Alerjik rinitli hastalarda serum ve nazal eozinofilik katyonik proteinin immünoterapi etkinliğinin değerlendirilmesindeki rolü

Year 2006, Volume: 16 Issue: 4, 155 - 159, 27.08.2006

Rauf Tahamiler Murat Yener Salih Çanakçıoğlu

Abstract

Amaç: Ev tozu akarlarına duyarlı olan alerjik rinithastalarında spesifik immünoterapinin SİT klinik etkinliğinin bir göstergesi olarak eozinofilik katyonikproteinin EKP rolü ve değeri araştırıldı.Hastalar ve Yöntemler: Çalışmaya sürekli alerjik riniti olan 49 hasta alındı. Hasta grubuna gerekli spesifikimmünoterapi uygulandı. Spesifik immünoterapi öncesinde, altıncı ayda ve tedavi bitiminden iki yıl sonra ölçülen nazal sekresyon ve serumdaki EKP seviyeleri hasta grubu içinde ve sağlıklı bireylerden oluşan 16 kişilik kontrol grubuyla karşılaştırıldı.Bulgular: Hasta grubunda SİT öncesi nazal EKP seviyeleri tedavi sonrası seviyelere oranla anlamlı derecede yüksek bulundu p

Keywords

Eozinofil katyonik protein, immünizasyon, rinit, alerjik, perennial

The use of serum and nasal eosinophilic cationic protein in the evaluation of the effectiveness of immunotherapy in patients with allergic rhinitis

Abstract

Objectives: We investigated the use of eosinophilic cationic protein ECP as an indicator of clinical effi- ciency of specific immunotherapy SIT in patients with allergic rhinitis sensitive to house dust mites.Patients and Methods: Specific immunotherapy was administered to 49 patients 20 males, 29 females; mean age 34.2 years; range 16 to 66 years with perennial allergic rhinitis. Nasal secretion and serum ECP levels were measured before, at the 6th month of, and two years after completion of, treatment.Comparisons were made within the patient group and with a control group of 16 healthy subjects 10 males, 6 females; mean age 23 years; range 17 to 26 years .Results: Pretreatment nasal ECP levels were sig- nificantly higher than those found after the treatment p<0.001 . Nasal ECP levels measured before SIT were significantly different from those of the control group p<0.05 . However, serum ECP levels did not differ significantly between the two groups p>0.05 .Serum ECP levels in the patient group tended to decrease with treatment p>0.05 .Conclusion: We conclude that, in addition to the symptoms and clinical findings, nasal ECP mea- surement may be a reliable and suitable laboratory method to monitor and evaluate the effectiveness of treatment.

Keywords

Eosinophil cationic protein, immunization, rhini­tis, allergic, perennial

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