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Two cases of nasal natural killer T-cell lymphoma

Year 2002, Volume: 9 Issue: 6, 376 - 379, 20.12.2002

Abstract

Nasal natural killer T-cell lymphoma is a very aggres- sive and destructive disease with a poor prognosis. We hereby present two male patients in whom diagnostic problems and a mortal course were encountered. One patient age 31 years had Progressive ulceration in the nasal area. Two biopsies that had been taken else- where were inconclusive. The other patient age 40 years was referred with a previous histopathologic diagnosis of squamous celi carcinoma. He complained of an unhealing wound in the hard palate. Biopsies were repeated in each case. Diagnosis was made by immunohistochemical examination. Both patients died shortly after the diagnosis. The importance of obtaining an adequate and deep biopsy sample and employing sophisticated immunohistochemical examination is emphasized for accurate diagnosis.

References

  • Ooi GC, Chim CS, Liang R, Tsang KW, Kwong YL. Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol 2000;174:1141-5.
  • Lee PY, Freeman NJ, Khorsand J, Weinstock MA. Angiocentric T-cell lymphoma presenting as lethal midline granuloma. Int J Dermatol 1997;36:419-27.
  • Vidal RW, Devaney K, Ferlito A, Rinaldo A, Carbone A. Sinonasal malignant lymphomas: a distinct clinico- pathological category. Ann Otol Rhinol Laryngol 1999; 108:411-9.
  • Chim CS, Ooi GC, Shek TW, Liang R, Kwong YL. Lethal midline granuloma revisited: nasal T/Natural- killer cell lymphoma. J Clin Oncol 1999;17:1322-5.
  • Davison SP, Habermann TM, Strickler JG, DeRemee RA, Earle JD, McDonald TJ. Nasal and nasopharyn- geal angiocentric T-cell lymphomas. Laryngoscope 1996;106(2 Pt 1):139-43.
  • O'Devaney K, Ferlito A, Hunter BC, Devaney SL, Rinaldo A. Wegener's granulomatosis of the head and neck. Ann Otol Rhinol Laryngol 1998;107(5 Pt 1):439-45.

İki olguda nazal natural killer T-hücreli lenfoma

Year 2002, Volume: 9 Issue: 6, 376 - 379, 20.12.2002

Abstract

Nazal natural killer T-hücreli lenfoma kötü prognozu olan agresif ve destrüktif bir hastalıktır. Burada hastalığın tanıda zorluklar gösterdiği ve ölümcül sü- reç izlediği iki olgu sunuldu. İlk olgunun yafl 31, erkek burun bölgesinde ilerleyici ülserasyon vardı. Daha önce baflka merkezlerde lezyon bölgesinden alınan iki biyopsi sonuç vermemiflti. İkinci hasta yafl 40, erkek skuamöz hücreli karsinom histopatolojik tanısıyla merkezimize gönderilmiflti. Hasta sert da- mağındaki iyileflmeyen yaradan flikayetçiydi. Her iki olguda da biyopsiler tekrarlandı. Alınan örneklerin immünhistokimyasal yöntemlerle incelenmesiyle tanı konabildi. İki hasta da tanıdan kısa bir süre son- ra yaflamını yitirdi. Bu yazıda, doğru tanı için yeterli büyüklükte, derin biyopsi örneği alımının ve modern immünhistokimyasal çalıflmaların önemi vurgulandı

References

  • Ooi GC, Chim CS, Liang R, Tsang KW, Kwong YL. Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol 2000;174:1141-5.
  • Lee PY, Freeman NJ, Khorsand J, Weinstock MA. Angiocentric T-cell lymphoma presenting as lethal midline granuloma. Int J Dermatol 1997;36:419-27.
  • Vidal RW, Devaney K, Ferlito A, Rinaldo A, Carbone A. Sinonasal malignant lymphomas: a distinct clinico- pathological category. Ann Otol Rhinol Laryngol 1999; 108:411-9.
  • Chim CS, Ooi GC, Shek TW, Liang R, Kwong YL. Lethal midline granuloma revisited: nasal T/Natural- killer cell lymphoma. J Clin Oncol 1999;17:1322-5.
  • Davison SP, Habermann TM, Strickler JG, DeRemee RA, Earle JD, McDonald TJ. Nasal and nasopharyn- geal angiocentric T-cell lymphomas. Laryngoscope 1996;106(2 Pt 1):139-43.
  • O'Devaney K, Ferlito A, Hunter BC, Devaney SL, Rinaldo A. Wegener's granulomatosis of the head and neck. Ann Otol Rhinol Laryngol 1998;107(5 Pt 1):439-45.
There are 6 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Volkan Işıksaçan This is me

İlhan Topaloğlu This is me

Güler Berkiten This is me

Kamil Peker This is me

Publication Date December 20, 2002
Published in Issue Year 2002 Volume: 9 Issue: 6

Cite

APA Işıksaçan, V., Topaloğlu, İ., Berkiten, G., Peker, K. (2002). İki olguda nazal natural killer T-hücreli lenfoma. The Turkish Journal of Ear Nose and Throat, 9(6), 376-379.
AMA Işıksaçan V, Topaloğlu İ, Berkiten G, Peker K. İki olguda nazal natural killer T-hücreli lenfoma. Tr-ENT. December 2002;9(6):376-379.
Chicago Işıksaçan, Volkan, İlhan Topaloğlu, Güler Berkiten, and Kamil Peker. “İki Olguda Nazal Natural Killer T-hücreli Lenfoma”. The Turkish Journal of Ear Nose and Throat 9, no. 6 (December 2002): 376-79.
EndNote Işıksaçan V, Topaloğlu İ, Berkiten G, Peker K (December 1, 2002) İki olguda nazal natural killer T-hücreli lenfoma. The Turkish Journal of Ear Nose and Throat 9 6 376–379.
IEEE V. Işıksaçan, İ. Topaloğlu, G. Berkiten, and K. Peker, “İki olguda nazal natural killer T-hücreli lenfoma”, Tr-ENT, vol. 9, no. 6, pp. 376–379, 2002.
ISNAD Işıksaçan, Volkan et al. “İki Olguda Nazal Natural Killer T-hücreli Lenfoma”. The Turkish Journal of Ear Nose and Throat 9/6 (December 2002), 376-379.
JAMA Işıksaçan V, Topaloğlu İ, Berkiten G, Peker K. İki olguda nazal natural killer T-hücreli lenfoma. Tr-ENT. 2002;9:376–379.
MLA Işıksaçan, Volkan et al. “İki Olguda Nazal Natural Killer T-hücreli Lenfoma”. The Turkish Journal of Ear Nose and Throat, vol. 9, no. 6, 2002, pp. 376-9.
Vancouver Işıksaçan V, Topaloğlu İ, Berkiten G, Peker K. İki olguda nazal natural killer T-hücreli lenfoma. Tr-ENT. 2002;9(6):376-9.