Oncological and Functional Outcomes of Supracricoid Partial Laryngectomy

Year 2021, , 75 - 80, 09.11.2021

Mustafa Caner Kesimli , Eren Yılmaz İbrahin Yağcı İsmet Aslan

https://doi.org/10.26650/Tr-ENT.2021.970267

Abstract

Objective: The aim of this study is to review the oncological outcomes of T1-T4 glottic or supraglottic tumor patients who underwent supracricoid partial laryngectomy in our clinic.

Material and Methods: A total of 43 patients with laryngeal squamous cell carcinoma who underwent supracricoid partial laryngectomy between January 2014 and December 2016 in the Otorhinolaryngology Department of Istinye University Hospital were retrospectively analyzed. Postoperative data of these patients regarding surgical margin, nasogastric feeding tube removal time, decannulation time, postoperative radiotherapy, local regional recurrence, and distant metastases were recorded.

Results: Cricohyoidoepiglotopexy was applied to 16 patients by preserving both arytenoids and applied to 7 patients with a single arytenoid; Cricohyoidopexy was applied to 14 patients with both arytenoids preserved, and 6 patients were treated with a single arytenoid.The five-year survival was compared for Cricohyoidopexy/Cricohyoidoepiglotopexy with single arytenoid to double arytenoid preservation and found to be 80%-76% (p=0.56). The mean 5-year survival was 88% in the post-operative radiotherapy group, and 86% in the non- radiotherapy group. The study compared patients with Cricohyoidopexy/Cricohyoidoepiglotopexy with a single arytenoid to those with double arytenoid preservation; the mean decannulation time was 54.23±34.12 to 35.62±27.08 (p=0.05). Postoperative radiotherapy prolonged the decannulation time (51.16±38.5 versus 32.68±20.1; p=0.043). The duration of nasogastric tube placement in the Cricohyoidopexy/Cricohyoidoepiglotopexy with a single arytenoid group was 50.3±14.3 and double arytenoid preservation was 35.17±32.9 (p=0.088). Nasogastric tube removal time was 53.29±50.2 in the post-operative radiotherapy group and was 30.24±16.8 in patients who did not receive post-operative radiotherapy (p=0.040).

Conclusion: Supracricoid partial laryngectomy with Cricohyoidoepiglotopexy and Cricohyoidopexy had satisfactory oncological outcomes, and laryngeal function was preserved by rebuilding the neolarynx.

Keywords

Partial laryngectomy, Head and neck carcinoma, Cricohyoidopexy, Cricohyoidoepiglotopexy, Supracricoid laryngectomy

References

• 1. Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin 2017;67(1):31-50. google scholar
• 2. American Cancer Society. Facts & Figures 2019: US Cancer Death Rate has Dropped 27% in 25 Years. Am Cancer Soc 2019;2019:2015-7. google scholar
• 3. Ciolofan MS, Vlâescu AN, Mogoantâ CA, lonitâ E, lonitâ I, Câpitânescu AN, et al. Clinical, Histological and Immunohistochemical Evaluation of Larynx Cancer. Curr Health Sci J 2017;43(4):367-375. google scholar
• 4. Gallo A, Manciocco V, Simonelli M, Pagliuca G, D’Arcangelo E, De Vincentiis M. Supracricoid partial laryngectomy in the treatment of laryngeal cancer: univariate and multivariate analysis of prognostic factors. Arch Otolaryngol Neck Surg 2005;131(7):620-5. google scholar
• 5. Lefebvre JL. Laryngeal preservation in head and neck cancer: multidisciplinary approach. Lancet Oncol 2006;7(9):747-55. google scholar
• 6. Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 2006;24(22):3693-704. google scholar
• 7. Weinstein GS, El-Sawy MM, Ruiz C, Dooley P, Chalian A, El-Sayed MM, et al. Laryngeal preservation with supracricoid partial laryngectomy results in improved quality of life when compared with total laryngectomy. Laryngoscope 2001;111(2):191-9. google scholar
• 8. Schindler A, Favero E, Nudo S, Albera R, Schindler O, Cavalot AL. Long-term voice and swallowing modifications after supracricoid laryngectomy: objective, subjective, and self-assessment data. Am J Otolaryngol 2006;27(6):378-83. google scholar
• 9. Gillespie MB, Brodsky MB, Day TA, Lee F, Martin-Harris B. Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope 2004;114(8):1362-7. google scholar
• 10. Majer H, Rieder W. Technique de laryngectomie permettant de conserver la permeabilite’respiratoire la cricohyoido-pexie. Ann Otolaryngol Chir Cervicofac 1959;76:677-83. google scholar
• 11. Edge SB, Edge SB. AJCC Cancer Staging Manual 8th Ed. Springer; 2017. google scholar
• 12. Nakayama M, Laccourreye O, Holsinger FC, Okamoto M, Hayakawa K. Functional organ preservation for laryngeal cancer: past, present and future. Jpn J Clin Oncol 2012;42(3):155-60. google scholar
• 13. Pfister DG, Ang KK, Brizel DM, Burtness BA, Busse PM, Caudell JJ, et al. National Comprehensive Cancer Network. Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2013;11(8):917-23. doi: 10.6004/jnccn.2013.0113. Erratum in: J Natl Compr Canc Netw 2013;11(12):1458. google scholar
• 14. Caicedo-Granados E, Beswick DM, Christopoulos A, Cunningham DE, Razfar A, Ohr JP et al. Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer. Otolaryngol Head Neck Surg 2013;148(2):235-42. google scholar
• 15. Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349(22):2091-8. google scholar
• 16. Department of Veterans Affairs Laryngeal Cancer Study Group. Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal Cancer. N Engl J Med 1991;324(24):1685-90. google scholar
• 17. Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg 2007;15(2):82-8. google scholar
• 18. Laccourreye H, Laccourreye O, Weinstein G, Menard M, Brasnu D. Supracricoid laryngectomy with cricohyoidopexy: a partial laryngeal procedure for selected supraglottic and transglottic carcinomas. Laryngoscope 1990;100(7):735-41. google scholar
• 19. Pinar E, Imre A, Calli C, Oncel S, Katilmis H. Supracricoid partial laryngectomy: analyses of oncologic and functional outcomes. Otolaryngol Neck Surg 2012;147(6):1093-8. google scholar
• 20. Wang PW, Abedini MR, Yang LX, Ding AA, Figeys D, Chang JY, et al. Gelsolin regulates cisplatin sensitivity in human head-and-neck cancer. Int J Cancer 2014;135(12):2760-9. google scholar
• 21. Wang Y, Li X, Pan Z. Analyses of functional and oncologic outcomes following supracricoid partial laryngectomy. Eur Arch Oto-Rhino-Laryngology 2015;272(11):3463-8. google scholar
• 22. Soudry E, Marmor Y, Hazan A, Marx S, Sadov R, Feinmesser R. Supracricoid partial laryngectomy: an alternative to total laryngectomy for locally advanced laryngeal cancers. J Laryngol Otol 2008;122(11):1219-23. google scholar
• 23. Enver N, Şahin A, Yumusakhuylu A, Sahin-Yilmaz A, Oysu C. Oncologic Results of Supracricoid Laryngectomy: Results From Two Tertitory Centers. Acta Oncol Turc 53(3):504-10. google scholar
• 24. Sanchez-Cuadrado I, Castro A, Bernaldez R, Del Palacio A, Gavilan J. Oncologic outcomes after supracricoid partial laryngectomy. Otolaryngol Neck Surg 2011;144(6):910-4. google scholar
• 25. Scola B, Fernandez-Vega M, MartINez T, Fernandez-Vega S, Ramirez C. Management of cancer of the supraglottis. Otolaryngol Neck Surg 2001;124(2):195-8. google scholar
• 26. Gonçalves AJ, Bertelli AAT, Malavasi TR, Kikuchi W, Rodrigues AN, Menezes MB. Results after supracricoid horizontal partial laryngectomy. Auris Nasus Larynx 2010;37(1):84-8. google scholar
• 27. Deganello A, Gallo O, De Cesare JM, Ninu MB, Gitti G, de’ Campora L, et al. Supracricoid partial laryngectomy as salvage surgery for radiation therapy failure. Head Neck 2008;30(8):1064-71. google scholar
• 28. Lewin JS, Hutcheson KA, Barringer DA, May AH, Roberts DB, Holsinger FC, et al. Functional analysis of swallowing outcomes after supracricoid partial laryngectomy. Head Neck 2008;30(5):559-66. google scholar
• 29. Park J-O, Joo Y-H, Cho K-J, Kim N-G, Kim M-S. Functional and oncologic results of extended supracricoid partial laryngectomy. Arch Otolaryngol Neck Surg 2011;137(11):1124-9. google scholar
• 30. Pellini R, Manciocco V, Spriano G. Functional outcome of supracricoid partial laryngectomy with cricohyoidopexy: radiation failure vs previously untreated cases. Arch Otolaryngol Neck Surg 2006;132(11):1221-5. google scholar
• 31. Cho KJ, Joo YH, Sun D Il, Kim MS. Supracricoid laryngectomy: oncologic validity and functional safety. Eur Arch oto-rhino-laryngology 2010;267(12):1919-25. google scholar
• 32. Szyfter W, Leszczynska M, Wierzbicka M. Outcome after supracricoid laryngectomies in the material of ENT Department, Poznan University of Medical Sciences. Eur Arch oto-rhino-laryngology 2011;268(6):879-83. google scholar
• 33. Saito K, Araki K, Ogawa K, Shiotani A. Laryngeal function after supracricoid laryngectomy. Otolaryngol Neck Surg 2009;140(4):487-92. google scholar
• 34. Decotte A, Woisard V, Percodani J, Pessey J-J, Serrano E, Vergez S. Respiratory complications after supracricoid partial laryngectomy. Eur Arch oto-rhino-laryngology 2010;267(9):1415-21. google scholar