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Detection of primary carcinoma by positron emission tomography in an unknown primary tumor with cervical metastasis: a case report

Year 2005, Volume: 14 Issue: 1, 39 - 43, 20.02.2005

Abstract

Unknown primary tumors with cervical metastasis account for about 1 -3% of patients with neck masses.İn many cases, the primary site cannot be detected by diagnostic procedures such as endoscopy, computed tomography, or magnetic resonance imaging, affecting the treatment and prognosis of these patients unfavor- ably. A 43-year-old male patient presented with a painless mass in the neck. He had previously undergone a neck biopsy, the result of which had been reported as metastatic carcinoma. The primary site could not be determined by extensive diagnostic procedures.Investigation with positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose suggested the base of the tongue as the primary site, which was then con- firmed by an endoscopic biopsy from the tongue. İt should be borne in mind that positron emission tomog­ raphy may be helpful in the diagnosis of unknown pri­ mary tumors with cervical metastasis.

References

  • Muir C. Cancer of unknown primary site. Cancer 1995;75(1 Suppl):353-6.
  • McGuirt WF. The neck mass. Med Clin North Am 1999;83:219-34.
  • Grau C, Johansen LV, Jakobsen J, Geertsen P, Andersen E, Jensen BB. Cervical lymph node metastases from unknown primary tumours. Results from a national survey by the Danish Society for Head and Neck Oncology. Radiother Oncol 2000;55:121-9.
  • Johansen J, Eigtved A, Buchwald C, Theilgaard SA, Hansen HS. Implication of 18F-fluoro-2-deoxy-D-glu- cose positron emission tomography on management of carcinoma of unknown primary in the head and neck: a Danish cohort study. Laryngoscope 2002;112:2009-14.
  • Stokkel MP, Bongers V, Hordijk GJ, van Rijk PP. FDG positron emission tomography in head and neck can- cer: pitfall or pathology? Clin Nucl Med 1999;24:950-4.
  • de Braud F, al-Sarraf M. Diagnosis and management of squamous cell carcinoma of unknown primary tumor site of the neck. Semin Oncol 1993;20:273-8.
  • McGuirt WF. Panendoscopy as a screening examina- tion for simultaneous primary tumors in head and neck cancer: a prospective sequential study and review of the literature. Laryngoscope 1982;92:569-76.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Stokkel MP, ten Broek FW, van Rijk PP. The role of FDG PET in the clinical management of head and neck can- cer. Oral Oncol 1998;34:466-71.
  • Stokkel MP, Terhaard CH, Hordijk GJ, van Rijk PP. The detection of unknown primary tumors in patients with cervical metastases by dual-head positron emission tomography. Oral Oncol 1999;35:390-4.
  • Farber LA, Benard F, Machtay M, Smith RJ, Weber RS, Weinstein GS, et al. Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emis- sion tomography. Laryngoscope 1999;109:970-5.
  • Laubenbacher C, Saumweber D, Wagner-Manslau C, Kau RJ, Herz M, Avril N, et al. Comparison of fluorine- 18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. J Nucl Med 1995;36:1747-57.
  • Stokkel MP, Terhaard CH, Mertens IJ, Hordijk GJ, van Rijk PP. Fluorine-18-FDG detection of laryngeal cancer postradiotherapy using dual-head coincidence imag- ing. J Nucl Med 1998;39:1385-7.
  • Stokkel MP, Hoekstra A, van Rijk PP. The detection of small carcinoma with 18F-FDG using a dual head coin- cidence camera. Eur J Radiol 1999;32:160-2.

Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu

Year 2005, Volume: 14 Issue: 1, 39 - 43, 20.02.2005

Abstract

Boyunda kitle şikayetiyle başvuran hastaların %1- 3’ünde primer odağı bilinmeyen boyun metastazlı kanserler bulunmaktadır. Primer odak çoğu kez en- doskopi, bilgisayarlı tomografi, manyetik rezonans görüntüleme gibi tanısal incelemeler ile saptanama- makta, bu da hastaların tedavisini ve prognozunu olumsuz yönde etkilemektedir. Kırk üç yaşında bir erkek hasta boynunda ağrısız şişlik şikayetiyle başvurdu. Hastanın bir dış merkezde daha önceden ya- pılan boyun biyopsisi metastatik karsinom olarak bildirilmişti. Boyundaki kitlenin pirimer odağı pek çok tanı yöntemi ile araştırılmış ancak saptanamamıştı. Hastanemizde yapılan floro-deoksi-glukoz ile pozit- ron emisyon tomografisi dil kökünün primer odak olabileceği gösterdi. Yapılan dil kökü biyopsisi bu tanıyı doğruladı. Bu görüntüleme tekniğinin, primeri bilinmeyen boyun metastazlı baş-boyun kanserli olgu- larda kullanılabileceği akılda tutulmalıdır

References

  • Muir C. Cancer of unknown primary site. Cancer 1995;75(1 Suppl):353-6.
  • McGuirt WF. The neck mass. Med Clin North Am 1999;83:219-34.
  • Grau C, Johansen LV, Jakobsen J, Geertsen P, Andersen E, Jensen BB. Cervical lymph node metastases from unknown primary tumours. Results from a national survey by the Danish Society for Head and Neck Oncology. Radiother Oncol 2000;55:121-9.
  • Johansen J, Eigtved A, Buchwald C, Theilgaard SA, Hansen HS. Implication of 18F-fluoro-2-deoxy-D-glu- cose positron emission tomography on management of carcinoma of unknown primary in the head and neck: a Danish cohort study. Laryngoscope 2002;112:2009-14.
  • Stokkel MP, Bongers V, Hordijk GJ, van Rijk PP. FDG positron emission tomography in head and neck can- cer: pitfall or pathology? Clin Nucl Med 1999;24:950-4.
  • de Braud F, al-Sarraf M. Diagnosis and management of squamous cell carcinoma of unknown primary tumor site of the neck. Semin Oncol 1993;20:273-8.
  • McGuirt WF. Panendoscopy as a screening examina- tion for simultaneous primary tumors in head and neck cancer: a prospective sequential study and review of the literature. Laryngoscope 1982;92:569-76.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Stokkel MP, ten Broek FW, van Rijk PP. The role of FDG PET in the clinical management of head and neck can- cer. Oral Oncol 1998;34:466-71.
  • Stokkel MP, Terhaard CH, Hordijk GJ, van Rijk PP. The detection of unknown primary tumors in patients with cervical metastases by dual-head positron emission tomography. Oral Oncol 1999;35:390-4.
  • Farber LA, Benard F, Machtay M, Smith RJ, Weber RS, Weinstein GS, et al. Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emis- sion tomography. Laryngoscope 1999;109:970-5.
  • Laubenbacher C, Saumweber D, Wagner-Manslau C, Kau RJ, Herz M, Avril N, et al. Comparison of fluorine- 18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. J Nucl Med 1995;36:1747-57.
  • Stokkel MP, Terhaard CH, Mertens IJ, Hordijk GJ, van Rijk PP. Fluorine-18-FDG detection of laryngeal cancer postradiotherapy using dual-head coincidence imag- ing. J Nucl Med 1998;39:1385-7.
  • Stokkel MP, Hoekstra A, van Rijk PP. The detection of small carcinoma with 18F-FDG using a dual head coin- cidence camera. Eur J Radiol 1999;32:160-2.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Hamdi Çaklı This is me

Fazilet Altın This is me

İlknur Ak This is me

M. Kezban Gürbüz This is me

Erkan Özüdoğru This is me

Publication Date February 20, 2005
Published in Issue Year 2005 Volume: 14 Issue: 1

Cite

APA Çaklı, H., Altın, F., Ak, İ., Gürbüz, M. K., et al. (2005). Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu. The Turkish Journal of Ear Nose and Throat, 14(1), 39-43.
AMA Çaklı H, Altın F, Ak İ, Gürbüz MK, Özüdoğru E. Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu. Tr-ENT. February 2005;14(1):39-43.
Chicago Çaklı, Hamdi, Fazilet Altın, İlknur Ak, M. Kezban Gürbüz, and Erkan Özüdoğru. “Primeri Bilinmeyen Boyun metastazında Pozitron Emisyon Tomografisi Ile Primer Kanserin saptanması: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat 14, no. 1 (February 2005): 39-43.
EndNote Çaklı H, Altın F, Ak İ, Gürbüz MK, Özüdoğru E (February 1, 2005) Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu. The Turkish Journal of Ear Nose and Throat 14 1 39–43.
IEEE H. Çaklı, F. Altın, İ. Ak, M. K. Gürbüz, and E. Özüdoğru, “Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu”, Tr-ENT, vol. 14, no. 1, pp. 39–43, 2005.
ISNAD Çaklı, Hamdi et al. “Primeri Bilinmeyen Boyun metastazında Pozitron Emisyon Tomografisi Ile Primer Kanserin saptanması: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat 14/1 (February 2005), 39-43.
JAMA Çaklı H, Altın F, Ak İ, Gürbüz MK, Özüdoğru E. Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu. Tr-ENT. 2005;14:39–43.
MLA Çaklı, Hamdi et al. “Primeri Bilinmeyen Boyun metastazında Pozitron Emisyon Tomografisi Ile Primer Kanserin saptanması: Olgu Sunumu”. The Turkish Journal of Ear Nose and Throat, vol. 14, no. 1, 2005, pp. 39-43.
Vancouver Çaklı H, Altın F, Ak İ, Gürbüz MK, Özüdoğru E. Primeri bilinmeyen boyun metastazında pozitron emisyon tomografisi ile primer kanserin saptanması: Olgu sunumu. Tr-ENT. 2005;14(1):39-43.