Endonasal approach for frontobasal malignant nerve sheath tumor: a case report

Year 2006, Volume: 16 Issue: 6, 269 - 272, 02.12.2006

Bernhard Shick Steffi Urbschat

Abstract

Malignant peripheral nerve sheath tumors MPNST are rarely encountered in the paranasal sinuses and frontal skull base. We present histopathological find- ings, cytometric DNA measurements, and the prelimi- nary results of comparative genomic hybridization studies of a 46-year-old male patient with a frontobasal MPNST. The tumor was resected via the endonasal approach. No tumor recurrence was detected during a follow-up of three years. Rhinologists are being more frequently involved in endonasal tumor resection.

Keywords

Nerve sheath neoplasms, nucleic acid hybridization, paranasal sinuses, skull base

Frontal bölge kafa tabanında malign sinir kılıfı tümörü için endonazal yaklaşım

Abstract

Paranazal sinüsleri ve frontal bölge kafa tabanını et- kileyen malign periferik sinir kılıfı tümörlerine nadir rastlanır. Bu yazıda, frontobazal bölge malign perife- rik sinir kılıfı tümörü saptanan 46 yaflındak erkek hastanın histopatolojik bulguları, sitometrik DNA analizleri ve karflılafltırmalı genomik hibridizasyonun ilk sonuçları sunuldu. Tümör endonazal yaklaflımla çıkarıldı ve üç yıllık izlem sırasında nüksle karflılaflıl- madı. Rinologlar endonazal tümör cerrahisine gide- rek daha sık baflvurmaktadır

Keywords

Sinir kılıfı tümörleri, nükleik asit hibridizasyon, paranazal sinus, kafa tabanı

References

• Hegazy HM, Snyderman CH, Fan CY, Kassam AB. Neurilemmomas of the paranasal sinuses. Am J Otolaryngol 2001;22:215-8.
• Nagayama I, Nishimura T, Furukawa M. Malignant schwannoma arising in a paranasal sinus. J Laryngol Otol 1993;107:146-8.
• Kautzky M, Sailer H, Franz P, Susani M. Malignant transformation of a peripheral nerve sheath tumor in the area of the paranasal sinuses. [Article in German] Laryngorhinootologie 1996;75:691-6.
• Marvel JB, Parke RB Jr. Malignant schwannoma of the nasal cavity. Otolaryngol Head Neck Surg 1990; 102:409-12.
• Mosharrafa TM, Kuppersmith RB, Porter JP, Donovan DT. Pathologic quiz case 1. Malignant peripheral nerve sheath tumor of the ethmoidal sinus. Arch Otolaryngol Head Neck Surg 1997;123:654,656-7.
• Schick B, Brunner C, Praetorius M, Plinkert PK, Urbschat S. First evidence of genetic imbalances in angiofibromas. Laryngoscope 2002;112:397-401.
• Brors D, Draf W. The treatment of inverted papilloma. Cur Opin Otolaryngol Head Neck Surg 1999;7:33-8.
• Schick B, el Rahman el Tahan A, Brors D, Kahle G, Draf W. Experiences with endonasal surgery in angiofibro- ma. Rhinology 1999;37:80-5.
• Schick B, Steigerwald C, el Rahman el Tahan A, Draf W. The role of endonasal surgery in the management of frontoethmoidal osteomas. Rhinology 2001;39:66-70.
• Schlosser RJ, Mason JC, Gross CW. Aggressive endo- scopic resection of inverted papilloma: an update. Otolaryngol Head Neck Surg 2001;125:49-53.
• Pasquini E, Sciarretta V, Farneti G, Ippolito A, Mazzatenta D, Frank G. Endoscopic endonasal approach for the treatment of benign schwannoma of the sinonasal tract and pterygopalatine fossa. Am J Rhinol 2002;16:113-8.
• Quesada JL, Enrique A, Lorente J, Lopez D, Quesada P. Sinonasal schwannoma treated with endonasal micro- surgery. Otolaryngol Head Neck Surg 2003;129:300-2.
• Rice DH. Endonasal approaches for sinonasal and nasopharyngeal tumors. Otolaryngol Clin North [Am] 2001;34:1087-93.
• Stammberger H, Anderhuber W, Walch C, Papaefthymiou G. Possibilities and limitations of endo- scopic management of nasal and paranasal sinus malig- nancies. Acta Otorhinolaryngol Belg 1999;53:199-205.
• Walch C, Stammberger H, Anderhuber W, Unger F, Kole W, Feichtinger K. The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. Laryngoscope 2000;110:635-40.
• Schmidt H, Wurl P, Taubert H, Meye A, Bache M, Holzhausen HJ, et al. Genomic imbalances of 7p and 17q in malignant peripheral nerve sheath tumors are clinically relevant. Genes Chromosomes Cancer 1999; 25:205-11.
• Knuutila S, Aalto Y, Autio K, Bjorkqvist AM, El-Rifai W, Hemmer S, et al. DNA copy number losses in human neoplasms. Am J Pathol 1999;155:683-94.
• Perry A, Kunz SN, Fuller CE, Banerjee R, Marley EF, Liapis H, et al. Differential NF1, p16, and EGFR pat- terns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morpho- logically similar spindle cell neoplasms. J Neuropathol Exp Neurol 2002;61:702-9.