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Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?

Year 2007, Volume: 17 Issue: 6, 324 - 328, 24.11.2007

Abstract

Objectives: This study was designed to compare the effectiveness of positron emission tomography PET and magnetic resonance imaging MRI in the prethera­ peutic staging of squamous celi carcinoma SCC of the head and neck.Patients and Methods: The study included 34 consecu- tive patients 27 males, 7 females; mean age 61 years; range 42 to 82 years with SCC of the head and neck. Ali thepatientsunderwentwholebody[18Flfluorodeoxyglucose FDG -PET and MRI seans for pretherapeutic evaluation.Diagnoses were confirmed by histopathologic examina- tion of endoscopic biopsy specimens.Results: The sites of the primary tumors were the oro- pharynx n=15, 44% , larynx n=10, 29% , hypopharynx n=8, 24% , and nasopharynx n=1, 3% . Surgery was the treatment of choice in 20 patients 59% , ineluding 23 neck disseetions. Fourteen patients 41% were treated with radiochemotherapy. Both PET and MRI were able to detect the primary tumor in 33 cases 97% . İn two patients 6% , PET was able to detect distant metastases in the lung and iliac bone, ali of which were confirmed by biop- sies. Seven neck specimens 30% showed lymph node metastasis. Sensitivity and specificity rates for deteetion of lymph node metastasis were 100% and 87.5% for PET, and 85.7% and 87.5% for MRI, respeetively.Conclusion: Although PET seems to be superior to MRI in deteeting nodal disease and distant metastases, it is stili early to recommend it as a primary tool for pre­ therapeutic evaluation of head and neck cancers due to its limited availability and higher cost.

References

  • Schifter T, Hoffman JM, Hanson MW, Donnal JF, Boyko OB, Schold SC, et al. Serial FDG-PET in the management of primary brain tumors. J Comput Assist Tomogr 1993;17:509-16.
  • Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, et al. Prediction of survival in glioma patients by means of positron emission tomog- raphy. J Neurosurg 1985;62:816-22.
  • Gupta NC, Frank AR, Dewan NA, Redepenning LS, Rothberg ML, Mailliard JA, et al. Solitary pulmonary nodules: detection of malignancy with PET with 2-[F- 18]-fluoro-2-deoxy-D-glucose. Radiology 1992;184:441-4.
  • Patz EF Jr, Lowe VJ, Hoffman JM, Paine SS, Burrowes P, Coleman RE, et al. Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scan- ning. Radiology 1993;188:487-90.
  • Minn H, Soini I. [18F]fluorodeoxyglucose scintigraphy in diagnosis and follow up of treatment in advanced breast cancer. Eur J Nucl Med 1989;15:61-6.
  • Strauss LG, Conti PS. The applications of PET in clini- cal oncology. J Nucl Med 1991;32:623-48.
  • Teknos TN, Rosenthal EL, Lee D, Taylor R, Marn CS. Positron emission tomography in the evaluation of stage III and IV head and neck cancer. Head Neck 2001; 23:1056-60.
  • Stoeckli SJ, Steinert H, Pfaltz M, Schmid S. Is there a role for positron emission tomography with 18F-fluo- rodeoxyglucose in the initial staging of nodal negative oral and oropharyngeal squamous cell carcinoma. Head Neck 2002;24:345-9.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Di Martino E, Nowak B, Hassan HA, Hausmann R, Adam G, Buell U, et al. Diagnosis and staging of head and neck cancer: a comparison of modern imaging modalities (positron emission tomography, computed tomography, color-coded duplex sonography) with panendoscopic and histopathologic findings. Arch Otolaryngol Head Neck Surg 2000;126:1457-61.
  • Snow GB, Annyas AA, van Slooten EA, Bartelink H, Hart AA. Prognostic factors of neck node metastasis. Clin Otolaryngol Allied Sci 1982;7:185-92.
  • Grandi C, Alloisio M, Moglia D, Podrecca S, Sala L, Salvatori P, et al. Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications. Head Neck Surg 1985;8:67-73.
  • Lonneux M, Lawson G, Ide C, Bausart R, Remacle M, Pauwels S. Positron emission tomography with fluo- rodeoxyglucose for suspected head and neck tumor recurrence in the symptomatic patient. Laryngoscope 2000;110:1493-7.
  • Farber LA, Benard F, Machtay M, Smith RJ, Weber RS, Weinstein GS, et al. Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emis- sion tomography. Laryngoscope 1999;109:970-5.
  • Stuckensen T, Kovacs AF, Adams S, Baum RP. Staging of the neck in patients with oral cavity squamous cell carcinomas: a prospective comparison of PET, ultra- sound, CT and MRI. J Craniomaxillofac Surg 2000;28: 319-24.
  • Hannah A, Scott AM, Tochon-Danguy H, Chan JG, Akhurst T, Berlangieri S, et al. Evaluation of 18F-fluo- rodeoxyglucose positron emission tomography and computed tomography with histopathologic correla- tion in the initial staging of head and neck cancer. Ann Surg 2002;236:208-17.
  • Kresnik E, Mikosch P, Gallowitsch HJ, Kogler D, Wiesser S, Heinisch M, et al. Evaluation of head and neck cancer with 18F-FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001;28:816-21.
  • Laubenbacher C, Saumweber D, Wagner-Manslau C, Kau RJ, Herz M, Avril N, et al. Comparison of fluo- rine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. J Nucl Med 1995;36:1747-57.
  • Wong WL, Chevretton EB, McGurk M, Hussain K, Davis J, Beaney R, et al. A prospective study of PET- FDG imaging for the assessment of head and neck squamous cell carcinoma. Clin Otolaryngol Allied Sci 1997;22:209-14.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Manolidis S, Donald PJ, Volk P, Pounds TR. The use of positron emission tomography scanning in occult and recurrent head and neck cancer. Acta Otolaryngol Suppl 1998;534:1-11.

Baş-boyun bölgesi yassı hücreli karsinomlarm tedavi öncesi değerlendirilmesinde PET MRG'den üstün müdür?

Year 2007, Volume: 17 Issue: 6, 324 - 328, 24.11.2007

Abstract

Amaç: Bu çalışmada, yassı hücreli baş-boyun karsinomlarının tedavi öncesi değerlendirilmesinde pozitron emisyon tomografisi PET ve manyetik rezonans görüntülemenin MRG etkinliğinin karşılaştırılması amaçlandı.Hastalar ve Yöntemler: Çalışmaya baş-boyun bölgesi yassı hücreli karsinomu olan 34 ardışık hasta alındı. Tüm hastalar tedavi öncesinde tüm vücut [18F]florodeoksiglukoz FDG -PET ve MRG görüntülemesi ile değerlendirildi. Tüm hastaların tanıları endoskopik biyopsi örneklerinin histopatolojik değerlendirilmesi ile doğrulandı.Bulgular: Primer tümörlerin yerleşimleri şöyleydi: orofarenks n=15, %44 , larenks n=10, %29 , hipofarenks n=8, %24 , nazofarenks n=1, %3 . Yirmi hastada %59 cerrahi tedavi uygulandı; bu hastalara 23 boyun diseksiyonu yapıldı. On dört hastada %41 radyoterapi uygulandı. Her iki görüntüleme yöntemi de 33 hastada %97 primer tümörü doğru olarak saptayabildi. Ayrıca, PET yardımıyla iki hastada %6 akciğer ve iliyak kemikte uzak metastazlar saptandı; bunların hepsi biyopsi sonuçlarıyla doğrulandı. Boyun diseksiyonlarının yedisinde %30 lenf nodu metastazı vardı. Lenf nodu tutulumunun gösterilmesinde duyarlılık ve özgüllük oranları PET için sırasıyla %100 ve %87.5, MRG için %85.7 ve %87.5 bulundu.Sonuç: Nodal hastalığın ve uzak metastazların saptanmasında PET MRGʼden daha üstün görünmesine rağmen, bu yöntemi baş-boyun kanserlerinin tedavi öncesi değerlendirilmesinde esas araç olarak önermek sınırlı kullanımı ve yüksek maliyeti nedeniyle erkendir

References

  • Schifter T, Hoffman JM, Hanson MW, Donnal JF, Boyko OB, Schold SC, et al. Serial FDG-PET in the management of primary brain tumors. J Comput Assist Tomogr 1993;17:509-16.
  • Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, et al. Prediction of survival in glioma patients by means of positron emission tomog- raphy. J Neurosurg 1985;62:816-22.
  • Gupta NC, Frank AR, Dewan NA, Redepenning LS, Rothberg ML, Mailliard JA, et al. Solitary pulmonary nodules: detection of malignancy with PET with 2-[F- 18]-fluoro-2-deoxy-D-glucose. Radiology 1992;184:441-4.
  • Patz EF Jr, Lowe VJ, Hoffman JM, Paine SS, Burrowes P, Coleman RE, et al. Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scan- ning. Radiology 1993;188:487-90.
  • Minn H, Soini I. [18F]fluorodeoxyglucose scintigraphy in diagnosis and follow up of treatment in advanced breast cancer. Eur J Nucl Med 1989;15:61-6.
  • Strauss LG, Conti PS. The applications of PET in clini- cal oncology. J Nucl Med 1991;32:623-48.
  • Teknos TN, Rosenthal EL, Lee D, Taylor R, Marn CS. Positron emission tomography in the evaluation of stage III and IV head and neck cancer. Head Neck 2001; 23:1056-60.
  • Stoeckli SJ, Steinert H, Pfaltz M, Schmid S. Is there a role for positron emission tomography with 18F-fluo- rodeoxyglucose in the initial staging of nodal negative oral and oropharyngeal squamous cell carcinoma. Head Neck 2002;24:345-9.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Di Martino E, Nowak B, Hassan HA, Hausmann R, Adam G, Buell U, et al. Diagnosis and staging of head and neck cancer: a comparison of modern imaging modalities (positron emission tomography, computed tomography, color-coded duplex sonography) with panendoscopic and histopathologic findings. Arch Otolaryngol Head Neck Surg 2000;126:1457-61.
  • Snow GB, Annyas AA, van Slooten EA, Bartelink H, Hart AA. Prognostic factors of neck node metastasis. Clin Otolaryngol Allied Sci 1982;7:185-92.
  • Grandi C, Alloisio M, Moglia D, Podrecca S, Sala L, Salvatori P, et al. Prognostic significance of lymphatic spread in head and neck carcinomas: therapeutic implications. Head Neck Surg 1985;8:67-73.
  • Lonneux M, Lawson G, Ide C, Bausart R, Remacle M, Pauwels S. Positron emission tomography with fluo- rodeoxyglucose for suspected head and neck tumor recurrence in the symptomatic patient. Laryngoscope 2000;110:1493-7.
  • Farber LA, Benard F, Machtay M, Smith RJ, Weber RS, Weinstein GS, et al. Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emis- sion tomography. Laryngoscope 1999;109:970-5.
  • Stuckensen T, Kovacs AF, Adams S, Baum RP. Staging of the neck in patients with oral cavity squamous cell carcinomas: a prospective comparison of PET, ultra- sound, CT and MRI. J Craniomaxillofac Surg 2000;28: 319-24.
  • Hannah A, Scott AM, Tochon-Danguy H, Chan JG, Akhurst T, Berlangieri S, et al. Evaluation of 18F-fluo- rodeoxyglucose positron emission tomography and computed tomography with histopathologic correla- tion in the initial staging of head and neck cancer. Ann Surg 2002;236:208-17.
  • Kresnik E, Mikosch P, Gallowitsch HJ, Kogler D, Wiesser S, Heinisch M, et al. Evaluation of head and neck cancer with 18F-FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001;28:816-21.
  • Laubenbacher C, Saumweber D, Wagner-Manslau C, Kau RJ, Herz M, Avril N, et al. Comparison of fluo- rine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. J Nucl Med 1995;36:1747-57.
  • Wong WL, Chevretton EB, McGurk M, Hussain K, Davis J, Beaney R, et al. A prospective study of PET- FDG imaging for the assessment of head and neck squamous cell carcinoma. Clin Otolaryngol Allied Sci 1997;22:209-14.
  • Hanasono MM, Kunda LD, Segall GM, Ku GH, Terris DJ. Uses and limitations of FDG positron emission tomography in patients with head and neck cancer. Laryngoscope 1999;109:880-5.
  • Manolidis S, Donald PJ, Volk P, Pounds TR. The use of positron emission tomography scanning in occult and recurrent head and neck cancer. Acta Otolaryngol Suppl 1998;534:1-11.
There are 21 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Ahmet Ural This is me

Amir Minovi This is me

Andreas Hertel This is me

Erich Horfmann This is me

Wolfgang Draf This is me

Ulrike Bockmuehl This is me

Publication Date November 24, 2007
Published in Issue Year 2007 Volume: 17 Issue: 6

Cite

APA Ural, A., Minovi, A., Hertel, A., Horfmann, E., et al. (2007). Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?. The Turkish Journal of Ear Nose and Throat, 17(6), 324-328.
AMA Ural A, Minovi A, Hertel A, Horfmann E, Draf W, Bockmuehl U. Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?. Tr-ENT. November 2007;17(6):324-328.
Chicago Ural, Ahmet, Amir Minovi, Andreas Hertel, Erich Horfmann, Wolfgang Draf, and Ulrike Bockmuehl. “Is PET Superior to MRI in the Pretherapeutic Evaluation of Head and Neck Squamous Celi Carcinoma?”. The Turkish Journal of Ear Nose and Throat 17, no. 6 (November 2007): 324-28.
EndNote Ural A, Minovi A, Hertel A, Horfmann E, Draf W, Bockmuehl U (November 1, 2007) Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?. The Turkish Journal of Ear Nose and Throat 17 6 324–328.
IEEE A. Ural, A. Minovi, A. Hertel, E. Horfmann, W. Draf, and U. Bockmuehl, “Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?”, Tr-ENT, vol. 17, no. 6, pp. 324–328, 2007.
ISNAD Ural, Ahmet et al. “Is PET Superior to MRI in the Pretherapeutic Evaluation of Head and Neck Squamous Celi Carcinoma?”. The Turkish Journal of Ear Nose and Throat 17/6 (November 2007), 324-328.
JAMA Ural A, Minovi A, Hertel A, Horfmann E, Draf W, Bockmuehl U. Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?. Tr-ENT. 2007;17:324–328.
MLA Ural, Ahmet et al. “Is PET Superior to MRI in the Pretherapeutic Evaluation of Head and Neck Squamous Celi Carcinoma?”. The Turkish Journal of Ear Nose and Throat, vol. 17, no. 6, 2007, pp. 324-8.
Vancouver Ural A, Minovi A, Hertel A, Horfmann E, Draf W, Bockmuehl U. Is PET superior to MRI in the pretherapeutic evaluation of head and neck squamous celi carcinoma?. Tr-ENT. 2007;17(6):324-8.