Kobay timpanik membranında insizyonel miringotomi sonrası uygulanan 5-florourasilin miringotominin kapanma süresine etkisi

Year 2006, Volume: 16 Issue: 5, 209 - 213, 14.10.2006

Mehmet Eken Cenk Evren Günay Ateş Ziya Bozkurt Arif Şanlı Sedat Aydın

Abstract

Amaç: Bu çalışmada miringotomiden sonra topikalolarak 5-florourasil uygulamasının perforasyonunkapanma süresine etkisi ve bunun ventilasyon tüpüne alternatif olup olamayacağı araştırıldı. Gereç ve Yöntem: Timpanik membranlarında deneysel perforasyon oluşturulan kobaylar iki grubaayrıldı. Çalışma grubunda, 20 timpanik membranüzerine miringotomi sonrasında beş dakika süreyle50 mg/ml 5-florourasil emdirilmiş sponjel yerleştirildi.Kontrol grubundaki 16 timpanik membrana serumfizyolojik emdirilmiş sponjel uygulandı. Gruplardaperforasyon kapanma süreleri, otore ve oluşabilecekdiğer komplikasyonlar kaydedildi.Bulgular: Miringotomiden sonra topikal 5-florourasiluygulanan grupta perforasyonun kapanma süresikontrol grubuna göre anlamlı derecede uzun bulundu sırasıyla, 11.3 gün ve 7.0 gün; p

Keywords

Florourasil, guinea pig, orta kulak ventilasyonu/yöntem, timpanik membran/ilaç etkisi

The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane

Abstract

Objectives: We investigated the effect of topical application of 5-fluorouracil after incisional myringo­ tomy on the patency time and its use as an alterna- tive to ventilation tube insertion.Materials and Methods: Experimental tympanic membrane perforations were induced in two groups of guinea pigs. One group 20 tympanic mem- branes was treated with a 50 mg/ml 5-fluorouracil- soaked sponge över the perforation for five minutes while the other 16 tympanic membranes with saline-soaked sponges for the same duration. The patency times, otorrhea, and other complications were recorded.Results: The mean patency of tympanic membrane perforations following incisional myringotomy was significantly longer in the 5-fluorouracil-treated group 11.3 days vs 7.0 days; p<0.01 . None of the ears exhibited permanent perforation.Conclusion: The length of patency provided by 5- fluorouracil is not sufficient for optimal ventilation time in otitis media with effusion. However, in cir- cumstances in which shorter patency times may pro- vide sufficient ventilation, 5-fluorouracil application may be an alternative to ventilation tube insertion.

Keywords

Fluorouracil, guinea pigs, middle ear ventilation/methods, tympanic membrane/drug effects

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