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Prognostic factors in larynx cancers

Year 2008, Volume: 18 Issue: 4, 221 - 226, 30.08.2008

Abstract

Objectives: We investigated the prognostic factors affecting survival and recurrence in laryngeal cancer. Patients and Methods: The study included 116 patients 4 females, 112 males; mean age 55±9 years; range 35 to 75 years who underwent surgery for squamous cell carcinoma of the larynx. Risk factors for survival and recurrence were analyzed using univariate analysis and Cox regression analysis. The mean follow-up period was 43±25 months. Results: Mortality occurred in 14 patients, nine of which were due to tumoral causes. In univariate analyses, lymphovascular invasion, cartilage invasion, positive surgical margins, postoperative deglutition time, and complications had a significant effect on survival, while recurrence was influenced by age, postoperative deglutition time, postoperative radiotherapy, and positive surgical margins p<0.05 . Cox regression analyses showed that postoperative deglutition time, radiotherapy, recurrence, and tumor localization significantly affected survival, and preoperative differentiation, tracheotomy, pre- and postoperative tumor stage, radiotherapy, cartilage invasion, and positive surgical margins were significant prognostic factors for recurrence p<0.05 . Conclusion: Evaluation of the prognostic factors in larynx cancer may serve as a guide to treatment and follow-up.

References

  • Silverberg E, Boring CC, Squires TS. Cancer statistics, 1990. CA Cancer J Clin 1990;40:9-26.
  • Gallo A, Manciocco V, Simonelli M, Pagliuca G, D’Arcangelo E, de Vincentiis M. Supracricoid partial laryngectomy in the treatment of laryngeal cancer: uni- variate and multivariate analysis of prognostic factors. Arch Otolaryngol Head Neck Surg 2005;131:620-5.
  • Zatterstrom UK, Wennerberg J, Ewers SB, Willen R, Attewell R. Prognostic factors in head and neck can- cer: histologic grading, DNA ploidy, and nodal status. Head Neck 1991;13:477-87.
  • Stell PM. Prognostic factors in laryngeal carcinoma. Clin Otolaryngol Allied Sci 1988;13:399-409.
  • Nicolai P, Redaelli de Zinis LO, Tomenzoli D, Barezzani MG, Bertoni F, Bignardi M, et al. Prognostic determi- nants in supraglottic carcinoma: univariate and Cox regression analysis. Head Neck 1997;19:323-34.
  • Woo JS, Baek SK, Kwon SY, Jung KY, Lee J. T3 supra- glottic cancer: treatment results and prognostic fac- tors. Acta Otolaryngol 2003;123:980-6.
  • Maier H, Gewelke U, Dietz A, Heller WD. Risk fac- tors of cancer of the larynx: results of the Heidelberg case-control study. Otolaryngol Head Neck Surg 1992; 107:577-82.
  • Stephenson WT, Barnes DE, Holmes FF, Norris CW. Gender influences subsite of origin of laryn- geal carcinoma. Arch Otolaryngol Head Neck Surg 1991;117:774-8.
  • Manni JJ, Terhaard CH, de Boer MF, Croll GA, Hilgers FJ, Annyas AA, et al. Prognostic factors for survival in patients with T3 laryngeal carcinoma. Am J Surg 1992;164:682-7.
  • Eiband JD, Elias EG, Suter CM, Gray WC, Didolkar MS. Prognostic factors in squamous cell carcinoma of the larynx. Am J Surg 1989;158:314-7.
  • Erişen L. Baş-boyun kanserlerinde boyuna yaklaşım. In: Engin K, Erişen L, editörler. Baş-boyun kanserleri. İstanbul: Nobel Tıp Kitabevleri; 2003. s. 437-502.
  • Yilmaz T, Hosal AS, Gedikoglu G, Onerci M, Gursel B. Prognostic significance of vascular and perineural invasion in cancer of the larynx. Am J Otolaryngol 1998; 19:83-8.
  • Ozdek A, Sarac S, Akyol U, Unal OF, Sungur A. Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas. Eur Arch Otorhinolaryngol 2000;257:389-92.
  • Johansen LV, Grau C, Overgaard J. Laryngeal carci- noma - multivariate analysis of prognostic factors in 1252 consecutive patients treated with primary radio- therapy. Acta Oncol 2003;42:771-8.
  • Kowalski LP, Franco EL, de Andrade Sobrinho J, Oliveira BV, Pontes PL. Prognostic factors in laryngeal cancer patients submitted to surgical treatment. J Surg Oncol 1991;48:87-95.
  • Merkel DE, McGuire WL. Ploidy, proliferative activity and prognosis. DNA flow cytometry of solid tumors. Cancer 1990;65:1194-205.
  • Alun-Jones T, Clarke PJ, Morrissey S, Hill J. Blood transfusion and laryngeal cancer. Clin Otolaryngol Allied Sci 1991;16:240-4.
  • Pera E, Moreno A, Galindo L. Prognostic factors in laryngeal carcinoma. A multifactorial study of 416 cases. Cancer 1986;58:928-34.
  • Akcam MT, Akkaya A, Deveci S, Onguru O, Gerek M, Ozkaptan Y. The prognostic significance of DNA ploidy in laryngeal cancers. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2002;9:414-23.
  • Harrison DF. Is surgery for the benefit of the patient or the surgeon. In: Kagan AR, Miles J, editors. Head and neck oncology: clinical management. New York: Pergamon Press; 1989. p. 116-20.
  • Brenner B, Marshak G, Sulkes A, Rakowsky E. Prognosis of patients with recurrent laryngeal carci- noma. Head Neck 2001;23:531-5.
  • Baatenburg de Jong RJ, Hermans J, Molenaar J, Briaire JJ, le Cessie S. Prediction of survival in patients with head and neck cancer. Head Neck 2001;23:718-24.

Larenks kanserlerinde prognostik faktörler

Year 2008, Volume: 18 Issue: 4, 221 - 226, 30.08.2008

Abstract

Amaç: Larenks kanserli hastalarda sağkalım ve nüksü etkileyen prognostik faktörler araştırıldı.Hastalar ve Yöntemler: Çalışmada larenks yassı hücreli karsinomu nedeniyle cerrahi tedavi uygulanan 116 hasta değerlendirildi. Sağkalım ve nüks için olası risk faktörleri tekyönlü varyans analizi ve Cox regresyon analizi ile değerlendirildi. Ortalama takip süresi 43±25 ay idi.Bulgular: Mortalite 14 hastada görüldü; bunların dokuzu tümörle ilgili nedenlere bağlıydı. Tekyönlü varyans analizinde, sağkalımı lenfovasküler yayılım, kartilaj tutulumu, cerrahi sınırda tümör olması, ameliyat sonrası yutmaya başlama zamanı ve komplikasyon varlığının; nüksü ise yaş, ameliyat sonrası yutmaya başlama zamanı, ameliyat sonrası radyoterapi uygulanması, cerrahi sınırda tümör bulunmasının anlamlı etkilediği görüldü p

References

  • Silverberg E, Boring CC, Squires TS. Cancer statistics, 1990. CA Cancer J Clin 1990;40:9-26.
  • Gallo A, Manciocco V, Simonelli M, Pagliuca G, D’Arcangelo E, de Vincentiis M. Supracricoid partial laryngectomy in the treatment of laryngeal cancer: uni- variate and multivariate analysis of prognostic factors. Arch Otolaryngol Head Neck Surg 2005;131:620-5.
  • Zatterstrom UK, Wennerberg J, Ewers SB, Willen R, Attewell R. Prognostic factors in head and neck can- cer: histologic grading, DNA ploidy, and nodal status. Head Neck 1991;13:477-87.
  • Stell PM. Prognostic factors in laryngeal carcinoma. Clin Otolaryngol Allied Sci 1988;13:399-409.
  • Nicolai P, Redaelli de Zinis LO, Tomenzoli D, Barezzani MG, Bertoni F, Bignardi M, et al. Prognostic determi- nants in supraglottic carcinoma: univariate and Cox regression analysis. Head Neck 1997;19:323-34.
  • Woo JS, Baek SK, Kwon SY, Jung KY, Lee J. T3 supra- glottic cancer: treatment results and prognostic fac- tors. Acta Otolaryngol 2003;123:980-6.
  • Maier H, Gewelke U, Dietz A, Heller WD. Risk fac- tors of cancer of the larynx: results of the Heidelberg case-control study. Otolaryngol Head Neck Surg 1992; 107:577-82.
  • Stephenson WT, Barnes DE, Holmes FF, Norris CW. Gender influences subsite of origin of laryn- geal carcinoma. Arch Otolaryngol Head Neck Surg 1991;117:774-8.
  • Manni JJ, Terhaard CH, de Boer MF, Croll GA, Hilgers FJ, Annyas AA, et al. Prognostic factors for survival in patients with T3 laryngeal carcinoma. Am J Surg 1992;164:682-7.
  • Eiband JD, Elias EG, Suter CM, Gray WC, Didolkar MS. Prognostic factors in squamous cell carcinoma of the larynx. Am J Surg 1989;158:314-7.
  • Erişen L. Baş-boyun kanserlerinde boyuna yaklaşım. In: Engin K, Erişen L, editörler. Baş-boyun kanserleri. İstanbul: Nobel Tıp Kitabevleri; 2003. s. 437-502.
  • Yilmaz T, Hosal AS, Gedikoglu G, Onerci M, Gursel B. Prognostic significance of vascular and perineural invasion in cancer of the larynx. Am J Otolaryngol 1998; 19:83-8.
  • Ozdek A, Sarac S, Akyol U, Unal OF, Sungur A. Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas. Eur Arch Otorhinolaryngol 2000;257:389-92.
  • Johansen LV, Grau C, Overgaard J. Laryngeal carci- noma - multivariate analysis of prognostic factors in 1252 consecutive patients treated with primary radio- therapy. Acta Oncol 2003;42:771-8.
  • Kowalski LP, Franco EL, de Andrade Sobrinho J, Oliveira BV, Pontes PL. Prognostic factors in laryngeal cancer patients submitted to surgical treatment. J Surg Oncol 1991;48:87-95.
  • Merkel DE, McGuire WL. Ploidy, proliferative activity and prognosis. DNA flow cytometry of solid tumors. Cancer 1990;65:1194-205.
  • Alun-Jones T, Clarke PJ, Morrissey S, Hill J. Blood transfusion and laryngeal cancer. Clin Otolaryngol Allied Sci 1991;16:240-4.
  • Pera E, Moreno A, Galindo L. Prognostic factors in laryngeal carcinoma. A multifactorial study of 416 cases. Cancer 1986;58:928-34.
  • Akcam MT, Akkaya A, Deveci S, Onguru O, Gerek M, Ozkaptan Y. The prognostic significance of DNA ploidy in laryngeal cancers. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2002;9:414-23.
  • Harrison DF. Is surgery for the benefit of the patient or the surgeon. In: Kagan AR, Miles J, editors. Head and neck oncology: clinical management. New York: Pergamon Press; 1989. p. 116-20.
  • Brenner B, Marshak G, Sulkes A, Rakowsky E. Prognosis of patients with recurrent laryngeal carci- noma. Head Neck 2001;23:531-5.
  • Baatenburg de Jong RJ, Hermans J, Molenaar J, Briaire JJ, le Cessie S. Prediction of survival in patients with head and neck cancer. Head Neck 2001;23:718-24.
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Erkan Vuralkan This is me

İstemihan Akın This is me

Gökhan Kuran This is me

Cem Saka This is me

Nihat Akçayöz This is me

Sibel Alicura Tokgöz This is me

Publication Date August 30, 2008
Published in Issue Year 2008 Volume: 18 Issue: 4

Cite

APA Vuralkan, E., Akın, İ., Kuran, G., Saka, C., et al. (2008). Larenks kanserlerinde prognostik faktörler. The Turkish Journal of Ear Nose and Throat, 18(4), 221-226.
AMA Vuralkan E, Akın İ, Kuran G, Saka C, Akçayöz N, Alicura Tokgöz S. Larenks kanserlerinde prognostik faktörler. Tr-ENT. August 2008;18(4):221-226.
Chicago Vuralkan, Erkan, İstemihan Akın, Gökhan Kuran, Cem Saka, Nihat Akçayöz, and Sibel Alicura Tokgöz. “Larenks Kanserlerinde Prognostik faktörler”. The Turkish Journal of Ear Nose and Throat 18, no. 4 (August 2008): 221-26.
EndNote Vuralkan E, Akın İ, Kuran G, Saka C, Akçayöz N, Alicura Tokgöz S (August 1, 2008) Larenks kanserlerinde prognostik faktörler. The Turkish Journal of Ear Nose and Throat 18 4 221–226.
IEEE E. Vuralkan, İ. Akın, G. Kuran, C. Saka, N. Akçayöz, and S. Alicura Tokgöz, “Larenks kanserlerinde prognostik faktörler”, Tr-ENT, vol. 18, no. 4, pp. 221–226, 2008.
ISNAD Vuralkan, Erkan et al. “Larenks Kanserlerinde Prognostik faktörler”. The Turkish Journal of Ear Nose and Throat 18/4 (August 2008), 221-226.
JAMA Vuralkan E, Akın İ, Kuran G, Saka C, Akçayöz N, Alicura Tokgöz S. Larenks kanserlerinde prognostik faktörler. Tr-ENT. 2008;18:221–226.
MLA Vuralkan, Erkan et al. “Larenks Kanserlerinde Prognostik faktörler”. The Turkish Journal of Ear Nose and Throat, vol. 18, no. 4, 2008, pp. 221-6.
Vancouver Vuralkan E, Akın İ, Kuran G, Saka C, Akçayöz N, Alicura Tokgöz S. Larenks kanserlerinde prognostik faktörler. Tr-ENT. 2008;18(4):221-6.