Abstract
In childhood; the incidence of intracranial thrombosis is 2 5 2 7 100000 They may present with different symptoms according to the location and size of the occluded vessel and age of the patient In most cases; cranial imaging is necessary to confirm the lesion Pediatric cerebrovascular thrombosis may be related to more than one etiologic factor so detailed evaluation is mandatory A thirteen year old boy presented to our emergency room with a complaint of seizure His cranial imaging showed thrombosis in left transversesigmoid sinuse His father had been diagnosed to have deep venous thrombosis In our case and in his father; protein S levels were found as 11 9 and 10 6 N: 80 120 respectively and they were started on anticoagulation therapy Our patient’s homocsyteine level was 15 5 mmol lt N:0 12 His methylene tetrahydrofolate reductase thermolabile enzyme C677T mutation was found homozygous He was also started on oral folic acid therapy A year after his first presentation his protein S level was 16 and homocysteine level was 7 5 mmol lt His last cranial imaging showed no progresssion in the prior lesion and no new lesion Key words: childhood homocysteine methylene tetrahydrofolate reductase proteins thrombosis
Keywords
Abstract
Çocukluk döneminde intrakraniyal tromboz görülme sıklığı 2 5 2 7 100 000’dir Semptomlar etkilenen damarın boyutuna intrakraniyal yerleşimine ve hastanın yaşına göre değişir Birçok faktör etiolojide rol oynayabileceği için hastaların ayrıntılı tetkik edilmesi gerekir Konvülziyon nedeni ile acil servisimize başvuran on üç yaşındaki erkek olgunun kraniyal görüntülemesinde sol tranvers sigmoid sinüste tromboz saptandı Babasında derin ven trombozu öyküsü olan olgumuzun protein S düzeyi 11 9 80 120 babasında ise protein S’i 10 6 saptanarak her ikisine de oral antikoagülasyon tedavisine başlandı Aynı zamanda homosistein düzeyi 15 5 mmol lt 0 12 bulunan hastamızdan metil tetrahidrofolat redüktaz enzim aktivitesi gönderildi Sonuç homozigot mutant olarak değerlendirildi C 6775 ve oral folik asit tedavisine başlandı Bir yıl sonra hastanın protein S düzeyi 16 ve homosistein düzeyi 7 5 mmol lt olarak saptandı Kraniyal manyetik rezonans görüntülemesinde yeni bir tromboz oluşumu yoktu ve konvülziyonu tekrarlamamıştı Anahtar Kelimeler: çocukluk çağı homosistein metil tetrahidrofolat redüktaz protein S tromboz
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | March 1, 2005 |
| Published in Issue | Year 2005 Volume: 40 Issue: 1 |