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Early evaluation of auditory dysfunction in patients with type 2 diabetes mellitus

Year 2008, Volume: 18 Issue: 4, 203 - 210, 30.08.2008

Abstract

Objectives: We investigated auditory dysfunction in type 2 diabetic patients with normal hearing. Patients and Methods: Forty patients 22 females; 18 males; mean age 55 years; range 32 to 76 years with type 2 diabetes were examined by distortion product otoacoustic emissions DPOAE and auditory brainstem responses ABR . The patients were evaluated with respect to disease duration, microangiopathy, peripheral neuropathy, and metabolic control. The results were compared with those of 22 healthy controls. Results: Compared to controls, diabetic subjects had decreased DPOAE amplitudes at all frequencies, being significant at 4 kHz p=0.011 ; ABR recordings showed a significant difference only in the III-V interwave interval latency p=0.042 . In the diabetic group, poor metabolic control was associated with significantly decreased DPOAE amplitudes at 4 kHz p=0.046 and 8 kHz p=0.020 ; the presence of microangiopathy was associated with prolonged ABR I-V interwave latency p=0.039 ; and neuropathy was associated with decreased DPOAE amplitudes at 0.75 kHz p=0.022 , 1 kHz p=0.019 , and 3 kHz p=0.049 , and ABR differences in the absolute latency of wave III p=0.007 and the I-III interwave latency p=0.023 . The duration of disease did not affect auditory function p>0.05 . Conclusion: Our results suggest that type 2 diabetes mellitus may lead to auditory dysfunction of cochlear and retrocochlear origin, and that microangiopathy, neuropathy, and poor metabolic control have adverse effects on auditory function.

References

  • Taylor IG, Irwin J. Some audiological aspects of diabe- tes mellitus. J Laryngol Otol 1978;92:99-113.
  • Lisowska G, Namysłowski G, Morawski K, Strojek K. Early identification of hearing impairment in patients with type 1 diabetes mellitus. Otol Neurotol 2001; 22:316-20.
  • Axelsson A, Fagerberg SE. Auditory function in dia- betics. Acta Otolaryngol 1968;66:49-64.
  • Jorgensen MB. The inner ear in diabetes mellitus. Histological studies. Arch Otolaryngol 1961;74:373-81.
  • Jorgensen MB, Buch NH. Studies on inner-ear func- tion and cranial nerves in diabetics. Acta Otolaryngol 1961;53:350-64.
  • Friedman SA, Schulman RH, Weiss S. Hearing and diabetic neuropathy. Arch Intern Med 1975;135:573-6.
  • Reske-Nielsen E, Lundbaek K, Gregersen G, Harmsen A. Pathological changes in the central and peripheral nervous system of young long-term diabetics. The ter- minal neuro-muscular apparatus. Diabetologia 1970;6: 98-103.
  • DeJong RN. CNS manifestations of diabetes mellitus. Postgrad Med 1977;61:101-7.
  • Oh SJ. Normal values for common nerve conduc- tion tests. In: Oh SJ, editor. Clinical electromyogra- phy: nerve conduction studies. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 86-106.
  • Feldman EL, Stevens MJ. Clinical testing in diabetic peripheral neuropathy. Can J Neurol Sci 1994;21:S3-7.
  • Cornblath DR, Chaudhry V, Carter K, Lee D, Seysedadr M, Miernicki M, et al. Total neuropathy score: valida- tion and reliability study. Neurology 1999;53:1660-4.
  • Orts Alborch M, Morant Ventura A, Garcia Callejo J, Perez del Valle B, Lorente R, Marco Algarra J. The study of otoacoustic emissions in diabetes mellitus. Acta Otorrinolaringol Esp 1998;49:25-8. [Abstract]
  • Di Leo MA, Di Nardo W, Cercone S, Ciervo A, Lo Monaco M, Greco AV, et al. Cochlear dysfunction in IDDM patients with subclinical peripheral neuropa- thy. Diabetes Care 1997;20:824-8.
  • Simoncelli C, Ricci G, Molini E, Scionti L, Giommetti S, Pennacchi A, et al. Evoked acoustic oto-emissions in patients with diabetes mellitus. Ann Otolaryngol Chir Cervicofac 1993;110:255-8. [Abstract] 210
  • Park MS, Park SW, Choi JH. Distortion product otoacoustic emissions in diabetics with normal hearing. Scand Audiol Suppl 2001;52:148-51.
  • Erdem T, Ozturan O, Miman MC, Ozturk C, Karatas E. Exploration of the early auditory effects of hyperlipoproteinemia and diabetes mellitus using otoacoustic emissions. Eur Arch Otorhinolaryngol 2003;260:62-6.
  • . Makishima K, Tanaka K. Pathological changes of the inner ear and central auditory pathway in diabetics. Ann Otol Rhinol Laryngol 1971;80:218-28.
  • . Kovar M. The inner ear in diabetes mellitus. ORL J Otorhinolaryngol Relat Spec 1973;35:42-51.
  • Triana RJ, Suits GW, Garrison S, Prazma J, Brechtelsbauer PB, Michaelis OE, et al. Inner ear damage secondary to diabetes mellitus. I. Changes in adolescent SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 1991;117:635-40.
  • . Lisowska G, Namysłowski G, Morawski K, Strojek K. Cochlear dysfunction and diabetic microangiopathy. Scand Audiol Suppl 2001;52:199-203.
  • Bayazit Y, Yilmaz M, Kepekci Y, Mumbuc S, Kanlikama M. Use of the auditory brainstem response testing in the clinical evaluation of the patients with diabetes mellitus. J Neurol Sci 2000;181:29-32.
  • Virtaniemi J, Laakso M, Karja J, Nuutinen J, Karjalainen S. Auditory brainstem latencies in type I (insulin-dependent) diabetic patients. Am J Otolaryngol 1993;14:413-8.
  • Goldsher M, Pratt H, Hassan A, Shenhav R, Eliachar I, Kanter Y. Auditory brainstem evoked potentials in insulin-dependent diabetics with and without peripheral neuropathy Acta Otolaryngol 1986;102:204-8.
  • Rust KR, Prazma J, Triana RJ, Michaelis OE 4th,Pillsbury HC. Inner ear damage secondary to diabetes mellitus. II. Changes in aging SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 1992;118:397-400.

Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi

Year 2008, Volume: 18 Issue: 4, 203 - 210, 30.08.2008

Abstract

Amaç: Normal işiten tip 2 diyabetli hastalarda ortaya çıkabilecek işitsel fonksiyon bozuklukları araştırıldı. Hastalar ve Yöntemler: Tip 2 diyabet tanılı 40 hasta distorsiyon ürünü otoakustik emisyonlar DPOAE ve işitsel beyin sapı yanıtları ABR ile araştırıldı. Tüm olgular hastalık süresi, mikroanjiyopati ve periferik nöropati varlığı ve metabolik kontrol açısından değerlendirildi. Sonuçlar, işitmesi normal ve diyabeti olmayan 22 kişilik kontrol grubuyla karşılaştırıldı.Bulgular: Kontrol grubuyla karşılaştırıldığında, diyabetli olgularda DPOAE düzeyleri, 4 KHz’de anlamlı olmak üzere p=0.011 , tüm frekanslarda daha zayıf bulundu; ABR’de ise, III-V dalgalar arası latans farklı idi p=0.042 . Metabolik kontrolü kötü olan olgularda DPOAE düzeylerinde 4 kHz için p=0.046; 8 kHz için p=0.020 anlamlı azalma, mikroanjiyopatisi olan olgularda ABR I-V dalgalar arası latansta uzama p=0.039 , nöropatisi olan olgularda ise hem DPOAE seviyelerinde 0.75 kHz için p=0.022; 1 kHz için p=0.019; 3 kHz için p=0.049 hem de ABR III dalga mutlak latansı p=0.007 ve I-III dalgalar arası latansta p=0.023 anlamlı farklılık görüldü. Hastalık süresi işitsel fonksiyon bozukluğu üzerine etkili bulunmadı p>0.05 .Sonuç: Bulgularımız, tip 2 diyabetin, koklear ve retrokoklear seviyede işitsel fonksiyonlarda bozulmaya yol açtığını; ayrıca, mikroanjiyopati, nöropati ve hastalığın metabolik kontrol derecesinin de bu bozulmada etkili olabileceğini göstermektedir

References

  • Taylor IG, Irwin J. Some audiological aspects of diabe- tes mellitus. J Laryngol Otol 1978;92:99-113.
  • Lisowska G, Namysłowski G, Morawski K, Strojek K. Early identification of hearing impairment in patients with type 1 diabetes mellitus. Otol Neurotol 2001; 22:316-20.
  • Axelsson A, Fagerberg SE. Auditory function in dia- betics. Acta Otolaryngol 1968;66:49-64.
  • Jorgensen MB. The inner ear in diabetes mellitus. Histological studies. Arch Otolaryngol 1961;74:373-81.
  • Jorgensen MB, Buch NH. Studies on inner-ear func- tion and cranial nerves in diabetics. Acta Otolaryngol 1961;53:350-64.
  • Friedman SA, Schulman RH, Weiss S. Hearing and diabetic neuropathy. Arch Intern Med 1975;135:573-6.
  • Reske-Nielsen E, Lundbaek K, Gregersen G, Harmsen A. Pathological changes in the central and peripheral nervous system of young long-term diabetics. The ter- minal neuro-muscular apparatus. Diabetologia 1970;6: 98-103.
  • DeJong RN. CNS manifestations of diabetes mellitus. Postgrad Med 1977;61:101-7.
  • Oh SJ. Normal values for common nerve conduc- tion tests. In: Oh SJ, editor. Clinical electromyogra- phy: nerve conduction studies. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 86-106.
  • Feldman EL, Stevens MJ. Clinical testing in diabetic peripheral neuropathy. Can J Neurol Sci 1994;21:S3-7.
  • Cornblath DR, Chaudhry V, Carter K, Lee D, Seysedadr M, Miernicki M, et al. Total neuropathy score: valida- tion and reliability study. Neurology 1999;53:1660-4.
  • Orts Alborch M, Morant Ventura A, Garcia Callejo J, Perez del Valle B, Lorente R, Marco Algarra J. The study of otoacoustic emissions in diabetes mellitus. Acta Otorrinolaringol Esp 1998;49:25-8. [Abstract]
  • Di Leo MA, Di Nardo W, Cercone S, Ciervo A, Lo Monaco M, Greco AV, et al. Cochlear dysfunction in IDDM patients with subclinical peripheral neuropa- thy. Diabetes Care 1997;20:824-8.
  • Simoncelli C, Ricci G, Molini E, Scionti L, Giommetti S, Pennacchi A, et al. Evoked acoustic oto-emissions in patients with diabetes mellitus. Ann Otolaryngol Chir Cervicofac 1993;110:255-8. [Abstract] 210
  • Park MS, Park SW, Choi JH. Distortion product otoacoustic emissions in diabetics with normal hearing. Scand Audiol Suppl 2001;52:148-51.
  • Erdem T, Ozturan O, Miman MC, Ozturk C, Karatas E. Exploration of the early auditory effects of hyperlipoproteinemia and diabetes mellitus using otoacoustic emissions. Eur Arch Otorhinolaryngol 2003;260:62-6.
  • . Makishima K, Tanaka K. Pathological changes of the inner ear and central auditory pathway in diabetics. Ann Otol Rhinol Laryngol 1971;80:218-28.
  • . Kovar M. The inner ear in diabetes mellitus. ORL J Otorhinolaryngol Relat Spec 1973;35:42-51.
  • Triana RJ, Suits GW, Garrison S, Prazma J, Brechtelsbauer PB, Michaelis OE, et al. Inner ear damage secondary to diabetes mellitus. I. Changes in adolescent SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 1991;117:635-40.
  • . Lisowska G, Namysłowski G, Morawski K, Strojek K. Cochlear dysfunction and diabetic microangiopathy. Scand Audiol Suppl 2001;52:199-203.
  • Bayazit Y, Yilmaz M, Kepekci Y, Mumbuc S, Kanlikama M. Use of the auditory brainstem response testing in the clinical evaluation of the patients with diabetes mellitus. J Neurol Sci 2000;181:29-32.
  • Virtaniemi J, Laakso M, Karja J, Nuutinen J, Karjalainen S. Auditory brainstem latencies in type I (insulin-dependent) diabetic patients. Am J Otolaryngol 1993;14:413-8.
  • Goldsher M, Pratt H, Hassan A, Shenhav R, Eliachar I, Kanter Y. Auditory brainstem evoked potentials in insulin-dependent diabetics with and without peripheral neuropathy Acta Otolaryngol 1986;102:204-8.
  • Rust KR, Prazma J, Triana RJ, Michaelis OE 4th,Pillsbury HC. Inner ear damage secondary to diabetes mellitus. II. Changes in aging SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 1992;118:397-400.
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İbrahim Aladağ This is me

Semiha Kurt This is me

Ahmet Eyibilen This is me

Mehmet Güven This is me

Ünal Erkorkmaz This is me

Publication Date August 30, 2008
Published in Issue Year 2008 Volume: 18 Issue: 4

Cite

APA Aladağ, İ., Kurt, S., Eyibilen, A., Güven, M., et al. (2008). Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi. The Turkish Journal of Ear Nose and Throat, 18(4), 203-210.
AMA Aladağ İ, Kurt S, Eyibilen A, Güven M, Erkorkmaz Ü. Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi. Tr-ENT. August 2008;18(4):203-210.
Chicago Aladağ, İbrahim, Semiha Kurt, Ahmet Eyibilen, Mehmet Güven, and Ünal Erkorkmaz. “Tip 2 Diyabetli Hastalarda işitsel Fonksiyon bozukluklarının Erken dönemde değerlendirilmesi”. The Turkish Journal of Ear Nose and Throat 18, no. 4 (August 2008): 203-10.
EndNote Aladağ İ, Kurt S, Eyibilen A, Güven M, Erkorkmaz Ü (August 1, 2008) Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi. The Turkish Journal of Ear Nose and Throat 18 4 203–210.
IEEE İ. Aladağ, S. Kurt, A. Eyibilen, M. Güven, and Ü. Erkorkmaz, “Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi”, Tr-ENT, vol. 18, no. 4, pp. 203–210, 2008.
ISNAD Aladağ, İbrahim et al. “Tip 2 Diyabetli Hastalarda işitsel Fonksiyon bozukluklarının Erken dönemde değerlendirilmesi”. The Turkish Journal of Ear Nose and Throat 18/4 (August 2008), 203-210.
JAMA Aladağ İ, Kurt S, Eyibilen A, Güven M, Erkorkmaz Ü. Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi. Tr-ENT. 2008;18:203–210.
MLA Aladağ, İbrahim et al. “Tip 2 Diyabetli Hastalarda işitsel Fonksiyon bozukluklarının Erken dönemde değerlendirilmesi”. The Turkish Journal of Ear Nose and Throat, vol. 18, no. 4, 2008, pp. 203-10.
Vancouver Aladağ İ, Kurt S, Eyibilen A, Güven M, Erkorkmaz Ü. Tip 2 diyabetli hastalarda işitsel fonksiyon bozukluklarının erken dönemde değerlendirilmesi. Tr-ENT. 2008;18(4):203-10.