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Gallstones in childhood: Retrospective analysis of 60 cases Original Article

Year 2010, Volume: 45 Issue: 2, 19 - 23, 01.06.2010
https://doi.org/10.4274/tpa.45.119

Abstract

Summary Aim: The purpose of this study was to documentation of the characteristics of children with cholelithiasis by means of age sex clinical manifestations and risk factors Material and Method: Sixty cases aged 0 18 years with ultrasonographic evidence of cholelithiasis were enrolled in the study nbsp; nbsp; Results: Mean age of the patients was 7 8 plusmn;5 1 years range: 0 25 18 years 38 63 3 of them were females Underlying risk factors were identified in 34 56 7 of cases 15 ceftriaxone use six hemolytic diseases five Down rsquo;s syndrome four obesity two total parenteral nutrition and sepsis one inflammatory disease and one chronic cholestatic liver disease No etiology could be found in 26 43 3 patients who were defined as idiopathic Of 46 patients who were followed at least for three months eight 17 4 had cholecystectomy 16 34 8 showed differences in stone size and the stones were resolved in 24 patients 52 2 When the cases related to ceftriaxone use were excluded the percentage of the disappaerance of the stones was found to be 28 3 Ursodeoxycolic acid was effective on resolution of symptoms in 69 2 of patients The complications of gallstones were recorded in five 8 3 patients Conclusions: Cholelithiasis is more common in children than previously thought The most common risk factors are ceftriaxone use and hemolytic diseases but about half of the cases are still idiopathic There is a need for close monitoring of patients in especially risk groups because of gallstone development and its complications Turk Arch Ped 2010; 45: 119 23 Key words: Childhood cholelithiasis ceftriaxone gallstones ursodeoxycolic acid

References

  • Kratzer W, Mason RA, Kachale V. Prevelance of gallstone in so- nographic surveys worldwide. J Clin Ultrasound 1999; 27: 1-7. (Abstract) / (PDF)
  • Palasciano G, Portincasa P, Vinciguerra V, et al. Gallstone pre- valence and gallbladder volume in children and adolescents: an epidemiological ultrasonography survey and relationship to body mass index. Am J Gastroenterol 1989; 84: 1378-82. (Abstract)
  • Gilger MA. Diseases of the gallbladder. In: Wyllie R, Hyams JS (eds). Pediatric Gastrointestinal Disease. 2. ed. Philedelphia: W.B Sounders Company,.1999; 651-62.
  • Wesdorp I, Bosman D, de Graaff A, Aronson D, van der Blij F, Taminiau J. Clinical presentations and predisposing factors of cholelithiasis and sludge in children. J Pediatr Gastroenterol Nutr 2000; 31: 411-7. (Abstract) / (Full Text) / (PDF)
  • Yılmaz A, Akçam M, Akıncı Ö, Karagüzel G, Artan R. Çocuklar- da kolelitiyazis: Antalya yöresinde yedi yıllık deneyim. Selçuk Tıp Derg 2006; 22: 17-20.
  • Özkan T, Kılıç Ş, Tarım A, Tanrıtanır A, Özeke T. Çocukluk çağında kolelitiazis. Bursa Devlet Has Bült 1997; 13: 121-5.
  • Holcomb GW. Cholelithiasis in infants, children and adoles- cents. Pediatr Rev 1991; 11: 268-74. (Abstract) / (PDF)
  • Della Corte C, Falchetti D, Nebbia G, et al. Management of cho- lelithiasis in Italian children: a national multicenter study World J Gastroenterol 2008; 14: 1383-8. (Abstract) / (Full Text) / (PDF)
  • Reif S, Sloven DG, Lebenthal E. Gallstones in children. Charac- terization by age, etiology, and outcome. Am J Dis Child 1991; 145: 105-8. (Abstract) / (Full Text)
  • Baily PV, Connors RH, Tracy TF Jr, Sotelo-Avila C, Lewis JE, Weber TR. Changing spectrum of cholelithiasis and cholecycti- tis in infant and children. Am J Surg 1989; 158: 585-8. (Abstract)
  • Graf GA, Li WP, Gerard RD, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest 2002; 110: 659-69. (Abstract) / (Full Text) / (PDF)
  • Holzbach R, Busch N. Nucleation and growth of cholesterol crys- tals. Gastroenterol Clin North Am 1991; 20:67-84. (Abstract)
  • Herzog D. Bouchard G. High rate of complicated idiyopathic gallstone disease in pediatric patients of a North American terti- ary care center. World J Gastroenterol 2008; 14: 1544-8. (Abstract) / (Full Text) / (PDF)
  • Park HZ, Lee SP, Schy AL. Ceftriaxone-associated gallbladder sludge. Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Gastroenterology 1991; 100:1665-70. (Abstract) / (PDF)
  • Papadopoulou F, Efremidis S, Karyda S, et al. Incidence of cef- triaxone-associated gallbladder pseudolithiasis. Acta Pædiatr 1999; 88: 1352-5. (Abstract) / (PDF)
  • Bor O, Dinleyici EC, Kebapçı M, Durmuş Aydoğdu S. Ceftriaxo- ne-associated biliary sludge and pseudocholelithiasis during childhood: a prospective study. Pediatrics International 2004; 46: 322-4. (Abstract) / (Full Text) / (PDF)
  • Klar A, Branski D, Akerman Y, et al. Sludge ball, pseudolithiasis, cholelithiasis and choledocholithiasis from intrauterine life to 2 years: a 13-year follow-up. J Pediatr Gastroenterol Nutr 2005; 40: 477-80. (Abstract) / (Full Text)
  • Boechat MC, Silva KS, Llerena JC Jr, Boechat PR. Cholelithia- sis and biliary sludge in Down’s syndrome patients. Sao Paulo Med J 2007;125:329-32. (Abstract) / (Full Text) / (PDF)
  • Llerena JC, Boy R, Neto JB, Vargas F. Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsympto- matic biliary tract disease. Am J Med Genet 1993; 46: 612. (Abstract) / (PDF)
  • Toscano E, Trivellini V, Andria G. Cholelithiasis in Down’s syndro- me. Arch Dis Child 2001; 85:242-3. (Abstract) / (Full Text) / (PDF)
  • Tasdemir HA, Çetinkaya MC, Polat C, Belet U, Kalaycı AG, Ak- baş S. Gallbladder motility in children with Down syndrome. J Pediatr Gastroenterol Nutr 2004; 39: 187-91. (Abstract) / (Full Text) / (PDF)
  • Salen G, Tint GS, Shefer S. Treatment of cholesterol gallstones with litholytic bile acids. Gastroenterol Clin North Am 1991; 20: 171-82. (Abstract)
  • Ikegami T, Matsuzaki Y. Ursodeoxycholic acid: mechanism of action and novel clinical applications. Hepatol Res 2008; 38: 123-31. (Abstract) / (Full Text) / (PDF)
  • Davidoff AM, Branum GD, Murray EA, et al. The technique of la- paroscopic cholecystectomy in children. Ann Surg 1992; 215:186-91. (Abstract) / (Full Text) / (PDF)

Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma

Year 2010, Volume: 45 Issue: 2, 19 - 23, 01.06.2010
https://doi.org/10.4274/tpa.45.119

Abstract

Özet Amaç: Safra kesesinde taş nedeniyle izlenen çocuk hastaların geriye dönük olarak değerlendirilerek yaş cinsiyet dağılımları risk etmenleri klinik özellikleri ve hastalığın seyrinin belirlenmesi amaçlanmıştır Gereç ve Yöntem: Ultrasonografik olarak safra kesesinde taş saptanan ve yaşları 0 18 yıl arasında olan 60 hasta çalışmaya alınmıştır Bulgular: Hastaların 38 rsquo;i kız 63 3 olup ortalama yaşları 7 8 plusmn;5 1 yıl 0 25 18 yıl idi Otuz dört 56 7 hastada altta yatan risk etmeni belirlenirken 15 seftriyakson kullanımı altı hemolitik hastalık beş Down sendromu dört şişmanlık iki total parenteral beslenme ve sepsis birer enflamatuar bağırsak hastalığı ve kronik kolestatik karaciğer hastalığı 26 43 3 hastada herhangi bir risk etmeni saptanamamış ve idiyopatik olarak değerlendirilmiştir En az üç ay izlemi yapılabilen 46 olgunun nbsp; sekizinin 17 4 kolesistektomiye gittiği 16 rsquo;sında 34 8 taşın devam ettiği ve 24 rsquo;ünde 52 2 taşın kaybolduğu gözlenmiştir Seftriyaksona bağlı gelişen tüm taşların kaybolduğu izlenmiş ve bu olgular hariç tutulduğunda taşın kaybolma oranı 28 3 bulunmuştur Ursodeoksikolik asit tedavisi ile hastaların 69 2 rsquo;sinde yakınmaların düzeldiği izlenmiştir Beş olguda 8 3 safra taşı ile ilgili komplikasyonlar gözlenmiştir Çıkarımlar: Çocuklarda safra kesesi taşları eskiye oranla daha sık rastlanmaktadır Risk etmeni olarak ilk sırada seftriyakson kullanımı ikinci sırada da hemolitik hastalıklar gelmekte ancak olguların yaklaşık yarısı hala idiyopatik olarak kalmaktadır Özellikle risk grubundaki hastaların safra taşı ve komplikasyonları açısından yakın izlenmesi gereklidir Türk Ped Arş 2010; 45: 119 23 Anahtar sözcükler: Çocukluk çağı safra kesesi taşı safra taşı seftriyakson ursodeoksikolik asit

References

  • Kratzer W, Mason RA, Kachale V. Prevelance of gallstone in so- nographic surveys worldwide. J Clin Ultrasound 1999; 27: 1-7. (Abstract) / (PDF)
  • Palasciano G, Portincasa P, Vinciguerra V, et al. Gallstone pre- valence and gallbladder volume in children and adolescents: an epidemiological ultrasonography survey and relationship to body mass index. Am J Gastroenterol 1989; 84: 1378-82. (Abstract)
  • Gilger MA. Diseases of the gallbladder. In: Wyllie R, Hyams JS (eds). Pediatric Gastrointestinal Disease. 2. ed. Philedelphia: W.B Sounders Company,.1999; 651-62.
  • Wesdorp I, Bosman D, de Graaff A, Aronson D, van der Blij F, Taminiau J. Clinical presentations and predisposing factors of cholelithiasis and sludge in children. J Pediatr Gastroenterol Nutr 2000; 31: 411-7. (Abstract) / (Full Text) / (PDF)
  • Yılmaz A, Akçam M, Akıncı Ö, Karagüzel G, Artan R. Çocuklar- da kolelitiyazis: Antalya yöresinde yedi yıllık deneyim. Selçuk Tıp Derg 2006; 22: 17-20.
  • Özkan T, Kılıç Ş, Tarım A, Tanrıtanır A, Özeke T. Çocukluk çağında kolelitiazis. Bursa Devlet Has Bült 1997; 13: 121-5.
  • Holcomb GW. Cholelithiasis in infants, children and adoles- cents. Pediatr Rev 1991; 11: 268-74. (Abstract) / (PDF)
  • Della Corte C, Falchetti D, Nebbia G, et al. Management of cho- lelithiasis in Italian children: a national multicenter study World J Gastroenterol 2008; 14: 1383-8. (Abstract) / (Full Text) / (PDF)
  • Reif S, Sloven DG, Lebenthal E. Gallstones in children. Charac- terization by age, etiology, and outcome. Am J Dis Child 1991; 145: 105-8. (Abstract) / (Full Text)
  • Baily PV, Connors RH, Tracy TF Jr, Sotelo-Avila C, Lewis JE, Weber TR. Changing spectrum of cholelithiasis and cholecycti- tis in infant and children. Am J Surg 1989; 158: 585-8. (Abstract)
  • Graf GA, Li WP, Gerard RD, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest 2002; 110: 659-69. (Abstract) / (Full Text) / (PDF)
  • Holzbach R, Busch N. Nucleation and growth of cholesterol crys- tals. Gastroenterol Clin North Am 1991; 20:67-84. (Abstract)
  • Herzog D. Bouchard G. High rate of complicated idiyopathic gallstone disease in pediatric patients of a North American terti- ary care center. World J Gastroenterol 2008; 14: 1544-8. (Abstract) / (Full Text) / (PDF)
  • Park HZ, Lee SP, Schy AL. Ceftriaxone-associated gallbladder sludge. Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Gastroenterology 1991; 100:1665-70. (Abstract) / (PDF)
  • Papadopoulou F, Efremidis S, Karyda S, et al. Incidence of cef- triaxone-associated gallbladder pseudolithiasis. Acta Pædiatr 1999; 88: 1352-5. (Abstract) / (PDF)
  • Bor O, Dinleyici EC, Kebapçı M, Durmuş Aydoğdu S. Ceftriaxo- ne-associated biliary sludge and pseudocholelithiasis during childhood: a prospective study. Pediatrics International 2004; 46: 322-4. (Abstract) / (Full Text) / (PDF)
  • Klar A, Branski D, Akerman Y, et al. Sludge ball, pseudolithiasis, cholelithiasis and choledocholithiasis from intrauterine life to 2 years: a 13-year follow-up. J Pediatr Gastroenterol Nutr 2005; 40: 477-80. (Abstract) / (Full Text)
  • Boechat MC, Silva KS, Llerena JC Jr, Boechat PR. Cholelithia- sis and biliary sludge in Down’s syndrome patients. Sao Paulo Med J 2007;125:329-32. (Abstract) / (Full Text) / (PDF)
  • Llerena JC, Boy R, Neto JB, Vargas F. Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsympto- matic biliary tract disease. Am J Med Genet 1993; 46: 612. (Abstract) / (PDF)
  • Toscano E, Trivellini V, Andria G. Cholelithiasis in Down’s syndro- me. Arch Dis Child 2001; 85:242-3. (Abstract) / (Full Text) / (PDF)
  • Tasdemir HA, Çetinkaya MC, Polat C, Belet U, Kalaycı AG, Ak- baş S. Gallbladder motility in children with Down syndrome. J Pediatr Gastroenterol Nutr 2004; 39: 187-91. (Abstract) / (Full Text) / (PDF)
  • Salen G, Tint GS, Shefer S. Treatment of cholesterol gallstones with litholytic bile acids. Gastroenterol Clin North Am 1991; 20: 171-82. (Abstract)
  • Ikegami T, Matsuzaki Y. Ursodeoxycholic acid: mechanism of action and novel clinical applications. Hepatol Res 2008; 38: 123-31. (Abstract) / (Full Text) / (PDF)
  • Davidoff AM, Branum GD, Murray EA, et al. The technique of la- paroscopic cholecystectomy in children. Ann Surg 1992; 215:186-91. (Abstract) / (Full Text) / (PDF)
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Original Article
Authors

Fatih Fakirullahoğlu This is me

Gönül Dinler This is me

Ayhan Gazi Kalaycı This is me

Publication Date June 1, 2010
Published in Issue Year 2010 Volume: 45 Issue: 2

Cite

APA Fakirullahoğlu, F., Dinler, G., & Kalaycı, A. G. (2010). Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma. Türk Pediatri Arşivi, 45(2), 19-23. https://doi.org/10.4274/tpa.45.119
AMA Fakirullahoğlu F, Dinler G, Kalaycı AG. Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma. Türk Pediatri Arşivi. June 2010;45(2):19-23. doi:10.4274/tpa.45.119
Chicago Fakirullahoğlu, Fatih, Gönül Dinler, and Ayhan Gazi Kalaycı. “Çocukluk çağında Safra taşları: 60 Olgunun Geriye dönük Incelenmesi Özgün Araştırma”. Türk Pediatri Arşivi 45, no. 2 (June 2010): 19-23. https://doi.org/10.4274/tpa.45.119.
EndNote Fakirullahoğlu F, Dinler G, Kalaycı AG (June 1, 2010) Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma. Türk Pediatri Arşivi 45 2 19–23.
IEEE F. Fakirullahoğlu, G. Dinler, and A. G. Kalaycı, “Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma”, Türk Pediatri Arşivi, vol. 45, no. 2, pp. 19–23, 2010, doi: 10.4274/tpa.45.119.
ISNAD Fakirullahoğlu, Fatih et al. “Çocukluk çağında Safra taşları: 60 Olgunun Geriye dönük Incelenmesi Özgün Araştırma”. Türk Pediatri Arşivi 45/2 (June 2010), 19-23. https://doi.org/10.4274/tpa.45.119.
JAMA Fakirullahoğlu F, Dinler G, Kalaycı AG. Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma. Türk Pediatri Arşivi. 2010;45:19–23.
MLA Fakirullahoğlu, Fatih et al. “Çocukluk çağında Safra taşları: 60 Olgunun Geriye dönük Incelenmesi Özgün Araştırma”. Türk Pediatri Arşivi, vol. 45, no. 2, 2010, pp. 19-23, doi:10.4274/tpa.45.119.
Vancouver Fakirullahoğlu F, Dinler G, Kalaycı AG. Çocukluk çağında safra taşları: 60 olgunun geriye dönük incelenmesi Özgün Araştırma. Türk Pediatri Arşivi. 2010;45(2):19-23.