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Our experience with surgery of non melanoma cutaneous malignancies of head and neck

Year 2009, Volume: 19 Issue: 3, 138 - 145, 08.06.2009

Abstract

Objectives: To evaluate the cases underwent surgery with the diagnosis of head and neck non melanoma skin malignancies. Patients and Methods: Clinical records of 89 patients 33 females, 56 males; mean age 65.4 years; ranges 41 to 87 years who underwent excision and reconstruction with the diagnosis of skin malignancy at ENT clinics of Ege University Hospital between April 2004 and March 2006 and 101 lesions were retrospectively reviewed. The patients who were diagnosed with non melanoma skin malignancy and whose surgical decisions were concluded at the common council of dermatology clinic, ear nose and throat clinic and oral diagnosis clinics were included in the study. In all cases pre- and postoperative pictures of lesions, pathological results and follow-up results were all evaluated. Results: The 32 of 101 lesions were located at nasal esthetical unit and 15 of these were at alar region subunit. The second most common location was lip with 29 lesions and 24 of them were located at lower lip. The evaluation of flap techniques performed for the reconstruction of excision defect revealed that extending flap was the second common method with 12 cases after primary closure with 23 cases. The pathological results of these lesions were found to be squamous cell carcinomas with 49 lesions and basal cell carcinomas with 41 lesions. In three cases the surgical margins were positive, meaning tumor still remains in normal tissue. Neck dissection was performed in seven patients. There was no patient with recurrent malignant lesion during the follow-up period mean=47.5 months range 37-57 months . Conclusion: Cutaneous malignancies are the most common malignancy type worldwide. Successful results are available if these lesions are diagnosed early, excised with correct methods and reconstructed with appropriate techniques.

References

  • Alkan Z, Çelikoyar M. Baş boyun cildinin melanom dışı kanserleri. In: Engin K, Erişen L, editörler. Baş boyun kanserleri. 21. Bölüm. İstanbul: Nobel Tıp Kitapevleri; 2003. s. 547-77.
  • Junqueira LC. Skin. In: Junqueira LC, Carneiro J, Kelley RO, editors. Basic histology. 8th ed. Norwalk: Appleton & Lange; 1995. p. 346-58.
  • Parker SL, Tong T, Bolden S, Wingo PA. Cancer statis- tics, 1996. CA Cancer J Clin 1996;461:5-27.
  • Marcil I, Stern RS. Risk of developing a subsequent non- melanoma skin cancer in patients with a history of non- melanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000; 136:1524-30.
  • Brown RO, Osguthorpe JD. Management of the neck in nonmelanocytic cutaneous carcinomas. Otolaryngol Clin North Am 1998;31:841-56.
  • Staples MP, Elwood M, Burton RC, Williams JL, Marks R, Giles GG. Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J Aust 2006;184:6-10.
  • Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Schuller DE, editors. Otolaryngology-head and neck surgery. 3rd ed. St. Louis: Mosby; 1998.
  • Stucker FJ, Nathan CO, Lian TS. Cutaneous malig- nancy. In: Bailey BJ, Calhoun KH, editors. Head and Neck surgery-Otolaryngology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins 2001. p. 1223-35.
  • Gray DT, Suman VJ, Su WP, Clay RP, Harmsen WS, Roenigk RK. Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992. Arch Dermatol 1997;133:735-40.
  • Giles GG, Marks R, Foley P. Incidence of non-melano- cytic skin cancer treated in Australia. Br Med J (Clin Res Ed) 1988;296:13-7.
  • Preston DS, Stern RS. Nonmelanoma cancers of the skin. N Engl J Med 1992;327:1649-62.
  • Raasch BA, Buettner PG. Multiple nonmelanoma skin cancer in an exposed Australian population. Int J Dermatol 2002;41:652-8.
  • Bergstresser PR, Halprin KM. Multiple sequential skin cancers. The risk of skin cancer in patients with previ- ous skin cancer. Arch Dermatol 1975;111:995-6.
  • Centers for Disease Control and Prevention (CDC). Cigar smoking among teenagers-United States, Massachusetts, and New York, 1996. MMWR Morb Mortal Wkly Rep 1997;46:433-40.
  • Wynder EL. Etiological aspects of squamous cancers of the head and neck. JAMA 1971;215:452-3.
  • Ezzoubi M, Benbrahim A, Fihri JF, Bahechar N, Boukind el H. Reconstruction after tumour’s excision in lip’s cancer: report of 100 cases. Rev Laryngol Otol Rhinol (Bord) 2005;126:141-6. [Abstract]
  • Kwa RE, Campana K, Moy RL. Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 1992; 26:1-26.
  • Wilson R, Jackson J, Rassekh C. A study of squamous cell carcinoma of the lip at West Virginia University Hospitals from 1980-2000. W V Med J 2005;101:217-9.
  • Bulut F, Demir CY. Burun defektlerinin onarımında paramedian alın flebi. Fırat Tıp Dergisi 2003;8:141-3.
  • Brodland DG. Paramedian forehead flap reconstruc- tion for nasal defects. Dermatol Surg 2005;31:1046-52.
  • Cook JL. Reconstructive utility of the bilobed flap: les- sons from flap successes and failures. Dermatol Surg 2005;31:1024-33.
  • Wang SQ, Behroozan DS, Goldberg LH. Perialar cres- centic advancement flap for upper cutaneous lip defects. Dermatol Surg 2005;31:1445-7.
  • Satorres Nieto M, Gargallo Albiol J, Gay Escoda C. Surgical management of actinic cheilitis. Med Oral 2001;6:205-17. [Abstract]
  • Manstein CH. Vermilionectomy and mucosal advance- ment. Plast Reconstr Surg 1997;100:1363.
  • Cordoro KM, Russell MA. Minimally invasive options for cutaneous defects: secondary intention healing, partial closure, and skin grafts. Facial Plast Surg Clin North Am 2005;13:215-30.
  • Adams DC, Ramsey ML. Grafts in dermatologic sur- gery: review and update on full- and split-thickness skin grafts, free cartilage grafts, and composite grafts. Dermatol Surg 2005;31:1055-67.
  • O’Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS, Jackson MA. Significance of clinical stage, extent of surgery, and pathologic findings in metastatic cutaneous squamous carcinoma of the parotid gland. Head Neck 2002;24:417-22.
  • O’Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS. Incidence of cervical node involvement in meta- static cutaneous malignancy involving the parotid gland. Head Neck 2001;23:744-8.
  • delCharco JO, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Mendenhall NP. Carcinoma of the skin metastatic to the parotid area lymph nodes. Head Neck 1998;20:369-73.
  • Stern RS, Laird N, Melski J, Parrish JA, Fitzpatrick TB, Bleich HL. Cutaneous squamous-cell carcinoma in patients treated with PUVA. N Engl J Med 1984; 310:1156-61.
  • Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcino- genesis. Photochem Photobiol 1996;63:432-5.
  • Lane JE, Kent DE. Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery. Curr Surg 2005;62:518-26.
  • Cohen PR, Schulze KE, Nelson BR. Cutaneous carci- noma with mixed histology: a potential etiology for skin cancer recurrence and an indication for Mohs microscopically controlled surgical excision. South Med J 2005;98:740-7.
  • Pennington BE, Leffell DJ Mohs micrographic sur- gery: established uses and emerging trends. Oncology (Williston Park) 2005;19:1165-71.
  • Choo R, Woo T, Assaad D, Antonyshyn O, Barnes EA, McKenzie D, et al. What is the microscopic tumor extent beyond clinically delineated gross tumor boundary in nonmelanoma skin cancers? Int J Radiat Oncol Biol Phys 2005;62:1096-9.
  • Levine HL, Bailin PL. Basal cell carcinoma of the head and neck: identification of the high risk patient. Laryngoscope 1980;90:955-61.
  • Roenigk RK, Ratz JL, Bailin PL, Wheeland RG. Trends in the presentation and treatment of basal cell carcino- mas. J Dermatol Surg Oncol 1986;12:860-5.
  • Pascal RR, Hobby LW, Lattes R, Crikelair GF. Prognosis of “incompletely excised” versus “com- pletely excised” basal cell carcinoma. Plast Reconstr Surg 1968;41:328-32.
  • Dellon AL, DeSilva S, Connolly M, Ross A. Prediction of recurrence in incompletely excised basal cell carci- noma. Plast Reconstr Surg 1985;75:860-71.
  • Gooding CA, White G, Yatsuhashi M. Significance of marginal extension in excised basal-cell carcinoma. N Engl J Med 1965;273:923-4.
  • Rowe DE, Carroll RJ, Day CL Jr. Long-term recurrence rates in previously untreated (primary) basal cell car- cinoma: implications for patient follow-up. J Dermatol Surg Oncol 1989;15:315-28.
  • Silverman MK, Kopf AW, Bart RS, Grin CM, Levenstein MS. Recurrence rates of treated basal cell carcinomas. Part 3: Surgical excision. J Dermatol Surg Oncol 1992;18:471-6.
  • Rowe DE, Carroll RJ, Day CL Jr. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol 1992;26:976-90.
  • Johnson TM, Rowe DE, Nelson BR, Swanson NA. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 1992;26:467-84.

Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz

Year 2009, Volume: 19 Issue: 3, 138 - 145, 08.06.2009

Abstract

Amaç: Baş boyun bölgesinde melanom dışı deri kanseri tanısı ile cerrahi tedavi uygulanan olgular değerlendirildi.Hastalar ve Yöntemler: Bu çalışmada Ege Üniversitesi Tıp Fakültesi KBB kliniğinde Nisan 2004-Mart 2006 tarihleri arasında deri kanseri nedeniyle eksizyon ve onarım uygulanan 89 hastada 33 kadın, 56 erkek; ort. yaş 65.4 yıl; dağılım 41-87 yıl saptanan 101 lezyonun kayıtları geriye dönük olarak incelendi. Çalışmaya ameliyat öncesi melanom dışı deri kanseri tanısı konmuş ve dermatoloji, kulak burun boğaz ve oral diyagnoz kliniklerinin ortak konseyinde değerlendirilerek cerrahi kararı alınan hastalar dahil edildi. Olgularının tümünde cerrahi öncesi ve sonrası lezyon fotoğrafları, patoloji sonuçları, takip sonuçları değerlendirildi.Bulgular: Cerrahi uygulanan 101 lezyonun 32’sinin burun estetik ünitesinde olduğu ve bunların 15’inde lezyonun ala nazi yerleşimli olduğu tespit edildi. Burun bölgesini takiben ikinci sıklıkta 29 lezyon ile dudak bölgesi gelmekteydi ve bunların da 24’ü alt dudak yerleşimliydi. Eksizyon sonrasında 23 hastaya primer kapatma ve ikinci sıklıkla 12 hastaya ilerletme flebi uygulandı. Lezyonların patoloji raporları incelendiğinde 49 lezyonda skuamöz hücreli karsinom ve 41 hastada bazal hücreli karsinom olduğu belirlendi. Üç hastada patoloji raporunda cerrahi sınırda tümörün devam ettiği bildirildi. Yedi hastaya boyun diseksiyonu uygulandı. Hastalarda takip süresinde ortalama 47.5 ay dağılım 37-57 ay primer tümöral lezyon açısından yineleme gözlenmedi.Sonuç: Deri kanserleri tüm dünyada en sık görülen kanser türüdür. Bu tümörler erken tanı konarak uygun teknikle eksize edilirse, onarım uygulandığında oldukça başarılı sonuçlar alınmaktadır

References

  • Alkan Z, Çelikoyar M. Baş boyun cildinin melanom dışı kanserleri. In: Engin K, Erişen L, editörler. Baş boyun kanserleri. 21. Bölüm. İstanbul: Nobel Tıp Kitapevleri; 2003. s. 547-77.
  • Junqueira LC. Skin. In: Junqueira LC, Carneiro J, Kelley RO, editors. Basic histology. 8th ed. Norwalk: Appleton & Lange; 1995. p. 346-58.
  • Parker SL, Tong T, Bolden S, Wingo PA. Cancer statis- tics, 1996. CA Cancer J Clin 1996;461:5-27.
  • Marcil I, Stern RS. Risk of developing a subsequent non- melanoma skin cancer in patients with a history of non- melanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000; 136:1524-30.
  • Brown RO, Osguthorpe JD. Management of the neck in nonmelanocytic cutaneous carcinomas. Otolaryngol Clin North Am 1998;31:841-56.
  • Staples MP, Elwood M, Burton RC, Williams JL, Marks R, Giles GG. Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J Aust 2006;184:6-10.
  • Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Schuller DE, editors. Otolaryngology-head and neck surgery. 3rd ed. St. Louis: Mosby; 1998.
  • Stucker FJ, Nathan CO, Lian TS. Cutaneous malig- nancy. In: Bailey BJ, Calhoun KH, editors. Head and Neck surgery-Otolaryngology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins 2001. p. 1223-35.
  • Gray DT, Suman VJ, Su WP, Clay RP, Harmsen WS, Roenigk RK. Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992. Arch Dermatol 1997;133:735-40.
  • Giles GG, Marks R, Foley P. Incidence of non-melano- cytic skin cancer treated in Australia. Br Med J (Clin Res Ed) 1988;296:13-7.
  • Preston DS, Stern RS. Nonmelanoma cancers of the skin. N Engl J Med 1992;327:1649-62.
  • Raasch BA, Buettner PG. Multiple nonmelanoma skin cancer in an exposed Australian population. Int J Dermatol 2002;41:652-8.
  • Bergstresser PR, Halprin KM. Multiple sequential skin cancers. The risk of skin cancer in patients with previ- ous skin cancer. Arch Dermatol 1975;111:995-6.
  • Centers for Disease Control and Prevention (CDC). Cigar smoking among teenagers-United States, Massachusetts, and New York, 1996. MMWR Morb Mortal Wkly Rep 1997;46:433-40.
  • Wynder EL. Etiological aspects of squamous cancers of the head and neck. JAMA 1971;215:452-3.
  • Ezzoubi M, Benbrahim A, Fihri JF, Bahechar N, Boukind el H. Reconstruction after tumour’s excision in lip’s cancer: report of 100 cases. Rev Laryngol Otol Rhinol (Bord) 2005;126:141-6. [Abstract]
  • Kwa RE, Campana K, Moy RL. Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 1992; 26:1-26.
  • Wilson R, Jackson J, Rassekh C. A study of squamous cell carcinoma of the lip at West Virginia University Hospitals from 1980-2000. W V Med J 2005;101:217-9.
  • Bulut F, Demir CY. Burun defektlerinin onarımında paramedian alın flebi. Fırat Tıp Dergisi 2003;8:141-3.
  • Brodland DG. Paramedian forehead flap reconstruc- tion for nasal defects. Dermatol Surg 2005;31:1046-52.
  • Cook JL. Reconstructive utility of the bilobed flap: les- sons from flap successes and failures. Dermatol Surg 2005;31:1024-33.
  • Wang SQ, Behroozan DS, Goldberg LH. Perialar cres- centic advancement flap for upper cutaneous lip defects. Dermatol Surg 2005;31:1445-7.
  • Satorres Nieto M, Gargallo Albiol J, Gay Escoda C. Surgical management of actinic cheilitis. Med Oral 2001;6:205-17. [Abstract]
  • Manstein CH. Vermilionectomy and mucosal advance- ment. Plast Reconstr Surg 1997;100:1363.
  • Cordoro KM, Russell MA. Minimally invasive options for cutaneous defects: secondary intention healing, partial closure, and skin grafts. Facial Plast Surg Clin North Am 2005;13:215-30.
  • Adams DC, Ramsey ML. Grafts in dermatologic sur- gery: review and update on full- and split-thickness skin grafts, free cartilage grafts, and composite grafts. Dermatol Surg 2005;31:1055-67.
  • O’Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS, Jackson MA. Significance of clinical stage, extent of surgery, and pathologic findings in metastatic cutaneous squamous carcinoma of the parotid gland. Head Neck 2002;24:417-22.
  • O’Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS. Incidence of cervical node involvement in meta- static cutaneous malignancy involving the parotid gland. Head Neck 2001;23:744-8.
  • delCharco JO, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Mendenhall NP. Carcinoma of the skin metastatic to the parotid area lymph nodes. Head Neck 1998;20:369-73.
  • Stern RS, Laird N, Melski J, Parrish JA, Fitzpatrick TB, Bleich HL. Cutaneous squamous-cell carcinoma in patients treated with PUVA. N Engl J Med 1984; 310:1156-61.
  • Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcino- genesis. Photochem Photobiol 1996;63:432-5.
  • Lane JE, Kent DE. Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery. Curr Surg 2005;62:518-26.
  • Cohen PR, Schulze KE, Nelson BR. Cutaneous carci- noma with mixed histology: a potential etiology for skin cancer recurrence and an indication for Mohs microscopically controlled surgical excision. South Med J 2005;98:740-7.
  • Pennington BE, Leffell DJ Mohs micrographic sur- gery: established uses and emerging trends. Oncology (Williston Park) 2005;19:1165-71.
  • Choo R, Woo T, Assaad D, Antonyshyn O, Barnes EA, McKenzie D, et al. What is the microscopic tumor extent beyond clinically delineated gross tumor boundary in nonmelanoma skin cancers? Int J Radiat Oncol Biol Phys 2005;62:1096-9.
  • Levine HL, Bailin PL. Basal cell carcinoma of the head and neck: identification of the high risk patient. Laryngoscope 1980;90:955-61.
  • Roenigk RK, Ratz JL, Bailin PL, Wheeland RG. Trends in the presentation and treatment of basal cell carcino- mas. J Dermatol Surg Oncol 1986;12:860-5.
  • Pascal RR, Hobby LW, Lattes R, Crikelair GF. Prognosis of “incompletely excised” versus “com- pletely excised” basal cell carcinoma. Plast Reconstr Surg 1968;41:328-32.
  • Dellon AL, DeSilva S, Connolly M, Ross A. Prediction of recurrence in incompletely excised basal cell carci- noma. Plast Reconstr Surg 1985;75:860-71.
  • Gooding CA, White G, Yatsuhashi M. Significance of marginal extension in excised basal-cell carcinoma. N Engl J Med 1965;273:923-4.
  • Rowe DE, Carroll RJ, Day CL Jr. Long-term recurrence rates in previously untreated (primary) basal cell car- cinoma: implications for patient follow-up. J Dermatol Surg Oncol 1989;15:315-28.
  • Silverman MK, Kopf AW, Bart RS, Grin CM, Levenstein MS. Recurrence rates of treated basal cell carcinomas. Part 3: Surgical excision. J Dermatol Surg Oncol 1992;18:471-6.
  • Rowe DE, Carroll RJ, Day CL Jr. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol 1992;26:976-90.
  • Johnson TM, Rowe DE, Nelson BR, Swanson NA. Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 1992;26:467-84.
There are 44 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Uygar Levent Demir This is me

Fazıl Apaydın This is me

Publication Date June 8, 2009
Published in Issue Year 2009 Volume: 19 Issue: 3

Cite

APA Demir, U. L., & Apaydın, F. (2009). Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz. The Turkish Journal of Ear Nose and Throat, 19(3), 138-145.
AMA Demir UL, Apaydın F. Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz. Tr-ENT. June 2009;19(3):138-145.
Chicago Demir, Uygar Levent, and Fazıl Apaydın. “Baş Boyun bölgesinin Melanom dışı Deri Kanserlerinde Cerrahi Deneyimimiz”. The Turkish Journal of Ear Nose and Throat 19, no. 3 (June 2009): 138-45.
EndNote Demir UL, Apaydın F (June 1, 2009) Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz. The Turkish Journal of Ear Nose and Throat 19 3 138–145.
IEEE U. L. Demir and F. Apaydın, “Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz”, Tr-ENT, vol. 19, no. 3, pp. 138–145, 2009.
ISNAD Demir, Uygar Levent - Apaydın, Fazıl. “Baş Boyun bölgesinin Melanom dışı Deri Kanserlerinde Cerrahi Deneyimimiz”. The Turkish Journal of Ear Nose and Throat 19/3 (June 2009), 138-145.
JAMA Demir UL, Apaydın F. Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz. Tr-ENT. 2009;19:138–145.
MLA Demir, Uygar Levent and Fazıl Apaydın. “Baş Boyun bölgesinin Melanom dışı Deri Kanserlerinde Cerrahi Deneyimimiz”. The Turkish Journal of Ear Nose and Throat, vol. 19, no. 3, 2009, pp. 138-45.
Vancouver Demir UL, Apaydın F. Baş boyun bölgesinin melanom dışı deri kanserlerinde cerrahi deneyimimiz. Tr-ENT. 2009;19(3):138-45.