Hemodynamic effects of local anesthetics with adrenaline during septal surgery

Year 2007, Volume: 17 Issue: 3, 127 - 129, 23.05.2007

Alper Ceylan Fikret İleri Sabri Uslu Korhan Asal Ahmet Ural

Abstract

Objectives: We investigated the hemodynamic effects of local anesthetics with adrenaline used before septal surgery.Patients and Methods: İn a prospective, controlled design, administration of local anesthetics was per- formed with and without adrenaline in 39 patients and 10 patients, respectively, undergoing septal surgery. Plasma adrenaline concentrations were measured before anesthesia, and after 2, 5, and 10 minutes from anesthesia. The patients were monitored with respect to pulse rate, electrocardiograph- ic findings, and blood pressure.Results: Preoperative plasma adrenaline levels were similar in patients receiving local anesthetics with or without adrenaline 0.8 nmol/l vs 0.7 nmol/l .Following adrenaline administration, adrenaline lev­ els showed significant increases to 2.2, 1.9, and 1.7 nmol/l after 2, 5, and 10 minutes, respectively p<0.001 , whereas they remained similar in the control group. No side effects related to adrenaline use were detected.Conclusion: Despite systemic absorption of local injections, adrenaline-related side effects during septal surgery are extremely rare when the patients are closely monitored.

Keywords

Anesthetics, local, epinephrine, nasal septum, vasoconstrictor agents

Nazal cerrahide adrenalinli lokal anestetiklerin hemodinamik etkileri

Abstract

Amaç: Septum cerrahisi öncesi kullanılan adrenalinli lokal anestetiklerin hemodinamik etkileri incelendi.Hastalar ve Yöntemler: İleriye dönük, kontrollü olarak kurgulanan bu çalışmada, septum cerrahisi sırasında submukozal adrenalinli lokal anestetik kullanılan 39 hasta ile adrenalinsiz lokal anestezi uygulanan 10 hastanın plazma adrenalin düzeyleri ölçüldü.Hastalardan anestezi öncesinde ve anestezidensonra 2, 5 ve 10. dakikalarda serum örnekleri alındıve işlem sırasında nabız hızı, elektrokardiyografibulguları ve kan basınçları yakından takip edildi.Bulgular: Ameliyat öncesinde ölçülen adrenalin düzeyi adrenalin kullanılan ve kullanılmayan gruplardabenzerdi 0.8 nmol/l ve 0.7 nmol/l . Adrenalin kullanılan grupta 2, 5 ve 10. dakikalarda ölçülen adrenalin düzeyi ameliyat öncesine göre anlamlı derecedeartış gösterdi sırasıyla, 2.2, 1.9, ve 1.7 nmol/l;p

Keywords

Anestetik, lokal, epinefrin, nazal septum, vazokonstriktör ajanlar

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