Primary manifestation of hepatocellular carcinoma as a cervical mass

Year 2007, Volume: 17 Issue: 1, 48 - 52, 12.01.2007

Emin Karaman Harun Cansız Engin Acıoğlu Emine Dilek Yılmazbayhan

Abstract

Metastasis of hepatocellular carcinoma to the head and neck region is unusual and its exact frequency is unknovvn. A 72-year-old male patient presented with a mass on the left side of the neck. Clinical examina- tion showed multiple, painless, immobile lym- phadenopathies in the cervical region. Computed tomography revealed both an irregular mass in the cervical region and hepatomegaly accompanied by a lobulated liver contour. The patient was diagnosed as having hepatocellular carcinoma following an exci- sional biopsy from the cervical mass and fine needle aspiration biopsy from the liver.

Keywords

Carcinoma, hepatocellular, head and neck neoplasms

Boyunda kitle ile ortaya ç›kan hepatoselüler karsinom

Abstract

Hepatoselüler kanserin baş-boyun bölgesine yayı- lımı çok nadirdir ve sıklığı tam olarak bilinmemek- tedir. Yetmiş iki yaşındaki erkek hasta boynun sol tarafında gelişen kitle nedeniyle kliniğimize baş- vurdu. Klinik muayenede servikal bölgede ağrısız, hareketsiz kitleler halinde çok sayıda lenfadenopa- ti saptandı. Bilgisayarlı tomografide servikal bölge- de düzensiz kitle görüldü, karaciğer lobüle yapıda ve büyüktü. Boyundaki kitleden yapılan eksizyonel biyopsi ve karaciğerden yapılan ince iğne aspiras- yon biyopsisi sonucunda hepatoselüler karsinom tanısı kondu

Keywords

Karsinom, hepatoselüler, bafl-boyun neoplazileri.

References

• Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y. Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 1990;66:2174-9.
• Simon JB. Hepatic and biliary disorders. In: Berdow R, Fletcher A, editors. The merck manual. Rahway: Merck Research Laboratories; 1992. p. 864-930.
• Chin A, Liang TS, Borislow AJ. Initial presentation of hepatocellular carcinoma as a mandibular mass: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:457-60.
• Lin DY, Liaw YF, Chu CM, Chang-Chien CS, Wu CS, Chen PC, et al. Hepatocellular carcinoma in noncir- rhotic patients. A laparoscopic study of 92 cases in Taiwan. Cancer 1984;54:1466-8.
• Maltz C, Lightdale CJ, Winawer SJ. Hepatocellular car- cinoma. New directions in etiology. Am J Gastroenterol 1980;74:361-5.
• Llanes F, Sanz-Ortega J, Suarez B, Sanz-Esponera J. Hepatocellular carcinomas diagnosed following metastasis to the oral cavity. Report of 2 cases. J Periodontol 1996;67:717-9.
• Okada H, Kamino Y, Shimo M, Kitamura E, Katoh T, Nishimura H, et al. Metastatic hepatocellular carcino- ma of the maxillary sinus: a rare autopsy case without lung metastasis and a review. Int J Oral Maxillofac Surg 2003;32:97-100.
• Morishita M, Fukuda J. Hepatocellular carcinoma metastatic to the maxillary incisal gingiva. J Oral Maxillofac Surg 1984;42:812-5.
• Chen CH, Sheu JC, Huang GT, Lee HS, Yang PM, Tsang YM, et al. Recurrent hepatocellular carcinoma presenting with superior vena cava syndrome. Hepatogastroenterology 2000;47:1117-9.
• Izquierdo J, Armengot M, Cors R, Perez A, Basterra J. Hepatocarcinoma: metastasis to the nose and paranasal sinuses. Otolaryngol Head Neck Surg 2000;122:932-3.
• Ramon Ramirez J, Seoane J, Montero J, Esparza Gomez GC, Cerero R. Isolated gingival metastasis from hepa- tocellular carcinoma mimicking a pyogenic granulo- ma. J Clin Periodontol 2003;30:926-9.
• Sohara N, Takagi H, Yamada T, Ichikawa T, Abe T, Itoh H, et al. Esophageal metastasis of hepatocellular carci- noma. Gastrointest Endosc 2000;51:739-41.
• Mochimatsu I, Tsukuda M, Furukawa S, Sawaki S. Tumours metastasizing to the head and neck-a report of seven cases. J Laryngol Otol 1993;107:1171-3.
• Pires FR, Sagarra R, Correa ME, Pereira CM, Vargas PA, Lopes MA. Oral metastasis of a hepatocellular car- cinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:359-68.
• Kew MC. Virchow-Troisier’s lymph node in hepatocel- lular carcinoma. J Clin Gastroenterol 1991;13:217-9.
• Barrera-Franco JL, Flores-Flores G, Mosqueda-Taylor A. Mandibular metastasis as the first manifestation of hepatocellular carcinoma: report of a case and review of the literature. J Oral Maxillofac Surg 1993;51:318-21.
• Mucitelli DR, Zuna RE, Archard HO. Hepatocellular carcinoma presenting as an oral cavity lesion. Oral Surg Oral Med Oral Pathol 1988;66:701-5.
• Brown NE, O’Brien DA, Megerian CA. Metastatic hepatocellular carcinoma to the temporal bone in a post-liver transplant patient. Otolaryngol Head Neck Surg 2004;130:370-1.
• Neff BA, Pribitkin EA, Willcox TO Jr. Hepatocellular cancer metastatic to the zygoma: primary resection and immediate reconstruction. Ear Nose Throat J 2002; 81:57-8.
• Zubler MA, Rivera R, Lane M. Hepatoma presenting as a retro-orbital metastasis. Cancer 1981;48:1883-5.
• Kanazawa H, Sato K. Gingival metastasis from primary hepatocellular carcinoma: report of a case and review of literature. J Oral Maxillofac Surg 1989; 47:987-90.