Oxidative stress and antioxidant factors in pathophysiology of allergic rhinitis

Year 2007, Volume: 17 Issue: 4, 189 - 196, 01.07.2007

Ercan Akbay Hamdi Arbağ Yavuz Uyar Kayhan Öztürk

Abstract

Objectives: We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis.Patients and Methods: The study included 40 patients 13 males, 27 females; mean age 30±14 years; range 4 to 63 years with allergic rhinitis. The mean symptom duration was 5.2±4.9 years. Blood and serum samples were analyzed spectrophotomet- rically. Myeloperoxidase MPO activity and vitamins A and E were measured as enzymatic and non-enzy- matic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde MDA level. Total antioxidant capacity TAC was measured as the a total antioxidant activity against oxidative stress prod- ucts. The results were compared with those of a con- trol group consisting of 40 healthy individuals.Results: Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were signifi­ cantly lower in the patient group p<0.05 .Conclusion: Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.

Keywords

Antioxidants/metabolism, oxidative stress, rhinitis, allergic, perennial/etiology

Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktörler

Abstract

Amaç: Bu çalışmada, alerjik rinit etyopatogenezinde oksidatif stres ve antioksidanların rolü değerlendirildi.Hastalar ve Yöntemler: Çalışmaya klinik ve laboratuvar incelemeler sonucunda alerjik rinit tanısı konan40 hasta alındı. Hastaların yakınma süresi ortalama5.2±4.9 yıldı. Kan ve serum örneklerinde spektrofotometrik ölçümlerle enzimatik antioksidan olarak miyeloperoksidaz MPO , non-enzimatik antioksidanolarak A ve E vitamini, oksidatif stres ürünü olan velipit peroksidasyonu sonucu oluşan metabolitlerdenmalondialdehit MDA ile oksidatif stres dengesinigösteren total antioksidan kapasiteye bakıldı. Sonuçlar, sağlıklı 40 bireyden oluşan kontrol grubuylakarşılaştırıldı.Bulgular: Hasta grubunda MDA düzeyleri kontrolgrubuna göre anlamlı derecede yüksek; MPO, A veE vitamini düzeyleri ve total antioksidan kapasite anlamlı derecede düşük bulundu p

Keywords

Antioksidan/metabolizma, oksidatif stres, rinit, alerjik, perennial/etyoloji.

References

• Lalwani AK, (editor). Current diagnosis & treatment in otolaryngology-head and neck surgery. New York: McGraw-Hill; 2004. Cingi C, Üre B. Nonalerjik ve al- lerjik rinit. Çeviri editörü: Cingi C. Current otorinola- ringoloji-Baş ve boyun cerrahisi tanı ve tedavi. Anka- ra: Güneş Kitabevi; 2005. s. 278.
• Uzun H. Rinit. In: Çelik O, editör. Kulak burun boğaz hastalıkları ve baş boyun cerrahisi. İstanbul: Turgut Yayıncılık; 2002. s. 378.
• Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: Complete guidelines of the Joint Task Force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol 1998; 81:478-518.
• Bowler RP, Crapo JD. Oxidative stress in allergic respi- ratory diseases. J Allergy Clin Immunol 2002;110:349-56.
• Yücel ÖT. Alerjik rinit fizyopatolojisi. In: Önerci M, editör. Alerjik rinosinüzitler. Ankara: Türkiye Eğitim ve Sağlık Vakfı Yayınevi; 2002. s. 116-22.
• Lee KJ, (editör). Essential otolaryngology head & neck surgery. McGraw-Hill; 1991. Özdek A. Burun ve para- nazal sinüsler. Çeviri editörü: Önerci M, Korkmaz H. Essential otolaryngology baş ve boyun cerrahisi. 8. baskı. Ankara: Güneş Kitabevi; 2004. s. 702.
• Keleş N. Alerjik rinit. In: Koç C, editör. Kulak burun boğaz hastalıkları ve baş-boyun cerrahisi. Ankara: Gü- neş Kitabevi; 2004. s. 515-36.
• Friedman AD, Shah JB, Takoudes TG, Haddad J Jr. The role of free radicals in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2002;128:1055-7.
• Alberty J, August C, Stoll W, Rudack C. The effect of endogenous nitric oxide on cholinergic ciliary stimula- tion of human nasal mucosa. Laryngoscope 2004; 114:1642-7.
• Palm JP, Alving K, Lundberg JO. Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME. Allergy 2003; 58:885-92.
• Roberts G, Hurley C, Bush A, Lack G. Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma. Thorax 2004;59:752-6.
• Daya H, Qian W, McClean P, Haight J, Zamel N, Papsin BC, et al. Nasal nitric oxide in children: a novel mea- surement technique and normal values. Laryngoscope 2002;112:1831-5.
• Djupesland PG, Chatkin JM, Qian W, Haight JS. Nitric oxide in the nasal airway: a new dimension in otorhi- nolaryngology. Am J Otolaryngol 2001;22:19-32.
• Testa B, Mesolella M, Testa D, Giuliano A, Costa G, Maione F, et al. Glutathione in the upper respiratory tract. Ann Otol Rhinol Laryngol 1995;104:117-9.
• Beier J, Beeh KM, Semmler D, Beike N, Buhl R. Increased concentrations of glutathione in induced sputum of patients with mild or moderate allergic asthma. Ann Allergy Asthma Immunol 2004;92:459-63.
• Podoshin L, Gertner R, Fradis M. Treatment of peren- nial allergic rhinitis with ascorbic acid solution. Ear Nose Throat J 1991;70:54-5.
• Shahar E, Hassoun G, Pollack S. Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2004; 92:654-8.
• Bucca C, Rolla G, Oliva A, Farina JC. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990;65:311-4.
• Trevino RJ. Air pollution and its effect on the upper respiratory tract and on allergic rhinosinusitis. Otolaryngol Head Neck Surg 1996;114:239-41.
• Giron-Caro F, Munoz-Hoyos A, Ruiz-Cosano C, Bonillo-Perales A, Molina-Carballo A, Escames G, et al. Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy. Int Arch Allergy Immunol 2001;126:91-6.
• Cavallo A. Melatonin and human puberty: current perspectives. J Pineal Res 1993;15:115-21.