Straumann A, et al. Corticosteroid-dependent eosinophilic oesophagitis: azathio- prine and 6-mercaptopurine can induce and maintain long- term remission. Eur J Gastroenterol Hepatol 2007; 19: 865-9. (Abstract) / (Full Text) / (PDF)
Eozinofilik özofajit Çağrılı Yazar
Year 2010,
Volume: 45 Issue: 3, 32 - 37, 01.09.2010
Özet Eozinofilik özofajit giderek daha çok dikkati çekmekte olan yeni fark edilmiş bir bozukluktur Hastalar gastroözofageal reflü bulguları gösterirler bilinen ya da daha karmaşık reflü tedavilerine yanıt vermezler Endoskopik ve histopatolojik belirteçlerin yanı sıra belirtileri içeren tanısal klavuzların geliştirilmesi klinisyenlerin farkındalığını ve tanı koyulan eozinofilik özofajit sayısını artırmıştır Eozinofilik özofajitin gastroözofageal reflü hastalığından klinik olarak ayrımındaki zorluklar daha belirginleşmiş ve daha bireysel tedavi seçeneklerine ihtiyaç duyulmaya başlanmıştır Hastaların 90 rsquo;ında neden gıda alerjileridir Hastalığın patojenezinin daha iyi şekilde anlaşılması klinik olarak tanımlanmasını sağlayarak tanısal yeterliliği arttıracak ve sonuçta hastaların daha iyi tedavi edilmesini sağlayacaktır Türk Ped Arş 2010; 45: 232 7 Anahtar sözcükler: Çocukluk çağı gıda alerjileri eozinofilik özofajit
Spergel JM. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol 2007; 7: 274-8. (Abstract)
Noel RJ, Putnam PE, Rothenberg ME. Eosinofilic esophagitis. N Engl J Med 2004; 351: 940-1. (Abstract) / (
Blanchard C, Wang N, Rothenberg ME. Eosinophilic esophagi- tis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol 2006; 118: 1054-9. (Abstract) / (Full Text) / (PDF)
Spergel JM, Brown-Whitehorn TF, Beausoleil JL, et al. 14 years of eosinophilic esophagitis: clinical features and progno- sis. J Pediatr Gastroenterol Nutr 2009; 48:30-6. (Abstract) / (Full Text) / (PDF)
Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatmant of eosinophilic esophagitis with spe- sific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 2005; 95: 336-43. (Abstract) / (PDF)
Simon D, Marti H, Heer P, Simon HU, Breathen LR, Straumann A. Eosiniphilic esophagitis is frequently associated with IgE- mediated allergic airway diseases. J Allergy Clin Immunol 2005; 115:1090-2. (Abstract) / (Full Text) / (PDF)
Dobbins JW, Sheahan DG, Behar J. Eosinophilic gastroenteri- tis with esophageal involvent. Gastroenterology 1977; 72: 1312-6. (Abstract)
Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroe- sophageal reflux: improvement with an aminoacid-based for- mula. Gastroenterology 1995; 109: 1503-12. (Abstract) / (PDF)
Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 2003; 98: 777-82. (Abstract) / (PDF)
Liacuras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005; 3: 1198-206. (Abstract) / (Full Text) / (PDF)
Çocukluklarda eozinofilik özofajitin doğal seyri (5)
Spergel JM, Beausoleil JL, Fiedler JM, Ginsberg J, Wagner K, Pawlowski NA. Correlation of initial food reactions to observed reactions on challenges. Ann Allergy Asthma Immmunol 2004; 92: 217-24. (Abstract) / (PDF)
Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol 2002; 363-8. (Abstract) / (Full Text) / (PDF)
Chedade M, Aveves SS. Food allergy and eosinophilic esophagi- tis. Curr Opin Allergy Clin Immunol 2010; 10: 231-7. (Abstract)
Attwood S, Smyrk T, Demeester T, Jones J. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syn- drome. Dig Dis Sci 1993; 38: 109-16. (Abstract)
Straumann A, Spichtin HP, Bernoulli R, Loosli J, Vogtlin J. Idiopathic eosinophilic esophagitis: a frequently overlooked dis- ease with typical clinical aspects and discrete endoscopic find- ings. SchweizMed Wochenschr 1994; 124: 1419-29. (Abstract)
Desai TK, Stecevis V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc 2005; 61: 795-801. (Abstract) / (Full Text) / (PDF)
Croese J, Fairley SK, Masson JW, et al. Clinical and endoscopics features of eosinophilic esophagitis in adults. Gastrointest Endosc 2003; 58: 516-22. (Abstract) / (Full Text) / (PDF)
Potter JW, Saeian K, Staff D, et al. Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features.Gastrointest Endosc 2004; 59: 355-61. (Abstract) / (Full Text) / (PDF)
Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003; 125: 1660-9. (Abstract) / (Full Text) / (PDF)
Orenstein S, Shalaby T, Lorenzo CD, Putnan P, Sigurdsson L, Kocochis S. The spectrum of pediatric eosinophilic esophagi- tis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000; 95: 1422-30. (Abstract)
Strauman A, Hruz P. What’s new in the diagnosis and therapy of eosinophilic esophagitis? Curr Opin Gastroenterol 2009; 25: 366-71. (Abstract)
Furuta GT, Straumann A. Review article: the pathogenesis and management of eosinophilic esophagitis. Aliment Pharmacol Ther 2006; 24: 173-82. (Abstract) / (Full Text) / (PDF)
Mungan Z, Pınarbaşı B, Kaymakoğlu S. Eosinophilic esophagitis: case report. Turk J Gastroenterol 2007; 18: 100-2. (PDF)
Straumann A, Degen L, Felder S, et al. Budesonide as induc- tion treatment for active eosinophilic asophagitis in adoles- cents and adults: a randomized, double-blind, placebo-con- trolled study. Gastroenterology 2008; 134: A-104.
Walsh S. Antonioli D, Goldman H, et al. Allergic esophagitis in children–a clinicopathological entity. Am J Surg Pathol 199; 23: 390-6.(Abstract)
Straumann A, Bauer M, Ficher B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a T(H)2- type allergic inflammatory response. J Allergy Clin Immunol 2001; 108: 954-61. (Abstract) / (Full Text) / (PDF)
Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to con- ventional gastroesophageal reflux therapy. Peditr Dev Pathol 1999; 2: 15-8. (Abstract) / (PDF)
Yan BM, Shaffer EA. Eosinophilic esophagitis: a newly established cause of dysphagia. World J Gastroenterol 2006; 12: 2328-34. (Abstract) / (Full Text) / (PDF)
Liacouras CA, Wenner WJ, Brown K, Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr 1998; 26: 380-5. (Abstract) / (Full Text)
Orenstein SR, Shalaby TM, Di Lorenzo C, et al. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000; 95: 1422-30. (Abstract)
Gonsalves N, Policarpio-Nicolas M, Zhang Q, Rao MS, Hirano I. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc 2006; 64: 313-9. (Abstract) / (Full Text) / (PDF)
Steiner SJ, Kernek KM, Fitzgerald JF. Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2006; 42: 506-9. (Abstract)
Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic rewiew and con- sensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342-63. (Abstract) / (Full Text) / (PDF)
Teitelbaum JE, Fox VL, Twarog FT, et al. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology 2002; 122: 1216-25. (Abstract) / (Full Text) / (PDF)
Konikoff MR, Noel RJ, Blanchard C, et al. A randomized, double- blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilc esophagitis. Gastroenterology 2006; 131: 1381-91. (Abstract) / (Full Text) / (PDF)
Schaafer ET, Fitzgerald JF, Molleston JP, et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis; a randomized trial in children. Clin Gastroenterol Hepatol 2008; 6: 165-73.
Netzer P, Gschossman KM, Straumann A, et al. Corticosteroid-dependent eosinophilic oesophagitis: azathio- prine and 6-mercaptopurine can induce and maintain long- term remission. Eur J Gastroenterol Hepatol 2007; 19: 865-9. (Abstract) / (Full Text) / (PDF)