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The protective effect of oral magnesium supplement on noise-induced hearing loss

Year 2006, Volume: 16 Issue: 1, 29 - 36, 13.01.2006

Abstract

Objectives: We investigated the beneficial effect of magnesium in the prevention of noise-induced cochlear damage in guinea pigs by transient evoked otoacoustic emissions TEOAE .Study Design: Thirty-nine guinea pigs with normal auropalpebral reflex were randomly divided into con- trol n=20 and study n=19 groups. Ali the animals were subjected to wide-band noise standardized at a mean of 98±2 dB for 16 hours a day for 10 days in a sound isolated cabin. The study animals received 39 mmol/l MgCI2 throughout the study period starting from 15 days before noise exposure. Otomicroscopic exam- ination, auditory brain stem response ABR and TEOAE measurements were performed before and after noise exposure. Tympanometric measurements were performed to eliminate possible middle ear pathologies.Results: Although the mean TEOAE response and reproducibility values shovved significant decreases after noise application in the control group p<0.001 , they were not affected significantly in magnesium-treated ani­ mals. Post-exposure mean TEOAE response and repro­ ducibility values significantly differed betvveen the two groups p<0.001 . Noise-induced elevations in ABR thresholds were significant in both groups p<0.001 ; hovvever, it was noted that hearing levels were better preserved in the study group.Conclusion: Our data suggest that oral magnesium intake may be beneficial in the prevention of cochlear damage in noise-induced hearing loss.

References

  • Dereköy FS. Biyoakustik deneylerde ve çevrede gürültü ölçme standartları. KBB Klinikleri 2003;5:48- 53.
  • Yağız R, Taş A, Taş M, Adalı MK, Koten M, Karasalihoğlu A. Gürültüye bağlı işitme kayıplı kişilerde psikolojik semptom dağılımının incelenmesi. Akustik Dergisi 2001;1:27-30.
  • Prasher D. New strategies for prevention and treat- ment of noise-induced hearing loss. Lancet 1998;352:1240-2.
  • Attias J, Pratt H. Auditory-evoked potential correlates of susceptibility to noise-induced hearing loss. Audiology 1985;24:149-56.
  • Osguthorpe JD, Klein AJ. Occupational hearing con- servation. Otolaryngol Clin North Am 1991;24:403-14.
  • Alberti PW. Occupatinal hearing loss. In: Ballenger JJ, Snow JB, editors. Otorhinolaryngology head and neck surgery. 15th ed. Philedelphia: Williams and Wilkins; 1996. p. 1087-102.
  • Cockayne S. Electrolytes. In: Saunders WB, Anderson SC, editors. Clinical chemistry concepts and applica- tions. 16 th ed. Philadelphia: WB Saunders Company; 1993. p. 385-405.
  • Uzun C, Yağız R, Koten M, Adalı MK, Karasalihoğlu AR. Kobaylarda taransient evoked otoakustik emisyon ölçüm yöntemi. Kulak Burun Boğaz İhtisas Dergisi 2000;7:97-105.
  • Ueda H, Hattori T, Sawaki M, Niwa H, Yanagita N. The effect of furosemide on evoked otoacoustic emis- sions in guinea pigs. Hear Res 1992;62:199-205.
  • Dobie RA. Prevention of noise-induced hearing loss. Arch Otolaryngol Head Neck Surg 1995;121:385-91.
  • Wright A. Anatomy and ultrastructure of the human ear. In: Keer AG, Gleeson M, editors. Scott-Brown’s otolaryngology. Vol. 1. 6th ed. London: Butterworth Heinemann Publish; 1997. p. 1-50.
  • Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxida- tion products in the cochlea. Brain Res 2000;878:163-73.
  • Kvaerner KJ, Engdahl B, Arnesen AR, Mair IW. Temporary threshold shift and otoacoustic emissions after industrial noise exposure. Scand Audiol 1995;24:137-41.
  • Derekoy FS, Dundar Y, Aslan R, Cangal A. Influence of noise exposure on antioxidant system and TEOAEs in rabbits. Eur Arch Otorhinolaryngol 2001;258:518-22.
  • Wang L, Jiang W, Jiang P, Li J. Inner ear damage in guinea pigs exposed to stable and impulse noise. Chin Med J (Engl) 1998;111:354-7.
  • Haupt H, Scheibe F. Preventive magnesium supple- ment protects the inner ear against noise-induced impairment of blood flow and oxygenation in the guinea pig. Magnes Res 2002;15:17-25.
  • Scheibe F, Haupt H, Ising H. Total magnesium concen- trations of perilymph, cerebrospinal fluid and blood in guinea pigs fed different magnesium-containing diets. Eur Arch Otorhinolaryngol 1999;256:215-9.
  • Ising H, Handrock M, Gunther T, Fischer R, Dombrowski M. Increased noise trauma in guinea pigs through magnesium deficiency. Arch Otorhinolaryngol 1982;236:139-46.
  • Scheibe F, Haupt H, Vlastos GA. Preventive magne- sium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig. Eur Arch Otorhinolaryngol 2000;257:355-61.
  • Konig O, Winter E, Fuchs J, Haupt H, Mazurek B, Weber N, et al. Protective effect of magnesium and MK 801 on hypoxia-induced hair cell loss in new-born rat cochlea. Magnes Res 2003;16:98-105.
  • Scheibe F, Haupt H, Ising H. Preventive effect of mag- nesium supplement on noise-induced hearing loss in the guinea pig. Eur Arch Otorhinolaryngol 2000;257:10-6.
  • Attias J, Bresloff I, Haupt H, Scheibe F, Ising H. Preventing noise induced otoacoustic emission loss by increasing magnesium (Mg2+) intake in guinea-pigs. J Basic Clin Physiol Pharmacol 2003;14:119-36.
  • Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z, et al. Oral magnesium intake reduces per- manent hearing loss induced by noise exposure. Am J Otolaryngol 1994;15:26-32.
  • Scheibe F, Haupt H, Ising H, Cherny L. Therapeutic effect of parenteral magnesium on noise-induced hear- ing loss in the guinea pig. Magnes Res 2002;15:27-36.
  • Yamasoba T, Schacht J, Shoji F, Miller JM. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line- derived neurotrophic factor in vivo. Brain Res 1999;815:317-25.
  • Yamasoba T, Harris C, Shoji F, Lee RJ, Nuttall AL, Miller JM. Influence of intense sound exposure on glu- tathione synthesis in the cochlea. Brain Res 1998;804:72-8.
  • Yamasoba T, Nuttall AL, Harris C, Raphael Y, Miller JM. Role of glutathione in protection against noise- induced hearing loss. Brain Res 1998;784:82-90.
  • Jacono AA, Hu B, Kopke RD, Henderson D, Van De Water TR, Steinman HM. Changes in cochlear antioxi- dant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998;117:31-8.
  • Karlidag T, Yalcin S, Ozturk A, Ustundag B, Gok U, Kaygusuz I, et al. The role of free oxygen radicals in noise induced hearing loss: effects of melatonin and methylprednisolone. Auris Nasus Larynx 2002;29:147- 52.
  • Güngör A, Poyrazoğlu E, Dündar K, Uğur G, Karagence D, Okar İ ve ark. Guinea pig kobaylarda oluşturulan ani akustik travmalarda hiperbarik oksi- jen tedavisinin etkinliğinin elektron mikroskopik olarak değerlendirilmesi. Kulak Burun Boğaz İhtisas Dergisi 1999;6:136-40.

Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi

Year 2006, Volume: 16 Issue: 1, 29 - 36, 13.01.2006

Abstract

Amaç: Kobaylarda gürültüye bağlı koklear hasarın önlenmesinde magnezyumun koruyucu etkisi transientevoked otoacoustic emission TEOAE kullanılarakaraştırıldı.Çalışma Planı: Normal auropalpebral refleksli 39 yetişkin kobay rastgele yöntemle kontrol n=20 ve deney n=19 gruplarına ayrıldı. Tüm kobaylara ses yalıtımlı kabinde, ortamdaki gürültü düzeyi ortalama 98±2 dB olacak şekilde, 10 gün süreyle günde 16 saat wide-bandgürültü uygulandı. Deney grubundaki kobaylara, gürültüuygulamasından 15 gün önce oral yoldan 39 mmol/lMgClverilmeye başlandı ve gürültü sonrası ölçümler tamamlanana kadar sürdürüldü. Gürültü uygulaması öncesi ve sonrasında her iki grupta otomikroskopik muayene,işitsel beyin sapı yanıtları ABR ve TEOAE ölçümleri yapıldı. Anormal bulgu saptanan kulaklarda orta kulak patolojisini elemek için timpanometri yapıldı. Bulgular: Kontrol grubunda, TEOAE response ve reprodüktibilite ortalamaları gürültü sonrasında anlamlıdüşüş gösterirken p

References

  • Dereköy FS. Biyoakustik deneylerde ve çevrede gürültü ölçme standartları. KBB Klinikleri 2003;5:48- 53.
  • Yağız R, Taş A, Taş M, Adalı MK, Koten M, Karasalihoğlu A. Gürültüye bağlı işitme kayıplı kişilerde psikolojik semptom dağılımının incelenmesi. Akustik Dergisi 2001;1:27-30.
  • Prasher D. New strategies for prevention and treat- ment of noise-induced hearing loss. Lancet 1998;352:1240-2.
  • Attias J, Pratt H. Auditory-evoked potential correlates of susceptibility to noise-induced hearing loss. Audiology 1985;24:149-56.
  • Osguthorpe JD, Klein AJ. Occupational hearing con- servation. Otolaryngol Clin North Am 1991;24:403-14.
  • Alberti PW. Occupatinal hearing loss. In: Ballenger JJ, Snow JB, editors. Otorhinolaryngology head and neck surgery. 15th ed. Philedelphia: Williams and Wilkins; 1996. p. 1087-102.
  • Cockayne S. Electrolytes. In: Saunders WB, Anderson SC, editors. Clinical chemistry concepts and applica- tions. 16 th ed. Philadelphia: WB Saunders Company; 1993. p. 385-405.
  • Uzun C, Yağız R, Koten M, Adalı MK, Karasalihoğlu AR. Kobaylarda taransient evoked otoakustik emisyon ölçüm yöntemi. Kulak Burun Boğaz İhtisas Dergisi 2000;7:97-105.
  • Ueda H, Hattori T, Sawaki M, Niwa H, Yanagita N. The effect of furosemide on evoked otoacoustic emis- sions in guinea pigs. Hear Res 1992;62:199-205.
  • Dobie RA. Prevention of noise-induced hearing loss. Arch Otolaryngol Head Neck Surg 1995;121:385-91.
  • Wright A. Anatomy and ultrastructure of the human ear. In: Keer AG, Gleeson M, editors. Scott-Brown’s otolaryngology. Vol. 1. 6th ed. London: Butterworth Heinemann Publish; 1997. p. 1-50.
  • Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxida- tion products in the cochlea. Brain Res 2000;878:163-73.
  • Kvaerner KJ, Engdahl B, Arnesen AR, Mair IW. Temporary threshold shift and otoacoustic emissions after industrial noise exposure. Scand Audiol 1995;24:137-41.
  • Derekoy FS, Dundar Y, Aslan R, Cangal A. Influence of noise exposure on antioxidant system and TEOAEs in rabbits. Eur Arch Otorhinolaryngol 2001;258:518-22.
  • Wang L, Jiang W, Jiang P, Li J. Inner ear damage in guinea pigs exposed to stable and impulse noise. Chin Med J (Engl) 1998;111:354-7.
  • Haupt H, Scheibe F. Preventive magnesium supple- ment protects the inner ear against noise-induced impairment of blood flow and oxygenation in the guinea pig. Magnes Res 2002;15:17-25.
  • Scheibe F, Haupt H, Ising H. Total magnesium concen- trations of perilymph, cerebrospinal fluid and blood in guinea pigs fed different magnesium-containing diets. Eur Arch Otorhinolaryngol 1999;256:215-9.
  • Ising H, Handrock M, Gunther T, Fischer R, Dombrowski M. Increased noise trauma in guinea pigs through magnesium deficiency. Arch Otorhinolaryngol 1982;236:139-46.
  • Scheibe F, Haupt H, Vlastos GA. Preventive magne- sium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig. Eur Arch Otorhinolaryngol 2000;257:355-61.
  • Konig O, Winter E, Fuchs J, Haupt H, Mazurek B, Weber N, et al. Protective effect of magnesium and MK 801 on hypoxia-induced hair cell loss in new-born rat cochlea. Magnes Res 2003;16:98-105.
  • Scheibe F, Haupt H, Ising H. Preventive effect of mag- nesium supplement on noise-induced hearing loss in the guinea pig. Eur Arch Otorhinolaryngol 2000;257:10-6.
  • Attias J, Bresloff I, Haupt H, Scheibe F, Ising H. Preventing noise induced otoacoustic emission loss by increasing magnesium (Mg2+) intake in guinea-pigs. J Basic Clin Physiol Pharmacol 2003;14:119-36.
  • Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z, et al. Oral magnesium intake reduces per- manent hearing loss induced by noise exposure. Am J Otolaryngol 1994;15:26-32.
  • Scheibe F, Haupt H, Ising H, Cherny L. Therapeutic effect of parenteral magnesium on noise-induced hear- ing loss in the guinea pig. Magnes Res 2002;15:27-36.
  • Yamasoba T, Schacht J, Shoji F, Miller JM. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line- derived neurotrophic factor in vivo. Brain Res 1999;815:317-25.
  • Yamasoba T, Harris C, Shoji F, Lee RJ, Nuttall AL, Miller JM. Influence of intense sound exposure on glu- tathione synthesis in the cochlea. Brain Res 1998;804:72-8.
  • Yamasoba T, Nuttall AL, Harris C, Raphael Y, Miller JM. Role of glutathione in protection against noise- induced hearing loss. Brain Res 1998;784:82-90.
  • Jacono AA, Hu B, Kopke RD, Henderson D, Van De Water TR, Steinman HM. Changes in cochlear antioxi- dant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998;117:31-8.
  • Karlidag T, Yalcin S, Ozturk A, Ustundag B, Gok U, Kaygusuz I, et al. The role of free oxygen radicals in noise induced hearing loss: effects of melatonin and methylprednisolone. Auris Nasus Larynx 2002;29:147- 52.
  • Güngör A, Poyrazoğlu E, Dündar K, Uğur G, Karagence D, Okar İ ve ark. Guinea pig kobaylarda oluşturulan ani akustik travmalarda hiperbarik oksi- jen tedavisinin etkinliğinin elektron mikroskopik olarak değerlendirilmesi. Kulak Burun Boğaz İhtisas Dergisi 1999;6:136-40.
There are 30 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Recep Yağız This is me

Çetin Yıldırım This is me

Cem Uzun This is me

Abdullah Taş This is me

Erdoğan Bulut This is me

Ahmet Karasalihoğlu This is me

Publication Date January 13, 2006
Published in Issue Year 2006 Volume: 16 Issue: 1

Cite

APA Yağız, R., Yıldırım, Ç., Uzun, C., Taş, A., et al. (2006). Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi. The Turkish Journal of Ear Nose and Throat, 16(1), 29-36.
AMA Yağız R, Yıldırım Ç, Uzun C, Taş A, Bulut E, Karasalihoğlu A. Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi. Tr-ENT. January 2006;16(1):29-36.
Chicago Yağız, Recep, Çetin Yıldırım, Cem Uzun, Abdullah Taş, Erdoğan Bulut, and Ahmet Karasalihoğlu. “Gürültüye bağlı işitme kaybında Magnezyumun Koruyucu Etkisi”. The Turkish Journal of Ear Nose and Throat 16, no. 1 (January 2006): 29-36.
EndNote Yağız R, Yıldırım Ç, Uzun C, Taş A, Bulut E, Karasalihoğlu A (January 1, 2006) Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi. The Turkish Journal of Ear Nose and Throat 16 1 29–36.
IEEE R. Yağız, Ç. Yıldırım, C. Uzun, A. Taş, E. Bulut, and A. Karasalihoğlu, “Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi”, Tr-ENT, vol. 16, no. 1, pp. 29–36, 2006.
ISNAD Yağız, Recep et al. “Gürültüye bağlı işitme kaybında Magnezyumun Koruyucu Etkisi”. The Turkish Journal of Ear Nose and Throat 16/1 (January 2006), 29-36.
JAMA Yağız R, Yıldırım Ç, Uzun C, Taş A, Bulut E, Karasalihoğlu A. Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi. Tr-ENT. 2006;16:29–36.
MLA Yağız, Recep et al. “Gürültüye bağlı işitme kaybında Magnezyumun Koruyucu Etkisi”. The Turkish Journal of Ear Nose and Throat, vol. 16, no. 1, 2006, pp. 29-36.
Vancouver Yağız R, Yıldırım Ç, Uzun C, Taş A, Bulut E, Karasalihoğlu A. Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi. Tr-ENT. 2006;16(1):29-36.