The effect of topical mitomycin-C application before or after incisional myringotomy on patency times of guinea pig tympanic membrane perforations

Year 2007, Volume: 17 Issue: 2, 100 - 104, 18.03.2007

Cenk Evren Mehmet Eken Günay Ateş Ziya Bozkurt Arif Şanlı

Abstract

Objectives: The aim of this study was to investigate the effect of topical mitomycin-C application before or after incisional myringotomy on patency times and to asess its use as an alternative to ventilation tube insertion.Materials and Methods: Nineteen guinea pigs were divided into two groups. İn the study group n=11 , mitomycin-C was applied in a concentration of 0.4 mg/ml över the perforation for five minutes before n=6 or after n=5 incisional myringotomies in both ears. Control animals n=8 received 0.1 mİ 0.09% NaCI for the same duration. Evaluations were made on days 1, 3, 5, 7, 10, 14, and 21. The patency times, otorrhea, and other complications were recorded.Results: Compared to Controls 7.0±1.5 days , the mean patency times of perforations were significantly longer in mitomycin-C treated groups before 11,6±5.2 days and after 14.2±4.7 days incisional myringo­ tomies p<0.05 . Patency times did not differ signifi­ cantly between the two mitomycin-C groups. None of the ears exhibited permanent perforation.Conclusion: The length of patency provided by mit­ omycin-C is not sufficient for optimal ventilation in otitis media with effusion. However, in cases requir- ing shorter patency times mitomycin-C application before or after myringotomy may be an alternative to ventilation tube insertion.

Keywords

Guinea pigs, middle ear ventilation, mitomycin C, otitis media with effusion, tympanic membrane/surgery

Kobay timpan membranında mitomisin-C uygulamasının insizyonel miringotominin kapanma süresine etkisi

Abstract

Amaç: Bu çalışmada miringotomiden önce ve sonratopikal mitomisin-C uygulamasının timpan membranperforasyonunun kapanma süresine etkisi ve bu uygulamanın ventilasyon tüpüne alternatif olup olamayacağı araştırıldı.Gereç ve Yöntem: Çalışmada 19 kobay guinea pig kullanıldı. Kobaylar çalışma n=11 ve kontrol n=8 olmak üzere iki gruba bölündü. Çalışma grubundakikobayların her iki timpan membranlarına 0.4 mg/ml mitomisin-C perforasyon öncesi n=6 veya sonrasında n=5 beş dakika süreyle uygulandı. Kontrol grubunaise aynı zaman ve süreyle 0.1 ml %0.09 NaCl uygulandı. Tüm gruplarının 1, 3, 5, 7, 10, 14 ve 21. günlerdekontrolleri yapıldı. Gruplarda perforasyonların kapanma süreleri, otore ve diğer komplikasyonlar kaydedildi.Bulgular: Miringotomiden önce ve sonra mitomisinC uygulanan gruplarda perforasyonların kapanmasüreleri sırasıyla 11.6±5.2 ve 14.2±4.7 gün kontrol grubuna 7.0±1.5 gün göre anlamlı derecede daha uzundu p

Keywords

Guinea pig, orta kulak ventilasyonu, mitomisin-C, efüzyonlu otitis media, timpanik membran/cerrahi

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