The protective effect of oral magnesium supplement on noise-induced hearing loss

Year 2006, Volume: 16 Issue: 1, 29 - 36, 13.01.2006

Recep Yağız Çetin Yıldırım Cem Uzun Abdullah Taş Erdoğan Bulut Ahmet Karasalihoğlu

Abstract

Objectives: We investigated the beneficial effect of magnesium in the prevention of noise-induced cochlear damage in guinea pigs by transient evoked otoacoustic emissions TEOAE .Study Design: Thirty-nine guinea pigs with normal auropalpebral reflex were randomly divided into con- trol n=20 and study n=19 groups. Ali the animals were subjected to wide-band noise standardized at a mean of 98±2 dB for 16 hours a day for 10 days in a sound isolated cabin. The study animals received 39 mmol/l MgCI2 throughout the study period starting from 15 days before noise exposure. Otomicroscopic exam- ination, auditory brain stem response ABR and TEOAE measurements were performed before and after noise exposure. Tympanometric measurements were performed to eliminate possible middle ear pathologies.Results: Although the mean TEOAE response and reproducibility values shovved significant decreases after noise application in the control group p<0.001 , they were not affected significantly in magnesium-treated ani­ mals. Post-exposure mean TEOAE response and repro­ ducibility values significantly differed betvveen the two groups p<0.001 . Noise-induced elevations in ABR thresholds were significant in both groups p<0.001 ; hovvever, it was noted that hearing levels were better preserved in the study group.Conclusion: Our data suggest that oral magnesium intake may be beneficial in the prevention of cochlear damage in noise-induced hearing loss.

Keywords

Magnesium, hearing loss, noise-induced, otoacoustic emissions, spontaneous, evoked potentials, auditory, brain stem

Gürültüye bağlı işitme kaybında magnezyumun koruyucu etkisi

Abstract

Amaç: Kobaylarda gürültüye bağlı koklear hasarın önlenmesinde magnezyumun koruyucu etkisi transientevoked otoacoustic emission TEOAE kullanılarakaraştırıldı.Çalışma Planı: Normal auropalpebral refleksli 39 yetişkin kobay rastgele yöntemle kontrol n=20 ve deney n=19 gruplarına ayrıldı. Tüm kobaylara ses yalıtımlı kabinde, ortamdaki gürültü düzeyi ortalama 98±2 dB olacak şekilde, 10 gün süreyle günde 16 saat wide-bandgürültü uygulandı. Deney grubundaki kobaylara, gürültüuygulamasından 15 gün önce oral yoldan 39 mmol/lMgClverilmeye başlandı ve gürültü sonrası ölçümler tamamlanana kadar sürdürüldü. Gürültü uygulaması öncesi ve sonrasında her iki grupta otomikroskopik muayene,işitsel beyin sapı yanıtları ABR ve TEOAE ölçümleri yapıldı. Anormal bulgu saptanan kulaklarda orta kulak patolojisini elemek için timpanometri yapıldı. Bulgular: Kontrol grubunda, TEOAE response ve reprodüktibilite ortalamaları gürültü sonrasında anlamlıdüşüş gösterirken p

Keywords

Magnezyum, işitme kaybı, gürültüye bağlı, otoakustik emisyonlar, spontan, uyarılmış potansiyeller, işitsel, beyin sapı

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