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A case of Ewing's sarcoma in the mandible and the skull base

Year 2003, Volume: 11 Issue: 5, 144 - 147, 13.10.2003

Abstract

A thirteen-year-old boy with Evving’s sarcoma was presented.The treatment was considerably delayed because of the initial diagnostic difficulties due to its insidious presentation and the unvvillingness of the child’s parents to further investigations and treatment. During a three-year delay, the tumor turned out to be a gross painful mass from a painless lesion.Cranial computed tomography and magnetic resonance imaging with contrast showed a destructive lesion extensively involving the right mandible and the skull base, with inva- sion to the intracranial space. Facial and intratemporal portions of the mass were removed totally, but the intracranial extension could not be totally excised because of cavernous sinüs involvement. Histologic and immunohistochemical find- ings were consistent with the diagnosis of Evving’s sarcoma.The patient received systemic chemotherapy and radiothera- py follovving surgery. A month after radiation therapy, radiologic investigations shovved a lung mass suggestive of metastasis. He died two days after hospitalization, from an intracra­ nial hemorrhage associated with the intracranial mass.

References

  • Vaccani JP, Forte V, de Jong AL, Taylor G. Ewing’s sar- coma of the head and neck in children. Int J Pediatr Otorhinolaryngol 1999;48:209-16.
  • Fiorillo A, Tranfa F, Canale G, Fariello I, D’Amore R, De Chiara C, et al. Primary Ewing’s sarcoma of the maxilla, a rare and curable localization: report of two new cases, successfully treated by radiotherapy and systemic chemotherapy. Cancer Lett 1996;103:177-82.
  • Siegal GP, Oliver WR, Reinus WR, Gilula LA, Foulkes MA, Kissane JM, et al. Primary Ewing’s sarc o m a involving the bones of the head and neck. Cancer 1987; 60:2829-40.
  • Burgert EO Jr, Nesbit ME, Garnsey LA, Gehan EA, Herrmann J, Vietti TJ, et al. Multimodal therapy for the management of nonpelvic, localized Ewing’s sarcoma of bone: interg roup study IESS-II. J Clin Oncol 1990;8:1514-24.
  • Daw NC, Mahmoud HH, Meyer WH, Jenkins JJ, Kaste SC, Poquette CA, et al. Bone sarcomas of the head and neck in children: the St Jude Children’s Research Hospital Experience. Cancer 2000;88:2172-80.
  • Wood RE, Nortje CJ, Hesseling P, Grotepass F. Ewing’s tumor of the jaw. Oral Surg Oral Med Oral Pathol 1990; 69:120-7.
  • Rosen G, Caparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, et al. Ewing’s sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 1981; 47:2204-13.
  • Dunst J, Sauer R, Burgers JM, Hawliczek R, Kurten R, Winkelmann W, et al. Radiation therapy as local tre a t- ment in Ewing’s sarcoma. Results of the Cooperative Ewing’s Sarcoma Studies CESS 81 and CESS 86. Cancer 1 9 9 1 ; 6 7 : 2 8 1 8 - 2 5 .
  • Hayes FA, Thompson EI, Meyer WH, Kun L, Parham D, Rao B, et al. Therapy for localized Ewing’s sarcoma of bone. J Clin Oncol 1989;7:208-13.
  • Bacci G, Picci P, Gitelis S, Borghi A, Campanacci M. The treatment of localized Ewing’s sarcoma: the expe- rience at the Istituto Ortopedico Rizzoli in 163 cases t reated with and without adjuvant chemotherapy. Cancer 1982;49:1561-70.

Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu

Year 2003, Volume: 11 Issue: 5, 144 - 147, 13.10.2003

Abstract

On üç yaflında bir erkek çocukta Ewing sarkomuna rast- landı. Tedavi, tümörün bafllangıçta az semptom vermesin- den kaynaklanan tanı güçlükleri ve hastanın anne-babası- nın daha ileri arafltırma ve tedaviyi kabul etmemeleri ne- deniyle önemli ölçüde gecikti. Yaklaflık üç yıllık bir gecik- meden sonra, tümörün ağrısız bir lezyondan ağrılı büyük bir kitleye dönüfltüğü görüldü. Bilgisayarlı tomografi ve kontrastlı manyetik rezonans görüntülerinde sağ mandibu- la ve kafa tabanını yaygın olarak tutan ve kafa içi uzanım gösteren tümör izlendi. Lezyonun yüzdeki ve intratempo- ral bölümleri tümüyle çıkarılırken, kafa içi uzanımı, kaver- nöz sinüs tutulumu yüzünden tümüyle çıkarılamadı. Histo- lojik ve immünkimyasal bulgular Ewing sarkomu tanısını destekler nitelikteydi. Hastaya cerrahi tedaviden sonra sis- temik kemoterapi ve radyoterapi uygulandı. Radyoterapi- den bir ay sonraki radyolojik incelemelerde akciğerde me- tastaz düflündüren bir kitle saptandı. Hasta, yatırılmasın- dan iki gün sonra, kafa içi kitleye bağlı geliflen intrakranyal kanama nedeniyle yaflamını yitirdi

References

  • Vaccani JP, Forte V, de Jong AL, Taylor G. Ewing’s sar- coma of the head and neck in children. Int J Pediatr Otorhinolaryngol 1999;48:209-16.
  • Fiorillo A, Tranfa F, Canale G, Fariello I, D’Amore R, De Chiara C, et al. Primary Ewing’s sarcoma of the maxilla, a rare and curable localization: report of two new cases, successfully treated by radiotherapy and systemic chemotherapy. Cancer Lett 1996;103:177-82.
  • Siegal GP, Oliver WR, Reinus WR, Gilula LA, Foulkes MA, Kissane JM, et al. Primary Ewing’s sarc o m a involving the bones of the head and neck. Cancer 1987; 60:2829-40.
  • Burgert EO Jr, Nesbit ME, Garnsey LA, Gehan EA, Herrmann J, Vietti TJ, et al. Multimodal therapy for the management of nonpelvic, localized Ewing’s sarcoma of bone: interg roup study IESS-II. J Clin Oncol 1990;8:1514-24.
  • Daw NC, Mahmoud HH, Meyer WH, Jenkins JJ, Kaste SC, Poquette CA, et al. Bone sarcomas of the head and neck in children: the St Jude Children’s Research Hospital Experience. Cancer 2000;88:2172-80.
  • Wood RE, Nortje CJ, Hesseling P, Grotepass F. Ewing’s tumor of the jaw. Oral Surg Oral Med Oral Pathol 1990; 69:120-7.
  • Rosen G, Caparros B, Nirenberg A, Marcove RC, Huvos AG, Kosloff C, et al. Ewing’s sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 1981; 47:2204-13.
  • Dunst J, Sauer R, Burgers JM, Hawliczek R, Kurten R, Winkelmann W, et al. Radiation therapy as local tre a t- ment in Ewing’s sarcoma. Results of the Cooperative Ewing’s Sarcoma Studies CESS 81 and CESS 86. Cancer 1 9 9 1 ; 6 7 : 2 8 1 8 - 2 5 .
  • Hayes FA, Thompson EI, Meyer WH, Kun L, Parham D, Rao B, et al. Therapy for localized Ewing’s sarcoma of bone. J Clin Oncol 1989;7:208-13.
  • Bacci G, Picci P, Gitelis S, Borghi A, Campanacci M. The treatment of localized Ewing’s sarcoma: the expe- rience at the Istituto Ortopedico Rizzoli in 163 cases t reated with and without adjuvant chemotherapy. Cancer 1982;49:1561-70.
There are 10 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Mahmut Tayyar Kalcıoğlu This is me

Murat Cem Miman This is me

Tamer Erdem This is me

Semih Öncel This is me

Bülent Mızrak This is me

Publication Date October 13, 2003
Published in Issue Year 2003 Volume: 11 Issue: 5

Cite

APA Kalcıoğlu, M. T., Miman, M. C., Erdem, T., Öncel, S., et al. (2003). Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu. The Turkish Journal of Ear Nose and Throat, 11(5), 144-147.
AMA Kalcıoğlu MT, Miman MC, Erdem T, Öncel S, Mızrak B. Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu. Tr-ENT. October 2003;11(5):144-147.
Chicago Kalcıoğlu, Mahmut Tayyar, Murat Cem Miman, Tamer Erdem, Semih Öncel, and Bülent Mızrak. “Mandibula Ve Kafa tabanında Ewing Sarkomu: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat 11, no. 5 (October 2003): 144-47.
EndNote Kalcıoğlu MT, Miman MC, Erdem T, Öncel S, Mızrak B (October 1, 2003) Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu. The Turkish Journal of Ear Nose and Throat 11 5 144–147.
IEEE M. T. Kalcıoğlu, M. C. Miman, T. Erdem, S. Öncel, and B. Mızrak, “Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu”, Tr-ENT, vol. 11, no. 5, pp. 144–147, 2003.
ISNAD Kalcıoğlu, Mahmut Tayyar et al. “Mandibula Ve Kafa tabanında Ewing Sarkomu: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat 11/5 (October 2003), 144-147.
JAMA Kalcıoğlu MT, Miman MC, Erdem T, Öncel S, Mızrak B. Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu. Tr-ENT. 2003;11:144–147.
MLA Kalcıoğlu, Mahmut Tayyar et al. “Mandibula Ve Kafa tabanında Ewing Sarkomu: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat, vol. 11, no. 5, 2003, pp. 144-7.
Vancouver Kalcıoğlu MT, Miman MC, Erdem T, Öncel S, Mızrak B. Mandibula ve kafa tabanında Ewing sarkomu: Olgu sunumu. Tr-ENT. 2003;11(5):144-7.