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Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis

Year 2007, Volume: 17 Issue: 4, 189 - 196, 01.07.2007

Abstract

Objectives: We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis.Patients and Methods: The study included 40 patients 13 males, 27 females; mean age 30±14 years; range 4 to 63 years with allergic rhinitis. The mean symptom duration was 5.2±4.9 years. Blood and serum samples were analyzed spectrophotomet- rically. Myeloperoxidase MPO activity and vitamins A and E were measured as enzymatic and non-enzy- matic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde MDA level. Total antioxidant capacity TAC was measured as the a total antioxidant activity against oxidative stress prod- ucts. The results were compared with those of a con- trol group consisting of 40 healthy individuals.Results: Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were signifi­ cantly lower in the patient group p<0.05 .Conclusion: Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.

References

  • Lalwani AK, (editor). Current diagnosis & treatment in otolaryngology-head and neck surgery. New York: McGraw-Hill; 2004. Cingi C, Üre B. Nonalerjik ve al- lerjik rinit. Çeviri editörü: Cingi C. Current otorinola- ringoloji-Baş ve boyun cerrahisi tanı ve tedavi. Anka- ra: Güneş Kitabevi; 2005. s. 278.
  • Uzun H. Rinit. In: Çelik O, editör. Kulak burun boğaz hastalıkları ve baş boyun cerrahisi. İstanbul: Turgut Yayıncılık; 2002. s. 378.
  • Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: Complete guidelines of the Joint Task Force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol 1998; 81:478-518.
  • Bowler RP, Crapo JD. Oxidative stress in allergic respi- ratory diseases. J Allergy Clin Immunol 2002;110:349-56.
  • Yücel ÖT. Alerjik rinit fizyopatolojisi. In: Önerci M, editör. Alerjik rinosinüzitler. Ankara: Türkiye Eğitim ve Sağlık Vakfı Yayınevi; 2002. s. 116-22.
  • Lee KJ, (editör). Essential otolaryngology head & neck surgery. McGraw-Hill; 1991. Özdek A. Burun ve para- nazal sinüsler. Çeviri editörü: Önerci M, Korkmaz H. Essential otolaryngology baş ve boyun cerrahisi. 8. baskı. Ankara: Güneş Kitabevi; 2004. s. 702.
  • Keleş N. Alerjik rinit. In: Koç C, editör. Kulak burun boğaz hastalıkları ve baş-boyun cerrahisi. Ankara: Gü- neş Kitabevi; 2004. s. 515-36.
  • Friedman AD, Shah JB, Takoudes TG, Haddad J Jr. The role of free radicals in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2002;128:1055-7.
  • Alberty J, August C, Stoll W, Rudack C. The effect of endogenous nitric oxide on cholinergic ciliary stimula- tion of human nasal mucosa. Laryngoscope 2004; 114:1642-7.
  • Palm JP, Alving K, Lundberg JO. Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME. Allergy 2003; 58:885-92.
  • Roberts G, Hurley C, Bush A, Lack G. Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Thorax 2004;59:752-6.
  • Daya H, Qian W, McClean P, Haight J, Zamel N, Papsin BC, et al. Nasal nitric oxide in children: a novel mea- surement technique and normal values. Laryngoscope 2002;112:1831-5.
  • Djupesland PG, Chatkin JM, Qian W, Haight JS. Nitric oxide in the nasal airway: a new dimension in otorhi- nolaryngology. Am J Otolaryngol 2001;22:19-32.
  • Testa B, Mesolella M, Testa D, Giuliano A, Costa G, Maione F, et al. Glutathione in the upper respiratory tract. Ann Otol Rhinol Laryngol 1995;104:117-9.
  • Beier J, Beeh KM, Semmler D, Beike N, Buhl R. Increased concentrations of glutathione in induced sputum of patients with mild or moderate allergic asthma. Ann Allergy Asthma Immunol 2004;92:459-63.
  • Podoshin L, Gertner R, Fradis M. Treatment of peren- nial allergic rhinitis with ascorbic acid solution. Ear Nose Throat J 1991;70:54-5.
  • Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2004; 92:654-8.
  • Bucca C, Rolla G, Oliva A, Farina JC. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990;65:311-4.
  • Trevino RJ. Air pollution and its effect on the upper respiratory tract and on allergic rhinosinusitis. Otolaryngol Head Neck Surg 1996;114:239-41.
  • Giron-Caro F, Munoz-Hoyos A, Ruiz-Cosano C, Bonillo-Perales A, Molina-Carballo A, Escames G, et al. Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy. Int Arch Allergy Immunol 2001;126:91-6.
  • Cavallo A. Melatonin and human puberty: current perspectives. J Pineal Res 1993;15:115-21.

Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler

Year 2007, Volume: 17 Issue: 4, 189 - 196, 01.07.2007

Abstract

Amaç: Bu çalışmada, alerjik rinit etyopatogenezinde oksidatif stres ve antioksidanların rolü değerlendirildi.Hastalar ve Yöntemler: Çalışmaya klinik ve laboratuvar incelemeler sonucunda alerjik rinit tanısı konan40 hasta alındı. Hastaların yakınma süresi ortalama5.2±4.9 yıldı. Kan ve serum örneklerinde spektrofotometrik ölçümlerle enzimatik antioksidan olarak miyeloperoksidaz MPO , non-enzimatik antioksidanolarak A ve E vitamini, oksidatif stres ürünü olan velipit peroksidasyonu sonucu oluşan metabolitlerdenmalondialdehit MDA ile oksidatif stres dengesinigösteren total antioksidan kapasiteye bakıldı. Sonuçlar, sağlıklı 40 bireyden oluşan kontrol grubuylakarşılaştırıldı.Bulgular: Hasta grubunda MDA düzeyleri kontrolgrubuna göre anlamlı derecede yüksek; MPO, A veE vitamini düzeyleri ve total antioksidan kapasite anlamlı derecede düşük bulundu p

References

  • Lalwani AK, (editor). Current diagnosis & treatment in otolaryngology-head and neck surgery. New York: McGraw-Hill; 2004. Cingi C, Üre B. Nonalerjik ve al- lerjik rinit. Çeviri editörü: Cingi C. Current otorinola- ringoloji-Baş ve boyun cerrahisi tanı ve tedavi. Anka- ra: Güneş Kitabevi; 2005. s. 278.
  • Uzun H. Rinit. In: Çelik O, editör. Kulak burun boğaz hastalıkları ve baş boyun cerrahisi. İstanbul: Turgut Yayıncılık; 2002. s. 378.
  • Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: Complete guidelines of the Joint Task Force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol 1998; 81:478-518.
  • Bowler RP, Crapo JD. Oxidative stress in allergic respi- ratory diseases. J Allergy Clin Immunol 2002;110:349-56.
  • Yücel ÖT. Alerjik rinit fizyopatolojisi. In: Önerci M, editör. Alerjik rinosinüzitler. Ankara: Türkiye Eğitim ve Sağlık Vakfı Yayınevi; 2002. s. 116-22.
  • Lee KJ, (editör). Essential otolaryngology head & neck surgery. McGraw-Hill; 1991. Özdek A. Burun ve para- nazal sinüsler. Çeviri editörü: Önerci M, Korkmaz H. Essential otolaryngology baş ve boyun cerrahisi. 8. baskı. Ankara: Güneş Kitabevi; 2004. s. 702.
  • Keleş N. Alerjik rinit. In: Koç C, editör. Kulak burun boğaz hastalıkları ve baş-boyun cerrahisi. Ankara: Gü- neş Kitabevi; 2004. s. 515-36.
  • Friedman AD, Shah JB, Takoudes TG, Haddad J Jr. The role of free radicals in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2002;128:1055-7.
  • Alberty J, August C, Stoll W, Rudack C. The effect of endogenous nitric oxide on cholinergic ciliary stimula- tion of human nasal mucosa. Laryngoscope 2004; 114:1642-7.
  • Palm JP, Alving K, Lundberg JO. Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME. Allergy 2003; 58:885-92.
  • Roberts G, Hurley C, Bush A, Lack G. Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Thorax 2004;59:752-6.
  • Daya H, Qian W, McClean P, Haight J, Zamel N, Papsin BC, et al. Nasal nitric oxide in children: a novel mea- surement technique and normal values. Laryngoscope 2002;112:1831-5.
  • Djupesland PG, Chatkin JM, Qian W, Haight JS. Nitric oxide in the nasal airway: a new dimension in otorhi- nolaryngology. Am J Otolaryngol 2001;22:19-32.
  • Testa B, Mesolella M, Testa D, Giuliano A, Costa G, Maione F, et al. Glutathione in the upper respiratory tract. Ann Otol Rhinol Laryngol 1995;104:117-9.
  • Beier J, Beeh KM, Semmler D, Beike N, Buhl R. Increased concentrations of glutathione in induced sputum of patients with mild or moderate allergic asthma. Ann Allergy Asthma Immunol 2004;92:459-63.
  • Podoshin L, Gertner R, Fradis M. Treatment of peren- nial allergic rhinitis with ascorbic acid solution. Ear Nose Throat J 1991;70:54-5.
  • Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2004; 92:654-8.
  • Bucca C, Rolla G, Oliva A, Farina JC. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990;65:311-4.
  • Trevino RJ. Air pollution and its effect on the upper respiratory tract and on allergic rhinosinusitis. Otolaryngol Head Neck Surg 1996;114:239-41.
  • Giron-Caro F, Munoz-Hoyos A, Ruiz-Cosano C, Bonillo-Perales A, Molina-Carballo A, Escames G, et al. Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy. Int Arch Allergy Immunol 2001;126:91-6.
  • Cavallo A. Melatonin and human puberty: current perspectives. J Pineal Res 1993;15:115-21.
There are 21 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ercan Akbay This is me

Hamdi Arbağ This is me

Yavuz Uyar This is me

Kayhan Öztürk This is me

Publication Date July 1, 2007
Published in Issue Year 2007 Volume: 17 Issue: 4

Cite

APA Akbay, E., Arbağ, H., Uyar, Y., Öztürk, K. (2007). Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler. The Turkish Journal of Ear Nose and Throat, 17(4), 189-196.
AMA Akbay E, Arbağ H, Uyar Y, Öztürk K. Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler. Tr-ENT. July 2007;17(4):189-196.
Chicago Akbay, Ercan, Hamdi Arbağ, Yavuz Uyar, and Kayhan Öztürk. “Alerjik Rinit Patofizyolojisinde Oksidatif Stres Ve Antioksidan faktörler”. The Turkish Journal of Ear Nose and Throat 17, no. 4 (July 2007): 189-96.
EndNote Akbay E, Arbağ H, Uyar Y, Öztürk K (July 1, 2007) Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler. The Turkish Journal of Ear Nose and Throat 17 4 189–196.
IEEE E. Akbay, H. Arbağ, Y. Uyar, and K. Öztürk, “Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler”, Tr-ENT, vol. 17, no. 4, pp. 189–196, 2007.
ISNAD Akbay, Ercan et al. “Alerjik Rinit Patofizyolojisinde Oksidatif Stres Ve Antioksidan faktörler”. The Turkish Journal of Ear Nose and Throat 17/4 (July 2007), 189-196.
JAMA Akbay E, Arbağ H, Uyar Y, Öztürk K. Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler. Tr-ENT. 2007;17:189–196.
MLA Akbay, Ercan et al. “Alerjik Rinit Patofizyolojisinde Oksidatif Stres Ve Antioksidan faktörler”. The Turkish Journal of Ear Nose and Throat, vol. 17, no. 4, 2007, pp. 189-96.
Vancouver Akbay E, Arbağ H, Uyar Y, Öztürk K. Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler. Tr-ENT. 2007;17(4):189-96.