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A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx

Year 2003, Volume: 11 Issue: 6, 183 - 188, 24.12.2003

Abstract

A thirty-seven-year-old male patient presented with dysphagia and hoarseness six months after complete remis­ sion of acute myeloid leukemia AML-MQ , which had been treated with chemotherapy. Physical examination revealed left vocal cord paralysis and involvement of the 9th, 10th, and 12th cranial nerves. Sagittal and axial magnetic resonance seans of the nasopharynx and neck shovved a mass in the left retropharyngeal and periverte- bral regions, 6x4 cm in size; another mass in the left val- lecula, and infiltration of the right preepiglottic tissue by another mass of 2 cm. There was no bone marrovv involvement. A diagnosis of granulocytic sarcoma vvithout leukemia relapse was made and the FLAG-lda regimen was administered, after which partial regression of the masses was observed. Hovvever, the patient died due to a pulmonary infeetion on the 17th day of chemotherapy.

References

  • Grande M. Central nervous system granulocytic sarco- ma in a patient with essential thrombocythemia. Am J Hematol 1996;51:64-7.
  • Kim FS, Rutka JT, Bernstein M, Resch L, Warner E, Pantalony D. Intradural granulocytic sarcoma pre- senting as a lumbar radiculopathy. J Neuro s u rg 1990; 7 2 : 6 6 3 - 7 .
  • Kaufman BA, Jones L, Zutter MM, Park TS. Megakaryoblastic leukemia presenting as a tempo- ral bone granulocytic sarcoma. J Neuro s u rg 1993;79: 1 2 8 - 3 1 .
  • Deme S, Deodhare SS, Tucker WS, Bilbao JM. Granulocytic sarcoma of the spine in nonleukemic patients: report of three cases. Neurosurgery 1997;40: 1283-7.
  • Magliocco AM, Demetrick DJ, Jones AR, Kossakowska AE. Granulocytic sarcoma of the ovary. An unusual case presentation. Arch Pathol Lab Med 1 9 9 1 ; 11 5 : 8 3 0 - 4 .
  • Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer 1986;58:2697-709.
  • Hancock JC, Prchal JT, Bennett JM, Listinsky CM. Trilineage extramedullary myeloid cell tumor in myelodysplastic syndrome. Arch Pathol Lab Med 1997; 121:520-3.
  • Cartwright PC, Faye-Petersen O, Bybee B, Snow BW. Leukemic relapse presenting with ureteral obstru c- tion caused by granulocytic sarcoma. J Urol 1991; 1 4 6 : 1 3 5 4 - 5 .
  • Karnak I, Ciftci AO, Senocak ME, Gogus S. Granulocytic sarcoma of the scapula: an unusual pre- sentation of acute myeloblastic leukemia. J Pediatr Surg 1 9 9 7 ; 3 2 : 1 2 1 - 2 .
  • Binder C, Tiemann M, Haase D, Humpe A, Kneba M. Isolated meningeal chloroma (granulocytic sarcoma)-a case report and review of the literature. Ann Hematol 2000;79:459-62.
  • Novick SL, Nicol TL, Fishman EK. Granulocytic sarco- ma (chloroma) of the sacrum: initial manifestation of leukemia. Skeletal Radiol 1998;27:112-4.
  • McCluggage WG, Boyd HK, Jones FG, Mayne EE, B h a rucha H. Mediastinal granulocytic sarcoma: a report of two cases. Arch Pathol Lab Med 1998;122: 545-7.
  • Bagg MD, Wettlaufer JN, Willadsen DS, Ho V, Lane D, Thrasher JB. Granulocytic sarcoma presenting as a dif- fuse renal mass before hematological manifestations of acute myelogenous leukemia. J Urol 1994;152:2092-3.
  • Vassallo J, Altemani AM, Cardinalli IA, Crespo AN, Lima CS, Eid KA, et al. Granulocytic sarcoma of the larynx preceding chronic myeloid leukemia. Pathol Res Pract 1993;189:1084-6.
  • Horny HP, Kaiserling E. Involvement of the larynx by hemopoietic neoplasms. An investigation of autopsy cases and review of the literature. Pathol Res Pract 1995; 191:130-8.
  • Remacle M, Marza L, Marbaix E. Granulocytic sarc o m a of the larynx. Report of a case and literature re v i e w. Acta O t o rhinolaryngol Belg 1995;49:11-7. [Abstract]
  • Au WY, Kwong YL, Ho WK, Shek TW. Primary granu- locytic sarcoma of the nasopharynx. Am J Hematol 2001; 67:273-4.
  • Bown NP, Rowe D, Reid MM. Granulocytic sarcoma with translocation (9;11) (p22;q23): two cases. Cancer Genet Cytogenet 1997;96:115-7.
  • Au WY, Ma SK, Chan AC, Liang R, Lam CC, Kwong YL. Near tetraploidy in three cases of acute myeloid leukemia associated with mediastinal granulocytic sarcoma. Cancer Genet Cytogenet 1998;102:50-3.
  • Hishima T, Fukayama M, Hayashi Y, Shiozawa Y, Funata N, Sakamaki H, et al. Granulocytic sarcoma of the thymus in a nonleukaemic patient. Virchows Arch 1999;435:447-51.
  • Mostafavi H, Lennarson PJ, Traynelis VC. Granulocytic s a rcoma of the spine. Neuro s u rgery 2000;46:78-4.
  • Bassichis B, McClay J, Wiatrak B. Chloroma of the mas- seteric muscle. Int J Pediatr Otorhinolaryngol 2000; 53:57-61.
  • Uyesugi WY, Watabe J, Petermann G. Orbital and facial granulocytic sarcoma (chloroma): a case report. Pediatr Radiol 2000;30:276-8.
  • Byrd JC, Weiss RB. Recurrent granulocytic sarcoma. Cancer 1994;73:2107-12.
  • Harris DW, Ostlere LS, Rustin MH. Cutaneous granu- locytic sarcoma (chloroma) presenting as the first sign of relapse following autologous bone marrow trans- plantation for acute myeloid leukaemia. Br J Dermatol 1992;127:182-4.
  • Johansson B, Fioretos T, Kullendorff CM, Wiebe T, Bekassy AN, Garwicz S, et al. Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements. Genes Chro m o s o m e s Cancer 2000;27:136-42.

Akut miyeloid löseminin tam remisyon döneminde ortaya çıkan ve multipl kitleler ile birlikte larenks ve nazofarenksi eşzamanlı tutan granülositik sarkom olgusu

Year 2003, Volume: 11 Issue: 6, 183 - 188, 24.12.2003

Abstract

Akut miyeloid lösemi AML-M0 tanısıyla uygulanan ke- moterapiden sonra komplet remisyona giren 37 yaflın- daki erkek hastada, remisyon sonrası altıncı ayda dis- faji ve ses kısıklığı flikayetleri görüldü. Fizik muayene- sinde sol vokal kord paralizisi ve 9, 10 ve 12. kranyal si- nir tutulumu saptandı. Nazofarenks ve boynun sagittal ve aksiyal manyetik rezonans kesitlerinde, sol retrofa- renjeal ve perivertebral bölgede yerleflim gösteren 6x4 cm boyutlarında bir kitle, sol vallekulada baflka kitle ve sağ preepiglottik dokuda infiltrasyona yol açan 2 cm büyüklüğünde baflka bir kitle belirlendi. Kemik iliği tutu- lumu saptanmadı. Lösemi nüksü olmaksızın granülosi- tik sarkom tanısıyla FLAG-Ida rejimi uygulanmasından sonra kitlelerde kısmi gerileme görülmesine rağmen, kemoterapinin 17. gününde hasta pulmoner enfeksiyon nedeniyle yaflamını yitirdi

References

  • Grande M. Central nervous system granulocytic sarco- ma in a patient with essential thrombocythemia. Am J Hematol 1996;51:64-7.
  • Kim FS, Rutka JT, Bernstein M, Resch L, Warner E, Pantalony D. Intradural granulocytic sarcoma pre- senting as a lumbar radiculopathy. J Neuro s u rg 1990; 7 2 : 6 6 3 - 7 .
  • Kaufman BA, Jones L, Zutter MM, Park TS. Megakaryoblastic leukemia presenting as a tempo- ral bone granulocytic sarcoma. J Neuro s u rg 1993;79: 1 2 8 - 3 1 .
  • Deme S, Deodhare SS, Tucker WS, Bilbao JM. Granulocytic sarcoma of the spine in nonleukemic patients: report of three cases. Neurosurgery 1997;40: 1283-7.
  • Magliocco AM, Demetrick DJ, Jones AR, Kossakowska AE. Granulocytic sarcoma of the ovary. An unusual case presentation. Arch Pathol Lab Med 1 9 9 1 ; 11 5 : 8 3 0 - 4 .
  • Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer 1986;58:2697-709.
  • Hancock JC, Prchal JT, Bennett JM, Listinsky CM. Trilineage extramedullary myeloid cell tumor in myelodysplastic syndrome. Arch Pathol Lab Med 1997; 121:520-3.
  • Cartwright PC, Faye-Petersen O, Bybee B, Snow BW. Leukemic relapse presenting with ureteral obstru c- tion caused by granulocytic sarcoma. J Urol 1991; 1 4 6 : 1 3 5 4 - 5 .
  • Karnak I, Ciftci AO, Senocak ME, Gogus S. Granulocytic sarcoma of the scapula: an unusual pre- sentation of acute myeloblastic leukemia. J Pediatr Surg 1 9 9 7 ; 3 2 : 1 2 1 - 2 .
  • Binder C, Tiemann M, Haase D, Humpe A, Kneba M. Isolated meningeal chloroma (granulocytic sarcoma)-a case report and review of the literature. Ann Hematol 2000;79:459-62.
  • Novick SL, Nicol TL, Fishman EK. Granulocytic sarco- ma (chloroma) of the sacrum: initial manifestation of leukemia. Skeletal Radiol 1998;27:112-4.
  • McCluggage WG, Boyd HK, Jones FG, Mayne EE, B h a rucha H. Mediastinal granulocytic sarcoma: a report of two cases. Arch Pathol Lab Med 1998;122: 545-7.
  • Bagg MD, Wettlaufer JN, Willadsen DS, Ho V, Lane D, Thrasher JB. Granulocytic sarcoma presenting as a dif- fuse renal mass before hematological manifestations of acute myelogenous leukemia. J Urol 1994;152:2092-3.
  • Vassallo J, Altemani AM, Cardinalli IA, Crespo AN, Lima CS, Eid KA, et al. Granulocytic sarcoma of the larynx preceding chronic myeloid leukemia. Pathol Res Pract 1993;189:1084-6.
  • Horny HP, Kaiserling E. Involvement of the larynx by hemopoietic neoplasms. An investigation of autopsy cases and review of the literature. Pathol Res Pract 1995; 191:130-8.
  • Remacle M, Marza L, Marbaix E. Granulocytic sarc o m a of the larynx. Report of a case and literature re v i e w. Acta O t o rhinolaryngol Belg 1995;49:11-7. [Abstract]
  • Au WY, Kwong YL, Ho WK, Shek TW. Primary granu- locytic sarcoma of the nasopharynx. Am J Hematol 2001; 67:273-4.
  • Bown NP, Rowe D, Reid MM. Granulocytic sarcoma with translocation (9;11) (p22;q23): two cases. Cancer Genet Cytogenet 1997;96:115-7.
  • Au WY, Ma SK, Chan AC, Liang R, Lam CC, Kwong YL. Near tetraploidy in three cases of acute myeloid leukemia associated with mediastinal granulocytic sarcoma. Cancer Genet Cytogenet 1998;102:50-3.
  • Hishima T, Fukayama M, Hayashi Y, Shiozawa Y, Funata N, Sakamaki H, et al. Granulocytic sarcoma of the thymus in a nonleukaemic patient. Virchows Arch 1999;435:447-51.
  • Mostafavi H, Lennarson PJ, Traynelis VC. Granulocytic s a rcoma of the spine. Neuro s u rgery 2000;46:78-4.
  • Bassichis B, McClay J, Wiatrak B. Chloroma of the mas- seteric muscle. Int J Pediatr Otorhinolaryngol 2000; 53:57-61.
  • Uyesugi WY, Watabe J, Petermann G. Orbital and facial granulocytic sarcoma (chloroma): a case report. Pediatr Radiol 2000;30:276-8.
  • Byrd JC, Weiss RB. Recurrent granulocytic sarcoma. Cancer 1994;73:2107-12.
  • Harris DW, Ostlere LS, Rustin MH. Cutaneous granu- locytic sarcoma (chloroma) presenting as the first sign of relapse following autologous bone marrow trans- plantation for acute myeloid leukaemia. Br J Dermatol 1992;127:182-4.
  • Johansson B, Fioretos T, Kullendorff CM, Wiebe T, Bekassy AN, Garwicz S, et al. Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements. Genes Chro m o s o m e s Cancer 2000;27:136-42.
There are 26 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Rıdvan Ali This is me

Tülay Özçelik This is me

Fahir Özkalemkaş This is me

Vildan Özkocaman This is me

Hamdi Hakan Coşkun This is me

Levent Erişen This is me

Gülaydan Filiz This is me

Publication Date December 24, 2003
Published in Issue Year 2003 Volume: 11 Issue: 6

Cite

APA Ali, R., Özçelik, T., Özkalemkaş, F., Özkocaman, V., et al. (2003). A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx. The Turkish Journal of Ear Nose and Throat, 11(6), 183-188.
AMA Ali R, Özçelik T, Özkalemkaş F, Özkocaman V, Coşkun HH, Erişen L, Filiz G. A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx. Tr-ENT. December 2003;11(6):183-188.
Chicago Ali, Rıdvan, Tülay Özçelik, Fahir Özkalemkaş, Vildan Özkocaman, Hamdi Hakan Coşkun, Levent Erişen, and Gülaydan Filiz. “A Case of Granulocytic Sarcoma During Complete Remission of Acute Myeloid Leukemia With Multiple Masses Involving the Larynx and Nasopharynx”. The Turkish Journal of Ear Nose and Throat 11, no. 6 (December 2003): 183-88.
EndNote Ali R, Özçelik T, Özkalemkaş F, Özkocaman V, Coşkun HH, Erişen L, Filiz G (December 1, 2003) A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx. The Turkish Journal of Ear Nose and Throat 11 6 183–188.
IEEE R. Ali, “A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx”, Tr-ENT, vol. 11, no. 6, pp. 183–188, 2003.
ISNAD Ali, Rıdvan et al. “A Case of Granulocytic Sarcoma During Complete Remission of Acute Myeloid Leukemia With Multiple Masses Involving the Larynx and Nasopharynx”. The Turkish Journal of Ear Nose and Throat 11/6 (December 2003), 183-188.
JAMA Ali R, Özçelik T, Özkalemkaş F, Özkocaman V, Coşkun HH, Erişen L, Filiz G. A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx. Tr-ENT. 2003;11:183–188.
MLA Ali, Rıdvan et al. “A Case of Granulocytic Sarcoma During Complete Remission of Acute Myeloid Leukemia With Multiple Masses Involving the Larynx and Nasopharynx”. The Turkish Journal of Ear Nose and Throat, vol. 11, no. 6, 2003, pp. 183-8.
Vancouver Ali R, Özçelik T, Özkalemkaş F, Özkocaman V, Coşkun HH, Erişen L, Filiz G. A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx. Tr-ENT. 2003;11(6):183-8.