Prognostic factors in larynx cancers

Year 2008, Volume: 18 Issue: 4, 221 - 226, 30.08.2008

Erkan Vuralkan İstemihan Akın Gökhan Kuran Cem Saka Nihat Akçayöz Sibel Alicura Tokgöz

Abstract

Objectives: We investigated the prognostic factors affecting survival and recurrence in laryngeal cancer. Patients and Methods: The study included 116 patients 4 females, 112 males; mean age 55±9 years; range 35 to 75 years who underwent surgery for squamous cell carcinoma of the larynx. Risk factors for survival and recurrence were analyzed using univariate analysis and Cox regression analysis. The mean follow-up period was 43±25 months. Results: Mortality occurred in 14 patients, nine of which were due to tumoral causes. In univariate analyses, lymphovascular invasion, cartilage invasion, positive surgical margins, postoperative deglutition time, and complications had a significant effect on survival, while recurrence was influenced by age, postoperative deglutition time, postoperative radiotherapy, and positive surgical margins p<0.05 . Cox regression analyses showed that postoperative deglutition time, radiotherapy, recurrence, and tumor localization significantly affected survival, and preoperative differentiation, tracheotomy, pre- and postoperative tumor stage, radiotherapy, cartilage invasion, and positive surgical margins were significant prognostic factors for recurrence p<0.05 . Conclusion: Evaluation of the prognostic factors in larynx cancer may serve as a guide to treatment and follow-up.

Keywords

Carcinoma, squamous cell/surgery, laryngeal neoplasms/mortality, laryngectomy, prognosis, survival rate

Larenks kanserlerinde prognostik faktörler

Abstract

Amaç: Larenks kanserli hastalarda sağkalım ve nüksü etkileyen prognostik faktörler araştırıldı.Hastalar ve Yöntemler: Çalışmada larenks yassı hücreli karsinomu nedeniyle cerrahi tedavi uygulanan 116 hasta değerlendirildi. Sağkalım ve nüks için olası risk faktörleri tekyönlü varyans analizi ve Cox regresyon analizi ile değerlendirildi. Ortalama takip süresi 43±25 ay idi.Bulgular: Mortalite 14 hastada görüldü; bunların dokuzu tümörle ilgili nedenlere bağlıydı. Tekyönlü varyans analizinde, sağkalımı lenfovasküler yayılım, kartilaj tutulumu, cerrahi sınırda tümör olması, ameliyat sonrası yutmaya başlama zamanı ve komplikasyon varlığının; nüksü ise yaş, ameliyat sonrası yutmaya başlama zamanı, ameliyat sonrası radyoterapi uygulanması, cerrahi sınırda tümör bulunmasının anlamlı etkilediği görüldü p

Keywords

Karsinom, yassı epitel hücreli/cerrahi, larenks neoplazileri/mortalite, larenjektomi, prognoz, sağkalım oranı

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