Landau-Kleffner syndrome acquired epileptic aphasia

Year 2003, Volume: 10 Issue: 1, 25 - 28, 10.04.2003

Tamer Erdem Tayfun Kirazlı Sarenur Tütüncüoğlu

Abstract

Landau-Kleffner syndrome is characterized by a complex group of symptoms including deterioration in language skills, seizures, and abnormal elec- troencephalography findings. A six-year-old male patient had aphasia for three years and generalized tonic-clonic epileptic seizures for two years. Pure- tone audiometry and auditory brain-stem response audiometry findings were normal. He had verbal auditory agnosia rather than true aphasia. Cranial computed tomography and magnetic resonance imaging studies did not show any abnormal findings.Single-photon emission computed tomography showed hypoperfusion in the right hemispheric tem­ poral lobe. Despite treatment with corticosteroids and intravenous immunoglobulins, multiple exacerbations were interspersed in a four-year follow-up period.

Keywords

Anticonvulsants/therapeutic use, aphasia/diagnosis/complications, child, electroencephalography, epilepsy/ complications, Landau-Kleffner syndrome/therapy, language disorders/etiology, seizures/complications, syndrome

Landau-Kleffner sendromu edinsel epileptik afazi

Abstract

Landau-Kleffner sendromu konuflma yetisinin bozul- ması, epilepsi nöbetleri ve anormal elektroensefa- lografi bulgularıyla kendini gösteren bir epilepsi türü- dür. Bu yazıda, üç yıldır konuflma zorluğu çeken ve son iki yıldır da jeneralize tonik-klonik nöbetleri olan altı yaflındaki bir erkek olgu sunuldu. Tonal odyomet- ri ve beyin sapı odyometrisinde anormal bulguya rastlanmadı. Hastada gerçek bir konuflamama afa- zi değil, sözlü iflitsel uyaranların ayırt edilemeyifli ve anlaflılamaması sözel-iflitsel agnozi vardı. Kranyal bilgisayarlı tomografi ve manyetik rezonans görüntü- leme bulguları normaldi. Single-photon emisyonlu bilgisayarlı tomografide sağ hemisfer temporal lob posteroinferior kısmında hipoperfüzyon bulgularına rastlandı. Kortikosteroid ve intravenöz immünglobu- lin tedavisine rağmen dört yıllık izlem sırasında has- talıkta dalgalı bir seyir gözlendi

Keywords

Antikonvulsan/terapötik kullanım, afazi/tanı/komplikasyon, çocuk, elektroensefalografi, epilepsi/komplikasyon, Landau-Kleffner sendromu/tedavi, konuflmabozuklukları/etyoloji, nöbet/komplikasyon, sendrom

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