Rhinocerebral mucormycosis: a report of two cases

Abstract

Rhinocerebral mucormycosis is an aggressive fungal disease that involves the nose, paranasal sinuses, orbit and Central nervous system. İt may rapidly be fatal.This infection usually occurs secondary to immune suppression, diabetic ketoacidosis, and prolonged use of antibiotics, steroids, and cytotoxic drugs. Management of the condition consists of treatment of underlying dis­ ease and surgical debridement combined with intra- venous amphotericin B. This paper presents two patients with rhinocerebral mucormycosis, both suffer- ing from diabetes. Complete recovery was achieved in one patient with surgical debridement of necrotic tissue combined with systemic antifungal treatment, whereas in the other, the disease was complicated with subarachnoid hemorrhage and the patient died on the third day of treatment.

Keywords

• Amphotericin B/therapeutic use, debridement, dermatomycoses/complications/therapy, diabetes complications, facial dermatoses, mucormycosis/pathology/therapy

Rinoserebral mukormikozis: İki olgu sunumu

Abstract

Rinoserebral mukormikozis burnu, paranazal si- nüsleri, orbitayı ve merkezi sinir sistemini tutan ag- resif seyirli fungal bir hastalıktır ve çok kısa sürede hızla ölümcül olabilir. Bu enfeksiyon genellikle ba- ğışıklık sisteminin baskılanmasına, diyabetik keto- asidoza ve uzun süreli antibiyotik, steroid ve sito- toksik ilaç kullanımına bağlı olarak gelişir. Esas te- davi, altta yatan hastalığın tedavisi ve cerrahi deb- ridman ile birlikte intravenöz amfoterisin B kullanı- mından oluşur. Bu yazıda diyabetli iki hastada gö- rülen rinoserebral mukormikozis sunuldu. Bir olgu- da, nekrotik dokuların cerrahi debridmanı ve siste- mik antifungal tedavi ile tam iyileşme elde edildi. Diğer olgu ise, hastalığın subaraknoid kanama ile kötüleşmesi sonucu tedavinin üçüncü gününde ya- şamını yitirdi

Keywords

• Amfoterisin B/terapötik kullanım, debridman, dermatomikozis/komplikasyon/tedavi, diyabet komplikasyonları, yüz dermatozu, mukormikozis/patoloji/tedavi

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