BibTex RIS Cite

The effect of neck metastasis on survival following surgery for laryngeal cancer

Year 2003, Volume: 11 Issue: 1, 11 - 15, 17.01.2003

Abstract

Objectives: We evaluated the effect of neck metastasis on the survival rate of patients who undervvent surgery for laryngeal cancer.Patients and Methods: A total of 256 patients who had undergone surgery betvveen 1995 and 1999 were retrospectively revievved. Of these, 186 patients 72%; 185 males, 1 female; mean age 57.5 years who were accessible for follow-up were evaluated with respect to the localization and type of the pri- mary tumor, neck metastasis, surgical procedures, and the sur­ vival. Survival rates were determined by the Kaplan-Meier method and compared by the log-rank test. The rates of neck metastasis and extracapsularspread in survivors and non-sur- vivors were compared with the use of the chi-square test. The minimum follow-up period was two years mean 41.2 months .Results: Twenty nine patients died from locoregional recurrences or distant metastasis and six patients died from other causes. The cumulative survival period was 69 months 75 months and 54 months with or vvithout neck metastasis, respectively; log rank test 27.96, p<0.0001 .The rates of neck metastasis and extracapsular spread in sur­ vivors 22%, 33/151; 7%, 10/151 and non-survivors 69%, 20/29; 59%, 17/29 were significantly different p<0.001 .Conclusion: Neck metastasis and cervical recurrence were found as the most important factors affecting the results of laryngeal cancer surgery.

References

  • Sasaki CT, Carlon RD. Malignant neoplasm of the lar- ynx. In: Cummings CW, Frederickson JM, Harker LA, Krause C, Schuller C, editors. Otolaryngology head and neck surg e r y. 2nd ed. St. Louis: Mosby; 1993. p. 1925-55.
  • Khafif RA, Gelbfish GA, Tepper P, Attie JN. Elective rad- ical neck dissection in epidermoid cancer of the head and neck. A re t rospective analysis of 853 cases of mouth, pharynx, and larynx cancer. Cancer 1991;67:67-71.
  • Gavilan J, Prim MP, De Diego JI, Hardisson D, Pozuelo A. Postoperative radiotherapy in patients with posi- tive nodes after functional neck dissection. Ann Otol Rhinol Laryngol 2000;109:844-8.
  • Ferlito A, Rinaldo A. Selective lateral neck dissection for laryngeal cancer in the clinically negative neck: is it justified? J Laryngol Otol 1998;112:921-4.
  • Li XM, Wei WI, Guo XF, Yuen PW, Lam LK. Cervical lymph node metastatic patterns of squamous carcino- mas in the upper aerodigestive tract. J Laryngol Otol 1996;110:937-41.
  • de Campora E, Radici M, Camaioni A, Pianelli C. Clinical experiences with surgical therapy of cervical metastases from head and neck cancer. Eur Arc h Otorhinolaryngol 1994;251:335-41.
  • Erisen L, Basel B, Coskun H, Basut O, Hizalan I, Tezel I, et al. Evaluation of the number of lymph nodes dis- sected and neck recurrences in comprehensive and selective neck dissections. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2001;8:391-6.
  • Hirabayashi H, Koshii K, Uno K, Ohgaki H, Nakasone Y, Fujisawa T, et al. Extracapsular spread of squamous cell carcinoma in neck lymph nodes: prognostic factor of laryngeal cancer. Laryngoscope 1991;101:502-6.
  • Byers RM. Modified neck dissection. A study of 967 cases from 1970 to 1980. Am J Surg 1985;150:414-21.
  • Leemans CR, Tiwari R, van der Waal I, Karim AB, Nauta JJ, Snow GB. The efficacy of comprehensive neck dissection with or without postoperative radio- therapy in nodal metastases of squamous cell carcino- ma of the upper respiratory and digestive tracts. Laryngoscope 1990;100:1194-8.
  • Bocca E, Calearo C, de Vincentiis I, Marullo T, Motta G, Ottaviani A. Occult metastases in cancer of the larynx and their relationship to clinical and histological aspects of the primary tumor: a four-year multicentric research. Laryngoscope 1984;94:1086-90.
  • Lee JG, Krause CJ. Radical neck dissection: Elective, therapeutic, and secondary. Arch Otolaryngol 1975; 101:656-9.
  • Inanlı S, Polat S, Kaya H, Tutkun A, Batman C, Uneri C, et al. The incidence of occult metastasis in elective neck dissections. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2001;8:312-6.

Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi

Year 2003, Volume: 11 Issue: 1, 11 - 15, 17.01.2003

Abstract

Amaç: Larenks kanseri nedeniyle ameliyat edilen hastagrubunda boyun metastazının sağkalım oranına etkisi değerlendirildi.Hastalar ve Yöntemler: 1995-1999 yılları arasında ameliyat edilen 256 hasta retrospektif olarak incelendi. Takipedilebilen 186 hasta %72; 185 erkek, 1 kadın; ort. yafl57.5 primer tümör tipi, yerleflimi, boyun metastazı, uygulanan cerrahi yöntem ve sağkalım oranları açısından değerlendirildi. Kümülatif yaflam süresinin hesaplanmasındaKaplan-Meier yöntemi, sonuçların karflılafltırılmasında iselog rank testi kullanıldı. Yaflayan ve yaflamayan hastalarda boyun metastazı ve kapsül dıflı yayılım oranlarının değerlendirilmesinde ki-kare testi kullanıldı. Hastaların izlemsüresi en az iki yıl ort. 41.2 ay idi.Bulgular: Yirmi dokuz hasta lokorejyonel nüks veya uzakmetastaz, altı hasta ise diğer nedenlerden yaflamını yitirdi.Ameliyat sonrası ortalama yaflam süresi 69 ay bulundu. Busüre boyun metastazı olmayanlarda 75 ay, olanlarda 54 ay idi log rank testi 27.96, p

References

  • Sasaki CT, Carlon RD. Malignant neoplasm of the lar- ynx. In: Cummings CW, Frederickson JM, Harker LA, Krause C, Schuller C, editors. Otolaryngology head and neck surg e r y. 2nd ed. St. Louis: Mosby; 1993. p. 1925-55.
  • Khafif RA, Gelbfish GA, Tepper P, Attie JN. Elective rad- ical neck dissection in epidermoid cancer of the head and neck. A re t rospective analysis of 853 cases of mouth, pharynx, and larynx cancer. Cancer 1991;67:67-71.
  • Gavilan J, Prim MP, De Diego JI, Hardisson D, Pozuelo A. Postoperative radiotherapy in patients with posi- tive nodes after functional neck dissection. Ann Otol Rhinol Laryngol 2000;109:844-8.
  • Ferlito A, Rinaldo A. Selective lateral neck dissection for laryngeal cancer in the clinically negative neck: is it justified? J Laryngol Otol 1998;112:921-4.
  • Li XM, Wei WI, Guo XF, Yuen PW, Lam LK. Cervical lymph node metastatic patterns of squamous carcino- mas in the upper aerodigestive tract. J Laryngol Otol 1996;110:937-41.
  • de Campora E, Radici M, Camaioni A, Pianelli C. Clinical experiences with surgical therapy of cervical metastases from head and neck cancer. Eur Arc h Otorhinolaryngol 1994;251:335-41.
  • Erisen L, Basel B, Coskun H, Basut O, Hizalan I, Tezel I, et al. Evaluation of the number of lymph nodes dis- sected and neck recurrences in comprehensive and selective neck dissections. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2001;8:391-6.
  • Hirabayashi H, Koshii K, Uno K, Ohgaki H, Nakasone Y, Fujisawa T, et al. Extracapsular spread of squamous cell carcinoma in neck lymph nodes: prognostic factor of laryngeal cancer. Laryngoscope 1991;101:502-6.
  • Byers RM. Modified neck dissection. A study of 967 cases from 1970 to 1980. Am J Surg 1985;150:414-21.
  • Leemans CR, Tiwari R, van der Waal I, Karim AB, Nauta JJ, Snow GB. The efficacy of comprehensive neck dissection with or without postoperative radio- therapy in nodal metastases of squamous cell carcino- ma of the upper respiratory and digestive tracts. Laryngoscope 1990;100:1194-8.
  • Bocca E, Calearo C, de Vincentiis I, Marullo T, Motta G, Ottaviani A. Occult metastases in cancer of the larynx and their relationship to clinical and histological aspects of the primary tumor: a four-year multicentric research. Laryngoscope 1984;94:1086-90.
  • Lee JG, Krause CJ. Radical neck dissection: Elective, therapeutic, and secondary. Arch Otolaryngol 1975; 101:656-9.
  • Inanlı S, Polat S, Kaya H, Tutkun A, Batman C, Uneri C, et al. The incidence of occult metastasis in elective neck dissections. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2001;8:312-6.
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Emre Yücel This is me

Yahya Güldiken This is me

Mehmet Ali Solmaz This is me

Mustafa Özdemir This is me

Kemal Değer This is me

Publication Date January 17, 2003
Published in Issue Year 2003 Volume: 11 Issue: 1

Cite

APA Yücel, E., Güldiken, Y., Solmaz, M. A., Özdemir, M., et al. (2003). Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi. The Turkish Journal of Ear Nose and Throat, 11(1), 11-15.
AMA Yücel E, Güldiken Y, Solmaz MA, Özdemir M, Değer K. Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi. Tr-ENT. January 2003;11(1):11-15.
Chicago Yücel, Emre, Yahya Güldiken, Mehmet Ali Solmaz, Mustafa Özdemir, and Kemal Değer. “Larenks Kanseri Cerrahisinde Boyun metastazının sağkalıma Etkisi”. The Turkish Journal of Ear Nose and Throat 11, no. 1 (January 2003): 11-15.
EndNote Yücel E, Güldiken Y, Solmaz MA, Özdemir M, Değer K (January 1, 2003) Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi. The Turkish Journal of Ear Nose and Throat 11 1 11–15.
IEEE E. Yücel, Y. Güldiken, M. A. Solmaz, M. Özdemir, and K. Değer, “Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi”, Tr-ENT, vol. 11, no. 1, pp. 11–15, 2003.
ISNAD Yücel, Emre et al. “Larenks Kanseri Cerrahisinde Boyun metastazının sağkalıma Etkisi”. The Turkish Journal of Ear Nose and Throat 11/1 (January 2003), 11-15.
JAMA Yücel E, Güldiken Y, Solmaz MA, Özdemir M, Değer K. Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi. Tr-ENT. 2003;11:11–15.
MLA Yücel, Emre et al. “Larenks Kanseri Cerrahisinde Boyun metastazının sağkalıma Etkisi”. The Turkish Journal of Ear Nose and Throat, vol. 11, no. 1, 2003, pp. 11-15.
Vancouver Yücel E, Güldiken Y, Solmaz MA, Özdemir M, Değer K. Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi. Tr-ENT. 2003;11(1):11-5.