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The management of pharyngocutaneous fistulas after total laryngectomy and the factors affecting their incidence

Year 2003, Volume: 11 Issue: 1, 5 - 10, 17.01.2003

Abstract

Objectives: This study sought to determine the inci­ dence and etiologic factors of pharyngocutaneous fistulas occurring after total laryngectomy.Patients and Methods: A total of 138 patients 136 males, 2 females; mean age 59.5 years; range 36 to 83 years underwent total laryngectomy for squamous celi carcinoma. Risk factors and the manage­ ment of pharyngocutaneous fistulas were assessed together with durations in relation to fistula occurrence, oral feeding, hospitalization, and healing.Results: Pharyngocutaneous fistulas were seen in 37 patients 26.8% . Significantly high rates of fistula occur- rence were detected in patients with alcohol consumption p=0.032 , and in those who undervvent partial pharyn- gectomy p=0.058 or bilateral neck dissection p=0.049 along with total laryngectomy. The occurrence of fistulas was significantly associated with prolonged lengths of time for oral feeding and hospital stay p<0.001 . Fistulas were repaired surgically in 24.3% of patients, in whom the time to oral feeding was significantly shorter than that of patients who received local wound çare p=0.03 .Conclusion: Our data show that early surgical intervention is more beneficial in preventing further morbidity associated with pharyngocutaneous fistulas.

References

  • Harris A, Komray RR. Cost-effective management of pharyngocutaneous fistulas following laryngectomy. Ostomy Wound Manage 1993;39:36-7, 40-2, 44.
  • Johansen LV, Overgaard J, Elbrond O. Pharyngo-cuta- neous fistulae after laryngectomy. Influence of previ- ous radiotherapy and prophylactic metro n i d a z o l e . Cancer 1988;61:673-8.
  • Soylu L, Kiroglu M, Aydogan B, Cetik F, Kiroglu F, Akcali C, et al. Pharyngocutaneous fistula following laryngectomy. Head Neck 1998;20:22-5.
  • Violaris N, Bridger M. Prophylactic antibiotics and post laryngectomy pharyngocutaneous fistulae. J Laryngol Otol 1990;104:225-8.
  • Medina JE, Khafif A. Early oral feeding following total laryngectomy. Laryngoscope 2001;111:368-72.
  • Papazoglou G, Doundoulakis G, Terzakis G, Dokianakis G. Pharyngocutaneous fistula after total laryngectomy: incidence, cause, and treatment. Ann Otol Rhinol Laryngol 1994;103:801-5.
  • Redaelli de Zinis LO, Ferrari L, Tomenzoli D, Premoli G, Parrinello G, Nicolai P. Postlaryngectomy pharyn- gocutaneous fistula: incidence, predisposing factors, and therapy. Head Neck 1999;21:131-8.
  • Celikkanat S, Koc C, Akyol MU, Ozdem C. Effect of blood transfusion on tumor re c u r rence and postopera- tive pharyngocutaneous fistula formation in patients subjected to total laryngectomy. Acta Otolaryngol 1995; 11 5 : 5 6 6 - 8 .
  • Volling P, Singelmann H, Ebeling O. Incidence of sali- vary fistulas in relation to timing of oral nutrition after laryngectomy. HNO 2001;49:276-82. [Abstract]
  • Boyce SE, Meyers AD. Oral feeding after total laryn- gectomy. Head Neck 1989;11:269-73.
  • Verma A, Panda NK, Mehta S, Mann SB, Mehra YN. Post laryngectomy complications and their mode of management-an analysis of 203 cases. Indian J Cancer 1989;26:247-54.
  • Girod DA, McCulloch TM, Tsue TT, Weymuller EA Jr. Risk factors for complications in clean-contaminated head and neck surgical procedures. Head Neck 1995; 17:7-13.
  • McCombe AW, Jones AS. Radiotherapy and complica- tions of laryngectomy. J Laryngol Otol 1993;107:130-2.
  • Hellin Meseguer D, Merino Galvez E, Rosique Arias M. Pharyngostoma following total laryngectomy. An Otorrinolaringol Ibero Am 1992;19:589-94. [Abstract]
  • Friedman M, Venkatesan TK, Yakovlev A, Lim JW, Tanyeri HM, Caldarelli DD. Early detection and treat- ment of postoperative pharyngocutaneous fistula. Otolaryngol Head Neck Surg 1999;121:378-80.
  • Herranz J, Sarandeses A, Fernandez MF, Barro CV, Vidal JM, Gavilan J. Complications after total laryn- gectomy in nonradiated laryngeal and hypopharyn- geal carcinomas. Otolaryngol Head Neck Surg 2000; 122:892-8.
  • Parikh SR, Irish JC, Curran AJ, Gullane PJ, Brown DH, Rotstein LE. Pharyngocutaneous fistulae in laryngec- tomy patients: the To ronto Hospital experience. J Otolaryngol 1998;27:136-40.
  • Wang CP, Tseng TC, Lee RC, Chang SY. The techniques of nonmuscular closure of hypopharyngeal defect fol- lowing total laryngectomy: the assessment of compli- cation and pharyngoesophageal segment. J Laryngol Otol 1997;111:1060-3.
  • Tomkinson A, Shone GR, Dingle A, Roblin DG, Quine S. Pharyngocutaneous fistula following total laryngec- tomy and post-operative vomiting. Clin Otolaryngol 1996;21:369-70.
  • Fradis M, Podoshin L, Ben David J. Post-laryngectomy pharyngocutaneous fistula-a still unresolved problem. J Laryngol Otol 1995;109:221-4.
  • Chee N, Siow JK. Pharyngocutaneous fistula after laryngectomy-incidence, predisposing factors and out- come. Singapore Med J 1999;40:130-2.
  • Seikaly H, Park P. Gastroesophageal reflux prophylax- is decreases the incidence of pharyngocutaneous fistu- la after total laryngectomy. Laryngoscope 1995;105: 1220-2.
  • Sarria Echegaray P, Tomas Barberan M, Mas Mercant S, Soler Vilarrasa R, Romaguera Lliso A. Pharmacological prophylaxis of gastro e s o p h a g e a l reflux. Incidence of pharyngocutaneous fistula after total laryngectomy. Acta Otorrinolaringol Esp 2000;51: 239-42. [Abstract]
  • Mendelsohn MS, Bridger GP. Pharyngocutaneous fis- tulae following laryngectomy. Aust N Z J Surg 1985; 55:177-9.
  • Moses BL, Eisele DW, Jones B. Radiologic assessment of the early postoperative total-laryngectomy patient. Laryngoscope 1993;103:1157-60.
  • Saydam L, Kalcioglu T, Kizilay A. Early oral feeding following total laryngectomy. Am J Otolaryngol 2002; 23:277-81.
  • Khan A. Temporary management of selected pharyn- gocutaneous fistulas with a silicone septal button. Eur Arch Otorhinolaryngol 1993;250:120-2.
  • Guntinas-Lichius O, Eckel HE. Temporary reduction of salivation in laryngectomy patients with pharyngo- cutaneous fistulas by botulinum toxin A injection. Laryngoscope 2002;112:187-9.

Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız

Year 2003, Volume: 11 Issue: 1, 5 - 10, 17.01.2003

Abstract

Amaç: Total larenjektomi TL uygulanan hastalardafarengokutanöz fistül FKF görülme sıklığı ve fistülgeliflimi ile ilgili faktörler arafltırıldı.Hastalar ve Yöntem: Yassı epitel hücreli karsinomnedeniyle 138 hastada TL uygulandı. Farengokutanözfistül oluflumunda rolü olduğu düflünülen faktörler vefistül geliflen olgularda fistülün ortaya çıkıfl, ağızdanbeslenmeye geçifl, hastanede yatıfl ve fistülün kapanma süreleri tedavi yaklaflımı ile birlikte değerlendirildi.Bulgular: Otuz yedi hastada %26.8 FKF saptandı.Alkollü içecek kullanmanın p=0.032 , cerrahiye parsiyel farenjektomi p=0.058 veya iki taraflı boyun diseksiyonu p=0.049 eklenmesinin FKF geliflimindeanlamlı rolü olduğu belirlendi. Ağızdan gıdaya geçiflve hastanede kalıfl süreleri FKF geliflen olgulardaanlamlı derecede yüksekti p

References

  • Harris A, Komray RR. Cost-effective management of pharyngocutaneous fistulas following laryngectomy. Ostomy Wound Manage 1993;39:36-7, 40-2, 44.
  • Johansen LV, Overgaard J, Elbrond O. Pharyngo-cuta- neous fistulae after laryngectomy. Influence of previ- ous radiotherapy and prophylactic metro n i d a z o l e . Cancer 1988;61:673-8.
  • Soylu L, Kiroglu M, Aydogan B, Cetik F, Kiroglu F, Akcali C, et al. Pharyngocutaneous fistula following laryngectomy. Head Neck 1998;20:22-5.
  • Violaris N, Bridger M. Prophylactic antibiotics and post laryngectomy pharyngocutaneous fistulae. J Laryngol Otol 1990;104:225-8.
  • Medina JE, Khafif A. Early oral feeding following total laryngectomy. Laryngoscope 2001;111:368-72.
  • Papazoglou G, Doundoulakis G, Terzakis G, Dokianakis G. Pharyngocutaneous fistula after total laryngectomy: incidence, cause, and treatment. Ann Otol Rhinol Laryngol 1994;103:801-5.
  • Redaelli de Zinis LO, Ferrari L, Tomenzoli D, Premoli G, Parrinello G, Nicolai P. Postlaryngectomy pharyn- gocutaneous fistula: incidence, predisposing factors, and therapy. Head Neck 1999;21:131-8.
  • Celikkanat S, Koc C, Akyol MU, Ozdem C. Effect of blood transfusion on tumor re c u r rence and postopera- tive pharyngocutaneous fistula formation in patients subjected to total laryngectomy. Acta Otolaryngol 1995; 11 5 : 5 6 6 - 8 .
  • Volling P, Singelmann H, Ebeling O. Incidence of sali- vary fistulas in relation to timing of oral nutrition after laryngectomy. HNO 2001;49:276-82. [Abstract]
  • Boyce SE, Meyers AD. Oral feeding after total laryn- gectomy. Head Neck 1989;11:269-73.
  • Verma A, Panda NK, Mehta S, Mann SB, Mehra YN. Post laryngectomy complications and their mode of management-an analysis of 203 cases. Indian J Cancer 1989;26:247-54.
  • Girod DA, McCulloch TM, Tsue TT, Weymuller EA Jr. Risk factors for complications in clean-contaminated head and neck surgical procedures. Head Neck 1995; 17:7-13.
  • McCombe AW, Jones AS. Radiotherapy and complica- tions of laryngectomy. J Laryngol Otol 1993;107:130-2.
  • Hellin Meseguer D, Merino Galvez E, Rosique Arias M. Pharyngostoma following total laryngectomy. An Otorrinolaringol Ibero Am 1992;19:589-94. [Abstract]
  • Friedman M, Venkatesan TK, Yakovlev A, Lim JW, Tanyeri HM, Caldarelli DD. Early detection and treat- ment of postoperative pharyngocutaneous fistula. Otolaryngol Head Neck Surg 1999;121:378-80.
  • Herranz J, Sarandeses A, Fernandez MF, Barro CV, Vidal JM, Gavilan J. Complications after total laryn- gectomy in nonradiated laryngeal and hypopharyn- geal carcinomas. Otolaryngol Head Neck Surg 2000; 122:892-8.
  • Parikh SR, Irish JC, Curran AJ, Gullane PJ, Brown DH, Rotstein LE. Pharyngocutaneous fistulae in laryngec- tomy patients: the To ronto Hospital experience. J Otolaryngol 1998;27:136-40.
  • Wang CP, Tseng TC, Lee RC, Chang SY. The techniques of nonmuscular closure of hypopharyngeal defect fol- lowing total laryngectomy: the assessment of compli- cation and pharyngoesophageal segment. J Laryngol Otol 1997;111:1060-3.
  • Tomkinson A, Shone GR, Dingle A, Roblin DG, Quine S. Pharyngocutaneous fistula following total laryngec- tomy and post-operative vomiting. Clin Otolaryngol 1996;21:369-70.
  • Fradis M, Podoshin L, Ben David J. Post-laryngectomy pharyngocutaneous fistula-a still unresolved problem. J Laryngol Otol 1995;109:221-4.
  • Chee N, Siow JK. Pharyngocutaneous fistula after laryngectomy-incidence, predisposing factors and out- come. Singapore Med J 1999;40:130-2.
  • Seikaly H, Park P. Gastroesophageal reflux prophylax- is decreases the incidence of pharyngocutaneous fistu- la after total laryngectomy. Laryngoscope 1995;105: 1220-2.
  • Sarria Echegaray P, Tomas Barberan M, Mas Mercant S, Soler Vilarrasa R, Romaguera Lliso A. Pharmacological prophylaxis of gastro e s o p h a g e a l reflux. Incidence of pharyngocutaneous fistula after total laryngectomy. Acta Otorrinolaringol Esp 2000;51: 239-42. [Abstract]
  • Mendelsohn MS, Bridger GP. Pharyngocutaneous fis- tulae following laryngectomy. Aust N Z J Surg 1985; 55:177-9.
  • Moses BL, Eisele DW, Jones B. Radiologic assessment of the early postoperative total-laryngectomy patient. Laryngoscope 1993;103:1157-60.
  • Saydam L, Kalcioglu T, Kizilay A. Early oral feeding following total laryngectomy. Am J Otolaryngol 2002; 23:277-81.
  • Khan A. Temporary management of selected pharyn- gocutaneous fistulas with a silicone septal button. Eur Arch Otorhinolaryngol 1993;250:120-2.
  • Guntinas-Lichius O, Eckel HE. Temporary reduction of salivation in laryngectomy patients with pharyngo- cutaneous fistulas by botulinum toxin A injection. Laryngoscope 2002;112:187-9.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Levent Erişen This is me

Fikret Kasapoğlu This is me

Hamdi Hakan Coşkun This is me

Oğuz Basut This is me

İlker Tezer This is me

İbrahim Hızalan This is me

Selçuk Onart This is me

Publication Date January 17, 2003
Published in Issue Year 2003 Volume: 11 Issue: 1

Cite

APA Erişen, L., Kasapoğlu, F., Coşkun, H. H., Basut, O., et al. (2003). Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız. The Turkish Journal of Ear Nose and Throat, 11(1), 5-10.
AMA Erişen L, Kasapoğlu F, Coşkun HH, Basut O, Tezer İ, Hızalan İ, Onart S. Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız. Tr-ENT. January 2003;11(1):5-10.
Chicago Erişen, Levent, Fikret Kasapoğlu, Hamdi Hakan Coşkun, Oğuz Basut, İlker Tezer, İbrahim Hızalan, and Selçuk Onart. “Total Larenjektomi Sonrası farengokutanöz fistül gelişimini Etkileyen faktörler Ve fistül Tedavisine yaklaşımımız”. The Turkish Journal of Ear Nose and Throat 11, no. 1 (January 2003): 5-10.
EndNote Erişen L, Kasapoğlu F, Coşkun HH, Basut O, Tezer İ, Hızalan İ, Onart S (January 1, 2003) Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız. The Turkish Journal of Ear Nose and Throat 11 1 5–10.
IEEE L. Erişen, F. Kasapoğlu, H. H. Coşkun, O. Basut, İ. Tezer, İ. Hızalan, and S. Onart, “Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız”, Tr-ENT, vol. 11, no. 1, pp. 5–10, 2003.
ISNAD Erişen, Levent et al. “Total Larenjektomi Sonrası farengokutanöz fistül gelişimini Etkileyen faktörler Ve fistül Tedavisine yaklaşımımız”. The Turkish Journal of Ear Nose and Throat 11/1 (January 2003), 5-10.
JAMA Erişen L, Kasapoğlu F, Coşkun HH, Basut O, Tezer İ, Hızalan İ, Onart S. Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız. Tr-ENT. 2003;11:5–10.
MLA Erişen, Levent et al. “Total Larenjektomi Sonrası farengokutanöz fistül gelişimini Etkileyen faktörler Ve fistül Tedavisine yaklaşımımız”. The Turkish Journal of Ear Nose and Throat, vol. 11, no. 1, 2003, pp. 5-10.
Vancouver Erişen L, Kasapoğlu F, Coşkun HH, Basut O, Tezer İ, Hızalan İ, Onart S. Total larenjektomi sonrası farengokutanöz fistül gelişimini etkileyen faktörler ve fistül tedavisine yaklaşımımız. Tr-ENT. 2003;11(1):5-10.