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Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports

Year 2024, , 66 - 70, 10.06.2024
https://doi.org/10.26650/Tr-ENT.2024.1407625

Abstract

Sinonasal system malignancies are rare, constituting only 1% of all malignancies and less than 5% of head and neck malignancies. The common form of plasma cell dyscrasias is called multiple myeloma (MM), and the localized forms are called solitary bone plasmacytoma and extramedullary plasmacytoma (EMP). EMP constitutes 3-4% of malignant plasma cell dyscrasias and 1% of all head and neck tumors. 90% of EMP cases occur in the head and neck region, because the nasal and paranasal sinus regions are rich in plasma cells at around 75%. This study aims to present two different cases of plasma cell tumors presenting in the paranasal region. Based on the imaging studies, the first case is seen to have been diagnosed as MM due to bone marrow involvement and to have received systemic chemotherapy treatment, whereas the second case is seen to have undergone endoscopic total excision of the lesion due to the absence of systemic involvement. In the first case, MM was considered to have gone into remission in the sixth month after chemotherapy; however, the patient died one year after diagnosis. In the second case, no recurrence was detected during the fifth year postoperative follow-up. As a result, patients who show sinonasal symptoms should be examined in detail.

References

  • 1. Harvey RJ, Dalgorf DM. Chapter 10: Sinonasal malignancies. Am J Rhinol Allergy 2013;27(Suppl 1):S35-8. google scholar
  • 2. Nowak-Sadzikowska J, Weiss M. Extramedullary plasmacytoma of the larynx. Analysis of 5 cases. Eur J Cancer 1998;34(9):1468. google scholar
  • 3. Nofsinger YC, Mirza N, Rowan PT, Lanza D, Weinstein G. Head and neck manifestations of plasma cell neoplasms. Laryngoscope 1997;107(6):741-6. google scholar
  • 4. Frassica DA, Frassica FJ, Schray MF, Sim FH, Kyle RA. Solitary plasmacytoma of bone: Mayo Clinic experience. Int J Radiat Oncol Biol Phys 1989;16:43-8. google scholar
  • 5. Çömez G, Pehlivan Y, Sevinç A, Kervancıoğlu S, Sarıca MA, Tutar E, et al. Extramedullary plasmacytoma with maxillary sinus involvement. UHOD 2008;2(18):112-5. google scholar
  • 6. Susnerwala SS, Shanks JH, Banerjee SS, Scarffe JH, Farrington WT, Slevin NJ. Extramedullary plasmacytoma of the head and neck region: Clinicopathological correlation in 25 cases. Br J Cancer 1997;75(6):921-7. google scholar
  • 7. Holland J, Trenker DA, Wasserman TH, Fineberg B. Plasmacytoma: treatment results and conversion to myeloma. Cancer 1992;69(6):1513-7. google scholar
  • 8. Ayan N, Yılmaz B, Çınar F, Çevikbaş U, Gürsel AO. Extramedullary plasmacytoma. KBB ve Baş Boyun Cerrahisi Dergisi 1995;3:73-5. google scholar
  • 9. Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez-Ordonez B, et al. Solitary extramedullary plasmacytoma of the head and neck-long-term outcome analysis of 68 cases Head Neck 2008;30(8):1012-9. google scholar
  • 10. Patel TD, Vâzquez A, Choudhary MM, Kam D, Baredes S, Eloy JA. Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis. Int Forum Allergy Rhinol 2015;5(9):862-9. google scholar
  • 11. Ramadan O. Outcomes of patients with nasopharyngeal plasmacytoma: A systematic review. Otolaryngol Open J 2017;3(2):30-40. google scholar
  • 12. Dores GM, Landgren O, McGlynn KA, Curtis RE, Linet MS, Devesa SS. Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol 2009;144:86-94. google scholar
  • 13. Straetmans J, Stokroos R. Extramedullary plasmacytomas in the head and neck region. Eur Arch Otorhinolaryngol 2008;265(11):1417-23. google scholar
  • 14. Vlad D, Trombitas V, Albu S. Extramedullary plasmacytoma of the paranasal sinuses: Combining surgery with external radiotherapy. Indian J Otolaryngol Head Neck Surg 2016;68(1):34-8. google scholar
  • 15. Sasaki R, Yasuda K, Abe E, Uchida N, Kawashima M, Uno T, et al. Multi-ınstitutional analysis of solitary extramed- ullary plasmacytoma of the head and neck treated with cura- tive radiotherapy. Int J Radiat Oncol Biol Phys 2012;82(2):626-34. google scholar
Year 2024, , 66 - 70, 10.06.2024
https://doi.org/10.26650/Tr-ENT.2024.1407625

Abstract

References

  • 1. Harvey RJ, Dalgorf DM. Chapter 10: Sinonasal malignancies. Am J Rhinol Allergy 2013;27(Suppl 1):S35-8. google scholar
  • 2. Nowak-Sadzikowska J, Weiss M. Extramedullary plasmacytoma of the larynx. Analysis of 5 cases. Eur J Cancer 1998;34(9):1468. google scholar
  • 3. Nofsinger YC, Mirza N, Rowan PT, Lanza D, Weinstein G. Head and neck manifestations of plasma cell neoplasms. Laryngoscope 1997;107(6):741-6. google scholar
  • 4. Frassica DA, Frassica FJ, Schray MF, Sim FH, Kyle RA. Solitary plasmacytoma of bone: Mayo Clinic experience. Int J Radiat Oncol Biol Phys 1989;16:43-8. google scholar
  • 5. Çömez G, Pehlivan Y, Sevinç A, Kervancıoğlu S, Sarıca MA, Tutar E, et al. Extramedullary plasmacytoma with maxillary sinus involvement. UHOD 2008;2(18):112-5. google scholar
  • 6. Susnerwala SS, Shanks JH, Banerjee SS, Scarffe JH, Farrington WT, Slevin NJ. Extramedullary plasmacytoma of the head and neck region: Clinicopathological correlation in 25 cases. Br J Cancer 1997;75(6):921-7. google scholar
  • 7. Holland J, Trenker DA, Wasserman TH, Fineberg B. Plasmacytoma: treatment results and conversion to myeloma. Cancer 1992;69(6):1513-7. google scholar
  • 8. Ayan N, Yılmaz B, Çınar F, Çevikbaş U, Gürsel AO. Extramedullary plasmacytoma. KBB ve Baş Boyun Cerrahisi Dergisi 1995;3:73-5. google scholar
  • 9. Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez-Ordonez B, et al. Solitary extramedullary plasmacytoma of the head and neck-long-term outcome analysis of 68 cases Head Neck 2008;30(8):1012-9. google scholar
  • 10. Patel TD, Vâzquez A, Choudhary MM, Kam D, Baredes S, Eloy JA. Sinonasal extramedullary plasmacytoma: a population-based incidence and survival analysis. Int Forum Allergy Rhinol 2015;5(9):862-9. google scholar
  • 11. Ramadan O. Outcomes of patients with nasopharyngeal plasmacytoma: A systematic review. Otolaryngol Open J 2017;3(2):30-40. google scholar
  • 12. Dores GM, Landgren O, McGlynn KA, Curtis RE, Linet MS, Devesa SS. Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol 2009;144:86-94. google scholar
  • 13. Straetmans J, Stokroos R. Extramedullary plasmacytomas in the head and neck region. Eur Arch Otorhinolaryngol 2008;265(11):1417-23. google scholar
  • 14. Vlad D, Trombitas V, Albu S. Extramedullary plasmacytoma of the paranasal sinuses: Combining surgery with external radiotherapy. Indian J Otolaryngol Head Neck Surg 2016;68(1):34-8. google scholar
  • 15. Sasaki R, Yasuda K, Abe E, Uchida N, Kawashima M, Uno T, et al. Multi-ınstitutional analysis of solitary extramed- ullary plasmacytoma of the head and neck treated with cura- tive radiotherapy. Int J Radiat Oncol Biol Phys 2012;82(2):626-34. google scholar
There are 15 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Case Report
Authors

Merve Mutlu 0000-0002-2532-1009

Hande Arslan 0000-0003-0344-2712

Doğukan Özdemir 0000-0003-2008-163X

Dursun Mehmet Mehel 0000-0002-5613-3393

Gökhan Akgül 0000-0003-0699-6585

Publication Date June 10, 2024
Submission Date December 27, 2023
Acceptance Date May 6, 2024
Published in Issue Year 2024

Cite

APA Mutlu, M., Arslan, H., Özdemir, D., Mehel, D. M., et al. (2024). Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports. The Turkish Journal of Ear Nose and Throat, 34(2), 66-70. https://doi.org/10.26650/Tr-ENT.2024.1407625
AMA Mutlu M, Arslan H, Özdemir D, Mehel DM, Akgül G. Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports. Tr-ENT. June 2024;34(2):66-70. doi:10.26650/Tr-ENT.2024.1407625
Chicago Mutlu, Merve, Hande Arslan, Doğukan Özdemir, Dursun Mehmet Mehel, and Gökhan Akgül. “Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports”. The Turkish Journal of Ear Nose and Throat 34, no. 2 (June 2024): 66-70. https://doi.org/10.26650/Tr-ENT.2024.1407625.
EndNote Mutlu M, Arslan H, Özdemir D, Mehel DM, Akgül G (June 1, 2024) Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports. The Turkish Journal of Ear Nose and Throat 34 2 66–70.
IEEE M. Mutlu, H. Arslan, D. Özdemir, D. M. Mehel, and G. Akgül, “Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports”, Tr-ENT, vol. 34, no. 2, pp. 66–70, 2024, doi: 10.26650/Tr-ENT.2024.1407625.
ISNAD Mutlu, Merve et al. “Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports”. The Turkish Journal of Ear Nose and Throat 34/2 (June 2024), 66-70. https://doi.org/10.26650/Tr-ENT.2024.1407625.
JAMA Mutlu M, Arslan H, Özdemir D, Mehel DM, Akgül G. Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports. Tr-ENT. 2024;34:66–70.
MLA Mutlu, Merve et al. “Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports”. The Turkish Journal of Ear Nose and Throat, vol. 34, no. 2, 2024, pp. 66-70, doi:10.26650/Tr-ENT.2024.1407625.
Vancouver Mutlu M, Arslan H, Özdemir D, Mehel DM, Akgül G. Plasma Cell Neoplasms of Paranasal Sinuses: Two Case Reports. Tr-ENT. 2024;34(2):66-70.