Sinonasal inflammatory myofibroblastic pseudotumor plasma cell granuloma

Abstract

Inflammatory myofibroblastic pseudotumor plasma cell granuloma is a soft tissue lesion consisting of myofibroblasts, mature lymphocytes, histiocytes, plasma cells, eosinophils, and extracellular collagen. Various sites in the body may harbor these lesions. Lungs, omentum, intestines, mesentery, and urinary system are the most susceptible areas. It is usually seen in children and young adults. The lesion is rarely detected in the head and neck region. The orbit and the upper respiratory system are the most common localizations in the head and neck region. Sinonasal tract is a rare site of involvement. The differential diagnosis includes squamous cell carcinoma spindle cell variant , inflammatory fibrosarcoma, leiomyosarcoma, schwannoma, and nonspecific inflammation. Our patient who had a sinonasal mass showed a benign tumor consisting of spindle tumor cells and inflammatory cells histopathologically. This case was presented due to its rare existence to this site.

Keywords

• Inflammatory myofibroblastic pseudotumor, plasma cell granuloma, sinonasal

Sinonazal enflamatuvar miyofibroblastik psödotümör plazma hücreli granülom

Abstract

Enflamatuvar miyofibroblastik psödotümör plazma hücreli granülom miyofibroblastlar, olgun lenfositler, histiositler, plazma hücreleri, eozinofiller ve ekstraselüler kollajenden oluşan bir yumuşak doku lezyonudur. Bu lezyonlar vücuttaki çeşitli bölgelerde bulunabilir. Akciğerler, omentum, bağırsaklar, mezenter ve üriner sistem riske en açık alanlardır. Genellikle çocuklar ve genç erişkinlerde görülür. Lezyon baş ve boyun bölgesinde nadiren tespit edilir. Baş ve boyun bölgesinde orbit ve üst solunum sistemi en yaygın yerleşim yerleridir. Sinonazal yol nadir bir tutulum bölgesidir. Ayırıcı tanı skuamöz hücreli karsinom iğsi hücreli varyant , enflamatuvar fibrosarkom, leiomiyosarkom, schwannom ve nonspesifik enflamasyonu içerir. Sinonazal kitlesi olan hastamızda histopatolojik olarak iğsi tümör hücreleri ve enflamatuvar hücrelerden oluşan iyi huylu bir tümör görüldü. Bu olgu bu alandaki nadir oluşumu nedeniyle sunuldu

Keywords

• Enflamatuvar miyofibroblastik psödotümör, plazma hücreli granülom, sinonazal

References

1. Kendall CH, Johnston MN. Pseudo-malignant laryngeal nodule (inflammatory myofibroblastic tumour) Histopathology 1998;32:286-7.
2. Naveen J, Sonalika W, Prabhu S, Gopalkrishnan K. Inflammatory pseudotumor of maxillary sinus: Mimicking as an aggressive malignancy. J Oral Maxillofac Pathol 2011;15:344-5.
3. Nonaka D, Birbe R, Rosai J. So-called inflammatory myofibroblastic tumour: a proliferative lesion of fibroblastic reticulum cells? Histopathology 2005;46:604-13.
4. Papachristou GI, Wu T, Marsh W, Plevy SE. Inflammatory pseudotumor of the liver associated with Crohn's disease. J Clin Gastroenterol 2004;38:818-22.
5. Gale N, Zidar N, Podboj J, Volavsek M, Luzar B. Inflammatory myofibroblastic tumour of paranasal sinuses with fatal outcome: reactive lesion or tumour?J Clin Pathol 2003;56:715-7.
6. Jung KH, Kim YW, So YK, Choi SI, Baek MJ. Inflammatory myofibroblastic tumor involving ear lobule. Auris Nasus Larynx 2012;39:631-3.
7. İşeri M, Ulubil SA, Kuru FD, Derin S, Oran A. Retroauricular inflammatory myofibroblastic tumor: a case report. Kulak Burun Bogaz Ihtis Derg 2012;22:43-5.
8. Maldjian JA, Norton KI, Groisman GM, Som PM. Inflammatory pseudotumor of the maxillary sinus in a 15-year-old boy. AJNR Am J Neuroradiol 1994;15:784-6.

9. Zhou SH, Ruan LX, Xu YY, Wang SQ, Ren GP, Ling L. Inflammatory myofibroblastic tumour in the left maxillary sinus: a case report. Chin Med J (Engl) 2004;117:1597-9.
10. Som PM, Brandwein MS, Maldjian C, Reino AJ, Lawson W. Inflammatory pseudotumor of the maxillary sinus: CT and MR findings in six cases. AJR Am J Roentgenol 1994;163:689-92.
11. Chuang CC, Lin HC, Huang CW. Inflammatory pseudotumor of the sinonasal tract. J Formos Med Assoc 2007;106:165-8.
12. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859-72.
13. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol 1991;15:1146-56.
14. Ji XL, Ma YM. Elementary analysis to pathological morphology development progress: from inflammatory pseudotumour to inflammatory myofibroblastic tumour. J Clin Exp Pathol (Chin) 2003;19:319-20.
15. Chuang CC, Lin HC, Huang CW. Inflammatory pseudotumor of the sinonasal tract. J Formos Med Assoc 2007;106:165-8.
16. Huang WH, Dai YC. Inflammatory pseudotumor of the nasal cavity. Am J Otolaryngol 2006;27:275-7.
17. Weisman RA, Osguthorpe JD. Pseudotumor of the head and neck masquerading as neoplasia. Laryngoscope 1988;98:610-4.
18. Barthold HJ, Harvey A, Markoe AM, Brady LW, Augsburger JJ, Shields JA. Treatment of orbital pseudotumors and lymphoma. Am J Clin Oncol 1986;9:527-32.
19. Kasliwal MK, Suri A, Gupta DK, Suri V, Rishi A, Sharma BS. Sphenoid wing inflammatory pseudotumor mimicking a clinoidal meningioma: case report and review of the literature. Surg Neurol 2008;70:509-13.
20. Lee HM, Choi G, Choi CS, Kim CH, Lee SH. Inflammatory pseudotumor of the maxillary sinus. Otolaryngol Head Neck Surg 2001;125:565-6.