The results of specific immunotherapy for house dust mites in patients with allergic rhinitis

Year 2008, Volume: 18 Issue: 2, 79 - 84, 18.04.2008

Ethem Şahin Ebru Taş Emine Nur Dağtekin Ergür B. Deniz Çuhalı A. Okan Gürsel

Abstract

Objectives: We evaluated three-year clinical and laboratory results of specific immunotherapy SIT for allergenic house dust mite species, Dermatophagoides pteronyssinus and D. farinae. Patients and Methods: The study included 26 patients 6 males, 20 females; mean age 28 years; range 17-56 years who had allergic rhinitis and were found to be sensitive to D. pteronyssinus and D. farinae. Due to unresponsiveness to other treatment modalities, the patients received subcutaneous SIT for three years. Symptoms nasal stuffiness, rhinorrhea, itching, sneezing, headache, eye symptoms, and smelling were graded before and at the end of SIT, and blood eosinophilia, total IgE and specific IgE levels were determined. Results: At the end of three years, the number of patients that showed strong positivity to D. pteronyssinus and D. farinae decreased from 26 100% to 3 11.5% p=0.0001 and from 18 69.3% to 4 15.4% p<0.005 , respectively. There were significant decreases in blood eosinophilia, total IgE and specific IgE levels, and in the severity of all symptoms related to the nose, head, and eye. Conclusion: Specific immunotherapy reduces symptoms in patients with allergic rhinitis. It is an effective treatment method for allergic rhinitis if performed by trained physicians in carefully selected patients.

Keywords

Desensitization, immunologic, immunization, mites/immunology, rhinitis, allergic, perennial/therapy

Alerjik rinitli hastalarda ev tozu akarlarına karşı uygulanan spesifik immünterapi sonuçları

Abstract

Amaç: Ev tozu akarlarından olan Dermatophagoides pteronyssinus ve D. farinae alerjenlerine karşı uygulanan spesifik immünterapinin SİT üç yıllık klinik ve laboratuvar sonuçları değerlendirildi.Hastalar ve Yöntemler: Alerjik rinit tanısı konan ve duyarlı olunan alerjenlere D. pteronyssinus ve D. farinae karşı diğer tedavi yöntemleriyle yeterli sonuç alınamayan 26 hastaya üç yıl boyunca subkutan SİT uygulandı. Tüm hastaların tedavi öncesi ve sonrası burun tıkanıklığı, burun akıntısı, burun kaşıntısı, hapşırık, baş ağrısı, göz yakınmaları, koku alma sorunları derecelendirildi ve periferik kan eozinofil, total IgE ve spesifik IgE değerleri ölçüldü. Bulgular: Deri testinde şiddetli D. pteronyssinus ve D. farinae pozitifliği tedavi öncesinde sırasıyla 26 %100 ve 18 hastada %69.3 , tedavi sonrasında ise üç %11.5 ve dört hastada %15.4 görüldü p=0.0001 ve p

Keywords

Desensitizasyon, immünolojik, immünizasyon, ev akarı/immünoloji, rinit, alerjik, perennial/tedavi

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