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Rosai-Dorfman disease presenting as laryngeal masses

Year 2008, Volume: 18 Issue: 2, 110 - 114, 18.04.2008

Abstract

Extranodal lesions may be the sole manifestation of Rosai-Dorfman disease RDD . Although the head and neck region is one of the most common extranodal sites, laryngeal involvement is very rare. A 44-yearold woman presented with a complaint of progressive dyspnea. She had a three-year history of treatment for asthma and a history of operation for a nasal mass that afflicted her for 15 years and was diagnosed as rhinoscleroma. On physical examination, she had three subcutaneous lesions, in the left lower eyelid, right epicanthal area, and left forearm, respectively. No lymphadenopathy was present. Laryngoscopic examination revealed three solid, polypoid masses in the subglottic region, 1 cm in diameter. With a two-staged operation, the laryngeal masses were excised totally together with the subcutaneous lesions. Histological examination of all the specimens showed proliferation of histiocytes. Immunohistochemical staining revealed typical S-100 protein-positive histiocytes and emperipolesis. Both laryngeal and subcutaneous lesions were diagnosed as RDD. A re-evaluation of sections from the previous operation specimen of the nasal mass showed the same morphological features. The patient was healthy without recurrence, nine months following surgery.

References

  • Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990;7:19-73.
  • Carpenter RJ 3rd, Banks PM, McDonald TJ, Sanderson DR. Sinus histiocytosis with massive lymphade- nopathy (Rosai-Dorfman disease): Report of a case with respiratory tract involvement. Laryngoscope 1978;88:1963-9.
  • Aluffi P, Prestinari A, Ramponi A, Castri M, Pia F. Rosai-Dorfman disease of the larynx. J Laryngol Otol 2000;114:565-7.
  • Carbone A, Passannante A, Gloghini A, Devaney KO, Rinaldo A, Ferlito A. Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck. Ann Otol Rhinol Laryngol 1999;108(11 Pt 1):1095-104.
  • Wenig BM, Devaney K, Wenig BL. Pseudoneoplastic lesions of the oropharynx and larynx simulating can- cer. Pathol Annu 1995;30(Pt 1):143-87.
  • Leighton SE, Gallimore AP. Extranodal sinus histio- cytosis with massive lymphadenopathy affecting the subglottis and trachea. Histopathology 1994;24:393-4.
  • Courteney-Harris RG, Goddard MJ. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman dis- ease): a rare case of subglottic narrowing. J Laryngol Otol 1992;106:61-2.
  • Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 52-1981. A 51-year-old man with upper-airway obstruction and lymphadenopathy. N Engl J Med 1981;305:1572-80.
  • Asrar L, Facharzt EH, Haque I. Rosai-Dorfman dis- ease: presenting as isolated extranodal involvement of larynx. J Otolaryngol 1998;27:85-6.
  • Rosai J. Lymph nodes. In: Rosai J, Ackerman LV, edi- tors. Ackerman’s surgical pathology. 8th ed. St. Louis: C. V. Mosby; 1996. p. 1694-5.
  • Unal OF, Koybasi S, Kaya S. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Int J Pediatr Otorhinolaryngol 1998;44:173-6.
  • Suarez CR, Zeller WP, Silberman S, Rust G, Messmore H. Sinus histiocytosis with massive lymphadenopathy: remission with chemotherapy. Am J Pediatr Hematol Oncol 1983;5:235-41.
  • Wenig BM, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodal sinus histiocytosis with mas- sive lymphadenopathy (Rosai-Dorfman disease) of the head and neck. Hum Pathol 1993;24:483-92.
  • McAlister WH, Herman T, Dehner LP. Sinus histiocy- tosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol 1990;20:425-32.
  • Baden E, Caveriviere P, Carbonnel S. Sinus histiocyto- sis with massive lymphadenopathy (Destombes-Rosai- Dorfman syndrome) occurring as a single enlarged submandibular lymph node: a light and immunohis- tochemical study with review of the literature. Oral Surg Oral Med Oral Pathol 1987;64:320-6.
  • Goodnight JW, Wang MB, Sercarz JA, Fu YS. Extranodal Rosai-Dorfman disease of the head and neck. Laryngoscope 1996;106(3 Pt 1):253-6.

Larenks kitleleri olarak kendini gösteren Rosai-Dorfman hastalığı

Year 2008, Volume: 18 Issue: 2, 110 - 114, 18.04.2008

Abstract

Ekstranodal lezyonlar Rosai-Dorfman hastalığının RDH tek bulgusu olabilir. Baş-boyun bölgesi RDH’de en sık tutulan bölgelerden biri olmasına karşın, hasta- lığın larengeal tutulumu çok nadirdir. Kırk dört yaşında bir kadın hasta ilerleyici nefes darlığı yakınmasıyla başvurdu. Öyküsünden, astım için üç yıldır tedavi gör- düğü ve kendisini 15 yıldır etkileyen bir burun kitlesi nedeniyle ameliyat geçirdiği, bu lezyona da rinosklero- ma tanısı konduğu öğrenildi. Fizik muayenede, sol alt gözkapağında, sağ epikantal bölgede ve sol önkolda üç adet subkutan lezyon görüldü. Lenfadenopatiye rastlanmadı. Larengoskopik incelemede, subglottik bölgede, 1 cm çapında üç adet solid polipoid kitle gözlendi. Larenksteki kitleler ve subkutan lezyonlar iki aşamalı bir ameliyatla çıkarıldı. Histolojik incelemede örneklerin hepsinde histiosit proliferasyonu görüldü. İmmünhistokimyasal boyamada tipik S-100 proteini için pozitiflik gösteren histiositler ve emperipolez göz- lendi. Larenks kitleleri ve subkutan lezyonların tanısı RDH şeklinde kondu. Hastanın daha önce geçirmiş olduğu ameliyatta çıkarılan burun kitlesine ait kesit- lerin yeniden incelenmesi aynı morfolojik özellikleri gösterdi. Ameliyattan dokuz ay sonra hasta sağlıklıydı ve nüks yoktu

References

  • Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990;7:19-73.
  • Carpenter RJ 3rd, Banks PM, McDonald TJ, Sanderson DR. Sinus histiocytosis with massive lymphade- nopathy (Rosai-Dorfman disease): Report of a case with respiratory tract involvement. Laryngoscope 1978;88:1963-9.
  • Aluffi P, Prestinari A, Ramponi A, Castri M, Pia F. Rosai-Dorfman disease of the larynx. J Laryngol Otol 2000;114:565-7.
  • Carbone A, Passannante A, Gloghini A, Devaney KO, Rinaldo A, Ferlito A. Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck. Ann Otol Rhinol Laryngol 1999;108(11 Pt 1):1095-104.
  • Wenig BM, Devaney K, Wenig BL. Pseudoneoplastic lesions of the oropharynx and larynx simulating can- cer. Pathol Annu 1995;30(Pt 1):143-87.
  • Leighton SE, Gallimore AP. Extranodal sinus histio- cytosis with massive lymphadenopathy affecting the subglottis and trachea. Histopathology 1994;24:393-4.
  • Courteney-Harris RG, Goddard MJ. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman dis- ease): a rare case of subglottic narrowing. J Laryngol Otol 1992;106:61-2.
  • Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 52-1981. A 51-year-old man with upper-airway obstruction and lymphadenopathy. N Engl J Med 1981;305:1572-80.
  • Asrar L, Facharzt EH, Haque I. Rosai-Dorfman dis- ease: presenting as isolated extranodal involvement of larynx. J Otolaryngol 1998;27:85-6.
  • Rosai J. Lymph nodes. In: Rosai J, Ackerman LV, edi- tors. Ackerman’s surgical pathology. 8th ed. St. Louis: C. V. Mosby; 1996. p. 1694-5.
  • Unal OF, Koybasi S, Kaya S. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Int J Pediatr Otorhinolaryngol 1998;44:173-6.
  • Suarez CR, Zeller WP, Silberman S, Rust G, Messmore H. Sinus histiocytosis with massive lymphadenopathy: remission with chemotherapy. Am J Pediatr Hematol Oncol 1983;5:235-41.
  • Wenig BM, Abbondanzo SL, Childers EL, Kapadia SB, Heffner DR. Extranodal sinus histiocytosis with mas- sive lymphadenopathy (Rosai-Dorfman disease) of the head and neck. Hum Pathol 1993;24:483-92.
  • McAlister WH, Herman T, Dehner LP. Sinus histiocy- tosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol 1990;20:425-32.
  • Baden E, Caveriviere P, Carbonnel S. Sinus histiocyto- sis with massive lymphadenopathy (Destombes-Rosai- Dorfman syndrome) occurring as a single enlarged submandibular lymph node: a light and immunohis- tochemical study with review of the literature. Oral Surg Oral Med Oral Pathol 1987;64:320-6.
  • Goodnight JW, Wang MB, Sercarz JA, Fu YS. Extranodal Rosai-Dorfman disease of the head and neck. Laryngoscope 1996;106(3 Pt 1):253-6.
There are 16 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Serdar Ensari This is me

Adin Selçuk This is me

Hüseyin Dere This is me

Noelia Perez This is me

Serpil Dizbay Sak This is me

Publication Date April 18, 2008
Published in Issue Year 2008 Volume: 18 Issue: 2

Cite

APA Ensari, S., Selçuk, A., Dere, H., Perez, N., et al. (2008). Rosai-Dorfman disease presenting as laryngeal masses. The Turkish Journal of Ear Nose and Throat, 18(2), 110-114.
AMA Ensari S, Selçuk A, Dere H, Perez N, Dizbay Sak S. Rosai-Dorfman disease presenting as laryngeal masses. Tr-ENT. April 2008;18(2):110-114.
Chicago Ensari, Serdar, Adin Selçuk, Hüseyin Dere, Noelia Perez, and Serpil Dizbay Sak. “Rosai-Dorfman Disease Presenting As Laryngeal Masses”. The Turkish Journal of Ear Nose and Throat 18, no. 2 (April 2008): 110-14.
EndNote Ensari S, Selçuk A, Dere H, Perez N, Dizbay Sak S (April 1, 2008) Rosai-Dorfman disease presenting as laryngeal masses. The Turkish Journal of Ear Nose and Throat 18 2 110–114.
IEEE S. Ensari, A. Selçuk, H. Dere, N. Perez, and S. Dizbay Sak, “Rosai-Dorfman disease presenting as laryngeal masses”, Tr-ENT, vol. 18, no. 2, pp. 110–114, 2008.
ISNAD Ensari, Serdar et al. “Rosai-Dorfman Disease Presenting As Laryngeal Masses”. The Turkish Journal of Ear Nose and Throat 18/2 (April 2008), 110-114.
JAMA Ensari S, Selçuk A, Dere H, Perez N, Dizbay Sak S. Rosai-Dorfman disease presenting as laryngeal masses. Tr-ENT. 2008;18:110–114.
MLA Ensari, Serdar et al. “Rosai-Dorfman Disease Presenting As Laryngeal Masses”. The Turkish Journal of Ear Nose and Throat, vol. 18, no. 2, 2008, pp. 110-4.
Vancouver Ensari S, Selçuk A, Dere H, Perez N, Dizbay Sak S. Rosai-Dorfman disease presenting as laryngeal masses. Tr-ENT. 2008;18(2):110-4.