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The incidence of primary thyroid lymphoma in thyroid malignancies

Year 2004, Volume: 12 Issue: 1, 11 - 15, 15.03.2004

Abstract

Objectives: We investigated the incidence of primary thyroid lymphoma in thyroid malignancies.Patients and Methods: A total of 304 patients whose diagnoses were made as thyroid malignancies betvveen January 1990 and December 2000 were retrospectively evaluated. Of these, primary thyroid lymphoma was documented in four female patients 1.3%; mean age 56.2 years; range 40 to 65 years . Findings from history, physical examination, blood biochemistry, thyroid hor- mone levels Tg, T4, TSH, thyroglobulin , thyroid scintig- raphy, fine-needle aspiration biopsy, and cervical com- puted tomography CT were evaluated. Histopathologic results were evaluated according to the Revised European-American Lymphoma REAL classification.Results: The most common complaints on admission were a rapidly grovving cervical mass, hoarseness, and dyspnea. İn ali the cases, thyroid hormone levels were normal, but thyroglobulin levels were 5 to 10 times as high as normal. Preoperative fine-needle aspiration was not helpful in two cases, vvhereas cervical CT was diag- nostic. Pathologic diagnosis was diffuse large B celi lym­ phoma in ali the cases. Postoperatively, three cases undervvent chemotherapy and one case chemotherapy combined with radiotherapy. AH the patients were operated on before 1997; one patient died, the remaining three patients have been under follow-up with no recurrences.Conclusion: İn our cases, treatment of localized thyroid lymphoma by surgery combined with chemotherapy or/and radiotherapy was effective.

References

  • Andeh MV, Memsic L, Silberman A. Anaplastic carci- noma, lymphoma, unusual malignancies and chemotherapy for thyroid cancer. In: Falk SA, editor. Thyroid disease. 1st ed. Philedelphia: Lippincott- Raven; 1997. p. 645-55.
  • Schlumberger M, Caillon B. Miscalaneous tumours of the thyroid. In: Braverman LE, Utiger RD, editors. The thyroid. 7th ed. Philedelphia: Lippincott-Raven; 1996. p. 961-65.
  • Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K. Malignant lymphomas of the thyroid gland. Analysis of 79 patients with emphasis on histo- logic prognostic factors. Cancer 1986;58:100-4.
  • Singer JA. Primary lymphoma of the thyroid. Am Surg 1998;64:334-7.
  • Klyachkin ML, Schwartz RW, Cibull M, Munn RK, Regine WF, Kenady DE, et al. Thyroid lymphoma: is there a role for surgery? Am Surg 1998;64:234-8.
  • Pasieka JL. Hashimoto’s disease and thyroid lym- phoma: role of the surgeon. World J Surg 2000;24:966-70.
  • Uzel C, Kapran Y, Vural G, Terzioglu T. Primary thy- roid lymphoma: a report of two cases. Turkish Journal of Endocrinology and Metabolism 2002;1:41-5.
  • Burman KD, Ringel MD, Wartofsky L. Unusual types of thyroid neoplasms. Endocrinol Metab Clin North [Am] 1996;25:49-68.
  • Takashima S, Sone S, Horii A, Honjho Y, Yoshida J. Subacute thyroiditis in Hashimoto’s thyroiditis which mimicked primary thyroid lymphoma. J Clin Ultrasound 1997;25:279-81.
  • Rasbach DA, Mondschein MS, Harris NL, Kaufman DS, Wang CA. Malignant lymphoma of the thyroid gland: a clinical and pathologic study of twenty cases. Surgery 1985;98:1166-70.
  • Sirota DK, Segal RL. Primary lymphomas of the thy- roid gland. Jama 1979;242:1743-6.
  • Holm LE, Blomgren H, Lowhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl J Med 1985;312:601-4.
  • Hamburger JI, Miller JM, Kini SR. Lymphoma of the thyroid. Ann Intern Med 1983;99:685-93.
  • Tomita Y, Ohsawa M, Kanno H, Matsuzuka F, Kuma K, Aozasa K. Sporadic activation of epstein-barr virus in thyroid lymphoma. Leuk Lymphoma 1995;19:129-34.
  • Hahn JS, Chung HC, Min YH, Ko YW, Park CS, Suh CO, et al. Primary lymphoma of the thyroid. Yonsei Med J 1995;36:315-21.
  • Pyke CM, Grant CS, Habermann TM, Kurtin PJ, Van Heerden JA, Bergstralh EJ, et al. Non-Hodgkin’s lym- phoma of the thyroid: is more than biopsy necessary? World J Surg 1992;16:604-9.
  • Compagno J, Oertel JE. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases. Am J Clin Pathol 1980;74:1-11.
  • Ogawa Y, Kato Y, Ikeda K, Aya M, Ogisawa K, Kitani K, et al. The value of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: an assessment of its diagnostic potential and pitfalls. Surg Today 2001;31:97-101.
  • Brownlie BE, Fitzharris BM, Abdelaal AS, Hay NM, Bremner JM, Hamer JW. Primary thyroid lymphoma: clinical features, treatment and outcome: a report of 8 cases. NZ Med J 1994;107:301-4.
  • Doria R, Jekel JF, Cooper DL. Thyroid lymphoma. The case for combined modality therapy. Cancer 1994;73:200-6.

Tiroit neoplazileri içinde primer tiroit lenfoma sıklığı

Year 2004, Volume: 12 Issue: 1, 11 - 15, 15.03.2004

Abstract

Amaç: Tirot malignitesi tanısı konan olgular içindeprimer tiroit lenfoma sıklığı araştırıldı.Hastalar ve Yöntemler: Ocak 1990 ile Aralık 2000 tarihleri arasında tirot malignitesi saptanan 304 olgunun geriye dönük incelemesinde dört olguda %1.3 primer tiroitlenfoması saptandı. Tümü kadın olan dört hastanın yaşortalaması 56.2 idi. Tüm hastalar fizikmuayene, tam biyokimya incelemesi, tiroit hormon düzeyleri T3, T4, TSH, tiroglobulin , tiroit sintigrafisi, tiroitince iğne aspirasyon biyopsisi ve boyun bilgisayarlı tomografisi BT ile değerlendirildi. Histopatolojik sonuçlarREAL Revised European-American Lymphoma sınıflandırmasına göre değerlendirildi.Bulgular: Hastalarda en yaygın şikayet boyunda büyüyen kitle, nefes darlığı ve horlamaydı. Tüm hastaların tiroit hormon seviyeleri normal, tiroglobulin düzeyleri ise normalden 5-10 kat yüksek bulundu. Ameliyat öncesi değerlendirmede iki hastada ince iğne aspirasyon biyopsisi sonuç vermezken boyun BT’si tanıda yardımcı oldu. Tüm hastalarda histopatolojik tanı B hücreli lenfoma idi. Ameliyat sonrasında üç hastaya kemoterapi, bir hastaya radyoterapi ve kemoterapi uygulandı. Hastaların tümü 1997 yılından önceameliyat edildi; bir hasta kaybedildi, üç hasta nüks olmaksızın izlenmektedir.Sonuç: Lokalize tiroit lenfomalı olgularımız dikkate alındığında, cerrahi tedavi ile birlikte kemoterapi ve/veyaradyoterapinin etkili olduğunu söyleyebiliriz

References

  • Andeh MV, Memsic L, Silberman A. Anaplastic carci- noma, lymphoma, unusual malignancies and chemotherapy for thyroid cancer. In: Falk SA, editor. Thyroid disease. 1st ed. Philedelphia: Lippincott- Raven; 1997. p. 645-55.
  • Schlumberger M, Caillon B. Miscalaneous tumours of the thyroid. In: Braverman LE, Utiger RD, editors. The thyroid. 7th ed. Philedelphia: Lippincott-Raven; 1996. p. 961-65.
  • Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K. Malignant lymphomas of the thyroid gland. Analysis of 79 patients with emphasis on histo- logic prognostic factors. Cancer 1986;58:100-4.
  • Singer JA. Primary lymphoma of the thyroid. Am Surg 1998;64:334-7.
  • Klyachkin ML, Schwartz RW, Cibull M, Munn RK, Regine WF, Kenady DE, et al. Thyroid lymphoma: is there a role for surgery? Am Surg 1998;64:234-8.
  • Pasieka JL. Hashimoto’s disease and thyroid lym- phoma: role of the surgeon. World J Surg 2000;24:966-70.
  • Uzel C, Kapran Y, Vural G, Terzioglu T. Primary thy- roid lymphoma: a report of two cases. Turkish Journal of Endocrinology and Metabolism 2002;1:41-5.
  • Burman KD, Ringel MD, Wartofsky L. Unusual types of thyroid neoplasms. Endocrinol Metab Clin North [Am] 1996;25:49-68.
  • Takashima S, Sone S, Horii A, Honjho Y, Yoshida J. Subacute thyroiditis in Hashimoto’s thyroiditis which mimicked primary thyroid lymphoma. J Clin Ultrasound 1997;25:279-81.
  • Rasbach DA, Mondschein MS, Harris NL, Kaufman DS, Wang CA. Malignant lymphoma of the thyroid gland: a clinical and pathologic study of twenty cases. Surgery 1985;98:1166-70.
  • Sirota DK, Segal RL. Primary lymphomas of the thy- roid gland. Jama 1979;242:1743-6.
  • Holm LE, Blomgren H, Lowhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl J Med 1985;312:601-4.
  • Hamburger JI, Miller JM, Kini SR. Lymphoma of the thyroid. Ann Intern Med 1983;99:685-93.
  • Tomita Y, Ohsawa M, Kanno H, Matsuzuka F, Kuma K, Aozasa K. Sporadic activation of epstein-barr virus in thyroid lymphoma. Leuk Lymphoma 1995;19:129-34.
  • Hahn JS, Chung HC, Min YH, Ko YW, Park CS, Suh CO, et al. Primary lymphoma of the thyroid. Yonsei Med J 1995;36:315-21.
  • Pyke CM, Grant CS, Habermann TM, Kurtin PJ, Van Heerden JA, Bergstralh EJ, et al. Non-Hodgkin’s lym- phoma of the thyroid: is more than biopsy necessary? World J Surg 1992;16:604-9.
  • Compagno J, Oertel JE. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases. Am J Clin Pathol 1980;74:1-11.
  • Ogawa Y, Kato Y, Ikeda K, Aya M, Ogisawa K, Kitani K, et al. The value of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: an assessment of its diagnostic potential and pitfalls. Surg Today 2001;31:97-101.
  • Brownlie BE, Fitzharris BM, Abdelaal AS, Hay NM, Bremner JM, Hamer JW. Primary thyroid lymphoma: clinical features, treatment and outcome: a report of 8 cases. NZ Med J 1994;107:301-4.
  • Doria R, Jekel JF, Cooper DL. Thyroid lymphoma. The case for combined modality therapy. Cancer 1994;73:200-6.
There are 20 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Halil Coşkun This is me

Alp Bozbora This is me

Yeşim Erbil This is me

Selçuk Özarmağan This is me

Yersu Kapran This is me

Publication Date March 15, 2004
Published in Issue Year 2004 Volume: 12 Issue: 1

Cite

APA Coşkun, H., Bozbora, A., Erbil, Y., Özarmağan, S., et al. (2004). The incidence of primary thyroid lymphoma in thyroid malignancies. The Turkish Journal of Ear Nose and Throat, 12(1), 11-15.
AMA Coşkun H, Bozbora A, Erbil Y, Özarmağan S, Kapran Y. The incidence of primary thyroid lymphoma in thyroid malignancies. Tr-ENT. March 2004;12(1):11-15.
Chicago Coşkun, Halil, Alp Bozbora, Yeşim Erbil, Selçuk Özarmağan, and Yersu Kapran. “The Incidence of Primary Thyroid Lymphoma in Thyroid Malignancies”. The Turkish Journal of Ear Nose and Throat 12, no. 1 (March 2004): 11-15.
EndNote Coşkun H, Bozbora A, Erbil Y, Özarmağan S, Kapran Y (March 1, 2004) The incidence of primary thyroid lymphoma in thyroid malignancies. The Turkish Journal of Ear Nose and Throat 12 1 11–15.
IEEE H. Coşkun, A. Bozbora, Y. Erbil, S. Özarmağan, and Y. Kapran, “The incidence of primary thyroid lymphoma in thyroid malignancies”, Tr-ENT, vol. 12, no. 1, pp. 11–15, 2004.
ISNAD Coşkun, Halil et al. “The Incidence of Primary Thyroid Lymphoma in Thyroid Malignancies”. The Turkish Journal of Ear Nose and Throat 12/1 (March 2004), 11-15.
JAMA Coşkun H, Bozbora A, Erbil Y, Özarmağan S, Kapran Y. The incidence of primary thyroid lymphoma in thyroid malignancies. Tr-ENT. 2004;12:11–15.
MLA Coşkun, Halil et al. “The Incidence of Primary Thyroid Lymphoma in Thyroid Malignancies”. The Turkish Journal of Ear Nose and Throat, vol. 12, no. 1, 2004, pp. 11-15.
Vancouver Coşkun H, Bozbora A, Erbil Y, Özarmağan S, Kapran Y. The incidence of primary thyroid lymphoma in thyroid malignancies. Tr-ENT. 2004;12(1):11-5.