Audiovestibular Manifestations in Autoimmune Disorders: A Case Clinical Control Study in Celiac Patients
Abstract
Objective: The aim of this study was to evaluate audiovestibulopathy in patients with celiac disease using vestibular evoked myogenic potentials (VEMP), video head impulse test (vHIT), and audiometric examinations.
Material and Methods: Thirty-one patients with celiac disease from the gastroenterology department of Cerrahpasa Medical School, and 30 healthy controls were included in the study between 2013 and 2015. Pure tone audiometry, tympanometry, acoustic reflex test, and vestibular evaluation with VEMP and vHIT were performed in both groups. The anti-tissue transglutaminase IgA levels of all participants and disease duration of affected individuals were documented.
Results: The mean age±SD was 35.9±12.82 (27-48) years and 37.6±11.6 (26-48) years for the patient and control groups, respectively. The pure tone thresholds did not differ between the two groups. However, a subgroup of patients with high antibody levels had significantly higher high-frequency hearing thresholds. The two groups had similar VEMP test results, but a comparison of the vestibuloocular reflex (VOR) gains of six semicircular canals (SSC) revealed significant decreases in the right anterior canal in the patient group.
Conclusion: Subclinical audiovestibular pathologies can occur in patients with celiac disease. Following these patients with periodic audiovestibular test batteries may reduce patient morbidity by providing early diagnosis and rehabilitation.
Keywords
References
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Abstract
References
- 1. McCabe BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979;88:585-9. google scholar
- 2. Harris J, Ryan A. Fundamental immune mechanisms of the brain and inner ear. Otolaryngol - Head Neck Surg 1995;112:639-53. google scholar
- 3. Öztürk A, Yalçin Ş, Kaygusuz I, Şahin S, Gök Ü, Karlidağ T, Ardıçoğlu Ö. High-frequency hearing loss and middle ear involvement in rheumatoid arthritis. Am J Otolaryngol 2004;25:411-7. google scholar
- 4. Farrell RJ, Kelly CP. Diagnosis of celiac sprue. Am J Gastroenterol 2001;96:3237-46. google scholar
- 5. Briani C, Zara G, Alaedini A, Grassivaro F, Ruggero S, Toffanin E, et al. Neurological complications of celiac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol 2008;195:171-5. google scholar
- 6. Alaedini A, Green PH. Narrative review: celiac disease: understanding a complex autoimmune disorder. Ann Intern Med 2005;142:289-98. google scholar
- 7. Green PH, Jabri B. Celiac disease. Annu Rev Med 2006;57:207-21. google scholar
- 8. Bovo R, Aimoni C, Martini A. Immune-mediated inner ear disease. Acta Otolaryngol 2006;126:1012-21. google scholar
- 9. Amor-Dorado JC, Barreira-Fernandez MP, Pina T, Vâzquez-Rodriguez TR, Llorca J, Gonzalez-Gay MA. Investigations into audiovestibular manifestations in patients with psoriatic arthritis. J Rheumatol 2014;41:2018-26. google scholar
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- 13. Karabulut H, Hizli S, Dagli M, Karabulut I, Acar B, Celik E, et al. Audiological findings in celiac disease. ORL J Otorhinolaryngol Relat Spec 2011;73:82-7. google scholar
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- 15. Heydari N, Hajiabolhassan F, Fatahi J, Movaseghi S, Jalaie S. Vestibular function can be affected by autoimmune processes in rheumatoid arthritis. Aud Vest Res 2015;24:193-200. google scholar
- 16. P Pawlak-Osinska K, Kazmierczak H, Kuczynska R, Szaflarska-Poptawska. Looking for the auditory and vestibular pathology in celiac disease [in Polish]. Otolaryngol Pol 2007;61:178-83. google scholar
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 7, 2021 |
| Submission Date | June 12, 2021 |
| Published in Issue | Year 2021 |