The Association of Antibody Levels with Body Mass Index, Stress Management Ability and Lipid Peroxidation in Patients with Hashimoto’s Thyroiditis
Abstract
Objective: The potential predictive value of body mass index, stress management ability, and thiobarbituric acid reactive substances (TBARS) levels for antibody levels in Hashimoto’s thyroiditis (HT) were evaluated.
Materials and Methods: Two hundred patients with HT were included in the study. The patients were allocated into four groups as Group 1, patients with a body mass index (BMI) of 30 or higher (n=54); Group 2, patients with stress management difficulties (n=59); Group 3, patients with a BMI higher than 30 and stress management difficulties (n=11), and Group 4 (control, n=76), those without obesity or stress management issues. The mean age of patients, BMI, stress management abilities, anti-thyroid peroxidase (anti-TPO) antibodies levels, weekly T4 drug dosages, duration of levothyroxine usage, quality of life scores, as well as thiobarbituric acid reactive substances (TBARS) were evaluated.
Results: The antibody levels were significantly associated with body mass index and stress management. The antibody level increased 533 times (p<0.0001) in the group without stress management difficulties, and was affected 525 times (p<0.0001) in the obesity group.
Conclusion: The findings of our investigation revealed that stress management ability and obesity are the important factors influencing antibody levels.
Keywords
Hashimoto’s thyroiditis thyroid peroxidase antibodies stress management ability quality of life scores TBARS
References
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- Ajjan R A, Weetman AP. The Pathogenesis of Hashimoto’s Thyroiditis: Further Developments in our Understanding. Horm Metab Res 2015;47(10):702-10. google scholar
- Ware JE Jr., Sherbourne CD, The MOS. 36-item short-form health survey (SF-36). I conceptual framework and item selection . Med Care 1992;30(6):473-83. google scholar
- Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24(4):385-96. google scholar
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Abstract
References
- Klubo-Gwiezdzinska J, Wartofsky L. Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment. Pol Arch Intern Med 2022;132(3):16222. google scholar
- Caturegli P, De Remigis A, Chuang K, Dembele M, Iwama A, Iwama S. Hashimoto’s thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid 2013;23(2):142-50. google scholar
- Nakamura H, Usa T, Motomura M, Ichikawa T, Nakao K, Kawasaki E et. al. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Ivest 2008;31(10):861-5. google scholar
- Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 2014;13(4-5):391-7. google scholar
- Anderson L, Middleton WD, Teefey SA, Reading CC, Langer J, Desser T, et. al. Hashimoto thyroiditis: Sonographic analysis of benign and malignant nodules in patients with diffuse Hashimoto thyroiditis. AJR Am J Roentgenol 2010;195(1):216-22. google scholar
- Weetman A. P. An update on the pathogenesis of Hashimoto’s thyroiditis. J Endocrinol Invest 2021;44(5):883-90. google scholar
- Ajjan RA, Weetman AP. The pathogenesis of Hashimoto’s thyroiditis: further developments in our understanding. Horm Metab Res 2015;47(10):702-710. google scholar
- Wiersinga W.M. Hashimoto’s thyroiditis. In Endocrinology; Springer Science and Business Media LLC: Berlin, Germany, 2018; pp. 205-47. google scholar
- Fallahi P, Ferrari S.M, Ruffilli I, Elia G, Biricotti M, Vita R, et. al. The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmun Rev 2016;15(12):1125-8. google scholar
- Ajjan R A, Weetman AP. The Pathogenesis of Hashimoto’s Thyroiditis: Further Developments in our Understanding. Horm Metab Res 2015;47(10):702-10. google scholar
- Ware JE Jr., Sherbourne CD, The MOS. 36-item short-form health survey (SF-36). I conceptual framework and item selection . Med Care 1992;30(6):473-83. google scholar
- Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24(4):385-96. google scholar
- Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302-10. google scholar
- Salazar-Viedma M, Vergaño-Salazar JG, Pastenes L, D’Afonseca V. Simulation Model for Hashimoto Autoimmune Thyroiditis Disease. Endocrinology 2021;162(12):bqab190. google scholar
- Yuan J, Qi S, Zhang X, Lai H, Li X, Xiaoheng C, et. al. Local symptoms of Hashimoto’s thyroiditis: A systematic review. Front Endocrinol (Lausanne). 2023; 19;13:1076793. google scholar
- Bektas Uysal H, Ayhan M. Autoimmunity afects healthrelated quality of life in patients with Hashimoto’s thyroiditis. Kaohsiung J Med Sci 2016;32(8):427-33. google scholar
- Barić A, Brčić L, Gračan S, Škrabić V, Brekalo M, Šimunac M, et. al. Thyroglobulin antibodies are associated with symptom burden in patients with Hashimoto’s thyroiditis: a cross-sectional study. Immunol Invest 2019;48(2):198-209. google scholar
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | October 4, 2023 |
| Submission Date | August 24, 2023 |
| Published in Issue | Year 2023 |