Abstract
The purpose of this study was to identify whether ketoconazole might has antithyroid effect Twenty six rats in two groups were included in this study Groups were designed as followed Group A: Control group; group B: 13 rats treated with oral ketoconazole 60 mg kg twice daily for thirty days In this study mean serum triiodothyronine T3 thyroxine T4 and thyroid stimulating hormone TSH concentrations were not statistically different between the beginning and 15th days of the therapy in group B p gt;0 05 But at the 30th days of the therapy mean serum T3 and T4 concentrations were decreased in group B and there was statistically different between the beginning and 30th days of the therapy p lt;0 05 In addition serum TSH levels were mild increased at the 30th days of therapy in the group B p gt;0 05 In the group B histopathological analysis of the thyroid glands were demonstrated the increased of cylindrical cells In control animals the epitelium was mostly cubical cells In conclusion on the basis of our findings decompensate hypothyroidism developed after treatment with 60 mg kg twice daily of ketoconazole for thirty days in the rats Key words: Ketoconazole Thyroid Gland
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Abstract
Bu çalışmada ketokonazolun tiroid fonksiyonları üzerinde etkisinin olup olmadığı araştırıldı Araştırma her biri 13 sıçandan oluşan iki grupta yapıldı Kontrol grubuna grup A normal içme suyu ve yem grup B ye 60 mg kg gün ketokonazol ağızdan otuz gün süreyle verildi B grubunda başlangıç ile 15 gün serum triyodotironin T3 tiroksin T4 ve tiroid uyarıcı hormon TSH düzeyleri arasında anlamlı fark bulunamadı p gt;0 05 ancak 30 gün ortalama serum T3 ve T4 seviyeleri azalmış idi ve başlangıç değerleri ile aralarında istatistiki olarak anlamlı fark olduğu görüldü p lt;0 05 Diğer taraftan ilaç verilen grupta 30 gün serum TSH düzeyinde bir miktar artış olduğu kaydedildi İlaç verilen grupta tiroidin histopatolojik tetkikinde silindirik hücrelerin ön planda olduğu görüldü Bu bulgularla otuz gün süreyle kullanılan ketokonazolun dekompanse tipte hipotiroidi tablosuna yol açtığı tespit edildi Anahtar kelimeler: Ketokonazol Tiroid Bezi
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Details
| Primary Language | Turkish |
|---|---|
| Journal Section | When the Turkish word exists |
| Authors | |
| Publication Date | June 1, 1996 |
| Published in Issue | Year 1996 Volume: 31 Issue: 2 |