A review on experimental sinusitis models in rabbits

Year 2003, Volume: 10 Issue: 3, 122 - 130, 01.06.2003

Cüneyt Orhan Kara Neşe Demirkan

Abstract

Experimental animal models are instrumental to study the pathogenesis of diseases and to examine the results of treatment. The great size and ease of acces-sibility have made rabbit sinuses popular in the investigation of experimental sinusitis. Microbiologic, histopathologic, and radiologic aspects of this model have been well-described and the effects of medical and surgical treatments on sinusitis have been examined. Ongoing research may provide further data to find more simple and non-invasive methods to induce sinusitis in rabbits that may more closely simulate sinusitis pathogenesis in humans. This article reviews the most recent data on technical, surgical, microbiologic, histopathologic, and radiologic aspects, and complications of sinusitis models in rabbits.

Keywords

Disease models, animal, maxillary sinüs/ pathology/microbiology, nasal cavity, nasal mucosa, rab­bits, sinusitis/pathology/microbiology

Tavşanda deneysel sinüzit modelleri üzerine bir inceleme

Abstract

Deneysel hayvan modelleri, hastalıkların patogene- zini arafltırmak ve tedavi sonuçlarını incelemek için çok uygun araçlardır. Tavflan sinüslerinin büyüklü- ğü ve kolay ulaflılabilirliği, tavflanın sinüzit arafltır- malarında sık kullanılmasına yol açmıfltır. Mikrobi- yolojik ve histopatolojik özellikleri iyi tanımlanmıfl olan bu model, tıbbi ve cerrahi tedavi sonuçlarının incelenmesinde baflarıyla uygulanmaktadır. Bunun- la birlikte, insandaki sinüzit patogenezini daha iyi taklit edebilen bir tavflan modeli gelifltirebilmek için daha basit ve invaziv olmayan yöntemler arafltırıl- m a k t a d ı r. Bu yazıda, tavflan sinüzit modelinin tek- nik, cerrahi, mikrobiyolojik, histopatolojik, radyolojik özellikleri ve komplikasyonları üzerine sonbilgiler gözden geçirildi

Keywords

Hastalık modeli, hayvan, maksiller sinüs/patoloji/mikrobiyoloji, burun boflluğu, burun mukozası, tavflan, sinüzit/patoloji/mikrobiyoloji

References

• Kelemen G. The nasal and paranasal cavities of the rabbit in experimental work. Arch Otolaryngol 1955; 61:497-512.
• Köybaflıoğlu A, İleri F, Beder L, İnal E. Tavflan mak- siller sinus anatomisi KBB Bafl Boyun Cerrahisi Dergisi 1997;5:41-44.
• Özüer MZ, Bayramoğlu İ, Kara CO, Akkemik B, Çallı N. Tavflan paranazal sinüslerinin anatomik ve radyo- lojik incelenmesi. Pamukkale Üniversitesi Tıp Fakülte- si Dergisi 1998;4:13-6.
• Hilding A. Experimental sinus surgery: effects of oper- ative windows on normal sinuses. Ann Otol Rhinol Laryngol 1941;50:379-92.
• Maeyama T. A study of experimental sinusitis in rab- bits. Auris Nasus Larynx 1981;8:87-97.
• Johansson P, Kumlien J, Carlsoo B, Drettner B, Nord CE. Experimental acute sinusitis in rabbits. A bacterio- logical and histological study. Acta Otolaryngol 1988; 105:357-66.
• D rettner B, Johansson P, Kumlien J. Experimental acute sinusitis in rabbit. A study of mucosal blood flow. Acta Otolaryngol 1987;103:432-4.
• Kumlien J, Schiratzki H. The vascular arrangement of the sinus mucosa. A study in rabbits. Acta Otolaryngol 1985;99:122-32.
• Kumlien JA, Schiratzki H, Drettner B. Blood flow in the rabbit maxillary sinus mucosa. Measurement with a dif- fusible and a non-diffusible tracer. Acta Otolaryngol 1 9 8 5 ; 9 9 : 1 4 4 - 5 3 .
• Özüer MZ, Çallı N, Bayramoğlu İ, Akkemik B. Tavflan- larda deneysel sinüzitin histopatolojik, mikrobiyolojik ve radyolojik incelenmesi. KBB Bafl Boyun Cerrahisi Dergisi 1997;5:98-104.
• Kara CO, Çetin CB, Çolakoğlu N, fiengül M, Pakdemirli E. Experimentally induced rhinosinusitis in rabbits. J Otolaryngol 2002;31:294-8.
• Marks SC. Acute sinusitis in the rabbit: a new rhino- genic model. Laryngoscope 1997;107(12 Pt 1):1579-85.
• Marks SC. Acute sinusitis in the rabbit model: histo- logic analysis. Laryngoscope 1998;108:320-5.
• Kara CO, Çetin CB, Çallı N, fiengül M, Topuz B, Pınar Hfi. Tavflanlarda rinojenik sinüzit modelinin radyolo- jik, histopatolojik ve mikrobiyolojik incelenmesi. 26. Ulusal Türk Otorinolarengoloji ve Bafl-Boyun Cerrahi- si Kongresi Özet Kitabı; 22-26 Eylül 2001; Antalya, Türkiye. 2001. s. 114.
• Döner F, Delibafl N, Doğru H, Sarı I, Yorgancıgil B. Malondialdehyde levels and superoxide dismutase activity in experimental maxillary sinusitis. Auris Nasus Larynx 1999;26:287-91.
• Ünal M, Öztürk C, Aslan G, Aydın Ö, Görür K. The effect of high single dose parenteral vitamin A in addi- tion to antibiotic therapy on healing of maxillary sinusitis in experimental acute sinusitis. Int J Pediatr Otorhinolaryngol 2002;65:219-23.
• Çetin CB, Kara CO, Çolakoğlu N, fiengül M, Pınar Hfi. Experimental sinusitis in nasally catheterised rabbits. Rhinology 2002;40:154-8.
• We s t e rg ren V, Otori N, Stierna P. Experimental nasal intubation: a study of changes in nasoantral mucosa and bacterial flora. Laryngoscope 1999;109(7 Pt 1):1068-73.
• Kerschner JE, Cruz MJ, Beste DJ, Donahue KM, Kehl KS. Computed tomography vs. magnetic resonance imaging of acute bacterial sinusitis: a rabbit model. Am J Otolaryngol 2000;21:298-305.
• Gnoy AR, Gannon PJ, Ganjian E, Fliegelman L, Farber D, Silvers A, et al. A potential role for nasal obstruction in development of acute sinusitis: an infection study in rabbits. Am J Rhinol 1998;12:399-404.
• Bolger WE, Leonard D, Dick EJ Jr, Stierna P. Gram neg- ative sinusitis: a bacteriologic and histologic study in rabbits. Am J Rhinol 1997;11:15-25.
• Westrin KM, Norlander T, Stierna P, Carlsoo B, Nord CE. Experimental maxillary sinusitis induced by Bacteroides fragilis. A bacteriological and histological study in rabbits. Acta Otolaryngol 1992;112:107-14.
• Vaidya AM, Chow JM, Stankiewicz JA, Young MR, Mathews HL. Correlation of middle meatal and maxil- lary sinus cultures in acute maxillary sinusitis. Am J Rhinol 1997;11:139-43.
• Kim CS, Jeon SY, Min YG, Rhyoo C, Kim JW, Yun JB, et al. Effects of beta-toxin of Staphylococcus aureus on ciliary activity of nasal epithelial cells. Laryngoscope 2000;110:2085-8.
• Beste DJ, Capper DT, Shaffer K, Kehl KS, Kajdacsy- Balla A. Antimicrobial effect on rabbit sinusitis after temporary ostial occlusion. Am J Rhinol 1997;11:485-9.
• Min YG, Lee YM, Lee BJ, Jung HW, Chang SO. The effect of ostial opening on experimental maxillary sinusitis in rabbits. Rhinology 1993;31:101-5.
• Min YG, Lim HJ, Kim CN, Jang YJ. Comparison of nat- ural ostiotomy and antibiotic therapy in the treatment of acute maxillary sinusitis in rabbits. Acta Otolaryngol 1 9 9 5 ; 11 5 : 4 3 3 - 7.
• Kutluhan A, Inalkac E, Kiroglu AF, Akpolat N, Kiris M. The relationship between ostial patency and med- ical treatment in acute maxillary sinusitis: an experi- mental study. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2002;9:275-81.
• Cable BB, Wassmuth Z, Mann EA, Hommer D, Connely G, Klem C, et al. The effect of corticosteroids in the tre a t- ment of experimental sinusitis. Am J Rhinol 2000;14:
• Norlander T, Kwon SH, Henriksson G, Westrin KM, Sandstedt K, Stierna P. Effect of systemic pretreatment with betamethasone on the bacterial flora, inflamma- tory response, and polyp formation in experimentally infected rabbit maxillary sinus mucosa. Laryngoscope 1998;108:411-7.
• Min YG, Kim HS, Suh SH, Jeon SY, Son YI, Yoon S. Paranasal sinusitis after long-term use of topical nasal decongestants. Acta Otolaryngol 1996;116:465-71.
• Suh SH, Chon KM, Min YG, Jeong CH, Hong SH. Effects of topical nasal decongestants on histology of nasal respiratory mucosa in rabbits. Acta Otolaryngol 1995;115:664-71.
• Bende M, Fukami M, Arfors KE, Mark J, Stierna P, Intaglietta M. Effect of oxymetazoline nose drops on acute sinusitis in the rabbit. Ann Otol Rhinol Laryngol 1996;105:222-5.
• Otori N, Paydas G, Stierna P, Westrin KM. The anti- inflammatory effect of fusafungine during experimen- tally induced rhinosinusitis in the rabbit. Eur Arch Otorhinolaryngol 1998;255:195-201.
• Min YG, Kim YK, Jeong SY. Application of polylactic acid polymer in the treatment of acute maxillary sinusitis in rabbits. Acta Otolaryngol 1995;115:548-52.
• Min YG, Kim YK, Choi YS, Shin JS, Juhn SK. Mucociliary activity and histopathology of sinus mucosa in experi- mental maxillary sinusitis: a comparison of systemic administration of antibiotic and antibiotic delivery by polylactic acid polymer. Laryngoscope 1995;105(8 Pt 1): 8 3 5 - 4 2 .
• Benninger MS, Kaczor J, Stone C. Natural ostiotomy vs. inferior antrostomy in the management of sinusitis: an animal model. Otolaryngol Head Neck Surg 1993; 109:1034-42.
• Kennedy DW, Shaalan H. Reevaluation of maxillary sinus surgery: experimental study in rabbits. Ann Otol Rhinol Laryngol 1989;98:901-6.
• Min YG, Kim IT, Park SH. Mucociliary activity and u l t r a s t ructural abnormalities of regenerated sinus mucosa in rabbits. Laryngoscope 1994;104:1482-6.
• Ingrams DR, Volk MS, Biesman BS, Pankratov MM, Shapshay SM. Sinus surgery: does mitomycin C reduce stenosis? Laryngoscope 1998;108:883-6.
• Forsgren K, Westrin KM, Fukami M, Stierna P. Effects of surgery on mucosal pathologic changes following experimental sinusitis in rabbit. Ann Otol Rhinol Laryngol 1998;107:155-63.
• Ercan I, Ozbek C, Kurtaran H, Arikan OK, Aydin M, Ozdem C. Examination of the effect of endoscopic sinus surgery on the mucociliary clearance by means of scintigraphy: a rabbit model. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2001;8:275-80.
• Perko D, Karin RR. Nasoantral windows: an experi- mental study in rabbits. Laryngoscope 1992;102:320-6.
• Tos M, Mogensen C. Mucus production in chronic maxillary sinusitis. A quantitative histopathological study. Acta Otolaryngol 1984;97:151-9.
• Norlander T, Shimizu T, Larsen P, Westrin KM, Hultenby K, Carlsoo B, et al. Early stages in the devel- opment of goblet cells in the paranasal sinuses: a mul- timethodological study in the rabbit. Acta Otolaryngol 1998;118:114-23.
• Norlander T, Fukami M, Westrin KM, Stierna P, Carlsoo B. Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection. Otolaryngol Head Neck Surg 1993;109(3 Pt 1):522-9.
• Norlander T, Forsgren K, Kumlien J, Stierna P, Carlsoo B. Cellular regeneration and recovery of the maxillary sinus mucosa. An experimental study in rabbits. Acta Otolaryngol Suppl 1992;492:33-7.
• Özüer MZ, Demirkan N, Bayramoglu İ, Akkemik B. Tavflanlarda maksiller sinüs rejenerasyonu. In: Korkut N, editör. 25. Ulusal Türk ORL ve Bafl-Boyun Cerrahi- si Kongre kitabı; 18-22 Eylül 1999; İzmir, Türkiye. İs- tanbul: TKBBV; 2002. s. 191-4.
• M e l g a re j o - M o reno PJ, Ribera-Cortada I, Hellin- Meseguer D. Submucosal glands after maxillary sinus surgery. An experimental study in rabbits. J Laryngol Otol 1996;110:644-8.
• Juan KH, Peng CF, Lin HJ. Bacteriology of maxillary sinuses in rabbits. Gaoxiong Yi Xue Ke Xue Za Zhi 1995; 11 : 5 5 2 - 6 .
• B e rglof A, Norlander T, Feinstein R, Otori N, Stierna P, Sandstedt K. Association of bro n c h o p n e u m o n i a with sinusitis due to Bordetella bronchiseptica in an experimental rabbit model. Am J Rhinol 2000;14: 1 2 5 - 3 0 .
• Kennedy CA, Jyonouchi H, Kajander KC, Sun S, Rimell FL. Middle ear pathologic changes associated with chro n- ic anaerobic sinusitis in rabbits. Laryngoscope 1999;109:
• Nakajima K, Ohi G. Aerophagia induced by the nasal obstruction on experimental animals. Jikken Dobutsu 1977;26:149-59.