Atypical presentation of Kaposi's sarcoma in the external ear

Year 2003, Volume: 11 Issue: 1, 17 - 20, 17.01.2003

Orhan Babuccu Eksal Kargı Mubin Hoşnuter Banu Gün Doğan

Abstract

We presented a case of Kaposi’s sarcoma that occurred in the external ear of a 36-year-old Caucasian man. He was othervvise healthy without a history of any predisposing factors. He had a nodular lesion in the left ear, of three-month duration. The lesion was excised completely. Histologic and immunohistologic findings were consistent with a diagnosis of Kaposi’s sarcoma.Serologic analyses were negative for anti-HIV antibody and anti-cytomegalovirus IgM and IgG and blood count was normal. Differential count of leucocytes and immunoglobulin electrophoresis were normal. During a two-year follow-up, no recurrences, development of new lesions, or HIV seroconversion were detected. To our knowledge, this case is the first to report a solitary lesion of Kaposi’s sarcoma occurring in the helix of the ear in a healthy young patient.

Keywords

Ear, external, ear neoplasms, sarcoma, Kaposi/ diagnosis/pathology

Dış kulakta Kaposi sarkomu: Olgu sunumu

Abstract

Bu makalede, 36 yaflındaki sağlıklı bir erkek hasta- da kulak kepçesinde saptanan Kaposi sarkomu su- nuldu. Hastanın sol kulağında üç aydır var olan no- düler lezyon için predispozan herhangi bir faktör belirlenemedi. Lezyon tümüyle çıkarıldı. Histolojik ve immünhistolojik bulgular Kaposi sarkomu ile uyumluydu. Serolojik analizlerde anti-HIV ile anti- sitomegalovirüs IgM ve IgG antikorları negatif bu- lundu. Kan sayımı normaldi. Lökosit altgruplarının sayımı ve immünglobulin elektroforezi normal so- nuçlar verdi. İki yıllık izlem dönemi içinde hastada lezyon nüksü, yeni lezyon geliflimi, ya da HIV sero- konversiyonu gözlenmedi. İlgili literatürlerin taran- masında, kulak kepçesinde Kaposi sarkomuna ait soliter lezyonun bildirildiği genç sağlıklı bir olguya r a s t l a m a d ı k

Keywords

Kulak, dış, kulak neoplazmları, sarkom, Kaposi / tanı / patoloji .

References

• Fishman AD, Sparano JA. Kaposi sarcoma. eMedicine Journal. Available at URL: www. e m e d i c i n e . c o m / m e d / t o p i c 1 2 1 8 . h t m
• Iscovich J, Boffetta P, Franceschi S, Azizi E, Sarid R. Classic kaposi sarcoma: epidemiology and risk factors. Cancer 2000;88:500-17.
• Dictor M. Human herpesvirus 8 and Kaposi's sarcoma. Semin Cutan Med Surg 1997;16:181-7.
• Greenblatt RM. Kaposi's sarcoma and human her- pesvirus-8. Infect Dis Clin North Am 1998;12:63-82.
• Boshoff C, Weiss RA. Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci 2001;356:517-34.
• Franceschi S, Geddes M. Epidemiology of classic Kaposi's sarcoma, with special reference to mediter- ranean population. Tumori 1995;81:308-14.
• Schulz TF. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogene- sis. J Antimicrob Chemother 2000;45 Suppl T3:15-27.
• Giraldo G, Beth E, Kyalwazi SK. Role of cytomegaloviru s in Kaposi's sarcoma. IARC Sci Publ 1984;(63):583-606.
• Wick MR. Kaposi's sarcoma unrelated to the acquired immunodeficiency syndrome. Curr Opin Oncol 1991; 3:377-83.
• Froehner M, Wirth MP. Etiologic factors in soft tissue sarcomas. Onkologie 2001;24:139-42.
• Zahm SH, Fraumeni JF Jr. The epidemiology of soft tis- sue sarcoma. Semin Oncol 1997;24:504-14.
• Gibbs RC. Kaposi's sarcoma involving the ears. Arch Dermatol 1968;98:104-5.
• P e rgolizzi S, Delia P, Grazioso Russi E, Raffaele L, Settineri N, D'Angelo A, et al. Radiotherapy of an unusual case of Kaposi's sarcoma of the "classic" type located in the external ear. Radiol Med 1995;89:910-3. [ A b s t r a c t ]
• Stearns MP, Hibbard AA, Patterson HC. Kaposi's S a rcoma of the ear: a case study. J Laryngol Otol 1983; 9 7 : 6 4 1 - 5 .